Lipodystrophia Centrifugalis Abdominalis Infantilis: Statistical Analysis of 168 Cases

Abstract:  Lipodystrophia centrifugalis abdominalis infantilis is a localized lipodystrophic disease affecting young children. A total of 168 cases were collected from dermatology literature. Where possible, details of the data were also obtained from the authors. Most of the patients were Japanese, Korean, or Chinese in origin. The Caucasian patients were from England, Italy, France, Germany, Spain, and the United States. The male-to-female ratio was 1:1.6. The depressed lesions developed during the first 4 years of life in the groin or axilla, surrounded by a slight erythematous change. Histologically, subcutaneous fatty tissue ...

Lipodystrophia Centrifugalis Abdominalis Infantilis: Statistical Analysis of 168 Cases is a post from: Skincare

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Inverse Gottron’s Papules: An Unusual Cutaneous Manifestation of Juvenile Dermatomyositis

Abstract:  Dermatomyositis is an autoimmune inflammatory myopathy characterized by unique cutaneous features. Gottron’s papules are pathognomonic, lichenoid papules that can be found overlying the joints of the dorsal hand. Papules on the palms of the hand are less commonly seen, especially in the pediatric age group. Recognition of these inverse Gottron’s papules as a sign of dermatomyositis is important as they may be the only cutaneous feature and may be a clue of underlying interstitial lung disease.

Inverse Gottron’s Papules: An Unusual Cutaneous Manifestation of Juvenile Dermatomyositis is a post from: ...

Inverse Gottron’s Papules: An Unusual Cutaneous Manifestation of Juvenile Dermatomyositis is a post from: Skincare

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Basal Cell Carcinoma in Childhood: A Case Report

Abstract:  Basal cell carcinoma is the most common tumor of skin. Its incidence increases with age, although it is relatively infrequent under the age of 50 years, and its occurrence in childhood is exceedingly rare. This article describes an otherwise typical basal cell carcinoma arising in young patient, with emphasis on histologic diagnosis.

Basal Cell Carcinoma in Childhood: A Case Report is a post from: Skincare

Basal Cell Carcinoma in Childhood: A Case Report is a post from: Skincare

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Irritant Contact Dermatitis Due to Ammonium Bifluoride in Two Infant Twins

Abstract:  Ammonium bifluoride is one of the most corrosive acids that may produce severe chemical burns when in contact with skin. This hazardous chemical is widely used in household products. We report two pediatric cases of irritant contact dermatitis after exposure to a rust remover, which contained ammonium bifluoride.

Irritant Contact Dermatitis Due to Ammonium Bifluoride in Two Infant Twins is a post from: Skincare

Irritant Contact Dermatitis Due to Ammonium Bifluoride in Two Infant Twins is a post from: Skincare

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Congenital Erosive and Vesicular Dermatosis: A New Case and Review of the Literature

Abstract:  Congenital erosive and vesicular dermatosis is a rare syndrome first described by Cohen et al in 1985. Most of the 18 cases published have been reported in premature newborns. Affected babies typically present with erosions and vesicles that tend to heal shortly after birth with reticulated scaring. We report an additional case, followed up for 5 years, in which we excluded a pathogenic mutation in the TP63 gene.

Congenital Erosive and Vesicular Dermatosis: A New Case and Review of the Literature is a post from: Skincare

Congenital Erosive and Vesicular Dermatosis: A New Case and Review of the Literature is a post from: Skincare

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Acute Morbidity Associated with Scabies and Other Ectoparasitoses Rapidly Improves After Treatment with Ivermectin

Abstract:  In resource-poor settings, scabies is associated with considerable morbidity. Which factors determine morbidity and how rapidly it recedes after specific treatment is not known. Patients with scabies were recruited in three urban slums in Fortaleza, Northeast Brazil. Diagnosis was established according to dermatoscopy, skin scraping, or adhesive film test. Severity of scabies-associated morbidity was assessed semiquantitatively. Patients and close contacts were treated with oral ivermectin (200 μg/kg, repeated after 7 days) and followed up for 2 weeks. Ninety-five patients were included in the study. Papules were the most common lesion type (98.9%). ...

Acute Morbidity Associated with Scabies and Other Ectoparasitoses Rapidly Improves After Treatment with Ivermectin is a post from: Skincare

Acute Morbidity Associated with Scabies and Other Ectoparasitoses Rapidly Improves After Treatment with Ivermectin via BuzzBlazer.com

Congenital Multiple Clustered Dermatofibroma in a 12-Year-Old Girl

Abstract:  Congenital multiple clustered dermatofibroma (MCDF) is a rare, idiopathic, benign tumor presenting at birth as an asymptomatic hyperpigmented patch that is stable until puberty, at which time it enlarges and develops papules. Ultimately, MCDF appears to follow a stable, benign course. We present a case of a 12-year-old girl with congenital MCDF. To our knowledge, this is only the third reported case of congenital presentation of MCDF and the only case featuring atrophoderma-like depression.

