Wednesday, January 18, 2012

A Systematic Review of worldwide incidence of Non-melanoma skin cancer

Abstract

Background:  Non-melanoma skin cancer (NMSC) is the most common cancer affecting Caucasians and the incidence is increasing worldwide. This systematic review brings together 75 studies conducted over the past half decade to look at geographic variations and trends worldwide in NMSC, and specifically incidence data is compared to recent UK cancer registry data.


Materials and Methods:  Following the development of a comprehensive search strategy, an assessment tool was adapted to look at the methodological quality of the eligible studies.


Results:  Most of the studies focused on Caucasian populations in Europe, USA and ...

A Systematic Review of worldwide incidence of Non-melanoma skin cancer is a post from: Skincare




A Systematic Review of worldwide incidence of Non-melanoma skin cancer via BuzzBlazer.com

Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism.

Summary

Background:  Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.


Objectives:  Single nucleotide polymorphisms (GSTP1) and copy number variants (GSTM1 and GSTT1) may be candidate low-penetrance variants with a role in susceptibility to malignant melanoma (MM).


Methods:  In this case-control study, 562 Spanish sporadic melanoma patients and 338 cancer-free control subjects were included, and the role of these GST polymorphisms was investigated. Genotypes were established by quantitative real time-PCR for GSTM1 ...

Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism. is a post from: Skincare




Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism. via BuzzBlazer.com

Primary cutaneous nocardiosis caused by Nocardia beijingensis

Primary cutaneous nocardiosis caused by Nocardia beijingensis is a post from: Skincare

Primary cutaneous nocardiosis caused by Nocardia beijingensis is a post from: Skincare




Primary cutaneous nocardiosis caused by Nocardia beijingensis via BuzzBlazer.com

Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp – a randomized multicentre study

Abstract

Background:  Photodynamic therapy (PDT) is an attractive therapy for non-melanoma skin cancers and actinic keratoses (AKs). Daylight-mediated PDT is a simple and tolerable treatment procedure for PDT. Methyl aminolevulinate (MAL) -PDT is approved for the treatment of thin or non-hyperkeratotic actinic keratoses on the face and scalp. However, thick AK lesions are often treated as well when present in the field-cancerized treatment area.


Objectives:  The aim of the study was in a randomized multicentre study to evaluate efficacy of daylight-mediated PDT for different severity grades of AKs.


Methods:  145 patients with a ...

Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp – a randomized multicentre study is a post from: Skincare




Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp – a randomized multicentre study via BuzzBlazer.com

A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone

A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone is a post from: Skincare

A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone is a post from: Skincare




A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone via BuzzBlazer.com

Sunday, January 15, 2012

Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid

Abstract

Background:  Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterised by circulating autoantibodies against BP180 and BP230. For BP180, the NC16A domain has previously been identified as the main antigenic target in BP, while data about the diagnostic value of epitopes on BP230 were inconclusive.


Objectives:  To identify the most appropriate epitopes on BP230 to be applied in a simple, sensitive, and highly specific ELISA for routine detection of serum autoantibodies.


Methods:  Ten overlapping linear fragments covering the whole length of BP230 were expressed in E. coli. Based on Western blot ...

Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid is a post from: Skincare




Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid via BuzzBlazer.com

Interventions for treating oral lichen planus

Abstract

Background:  Oral lichen planus (OLP) is a common chronic inflammatory disease associated with cell-mediated immunological dysfunction. Symptomatic OLP is painful and complete healing is rare.


Objectives. To assess the evidence for the efficacy and safety of treatments for symptomatic OLP.


Methods:  Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched in January 2011 to identify all randomized controlled trials evaluating any intervention for the treatment of symptomatic OLP.


Results:  28 trials were included in this Cochrane review. There is no evidence from 3 ...

Interventions for treating oral lichen planus is a post from: Skincare




Interventions for treating oral lichen planus via BuzzBlazer.com

Critical temperature threshold measurement for cold urticaria: a randomised controlled trial of H1-antihistamine up-dosing

Abstract

Background:  Cold urticaria is a rare but severe and potentially lethal condition. It is primarily treated symptomatically with H1-antihistamines. However, patients have a variable response to these drugs and up-to-now it has not been possible to readily predict response to therapy of individual patients.


Objectives:  The aim of this study was to assess the severity of the cold urticaria in naïve patients and the response to therapy of patients treated with increasing doses of an H1-antihistamine by measurement of critical temperature thresholds (CTT) for producing wheals on the forearm.


Methods:  This two ...

Critical temperature threshold measurement for cold urticaria: a randomised controlled trial of H1-antihistamine up-dosing is a post from: Skincare




Critical temperature threshold measurement for cold urticaria: a randomised controlled trial of H1-antihistamine up-dosing via BuzzBlazer.com

The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score

Abstract

Background:  There is increased expression of type I interferon (IFN)-regulated proteins in the blood and target tissues of patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). Patients with SLE have increased IFN-regulated gene expression pointing towards a possible underlying genetic defect.


Objectives:  We measured expression levels of five type I IFN-regulated genes that are highly expressed in SLE in the peripheral blood of patients with CLE and correlated expression levels with cutaneous disease activity.


Methods:  Peripheral blood was obtained from 10 healthy controls and 30 patients with CLE, including ...

The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score is a post from: Skincare




The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score via BuzzBlazer.com

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

Abstract

Background:  Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT-induced immunosuppression leading to ineffective anti-tumour immune responses may be a factor in treatment failure.


Objective:  To examine the impact of topical PDT on leucocyte trafficking following clinical treatment of BCC.


Methods:  Superficial BCC in eight white Caucasian patients were treated with methyl aminolaevulinate (MAL)-PDT. Biopsies for immunohistochemical assessment were taken from BCC pre-PDT, 1h and 24h post-PDT and from untreated healthy skin.


Results:  Treatment of BCC with MAL-PDT produced a rapid neutrophil infiltration, commencing by 1h and ...

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma is a post from: Skincare




Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma via BuzzBlazer.com

The Pleasurability of Scratching an Itch: A Psychophysical and Topographical Assessment

Abstract

Background:  Scratching an itch is perceived as being pleasurable. However, an analysis of topographical variations in itch intensity, the effectiveness of scratching to provide itch relief and the associated pleasurability has not been performed at different body sites.


