Sentinel Node Biopsy Should Be Offered in Thin Melanoma with Mitotic Rate Greater than One

BACKGROUND
The American Joint Committee on Cancer recently added mitotic rate (MR) to their seventh edition staging system for melanomas, which went into effect on January 1, 2010. MR has replaced the Clark level of invasion for T1 melanomas. Dermatologists and dermatopathologists should be aware of these new guidelines.


OBJECTIVE
To clarify how MR may be used to determine the prognosis of thin melanomas and to identify patients with thin melanomas who would be candidates for a sentinel lymph node biopsy (SLNB).


METHODS
Reports in the literature were reviewed regarding mitotic rate ...

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