Congenital Multiple Clustered Dermatofibroma in a 12-Year-Old Girl is a post from: Skincare

Congenital Multiple Clustered Dermatofibroma in a 12-Year-Old Girl is a post from: Skincare

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Intractable Diffuse Alopecia Caused by Multifactorial Side-Effects in Treatment of Acute Lymphocytic Leukemia: Connection to Iatrogenic Failure of Estrogen Secretion

Abstract:  Treatment of infantile acute lymphocytic leukemia (ALL) may cause failure to thrive and hypogonadism due to hypopituitarism induced by chemotherapy and whole-brain radiotherapy. We report the case of a 22-year-old girl with a genetic predisposition to pattern hair loss who developed inveterate diffuse alopecia. The patient had onset of ALL at 8 years old and underwent bone marrow transplantation (BMT). Diffuse alopecia gradually advanced over her whole body. Her vellus scalp hair gradually came out, and hair loss progressed again at 8 years, after BMT. She later developed iatrogenic failure of ...

Intractable Diffuse Alopecia Caused by Multifactorial Side-Effects in Treatment of Acute Lymphocytic Leukemia: Connection to Iatrogenic Failure of Estrogen Secretion is a post from: Skincare

Intractable Diffuse Alopecia Caused by Multifactorial Side-Effects in Treatment of Acute Lymphocytic Leukemia: Connection to Iatrogenic Failure of Estrogen Secretion via BuzzBlazer.com

Outcomes in Pediatric Atypical Spitz Tumors Treated Without Sentinel Lymph Node Biopsy

Abstract:  The diagnosis of atypical Spitz tumor (AST) in a pediatric patient conveys an uncertain potential for malignancy. Although pediatric melanoma is rare, AST may be treated aggressively with sentinel lymph node biopsy (SLNB) and subsequent completion lymphadenectomy. These procedures have unclear therapeutic benefit and potential morbidity. We aimed to collect outcomes on children with AST treated with excision alone to assist in the management of these lesions. We queried our institution’s pathology database for AST specimens submitted between 1994 and 2009. A dermatopathologist reviewed pathology slides to confirm AST ...

Outcomes in Pediatric Atypical Spitz Tumors Treated Without Sentinel Lymph Node Biopsy is a post from: Skincare

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Validated UV-spectrophotometric method for the evaluation of the efficacy of makeup remover

Synopsis

A UV-spectrophotometric method for the analysis of makeup remover was developed and validated according to ICH guidelines. Three makeup removers for which the main ingredients consisted of vegetable oil (A), mineral oil and silicone (B) and mineral oil and water (C) were sampled in this study. Ethanol was the optimal solvent because it did not interfere with the maximum absorbance of the liquid foundation at 250 nm. The linearity was determined over a range of makeup concentrations from 0.540 – 1.412 mg/ml (R2 = 0.9977). The accuracy of this method ...

Validated UV-spectrophotometric method for the evaluation of the efficacy of makeup remover is a post from: Skincare

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Successful treatment of systemic cold contact urticaria with Etanercept in a patient with psoriasis.

Successful treatment of systemic cold contact urticaria with Etanercept in a patient with psoriasis. is a post from: Skincare

Successful treatment of systemic cold contact urticaria with Etanercept in a patient with psoriasis. is a post from: Skincare

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The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations

Summary

Background:  Vitiligo is an acquired depigmentation disorder resulting from selective destruction of melanocytes. The aryl hydrocarbon receptor (AHR) is vital to the regulation of melanogenesis and melanocyte proliferation and differentiation through modulating the expressions of the melanogenesis related genes. AHR mutations may negatively affect AHR proteins and its target genes. Therefore, we hypothesized that AHR polymorphisms might be involved in vitiligo via impacting the transcriptional activities of related genes as mentioned above.


Objectives:  To evaluate the potential association between AHR polymorphisms and vitiligo susceptibility.


Methods:  We performed a hospital-based, case–control study of ...

The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations is a post from: Skincare

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Core beliefs and psychological distress in patients with psoriasis and atopic eczema attending secondary care: The role of schemas in chronic skin disease

Abstract

Background:  The role of ingrained cognitive and emotional patterns (schemas) in patients with psoriasis and eczema has not previously been investigated. High levels of psychiatric morbidity and psychological distress observed in these populations suggest the presence of maladaptive schemas and therefore a possible target for future successful psychological intervention.


Objectives:  To investigate the presence of Early Maladaptive Schemas (EMS) in patients with psoriasis and eczema and explore their links with psychological distress.


Patients/Methods:  A sample of one-hundred and eighty-five adults (psoriasis n=55, atopic eczema, n=54, chronic disease control n=23, normal control n=53) ...