Objective:  To examine the role of scratching pleasurability in providing itch relief by investigating whether itch intensity is perceived differently at 3 different sites and to assess a potential correlation between the pleasurability and itch attenuation induced by scratching.


Methods:  Itch was induced on the forearm, ankle and back using cowhage spicules in eighteen ...

The Pleasurability of Scratching an Itch: A Psychophysical and Topographical Assessment is a post from: Skincare




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Five Japanese cases of anti-Dsg1 antibody positive and anti-Dsg3 antibody negative pemphigus with oral lesions

Abstract

Background:  Oral mucosal lesions developed in pemphigus vulgaris, but not in pemphigus foliaceus. This clinical phenomenon is explained by ‘desmoglein (Dsg) compensation theory’. Dsg3 and Dsg1 are major autoantigens for pemphigus vulgaris and pemphigus foliaceus, respectively. Dsg3 is overexpressed and Dsg1 is weakly expressed on the oral mucosa. Thus, on the oral mucosa, suppression of Dsg3 function by anti-Dsg3 autoantibodies is not compensated by weakly expressed Dsg1 in pemphigus vulgaris, while suppression of Dsg1function by anti-Dsg1 autoantibodies is perfectly compensated by richly expressed Dsg3 in pemphigus foliaceus.


Objectives:  We present five ...

Five Japanese cases of anti-Dsg1 antibody positive and anti-Dsg3 antibody negative pemphigus with oral lesions is a post from: Skincare




Five Japanese cases of anti-Dsg1 antibody positive and anti-Dsg3 antibody negative pemphigus with oral lesions via BuzzBlazer.com

Phototherapy in France: Quantitative data from the National Health Insurance register

Phototherapy in France: Quantitative data from the National Health Insurance register is a post from: Skincare

Phototherapy in France: Quantitative data from the National Health Insurance register is a post from: Skincare




Phototherapy in France: Quantitative data from the National Health Insurance register via BuzzBlazer.com

Dermatological emergencies: a comparative study of activity in 2000 and 2010

Abstract

Background and objective  Studies of dermatological emergencies (DE) are few. We evaluated the activity in our DE unit in a 1-month retrospective study and compared the results with a similar study performed in the same department in 2000.


Methods  We reviewed the charts of all outpatients seen in the DE unit in January 2010, collecting data on age, sex, place of residence, referral mode, day and hour of consultation, true emergency or non-emergency, diagnosis and follow-up.


Results  In January 2010, we serviced 605 patients (58% males, mean age 40 ± 21 years), 21% more ...

Dermatological emergencies: a comparative study of activity in 2000 and 2010 is a post from: Skincare




Dermatological emergencies: a comparative study of activity in 2000 and 2010 via BuzzBlazer.com

Validation of self-reported erythema: comparison of self-reports, researcher assessment and objective measurements in sun worshippers and skiers

Abstract

Background  Most epidemiological data of sunburn related to skin cancer have come from self-reporting in diaries and questionnaires. We thought it important to validate the reliability of such data.


Objective  To validate the quality of self-reported erythema by sun worshippers and skiers, and to validate the ability to determine erythema visually compared with objectively measured erythema.


Methods  The skin in a group of sun worshippers in Tenerife and of skiers in Austria was closely monitored over a week. The participants used a diary to record any erythema assessed on different skin sites ...

Validation of self-reported erythema: comparison of self-reports, researcher assessment and objective measurements in sun worshippers and skiers is a post from: Skincare




Validation of self-reported erythema: comparison of self-reports, researcher assessment and objective measurements in sun worshippers and skiers via BuzzBlazer.com

Skin fragility and blistering secondary to imatinib

Skin fragility and blistering secondary to imatinib is a post from: Skincare

Skin fragility and blistering secondary to imatinib is a post from: Skincare




Skin fragility and blistering secondary to imatinib via BuzzBlazer.com

The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris

Abstract

Background  Although there are several studies about the alteration in skin flora, limited number of reports about changes in the microbial contents and their resistance profile of other body sites in patients treated with isotretinoin for acne vulgaris.


Objectives  The aim of this study was to investigate the effects of systemic isotretinoin and antibiotic therapy on the microbial floras of oropharynx, nose and feces in acne patients.


Methods  Treatment groups of isotretinoin and antibiotics consisting of 20 and 15 patients, respectively were included. Microbiological culture samples were taken at baseline and once ...

The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris is a post from: Skincare




The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris via BuzzBlazer.com

Studies on serum 8-hydroxy guanosine (8-OHdG) as reliable biomarker for psoriasis

Abstract

Background  Oxidative stress was implicated in the psoriasis disease development and may damage DNA leading to keratinocytes cell death. No serum biomarker was available for the oxidative DNA damage.


Objectives  To evaluate the 8-OHdG (8-Hydroxy guanosine) as reliable biomarker for the oxidative stress in psoriatic patients with severity.


Methods  A total of 30 patients were considered for the study and graded according to the Psoriasis Area Severity Index (PASI) and 10 healthy controls. Blood was collected under aseptic condition, and serum was separated. Serum 8-OHdG and total antioxidant capacity was measured by ...

Studies on serum 8-hydroxy guanosine (8-OHdG) as reliable biomarker for psoriasis is a post from: Skincare




Studies on serum 8-hydroxy guanosine (8-OHdG) as reliable biomarker for psoriasis via BuzzBlazer.com

Erysipelas-like erythema as the presenting feature of familial Mediterranean fever

Abstract

Background  ‘Erysipelas-like’ erythema (ELE) is a well recognized, although uncommon, manifestation of familial Mediterranean fever (FMF), which is frequently mistaken for infectious erysipelas, especially when forming the initial disease presentation.


Aim  To clinically and genetically characterize ELE as the first manifestation of FMF.


Methods  FMF patients with ELE as the first disease presentation (study group), were compared with FMF patients with ELE, appearing during the disease course (control group I), and to those FMF patients who never had ELE (control group II).


Results  Patients of the study group were comparable to patients without ...