Core beliefs and psychological distress in patients with psoriasis and atopic eczema attending secondary care: The role of schemas in chronic skin disease is a post from: Skincare

Core beliefs and psychological distress in patients with psoriasis and atopic eczema attending secondary care: The role of schemas in chronic skin disease via BuzzBlazer.com

FZD6 encoding the Wnt receptor frizzled-6 is mutated in autosomal-recessive nail dysplasia

Abstract

Isolated nail dysplasia is rare and has only been reported in a small number of families. In this report, we describe two Pakistani families with an autosomal-recessive inherited nail dysplasia. We mapped this genodermatosis to chromosome 8q22.3, and identified a homozygous nonsense mutation c.1750G>T (p.E584X) in the frizzled 6 (FZD6) gene in all affecteds. Expression analyses in nail sections from healthy individuals revealed strong expression of FZD6 in the ventral nail matrix and a less pronounced expression of FZD6 in the nail bed. FZD6 belongs to a family of proteins ...

FZD6 encoding the Wnt receptor frizzled-6 is mutated in autosomal-recessive nail dysplasia is a post from: Skincare

FZD6 encoding the Wnt receptor frizzled-6 is mutated in autosomal-recessive nail dysplasia via BuzzBlazer.com

Miniature swine model of phototoxicity testing

Summary

Background/Purpose

This study determined the threshold doses for ‘solar erythema’ and for phototoxic responses to 8-methoxypsoralen (8-MOP) in white skin Hanford and grey skin Yucatan miniature swine.



Methods

For threshold erythema determinations, the UVR exposures included both UVA (315–400 nm) and UVB (290–315 nm) radiation by positioning one fluorescent ‘sunlamp’ among 10 ‘PUVA’ lamps. With this configuration the UVR exposures ranged from 0.5–2.8 times the ‘instrumental MED’ (MEDi) for Hanford and from 1.0–5.6 times the MEDi for Yucatan. For phototoxicity determinations (i.e., with and without topically-applied graduated concentrations of 8-MOP), the UVB component was minimized ...

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Neonatal mice do not have increased sensitivity to induction of squamous cell carcinomas

Summary

Background

Squamous cell carcinoma (SCC) is linked with the lifelong cumulative effect of ultraviolet radiation (UVR). In contrast, epidemiological data have shown that sunburn in childhood is a stronger risk factor for cutaneous malignant melanoma than continuous UVR, indicating a higher carcinogenic sensitivity early in life.



Methods

We investigated how a high neonatal dose of UVR affects the development of SCC in mice irradiated later in life. We used simulated solar radiation (sun) and solarium radiation (solarium). Ninety-nine C3.Cg/TifBomTac-immunocompetent hairless mice received 0, 25 or 35 standard erythema doses (SED) UVR when they ...

Neonatal mice do not have increased sensitivity to induction of squamous cell carcinomas is a post from: Skincare

Neonatal mice do not have increased sensitivity to induction of squamous cell carcinomas via BuzzBlazer.com

Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study

Summary

Background and Aims

Psoralen ultraviolet A (PUVA) is an important modality in treating vitiligo. Its effect on melanocytes and keratinocytes is not sufficiently studied. In this work, we investigated 30 cases of non-segmental vitiligo regarding the changes of melanocytes and keratinocytes in both vitiliginous and nearby areas before and after PUVA therapy.



Methods

Three skin biopsies were obtained from each patient from the vitiliginous, marginal and perilesional areas before and after 12 months of PUVA. Biopsies were examined histologically using haematoxylin and eosin, Masson–Fontana stains and 3,4-dihydroxyphenylalanine (DOPA) reaction and histochemically using human ...

Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study is a post from: Skincare

Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study via BuzzBlazer.com

Protective effects of β-carotene and melanin against protoporphyrine IX-induced phototoxicity in the photo hen’s egg test

Summary

Purpose

The aim of our study was to evaluate the photoprotective potential of melanin and β-carotene against protoporphyrine IX-induced phototoxicity via photo hen’s egg test.



Methods

In three independent test groups, the yolk sac blood vessel system of hen’s eggs was exposed to protoporphyrine IX and irradiated with ultraviolet A (UVA). One of the test groups also received melanin to investigate its photoprotective capacity; another test group received β-carotene for the same purpose. Morphological changes and embryo lethality were recorded in these three test groups for a period of 24 h. The same parameters ...

Protective effects of β-carotene and melanin against protoporphyrine IX-induced phototoxicity in the photo hen’s egg test is a post from: Skincare

Protective effects of β-carotene and melanin against protoporphyrine IX-induced phototoxicity in the photo hen’s egg test via BuzzBlazer.com

Excimer light photototherapy of segmental and non-segmental vitiligo: experience in Taiwan

Abstract

Purpose

To determine the efficacy of excimer light in the treatment vitiligo and to assess parameters affecting therapeutic results.



Methods

This retrospective study analyzed 227 patches of vitiligo in 142 patients. Treatment was performed twice weekly and treatment efficacy was assessed by two independent dermatologists. Patients who received less than 24 treatment sessions were excluded from the analysis of predictive factors for response.



Results

Sixty-eight (30.0%) patches achieved more than 50% repigmentation, and 42 (18.5%) achieved more than 75% repigmentation. The mean treatment numbers to achieve any repigmentation and more than 50% repigmentation were 19.41 ...

Excimer light photototherapy of segmental and non-segmental vitiligo: experience in Taiwan is a post from: Skincare

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Photoinduced dermatitis and oral lichenoid reaction in a chronic myeloid leukemia patient treated with imatinib mesylate

Summary

Background

Imatinib mesylate (IM) is a phenylaminopyrimidine that represents the first-line treatment for chronic myeloid leukemia (CML), Philadelphia chromosome-positive. It acts as a potent and selective inhibitor of the bcr-abl fusion protein by a competitive inhibition at the adenosine triphosphate-binding site of the enzyme, which leads to the inhibition of tyrosine phosphorylation of the proteins involved in bcr-abl signal transduction. IM is generally well tolerated and usually provokes only mild side effects consisting of nausea, myalgia, edema and muscle cramps.



Observation

This is a report of a patient affected by CML, who developed ...

Photoinduced dermatitis and oral lichenoid reaction in a chronic myeloid leukemia patient treated with imatinib mesylate is a post from: Skincare

Photoinduced dermatitis and oral lichenoid reaction in a chronic myeloid leukemia patient treated with imatinib mesylate via BuzzBlazer.com

Highlights for February

Highlights for February is a post from: Skincare

Highlights for February is a post from: Skincare

Highlights for February via BuzzBlazer.com

A Feature-Preserving Hair Removal Algorithm for Dermoscopy Images

Background/purpose

Accurate segmentation and repair of hair-occluded information from dermoscopy images are challenging tasks for computer-aided detection (CAD) of melanoma. Currently, many hair-restoration algorithms have been developed, but most of these fail to identify hairs accurately and their removal technique is slow and disturbs the lesion’s pattern.



Methods

In this article, a novel hair-restoration algorithm is presented, which has a capability to preserve the skin lesion features such as color and texture and able to segment both dark and light hairs. Our algorithm is based on three major steps: the rough hairs are ...

A Feature-Preserving Hair Removal Algorithm for Dermoscopy Images is a post from: Skincare

A Feature-Preserving Hair Removal Algorithm for Dermoscopy Images via BuzzBlazer.com

Sebum, acne, skin elasticity, and gender difference – which is the major influencing factor for facial pores?

Background

Enlarged facial pores have been esthetic problems and have become a matter of cosmetic concern. Several factors are supposed to be related to the enlargement of facial pores, although scientific evaluations were not performed yet.



Objective

To assess the correlation between facial pores and possible relating factors such as age, gender, sebum secretion, skin elasticity, and the presence of acne, using objective bioengineering instruments.



Methods

Sixty volunteers, 30 males and 30 females, participated in this study. Various parameters of facial pores were assessed using the Robo Skin Analyzer®. The facial sebum secretion and skin ...

Sebum, acne, skin elasticity, and gender difference – which is the major influencing factor for facial pores? is a post from: Skincare

Sebum, acne, skin elasticity, and gender difference – which is the major influencing factor for facial pores? via BuzzBlazer.com

Polymorphism in interleukin 1A but not in interleukin 8 gene predisposes to acne vulgaris in Polish population

Polymorphism in interleukin 1A but not in interleukin 8 gene predisposes to acne vulgaris in Polish population is a post from: Skincare

Polymorphism in interleukin 1A but not in interleukin 8 gene predisposes to acne vulgaris in Polish population is a post from: Skincare

Polymorphism in interleukin 1A but not in interleukin 8 gene predisposes to acne vulgaris in Polish population via BuzzBlazer.com

Giant basal cell carcinoma of the skin: literature review and personal experience

Abstract

As the most common form of skin cancer, basal cell carcinoma (BCC) is typified by locally infiltrative growth and a very low risk of metastasis. On occasion, however, this otherwise indolent neoplasm may behave aggressively, demonstrating deep tissue invasion and a high rate of postsurgical recurrence. The pathogenesis and determinants of such tenacious growth are not completely understood. Only 1% of all BCC’s achieve the status of ‘giant’, as defined in 1988 by the American Joint Committee on Cancer. In this article, the authors provide a comprehensive review of the ...

Giant basal cell carcinoma of the skin: literature review and personal experience is a post from: Skincare

Giant basal cell carcinoma of the skin: literature review and personal experience via BuzzBlazer.com

Daylight photodynamic therapy for actinic keratosis: an international consensus

Abstract

Photodynamic therapy (PDT) is an attractive therapy for non-melanoma skin cancers including actinic keratoses (AKs) because it allows treatment of large areas; it has a high response rate and results in an excellent cosmesis. However, conventional PDT for AKs is associated with inconveniently long clinic visits and discomfort during therapy. In this article, we critically review daylight-mediated PDT, which is a simpler and more tolerable treatment procedure for PDT. We review the effective light dose, efficacy and safety, the need for prior application of sunscreen, and potential clinical scope of ...