Erysipelas-like erythema as the presenting feature of familial Mediterranean fever is a post from: Skincare




Erysipelas-like erythema as the presenting feature of familial Mediterranean fever via BuzzBlazer.com

The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data

Abstract

Twins have always fascinated medical research even before the discovery of DNA and the understanding of the differences between identical and non-identical twins. Dermatology with the benefit of being able to visualize phenotypes was one of the first specialities reporting on the fascinating concordance in identical (MZ) twins in the 1920’s. Over the last 20 years, the heritability of skin diseases using twins has been clearly demonstrated, across a wide variety of traits including melanoma, polymorphic light eruption, psoriasis, eczema and acne. Other rarer diseases have also been shown to have ...

The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data is a post from: Skincare




The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data via BuzzBlazer.com

Long-Term Effectiveness and Safety of Small-Gel-Particle Hyaluronic Acid for Hand Rejuvenation


Background

Fillers to reverse the effects of fat atrophy can help restore the hands’ youthful appearance.



Objective

To evaluate the effectiveness and safety of small-gel-particle hyaluronic acid (SGP-HA) for hand rejuvenation through 1 year.



Materials and Methods

A prospective open-label study recruited adults with moderate to severe vascular, bony, and tendon prominence. After a topical anesthetic was applied, SGP-HA (maximum dose of 4.0 mL) was injected into the dorsum using a threading technique and distributed by massage.



Results

There were 16 patients with a mean ± SD age of 60.1 ± 5.3. Two weeks after treatment, vascular, tendon, and bony prominence and skin ...

Long-Term Effectiveness and Safety of Small-Gel-Particle Hyaluronic Acid for Hand Rejuvenation is a post from: Skincare




Long-Term Effectiveness and Safety of Small-Gel-Particle Hyaluronic Acid for Hand Rejuvenation via BuzzBlazer.com

Friday, January 13, 2012

Gender-dependent differences in degree of facial wrinkles


Background/purpose

This study aimed to reveal gender-dependent differences in the degree of facial wrinkles.



Methods

Subjects comprised 173 Japanese men and women, divided into four groups according to age. Photographs were taken from nine facial regions and used to classify the intensity of wrinkles into five grades. In addition, replicas were taken from five facial sites and used to measure surface roughness. Data were compared between men and women within each age group.



Results

In all age groups, men showed increased forehead wrinkles compared with women. In contrast, no gender-dependent differences were found in upper ...

Gender-dependent differences in degree of facial wrinkles is a post from: Skincare




Gender-dependent differences in degree of facial wrinkles via BuzzBlazer.com

Automatic dirt trail analysis in dermoscopy images


Background

Basal cell carcinoma (BCC) is the most common cancer in the US. Dermatoscopes are devices used by physicians to facilitate the early detection of these cancers based on the identification of skin lesion structures often specific to BCCs. One new lesion structure, referred to as dirt trails, has the appearance of dark gray, brown or black dots and clods of varying sizes distributed in elongated clusters with indistinct borders, often appearing as curvilinear trails.



Methods

In this research, we explore a dirt trail detection and analysis algorithm for extracting, measuring, and characterizing ...

Automatic dirt trail analysis in dermoscopy images is a post from: Skincare




Automatic dirt trail analysis in dermoscopy images via BuzzBlazer.com

Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration


Background

Curcumin is known for its anti-inflammatory, antioxidative, and anticarcinogenic properties. However, the strong lipophilic compound is not easily applicable, neither in water, nor directly in o/w formulations. So far, loading of nano or micro scaled carriers has enabled only an uptake up to 30% of curcumin.



Method

In the present article, curcumin was successfully encapsulated into two different safe and inexpensive polymers, ethyl cellulose and methyl cellulose blended ethyl cellulose with a loading capacity of ~ 46–48%. In addition, the in vitro skin penetration of the two curcumin encapsulated particular systems, which were ...

Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration is a post from: Skincare




Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration via BuzzBlazer.com

Influence of hypodermic needle dimensions on subcutaneous injection delivery – a pig study of injection deposition evaluated by CT scanning, histology, and backflow


Background

Thinner and shorter needles for subcutaneous administration are continuously developed. Previous studies have shown that a thinner needle causes fewer occurrences of painful needle insertions and that a shorter needle decreases the occurrence of painful intramuscular injections. However, little is known about local drug delivery in relation to needle length and thickness. This study aimed to compare deposition depth and backflow from three hypodermic needles of 3 mm 34G (0.19 mm), 5 mm 32G (0.23 mm), and 8 mm 30G (0.30 mm) in length and thickness.



Methods

Ex vivo experiments were carried out on pigs, in neck tissue ...

Influence of hypodermic needle dimensions on subcutaneous injection delivery – a pig study of injection deposition evaluated by CT scanning, histology, and backflow is a post from: Skincare




Influence of hypodermic needle dimensions on subcutaneous injection delivery – a pig study of injection deposition evaluated by CT scanning, histology, and backflow via BuzzBlazer.com

Skin wrinkling morphology changes suddenly in the early 30s


Background/purpose

Does the morphology of wrinkles alter gradually with aging or suddenly at a certain age? On the basis of the theoretic wrinkle simulation of ideal skin, we have suggested that the wrinkle morphology suddenly changes from stratum corneum wrinkling to epidermis wrinkling; the former induces shallow fine furrows, and the latter induces deep prominent wrinkles. To examine the existence of drastic change in wrinkling morphology, we developed a new measurement system for facial skin wrinkling test.



Methods

The mechanical compression test of facial skin was carried out for 102 Japanese women aged ...

Skin wrinkling morphology changes suddenly in the early 30s is a post from: Skincare




Skin wrinkling morphology changes suddenly in the early 30s via BuzzBlazer.com

Computerised image analysis of vitiligo lesion: evaluation using manually defined lesion areas


Background

Vitiligo is a cutaneous pigmentary disorder characterized by depigmented macules and patches that result from loss of epidermal melanocytes. Physician evaluates the efficacy of treatment by comparing the extent of vitiligo lesions before and after treatment based on the overall visual impression of the treatment response. This method is called the physician’s global assessment (PGA) which is subjective. In this article, we present an innovative digital image processing method to determine vitiligo lesion area in an objective manner.



Method

The digital method uses Independent Component Analysis (ICA) to generate melanin-based images representing ...

Computerised image analysis of vitiligo lesion: evaluation using manually defined lesion areas is a post from: Skincare




Computerised image analysis of vitiligo lesion: evaluation using manually defined lesion areas via BuzzBlazer.com

Thursday, January 12, 2012

Characterisation of fibrillar collagen types using multi-dimensional multiphoton laser scanning microscopy


In dermal photodamage the ratio of the collagen types III to I changes. This makes the investigation of the fibrillar collagen type characteristics interesting for skin research. In this study collagen types were characterized using 5-dimensional multiphoton laser scanning microscopy (5D-IVT) that can be applied in vivo. Second harmonic generation (SHG) signals and fluorescence lifetimes of the collagen autofluorescence were analysed. Collagen type I generates a higher SHG intensity and a longer fluorescence lifetime compared to collagen type III. Thus, the SHG intensity decrease found in photodamaged skin might be ...

Characterisation of fibrillar collagen types using multi-dimensional multiphoton laser scanning microscopy is a post from: Skincare




Characterisation of fibrillar collagen types using multi-dimensional multiphoton laser scanning microscopy via BuzzBlazer.com

Wednesday, January 11, 2012

Frontal Fibrosing Alopecia in black patients

Frontal Fibrosing Alopecia in black patients is a post from: Skincare

Frontal Fibrosing Alopecia in black patients is a post from: Skincare




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Genitoperineal papular acantholytic dyskeratosis is allelic to Hailey-Hailey disease

Genitoperineal papular acantholytic dyskeratosis is allelic to Hailey-Hailey disease is a post from: Skincare

Genitoperineal papular acantholytic dyskeratosis is allelic to Hailey-Hailey disease is a post from: Skincare




Genitoperineal papular acantholytic dyskeratosis is allelic to Hailey-Hailey disease via BuzzBlazer.com

Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene

Summary

Background:  Pseudoxanthoma elasticum (PXE) manifests with cutaneous lesions consisting of yellowish papules coalescing into plaques of inelastic skin. Histopathology demonstrates accumulation of pleiomorphic elastic structures with progressive mineralization. The classic form of PXE is caused by mutations in the ABCC6 gene.


Objectives:  A 2-year old patient with PXE of the neck, inguinal folds and lower abdomen, and with extensive tissue mineralization was evaluated for the underlying mutations in candidate genes known to be involved in ectopic mineralization disorders.


Methods:  The patient’s genotype was studied by sequencing ABCC6, MGP and ENPP1 genes, encoding ...

Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene is a post from: Skincare




Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene via BuzzBlazer.com

Identification of a novel S249C FGFR3 mutation in a keratinocytic epidermal nevus syndrome

Identification of a novel S249C FGFR3 mutation in a keratinocytic epidermal nevus syndrome is a post from: Skincare

Identification of a novel S249C FGFR3 mutation in a keratinocytic epidermal nevus syndrome is a post from: Skincare




Identification of a novel S249C FGFR3 mutation in a keratinocytic epidermal nevus syndrome via BuzzBlazer.com

Peripheral Natural Killer cells exhibit qualitative and quantitative changes in psoriasis and atopic dermatitis patients

Summary

Background:  Psoriasis and atopic dermatitis are the most recurrent skin inflammatory disorders. Despite their distinct etiology and clinical aspects, these diseases share several immunological features. Besides the largely documented role of T cells, emerging literature supports a potential involvement of innate immune effectors, the Natural Killer (NK) cells, in both pathologies. In the peripheral blood, NK cells consist of CD3-CD56dim and CD3-CD56bright cell subsets, harboring distinct cell surface phenotype, but both endowed with the main NK cell effector functions: cytotoxicity and cytokine production.


Objectives:  We investigated whether the frequency, the cell ...

Peripheral Natural Killer cells exhibit qualitative and quantitative changes in psoriasis and atopic dermatitis patients is a post from: Skincare




Peripheral Natural Killer cells exhibit qualitative and quantitative changes in psoriasis and atopic dermatitis patients via BuzzBlazer.com

Efficacy and Safety of Topical Antifungals in the Treatment of Dermatomycosis: A Systematic Review

Summary

Background:  Analysis of the comparative efficacy and safety of topical antifungals in the literature is restricted to the treatment of tinea pedis and onychomycosis.


Objectives:  To evaluate and compare the efficacy and safety of topical antifungals used in the treatment of dermatomycosis.


Methods:  We performed a comprehensive search for randomized controlled trials (RCTs) in the following databases: Medline, Cochrane Central Register of Controlled Trials, Embase, Lilacs and International Pharmaceutical Abstracts. We identified studies that compared the use of topical antifungals with other antifungals or with placebo published up to July 2010 in ...

Efficacy and Safety of Topical Antifungals in the Treatment of Dermatomycosis: A Systematic Review is a post from: Skincare




Efficacy and Safety of Topical Antifungals in the Treatment of Dermatomycosis: A Systematic Review via BuzzBlazer.com

A Novel N822K C-KIT Mutation in CD30-positive Cutaneous Pleomorphic Mastocytosis after Germ Cell Tumor of the Ovary

A Novel N822K C-KIT Mutation in CD30-positive Cutaneous Pleomorphic Mastocytosis after Germ Cell Tumor of the Ovary is a post from: Skincare

A Novel N822K C-KIT Mutation in CD30-positive Cutaneous Pleomorphic Mastocytosis after Germ Cell Tumor of the Ovary is a post from: Skincare




A Novel N822K C-KIT Mutation in CD30-positive Cutaneous Pleomorphic Mastocytosis after Germ Cell Tumor of the Ovary via BuzzBlazer.com

Granulomatous foreign-body reaction with facial dermal fillers after omalizumab treatment for severe persistent allergic asthma: a case report

Abstract:

Complications with the increased use of dermal fillers and new therapies with immunomodulatory effects may be increasing. We report on a 50-year-old woman who presented disfiguring facial edema 1 month after the initiation of omalizumab treatment for severe persistent allergic asthma. She had received multiple cosmetic filler injections, including hyaluronic acid and calcium hydroxylapatite, for 4 years without any previous side effects. A biopsy of a lip nodule revealed a foreign-body granulomatous reaction. Treatment was with high-dose prednisone and doxycycline, with clinical improvement.


As was previously reported with interferon, foreign-body granulomatous ...