Daylight photodynamic therapy for actinic keratosis: an international consensus is a post from: Skincare

Daylight photodynamic therapy for actinic keratosis: an international consensus via BuzzBlazer.com

Clinical significance of serum retinol binding protein-4 levels in patients with systemic sclerosis

Abstract

Background  Retinol binding protein-4 (RBP-4) is a member of adipocytokines, which is potentially associated with fibrosis, vasodilation, and angiogenesis in addition to insulin resistance.


Objective  To investigate the clinical significance of serum RBP4 levels in patients with systemic sclerosis (SSc), which is a systemic autoimmune disease characterized by fibrosis and vasculopathy.


Methods  Serum RBP4 levels were determined by enzyme-linked immunosorbent assay in 62 SSc patients and 19 healthy controls.


Results  Similar to patients with chronic kidney disease, serum RBP4 levels inversely correlated with estimated glomerular filtration rate in SSc patients with renal dysfunction. ...

Clinical significance of serum retinol binding protein-4 levels in patients with systemic sclerosis is a post from: Skincare

Clinical significance of serum retinol binding protein-4 levels in patients with systemic sclerosis via BuzzBlazer.com

Cytokines, chemokines and growth factors in wound healing

Abstract

In wound healing, a variety of mediators have been identified throughout the years. The mediators discussed here comprise growth factors, cytokines and chemokines. These mediators act via multiple (specific) receptors to facilitate wound closure. As research in the last years has led to many new findings, there is a need to give an overview on what is known, and on what might possibly play a role as a molecular target for future wound therapy. This review aims to keep the reader up to date with selected important and novel findings ...

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Cytokines, chemokines and growth factors in wound healing via BuzzBlazer.com

The incidence of basal cell carcinoma in the under-30s in the UK

Summary

Background.  Basal cell carcinoma (BCC) is the commonest cancer in many countries, but the current incidence in young people from the UK is unknown.


Aim.  To ascertain a recent incidence of BCC in the under-30 population in the UK.


Methods.  Cancer registry data from part of the Eastern Region of the UK was analysed for two periods: 1981–1989 and 1998–2006. Case notes were examined for a cohort of the patients from 1998 to 2006.


Results.  The incidence of BCC increased from 0.73 to 1.79 per 100 000 in those aged < 30 years over the study ...

The incidence of basal cell carcinoma in the under-30s in the UK is a post from: Skincare

The incidence of basal cell carcinoma in the under-30s in the UK via BuzzBlazer.com

The protective effects of Ginkgo biloba extract (EGb-761) on radiation-induced dermatitis: an experimental study

Summary

Background.  Irradiation of the skin induces production of free radicals, resulting in oxidative stress. EGb-761, an extract from the leaves of the Ginkgo biloba tree, has been reported to be an effective exogenous antioxidant based on its free-radical scavenger properties.


Aim.  To investigate the protective effect of G. biloba extract (EGb-761) on radiation-induced dermatitis in rats.


Methods.  Forty male Wistar rats were divided equally into four groups: group 1 received sham radiotherapy (RT) without EGb-761, group 2 received sham RT with EGb-761, group 3 received RT without EGb-761, and group 4 received RT ...

The protective effects of Ginkgo biloba extract (EGb-761) on radiation-induced dermatitis: an experimental study is a post from: Skincare

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Botryomycosis presenting as nasal cutaneous fistulas caused by Prevotella melaninogenica

Summary Botryomycosis is an uncommon chronic suppurative granulomatous bacterial infection that can affect the skin and viscera. Clinically, lesions typically consist of small tender nodules from which draining sinuses may develop to expel a purulent discharge. Histopathological features include characteristic aggregation of microorganisms (grain) within the inflammatory infiltrate. The commonest causative organisms are Staphylococcus aureus and Pseudomonas aeruginosa, of others. Botryomycosis resulting from Prevotella melaninogenica has not been reported previously. We report the case of a middle-aged patient with botryomycosis presenting as nasal cutaneous fistulas caused by P. melaninogenica, which was ...

Botryomycosis presenting as nasal cutaneous fistulas caused by Prevotella melaninogenica is a post from: Skincare

Botryomycosis presenting as nasal cutaneous fistulas caused by Prevotella melaninogenica via BuzzBlazer.com

FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis

Abstract

Background:  Benign lichenoid keratoses (BLK) are solitary skin lesions which have been proposed to represent a regressive form of pre-existent epidermal tumors such as solar lentigo or seborrheic keratosis. However, the genetic basis of BLK is unknown.


Objectives: FGFR3, PIK3CA and RAS mutations have been shown to be involved in the pathogenesis of seborrheic keratosis and solar lentigo. We thus investigated whether these mutations are also present in BLK.


Methods:  After manual microdissection and DNA isolation, 52 BLK were screened for FGFR3, PIK3CA and RAS hotspot mutations using SNaPshot® multiplex assays.


Results:  We identified ...

FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis is a post from: Skincare

FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis via BuzzBlazer.com

Plasma cell rich lymphangiosarcoma an under-recognised variant and potential diagnostic pitfall

Plasma cell rich lymphangiosarcoma an under-recognised variant and potential diagnostic pitfall is a post from: Skincare

Plasma cell rich lymphangiosarcoma an under-recognised variant and potential diagnostic pitfall is a post from: Skincare

Plasma cell rich lymphangiosarcoma an under-recognised variant and potential diagnostic pitfall via BuzzBlazer.com

Scalp Discoloration from Selenium Sulfide: Revisiting a Report of Terra Firma-Forme Dermatosis of the Scalp

Scalp Discoloration from Selenium Sulfide: Revisiting a Report of Terra Firma-Forme Dermatosis of the Scalp is a post from: Skincare

Scalp Discoloration from Selenium Sulfide: Revisiting a Report of Terra Firma-Forme Dermatosis of the Scalp is a post from: Skincare

Scalp Discoloration from Selenium Sulfide: Revisiting a Report of Terra Firma-Forme Dermatosis of the Scalp via BuzzBlazer.com

Study design Mathé at al does not allow causal inference

Study design Mathé at al does not allow causal inference is a post from: Skincare

Study design Mathé at al does not allow causal inference is a post from: Skincare

Study design Mathé at al does not allow causal inference via BuzzBlazer.com

Possible Role of IL-17 In The Pathogenesis of Lichen Planus

Possible Role of IL-17 In The Pathogenesis of Lichen Planus is a post from: Skincare

Possible Role of IL-17 In The Pathogenesis of Lichen Planus is a post from: Skincare

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A Comprehensive Review of Current Treatments for Granulomatous Cheilitis

Abstract

Granulomatous cheilitis (GC) is a poorly understood disease process belonging to the larger group of orofacial granulomatosis. The treatment of GC has proven exceedingly difficult. While a variety of treatments have been applied to GC, there has been no uniform or predictably successful model demonstrated in the literature. The poorly understood etiologic mechanisms underpinning GC has significantly hampered the development an effective approach to treatment. Those therapies that have shown promise principally consist of agents with anti-inflammatory activity such as corticosteroids and immunomodulatory medications. On a careful review of the ...

A Comprehensive Review of Current Treatments for Granulomatous Cheilitis is a post from: Skincare

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A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus

Abstract

Background  To look into new potential indications for physical plasma and because some reports suggest plasma having antipruritic effects, we investigated the treatment of pruritus that often represents a therapeutic challenge.


Objectives  To assess the efficacy and safety of cold atmospheric argon plasma as add-on-therapy in pruritic diseases.


Methods  We treated 46 patients with various pruritic diseases with cold plasma for 2 min daily in addition to standard treatment. All patients served as their own control, when their pruritic disease was treated with argon gas (placebo). The outcome measure was a long-term and ...

A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus is a post from: Skincare

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Assessment of serum leptin, insulin resistance and metabolic syndrome in patients with skin tags

Abstract

Background  Skin tags are common cutaneous lesions with an indefinite aetiology.


Objectives  To assess serum leptin, insulin resistance and metabolic syndrome in different body mass index (BMI) patients with skin tags.


Methods  Three equally distributed groups of patients with multiple skin tags: 30 normal BMI, 30 overweight and 30 obese were included. Controls were age-, gender- and BMI-matched healthy subjects. Serum leptin, insulin resistance based on homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome were assessed in all groups.


Results  Number and extent of skin tags increase with the increase in ...

Assessment of serum leptin, insulin resistance and metabolic syndrome in patients with skin tags is a post from: Skincare

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The oral mucosal lesions in pre-school and school age Turkish children oral lesions in Turkish children

The oral mucosal lesions in pre-school and school age Turkish children oral lesions in Turkish children is a post from: Skincare

The oral mucosal lesions in pre-school and school age Turkish children oral lesions in Turkish children is a post from: Skincare

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Light-Emitting Diode Laser Versus Pulsed Dye Laser-Assisted Photodynamic Therapy in the Treatment of Actinic Keratosis and Bowen’s Disease

Light-Emitting Diode Laser Versus Pulsed Dye Laser-Assisted Photodynamic Therapy in the Treatment of Actinic Keratosis and Bowen’s Disease is a post from: Skincare

Light-Emitting Diode Laser Versus Pulsed Dye Laser-Assisted Photodynamic Therapy in the Treatment of Actinic Keratosis and Bowen’s Disease is a post from: Skincare

Light-Emitting Diode Laser Versus Pulsed Dye Laser-Assisted Photodynamic Therapy in the Treatment of Actinic Keratosis and Bowen’s Disease via BuzzBlazer.com

Melanotan-associated transverse melanonychia

Melanotan-associated transverse melanonychia is a post from: Skincare

Melanotan-associated transverse melanonychia is a post from: Skincare

Melanotan-associated transverse melanonychia via BuzzBlazer.com

New clues on the path of understanding unilateral naevoid telangiectasia

New clues on the path of understanding unilateral naevoid telangiectasia is a post from: Skincare

New clues on the path of understanding unilateral naevoid telangiectasia is a post from: Skincare