Granulomatous foreign-body reaction with facial dermal fillers after omalizumab treatment for severe persistent allergic asthma: a case report is a post from: Skincare




Granulomatous foreign-body reaction with facial dermal fillers after omalizumab treatment for severe persistent allergic asthma: a case report via BuzzBlazer.com

Peristomal skin ulcer with intestinal metaplasia

Peristomal skin ulcer with intestinal metaplasia is a post from: Skincare

Peristomal skin ulcer with intestinal metaplasia is a post from: Skincare




Peristomal skin ulcer with intestinal metaplasia via BuzzBlazer.com

Serum and tissue CTACK/CCL27 chemokine levels in early mycosis fungoides and disease control by ifn-a and puva therapy.

Summary

Background:  Neoplastic T cells recruitment into the skin is a critical step in mycosis fungoides (MF) pathogenesis and the cutaneous T-cell attracting chemokine CTACK/CCL27 might be involved.


Objectives:  Aim of our study was to investigate the clinical and prognostic significance of CTACK/CCL27 levels in patients with early stage MF.


Methods:  Serum samples and skin biopsy specimens were collected from 15 patients at the time of the diagnosis, and after the end of treatment with PUVA/IFNα2b combination therapy. Serum samples were also collected from 20 healthy donors as controls. CTACK/CCL27 serum levels were ...

Serum and tissue CTACK/CCL27 chemokine levels in early mycosis fungoides and disease control by ifn-a and puva therapy. is a post from: Skincare




Serum and tissue CTACK/CCL27 chemokine levels in early mycosis fungoides and disease control by ifn-a and puva therapy. via BuzzBlazer.com

Monday, January 9, 2012

GSTM1, GSTT1 and GSTP1 gene polymorphism in polymorphous light eruption

Abstract

Background  Polymorphous light eruption (PLE) is the most common chronic and idiopathic photodermatosis. PLE is assumed to represent an immunological hypersensitivity reaction to a radiation-induced cutaneous antigen involving reactive oxygen species (ROS) on the basis of a genetic predisposition. Among others, cellular protection against ROS is provided by glutathione S-transferases (GSTs). Different variants of the GST enzymes may influence the activity and efficiency of detoxification and biotransformation of unknown UV-induced skin-antigens and other factors that may play an important role in the pathogenesis of PLE.


Methods  In this study the relationship ...

GSTM1, GSTT1 and GSTP1 gene polymorphism in polymorphous light eruption is a post from: Skincare




GSTM1, GSTT1 and GSTP1 gene polymorphism in polymorphous light eruption via BuzzBlazer.com

Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis

Abstract

Background  Topical nitrogen mustard is a chemotherapeutic agent used in treatment of mycosis fungoides (MF).


Objective  To evaluate the response and side effects in patients with MF and parapsoriasis treated with topical nitrogen mustard.


Methods  A retrospective study of treatment response in 116 patients diagnosed with MF and 71 patients with parapsoriasis and treated with topical nitrogen mustard from 1991 to 2009.


Results  Overall response rate and complete response (CR) rate was 91.4% and 53.4% in patients with MF and 90.1% and 40.8% in patients with parapsoriasis, respectively. Relapse following CR was observed ...

Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis is a post from: Skincare




Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis via BuzzBlazer.com

Lipid profiles in untreated patients with dermatomyositis

Abstract

Background and Objective  Altered lipid levels may occur in autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. However, serum lipid profiles in patients with dermatomyositis (DM) have not been investigated. Our aim was to identify lipid profiles in untreated DM patients, and to assess the relationship of the inflammatory condition of DM with lipid profiles.


Methods  This work was designed and conducted as a case-control study. Forty-one DM patients and 41 age- and gender-matched healthy controls were included. None of the patients had received corticosteroids or disease-modifying antirheumatic drugs ...

Lipid profiles in untreated patients with dermatomyositis is a post from: Skincare




Lipid profiles in untreated patients with dermatomyositis via BuzzBlazer.com

Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients

Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients is a post from: Skincare

Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients is a post from: Skincare




Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients via BuzzBlazer.com

Sunday, January 8, 2012

A comparative study of hair shafts in scalp psoriasis and seborrheic dermatitis using atomic force microscopy


Background

As the inflammatory scalp conditions share similar clinical manifestations of scaling, inflammation, and pruritus, the differential diagnosis of these lesions; especially between scalp psoriasis (SP) and seborrheic dermatitis (SD) is sometimes difficult.



Objectives

The aim of this study was to investigate the differences on the hair surface in SP and SD for a clinical diagnosis, using atomic force microscopy (AFM).



Methods

The hair shafts of 14 patients and 28 patients with SP and SD respectively, were taken from the lesional region. Hairs from healthy adults not having any hair diseases were also examined in ...

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Liquid-crystalline membrane permeation ability for selected nitro hair dyes


Aim

A comparison of permeation ability of selected semi-permanent hair dyes and an attempt to estimate the influence of fundamental physicochemical parameters on dyes’ epidermal penetration rate.



Methods

Dyes’ permeation ability through liposome membrane (as a model of stratum corneum) with side-by-side cells was assessed.



Results

It has been shown that the chosen dyes are capable of permeating the membrane. High penetration coefficients (Kp) were obtained for a simple nitrophenylenediamines and nitroaminophenols. Their N-, O-hydroxyalkyl substitution significantly limits penetration. H-bonding capability has a major impact on the investigated dyes’ permeation ability. Substituents with H-bonding properties ...

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Saturday, January 7, 2012

High prevalence of thyroid peroxidase antibodies in patients with alopecia areata

High prevalence of thyroid peroxidase antibodies in patients with alopecia areata is a post from: Skincare

High prevalence of thyroid peroxidase antibodies in patients with alopecia areata is a post from: Skincare




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Patient preferences for psoriasis treatments: impact of treatment experience

Abstract

Background  Patient preferences for psoriasis treatments can impact treatment satisfaction and adherence and may therefore influence clinical outcome.


Objective  To assess the impact of treatment experience (satisfaction with current treatment, number of prior visits, disease duration, number of preceding therapies and currently prescribed treatment modalities) on treatment preferences.


Methods  A computer-based conjoint analysis experiment was conducted to analyse preferences of patients with moderate or severe psoriasis (n = 163) treated at a German University Medical Center for outcome (probability, magnitude and duration of benefit; probability, severity and reversibility of side effects) and process attributes ...

Patient preferences for psoriasis treatments: impact of treatment experience is a post from: Skincare




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Thursday, January 5, 2012

Screening of plant extracts for human tyrosinase inhibiting effects

Synopsis

Screening for tyrosinase (TYR) inhibitors potentially useful for control of skin pigmentation has been hampered by the limited availability of human TYR. To overcome this hurdle, we have established HEK293-TYR cells that constitutively express human TYR. In the current study, we assayed human TYR inhibition activities of 50 plant extracts using the lysates of transformed HEK293-TYR cells. The strongest inhibition of human TYR was shown by the extract of Vaccinium bracteatum Thunberg, followed by the extract of Morus bombycis Koidzumi. The former extract did not inhibit mushroom TYR activity whereas ...

Screening of plant extracts for human tyrosinase inhibiting effects is a post from: Skincare




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Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation

Abstract

Background  Ultraviolet (UV) exposure results in the production reactive oxygen species. Resveratrol has attracted considerable attentions owing to its natural abundance and multiple biological effects.


Objective  To investigate the protective effects of resveratrate against damage to human skin induced by repetitive solar simulator ultraviolet radiation (ssUVR).


Materials and methods  Fifteen healthy volunteers were enrolled, and six sites on the non-exposed dorsal skin of each volunteer were marked for study. Sites 1–4 were exposed to ssUVR at a dosage of 1.5 minimal erythema dose for consecutive 4 days. Immediately after each exposure, one test ...

Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation is a post from: Skincare




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Correlation of antibodies against desmogleins 1 and 3 with indirect immunofluorescence and disease status in a Greek population with pemphigus vulgaris

Abstract

Background  The use of ELISA testing of antibodies to desmogleins 1 and 3 (anti-Dsg1 and anti-Dsg3) and indirect immunofluorescence (IIF) has been strongly supported for the serologic diagnosis of pemphigus. The purpose of this study was to correlate anti-Dsg1 and anti-Dsg3 with IIF values, disease localization, treatment and clinical course in Greek patients with pemphigus vulgaris (PV).


Methods  A total of 54 patients with PV had ELISA serum testing for the presence and titers of anti-Dsg1, anti-Dsg3 and IIF. Anti-Dsg1, anti-Dsg3 and IIF were correlated with treatment and disease localization. For ...

Correlation of antibodies against desmogleins 1 and 3 with indirect immunofluorescence and disease status in a Greek population with pemphigus vulgaris is a post from: Skincare




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Photodynamic therapy for skin field cancerization: an international consensus. International Society for Photodynamic Therapy in Dermatology

Abstract

Field cancerization is a term that describes the presence of genetic abnormalities in a tissue chronically exposed to a carcinogen. These abnormalities are responsible for the presence of multilocular clinical and sub-clinical cancerous lesions that explains the increased risks of multiple cancers in this area. With respect to the skin, this term is used to define the presence of multiple non-melanoma skin cancer, its precursors, actinic keratoses and dysplastic keratinocytes in sun exposed areas. The multiplicity of the lesions and the extent of the area influence the treatment decision. Providing ...

Photodynamic therapy for skin field cancerization: an international consensus. International Society for Photodynamic Therapy in Dermatology is a post from: Skincare




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Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis

Abstract

Background  Recently, we have reported filaggrin mutations (FLG) of atopic dermatitis in southern China. However, there have been few detailed reports of FLG mutations of patients with AD in northern China by now.


Objectives  The present aim was to establish the mutation spectrum of FLG gene in AD patients in northern China.


Methods  A total of 339 cases met Hanifin and Rajka diagnostic criteria of AD were recruited. A comprehensive sequencing of the entire FLG coding region in these patients was conducted. All detected FLG null mutations were screened in a cohort ...

Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis is a post from: Skincare




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Cathepsin K expression in basal cell carcinoma

Abstract

Background  Cathepsin K is a cysteine protease with strong collagenolytic and elastolytic properties. Recently, cathepsin K expression in tumour cells of malignant melanoma and in the stromal cells of squamous cell carcinoma of the skin has been reported to play an important role in tumour progression. However, its expression profile in basal cell carcinoma (BCC) has not yet been clarified.


Objective  The aim of this study is to examine the expression profile of cathepsin K in both the tumour cells and the peritumoural stromal cells of BCC in comparison with its ...

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Digital dermatoscopic follow-up of 1027 melanocytic lesions in 121 patients at risk of malignant melanoma

Abstract

Objective  The aim of the presented prospective study was to use a digital dermatoscopic system to follow-up patients with multiple melanocytic naevi, and to evaluate the frequency and character of dermatoscopic changes.


Methods  We monitored selected melanocytic lesions with the use of a 6-month follow-up interval between check-ups. We searched for changes in size, shape, symmetry, structure and colour. We defined the criteria for surgical excision and histopathological examination of changing lesions. We created a small group of excised unchanged atypical melanocytic naevi.


Results  We completed dermatoscopic monitoring of 1027 melanocytic lesions ...

Digital dermatoscopic follow-up of 1027 melanocytic lesions in 121 patients at risk of malignant melanoma is a post from: Skincare




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Wednesday, January 4, 2012

Estimation of tissue osteopontin levels before and after different traditional therapeutic modalities in psoriatic patients

Abstract

Background  Several lines of evidences support a major role for Th1 cells in psoriasis. Treatment of psoriasis with cyclosporine, methotrexate and psoralen plus ultraviolet A (PUVA) is associated with clinical improvement and decrease in epidermal hyperplasia. Osteopontin (OPN) exerts a T-helper type 1 (Th1) cytokine function, regulating inflammatory cell accumulation and function.


Objective  To detect the effects of methotrexate, cyclosporine and PUVA on OPN expression in psoriatic plaques, and whether these changes correlate with clinical response.


Methods  For three groups of psoriatic patients (each including 12 patients), the Psoriasis Area Severity Index ...

Estimation of tissue osteopontin levels before and after different traditional therapeutic modalities in psoriatic patients is a post from: Skincare




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Status of oxidative stress on lesional skin surface of plantar warts

Abstract

Background  Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of the patients. Sometimes the disease is difficult to treatment, and also, the relationship between HPV and some forms of skin cancers is important. The cutaneous oxidative stress status of warts is absent in the literature.


Objectives  To evaluate the role of oxidative stress in affected skin areas in a group of patients with plantar warts.


Methods  Thirty-six consecutive patients with a diagnosis of plantar warts were enrolled. The samples were obtained by scraping the skin ...