New clues on the path of understanding unilateral naevoid telangiectasia via BuzzBlazer.com

Lack of association between filaggrin gene mutations and onset of psoriasis in childhood

Abstract

Background  Atopic dermatitis (AD; OMIM#603165) and psoriasis (OMIM#177900) are two common inflammatory skin disorders. Both are genetically complex, multifactorial and do not follow a Mendelian pattern of inheritance. Both diseases share several genetic susceptibility loci such as the epidermal differentiation complex (EDC) on chromosome 1q21. Within the EDC, mutations in the filaggrin (FLG) gene are strongly associated with AD whereas no association has been replicated with psoriasis. However, reduced levels of filaggrin have been reported in psoriatic skin. Further, filaggrin deficiency was shown to be a modifying factor for the ...

Lack of association between filaggrin gene mutations and onset of psoriasis in childhood is a post from: Skincare

Lack of association between filaggrin gene mutations and onset of psoriasis in childhood via BuzzBlazer.com

Antifibrotic effect after low-dose imatinib mesylate treatment in patients with nephrogenic systemic fibrosis: an open-label non-randomized, uncontrolled clinical trial

Abstract

Background  Nephrogenic systemic fibrosis is a disease affecting the connective tissue of the skin and internal organs in patients with renal failure. No effective treatments are available.


Objectives  To investigate if the tyrosine kinase inhibitor, imatinib mesylate was effective in patients with moderate to severe nephrogenic systemic fibrosis.


Methods  Among 25 patients with nephrogenic systemic fibrosis evaluated for the study from 1 October 2009 to 1 December 2010, four were included. They were treated with oral imatinib mesylate at a start dose of 400 mg/day. Main outcome measure: Reduction of skin fibrosis and ...

Antifibrotic effect after low-dose imatinib mesylate treatment in patients with nephrogenic systemic fibrosis: an open-label non-randomized, uncontrolled clinical trial is a post from: Skincare

Antifibrotic effect after low-dose imatinib mesylate treatment in patients with nephrogenic systemic fibrosis: an open-label non-randomized, uncontrolled clinical trial via BuzzBlazer.com

Oral etoposide as first-line therapy in the treatment of patients with advanced classic Kaposi’s sarcoma (CKS): a single-arm trial (oral etoposide in CKS)

Abstract

Background  Classic Kaposi’s sarcoma (CKS) affects an elderly population; it is important to have effective treatment options with high activity and relatively low toxicity, and availability to be used for long periods.


Objective  We investigated the activity and safety of single-agent etoposide with an oral administration schedule in patients with advanced CKS.


Methods  Histologically confirmed, CKS patients were eligible for study. All had a negative test for HIV and good performance status. All patients received oral etoposide 50 mg twice daily for 10 days every 3 weeks.


Results  Thirty patients (median age 66 and 22 males) ...

Oral etoposide as first-line therapy in the treatment of patients with advanced classic Kaposi’s sarcoma (CKS): a single-arm trial (oral etoposide in CKS) is a post from: Skincare

Oral etoposide as first-line therapy in the treatment of patients with advanced classic Kaposi’s sarcoma (CKS): a single-arm trial (oral etoposide in CKS) via BuzzBlazer.com

Patient-reported outcomes in moderate-to-severe plaque psoriasis with scalp involvement: results from a randomized, double-blind, placebo-controlled study of etanercept

Patient-reported outcomes in moderate-to-severe plaque psoriasis with scalp involvement: results from a randomized, double-blind, placebo-controlled study of etanercept is a post from: Skincare

Patient-reported outcomes in moderate-to-severe plaque psoriasis with scalp involvement: results from a randomized, double-blind, placebo-controlled study of etanercept is a post from: Skincare

Patient-reported outcomes in moderate-to-severe plaque psoriasis with scalp involvement: results from a randomized, double-blind, placebo-controlled study of etanercept via BuzzBlazer.com

Acrochordons as a cutaneous sign of impaired carbohydrate metabolism, hyperlipidemia, liver enzyme abnormalities and hypertension: a case–control study

Abstract

Background  Acrochordons are common and benign skin tumours. A few studies with contradictory results have been reported regarding the abnormalities of carbohydrate and/or lipid metabolisms in patients with acrochordons.


Objectives  We aimed to determine if the presence of acrochordons could be a marker of diabetes, hyperlipidemia, liver enzyme abnormalities and hypertension by comparing with a control group.


Methods  A total of 110 patients having two or more acrochordons and age- and gender-matched 110 controls were included in the study. Localization, size and the total number of acrochordons were recorded in the patient ...

Acrochordons as a cutaneous sign of impaired carbohydrate metabolism, hyperlipidemia, liver enzyme abnormalities and hypertension: a case–control study is a post from: Skincare

Acrochordons as a cutaneous sign of impaired carbohydrate metabolism, hyperlipidemia, liver enzyme abnormalities and hypertension: a case–control study via BuzzBlazer.com

Treatment of granuloma annulare with the 595-nm pulsed dye laser, a multicentre retrospective study with long-term follow-up

Abstract

Background  Granuloma annulare (GA) is limited in most cases to isolated lesions, but more widespread generalized forms can be observed. In both cases, the treatment remains highly challenging. Isolated case reports suggested the interest of treating GA with a pulsed dye laser (PDL).