Status of oxidative stress on lesional skin surface of plantar warts is a post from: Skincare




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Guidelines on the safety of light-based home-use hair removal devices from the European Society for Laser Dermatology

Abstract

In the past 5 years since their US introduction, there has been a rapid proliferation of light-based hair removal devices intended for home-use. In the last 2 years in Europe, sales already run into many tens of thousands of units with well-known multi-national companies entering the market. These guidelines provide a definition of light-based home-use technology, to inform healthcare professionals about home-use light-based technology and encourage manufacturers wishing to sell in Europe to adopt ‘best practice’. The review presents the current status on standards and regulation issues and considers home-use safety issues, ...

Guidelines on the safety of light-based home-use hair removal devices from the European Society for Laser Dermatology is a post from: Skincare




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Frequency of non-histologically diagnosed basal cell carcinomas in daily Dutch practice

Abstract

Background  Population-based basal cell carcinoma (BCC) incidences are based on cancer registry data; however, these only include histologically diagnosed tumours.


Objectives  First, to investigate the number of subsequent non-histologically diagnosed BCC(s) in patients with a first histologically diagnosed BCC in 2004. Secondly, to observe differences in tumour characteristics between subsequent histologically and subsequent non-histologically diagnosed BCC(s).


Methods  All patients, from four hospitals located in the serving area of the Eindhoven Cancer Registry, with a first histologically diagnosed BCC in 2004 (n = 1290) were selected. A linkage was made with PALGA, the nationwide network ...

Frequency of non-histologically diagnosed basal cell carcinomas in daily Dutch practice is a post from: Skincare




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A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions

Abstract

Background  The usefulness of the drug patch testing for Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is still controversial. Recent studies have shown that HLA-B*1502 is strongly associated with CBZ-SJS/TEN in Chinese and Southeast Asian populations.


Objective  To evaluate the usefulness of patch tests for patients with carbamazepine (CBZ)-induced SJS, TEN and drug reaction with eosinophilia and systemic symptoms (DRESS) and the cross-reactivity in patch tests among the aromatic antiepileptic drugs.


Methods  We measure the frequency of positive patch test reactions and cross-sensitivity to structure-related aromatic anti-epileptic drugs (AEDs) for patients after ...

A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions is a post from: Skincare




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Survey on the management of skin toxicity associated with EGFR inhibitors amongst French Physicians

Abstract

Background  Epidermal growth factor receptor (EGFR) inhibitors are part of the therapeutic arsenal available for advanced cancer. However, they are frequently associated with cutaneous side-effects, which can hamper compliance, lead to treatment refusal and impair quality of life.


Objective  To know the attitudes of French oncologists who deal with this skin toxicity. This work is one of the steps to build a therapeutic algorithm of side-effects induced by EGFR inhibitors taking both evidence-based medicine and standard practices into account.


Methods  Physicians completed a questionnaire as part of regional meetings, before any discussion. ...

Survey on the management of skin toxicity associated with EGFR inhibitors amongst French Physicians is a post from: Skincare




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Reflectance confocal microscopy for diagnosis of mammary and extramammary Paget’s disease

Abstract

Background  Paget’s disease is an intraepidermal adenocarcinoma that is difficult to diagnose clinically as it mimics inflammatory or infectious diseases. As a consequence, it may be clinically misdiagnosed resulting in a delay in appropriate management. Reflectance confocal microscopy allows the visualization of the upper layers of the skin and mucosa at cellular resolution. Paget’s disease is characterized histologically by the presence of neoplastic cells scattered throughout all layers of the epidermis in a pattern similar to that also observed in melanoma (and termed Pagetoid spread).


Objective In vivo confocal microscopy is an ...

Reflectance confocal microscopy for diagnosis of mammary and extramammary Paget’s disease is a post from: Skincare




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Mucocutaneous manifestations of HIV-infected patients in the era of HAART in Guangxi Zhuang Autonomous Region, China

Abstract

Background  Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are frequently associated with diverse mucocutaneous manifestations. However, few studies of HIV/AIDS-related mucocutaneous manifestations have been reported in China.


Objective  To investigate the occurrence of mucocutaneous disorders and their relationship with the degree of immunosuppression in 348 HIV-infected Chinese patients. The influence of highly active antiretroviral therapy (HAART) on the spectrum of mucocutaneous manifestations was also evaluated.


Methods  A cross-sectional study was performed on 348 HIV-infected Chinese patients seen at the Guangxi Longtan Hospital from August 2010 to November 2010. Collected ...

Mucocutaneous manifestations of HIV-infected patients in the era of HAART in Guangxi Zhuang Autonomous Region, China is a post from: Skincare




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Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women

Abstract

Background  Melasma is a common acquired chronic hypermelanosis of sun-exposed areas which significantly impacts quality of life. There are few epidemiological studies in medical literature concerning these patients.


Objective  Characterize clinical and epidemiological data on Brazilian female patients with melasma.


Methods  A semi-structured questionnaire was administered to melasma patients treated at a dermatology clinic between 2005 and 2010. Association between variables was performed by multivariate regression models.


Results  We assessed 302 patients; intermediate skin phototypes III (34.4%) and IV (38.4%) were prevalent. Mean disease onset age was 27.5 ± 7.8 years and familiar occurrence of melasma ...

Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women is a post from: Skincare




Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women via BuzzBlazer.com

Bacterial skin and soft tissue infections: review of the epidemiology, microbiology, aetiopathogenesis and treatment

Abstract

Bacterial skin and soft tissues infections (SSTI) often determine acute disease and frequent emergency recovering, and they are one of the most common causes of infection among groups of different ages. Given the variable presentation of SSTI, a thorough assessment of their incidence and prevalence is difficult. The presence of patient-related (local or systemic) or environmental risk factors, along with the emergence of multi-drug resistant pathogens, can promote SSTI. These infections may present with a wide spectrum of clinical features and different severity, and can be classified according to various ...

Bacterial skin and soft tissue infections: review of the epidemiology, microbiology, aetiopathogenesis and treatment is a post from: Skincare




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Tuesday, January 3, 2012

Reconstruction of Circumferential Skin Defect of the Penile Shaft Using a Bipedicle Scrotal Flap

Reconstruction of Circumferential Skin Defect of the Penile Shaft Using a Bipedicle Scrotal Flap is a post from: Skincare

Reconstruction of Circumferential Skin Defect of the Penile Shaft Using a Bipedicle Scrotal Flap is a post from: Skincare




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Development and Application of a HPLC Method for Eight Sunscreen Agents in Suncare Products

Abstract

This work describes the development, validation and application of a simple and fast HPLC-DAD method for the determination of eight sunscreen agents: benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate (used in two isomeric forms), butyl methoxydibenzoylmethane, 4-methylbenzylidene camphor and ethylhexyl dimethyl PABA in sunscreen formulations. The separation of the eight sunscreen compounds was achieved using an ACE C18 column (250 mm x 4.6 mm, 5 μm), with a column temperature 20 °C, and a mobile phase of 88:12 (v/v) methanol-water with isocratic elution. Column temperature strongly influences the retention time ...

Development and Application of a HPLC Method for Eight Sunscreen Agents in Suncare Products is a post from: Skincare




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Sunday, January 1, 2012

Musculoskeletal Disorders and Ergonomics in Dermatologic Surgery: A Survey of Mohs Surgeons in 2010


Background

Dermatologic surgeons perform numerous procedures that put them at risk of developing work-related musculoskeletal disorders.



Objective

To study the prevalence of work-related musculoskeletal disorders and role of ergonomics in dermatologic surgery.



Methods and Materials

A survey study was sent to members of the American College of Mohs Surgery in 2010. The main outcome measures were survey responses relating to surgeon demographics, musculoskeletal symptoms, workstyle habits and attitudes, and ergonomic practices.



Results

Ninety percent of respondents reported some type of musculoskeletal symptoms or injuries. The most common complaints were neck, lower back, shoulder, and upper back pain. ...

Musculoskeletal Disorders and Ergonomics in Dermatologic Surgery: A Survey of Mohs Surgeons in 2010 is a post from: Skincare




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Comparison of Laser Versus Sclerotherapy in the Treatment of Lower Extremity Telangiectases: A Prospective Study


Background

Lower extremity telangiectasia affects approximately 40% of women. The demand for aesthetic treatment of these veins continues to grow. Few studies have compared laser and sclerotherapy to treat leg telangiectasias.



Objective

To compare the efficacy of conventional sclerotherapy and neodymium-doped yttrium aluminum garnet (Nd:YAG) laser in the treatment of leg telangiectasias.



Methods and Materials

Thirty women were enrolled in the study. One leg was randomly assigned laser treatment and the other sclerotherapy with 75% glucose solution. All patients were photographed before and after treatment. The applying physician and two independent observers rated photographic improvement ...

Comparison of Laser Versus Sclerotherapy in the Treatment of Lower Extremity Telangiectases: A Prospective Study is a post from: Skincare




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The Keystone Fasciocutaneous Flap in the Reconstruction of Lower Extremity Wounds

The Keystone Fasciocutaneous Flap in the Reconstruction of Lower Extremity Wounds is a post from: Skincare

The Keystone Fasciocutaneous Flap in the Reconstruction of Lower Extremity Wounds is a post from: Skincare




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Surgical Treatment of Sinuses by Deroofing in Hidradenitis Suppurativa

Surgical Treatment of Sinuses by Deroofing in Hidradenitis Suppurativa is a post from: Skincare

Surgical Treatment of Sinuses by Deroofing in Hidradenitis Suppurativa is a post from: Skincare




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Removal of Sea Urchin Spines Using Erbıum-Doped Yttrium Aluminum Garnet Ablatıon

Removal of Sea Urchin Spines Using Erbıum-Doped Yttrium Aluminum Garnet Ablatıon is a post from: Skincare

Removal of Sea Urchin Spines Using Erbıum-Doped Yttrium Aluminum Garnet Ablatıon is a post from: Skincare




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Randomized Clinical Trial Comparing Two Methods for Endovenous Laser Ablation of Incompetent Perforator Veins in Thigh and Great Saphenous Vein Without Evidence of Saphenofemoral Reflux


BACKGROUND

Percutaneous ablation of incompetent perforators has been introduced as a safe and efficacious alternative.



Objective

To compare two methods of treating incompetent thigh perforator and great saphenous veins (GSV).



Materials and Methods

Patients with varicose veins of CEAP C2 and C3 with incompetent perforating veins (IPVs) in the thigh without evidence of saphenofemoral reflux and with obvious venous reflux from IPVs into the GSV distal to IPVs were included. Endovenous laser ablation was done using two methods (IPV ablation (IPVA) versus GSV ablation: GSVA). Their technical success rate, clinical success rate, and complications were ...

Randomized Clinical Trial Comparing Two Methods for Endovenous Laser Ablation of Incompetent Perforator Veins in Thigh and Great Saphenous Vein Without Evidence of Saphenofemoral Reflux is a post from: Skincare




Randomized Clinical Trial Comparing Two Methods for Endovenous Laser Ablation of Incompetent Perforator Veins in Thigh and Great Saphenous Vein Without Evidence of Saphenofemoral Reflux via BuzzBlazer.com

Treatment of Actinic Cheilitis Using a 1,927-nm Thulium Fractional Laser

Treatment of Actinic Cheilitis Using a 1,927-nm Thulium Fractional Laser is a post from: Skincare

Treatment of Actinic Cheilitis Using a 1,927-nm Thulium Fractional Laser is a post from: Skincare




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Use of Fractionated Microneedle Radiofrequency for the Treatment of Inflammatory Acne Vulgaris in 18 Korean Patients


Background

Nonablative radiofrequency (RF) devices have been shown to be clinically effective for the treatment of moderate to severe acne lesions.



Objective

To evaluate the efficacy and safety of a fractionated microneedle RF device in the treatment of inflammatory acne vulgaris.



Methods

Eighteen patients (15 male, 3 female; mean age 27, range: 19–33; Fitzpatrick skin type IV) with moderate to severe acne vulgaris who were treated with two sessions of fractionated microneedle RF at 1-month intervals were enrolled in this study.



Results

Evaluation of improvement, which took into account number of inflammatory acne lesions, showed that two ...

Use of Fractionated Microneedle Radiofrequency for the Treatment of Inflammatory Acne Vulgaris in 18 Korean Patients is a post from: Skincare




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