Objective  To evaluate the PDL in treating GA.


Materials and methods  Retrospective multicentre study. Each patient should have at least two lesions of GA including at least one that remained untreated to serve as a control. The evaluation was performed on an Investigator Global Assessment for each lesion as ...

Treatment of granuloma annulare with the 595-nm pulsed dye laser, a multicentre retrospective study with long-term follow-up is a post from: Skincare

Treatment of granuloma annulare with the 595-nm pulsed dye laser, a multicentre retrospective study with long-term follow-up via BuzzBlazer.com

Authors reply: New clues on the path of understanding unilateral naevoid telangiectasia

Authors reply: New clues on the path of understanding unilateral naevoid telangiectasia is a post from: Skincare

Authors reply: New clues on the path of understanding unilateral naevoid telangiectasia is a post from: Skincare

Authors reply: New clues on the path of understanding unilateral naevoid telangiectasia via BuzzBlazer.com

Human 6-sulfo LacNAc (slan) dendritic cells are a major population of dermal dendritic cells in steady state and inflammation

Summary

Background.  The immune system of the skin has a network of resident dendritic cells (DCs) consisting of epidermal Langerhans cells and various subsets of dermal DCs. We recently reported on a new population of dermal DCs, called slan (6-sulfoLacNAc+) DCs, which have a potent capacity to stimulate Th17/Th1 T-cell responses.


Aim.  To understand the characteristics of slanDCs as a new population of dermal DCs in the context of other DC populations in healthy and psoriatic skin.


Methods.  We immunofluorescently stained skin samples from healthy controls and from patients with psoriasis.


Results.  Staining healthy ...

Human 6-sulfo LacNAc (slan) dendritic cells are a major population of dermal dendritic cells in steady state and inflammation is a post from: Skincare

Human 6-sulfo LacNAc (slan) dendritic cells are a major population of dermal dendritic cells in steady state and inflammation via BuzzBlazer.com

Analyses of CDC2L1 gene mutations in keloid tissue

Summary

Background.  Keloid disease is the result of a deregulated wound-healing process. Loss of heterozygosity on chromosome 1p36 has been shown to be associated with keloid formation in humans. The cell division cycle 2-like 1 (CDC2L1) gene is known to be essential for eukaryotic cell-cycle control, and has also been mapped to 1p36.


Aim.  To verify the possible association between keloid disease and somatic mutation of the CDC2L1 gene on chromosome 1p36.


Methods.  Mutations of the CDC2L1 gene in keloid and healthy skin tissues were screened by denaturing high-performance liquid chromatography, and confirmed ...

Analyses of CDC2L1 gene mutations in keloid tissue is a post from: Skincare

Analyses of CDC2L1 gene mutations in keloid tissue via BuzzBlazer.com

Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles

Summary

Background.  Better understanding of the relevance of the immune response to common environmental allergens, such as the major house dust mite (HDM) allergen Der p 2, requires characterization of constituent T-cell epitopes.


Aim.  To identify CD4+ T-cell epitopes within Der p 2 recognized by commonly expressed human leucocyte antigen (HLA) alleles.


Methods.  HLA-blocking antibodies, peptide pools and truncations were used in ELISpot assays to establish restricted T-cell epitopes.


Results.  People with and without atopic dermatitis have detectable Der p 2-specific T cells in the peripheral blood, which can proliferate in response to Der ...

Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles is a post from: Skincare

Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles via BuzzBlazer.com

Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicenter, randomized, placebo-controlled double-blind trial

Summary

Background:  There is a need for the development of novel non-steroidal topical drugs for the treatment of atopic dermatitis.


Objectives:  The primary objective was to evaluate the efficacy of WBI-1001 over 6 weeks of treatment of mild to severe AD.


Methods:  Patients with atopic dermatitis (AD) affecting 3-20% of their body surface area (BSA) and with an Investigator’s Global Assessment (IGA) of 2 to 4 were randomized (1:1:1) to receive placebo, 0.5% WBI-1001, or 1.0% WBI-1001 in a cream formulation applied twice daily for 6 weeks. At the end of this phase, patients receiving WBI-1001 ...

Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicenter, randomized, placebo-controlled double-blind trial is a post from: Skincare

Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicenter, randomized, placebo-controlled double-blind trial via BuzzBlazer.com

Mucous membrane pemphigoid with generalized blisters: IgA and IgG autoantibodies target both laminin-332 and type XVII collagen

Abstract

Mucous membrane pemphigoid (MMP) is a mucous membrane-dominated, subepidermal autoimmune blistering disease in which autoantibodies usually react with the C-terminal domain of type XVII collagen (COL17) or with laminin-332. Only a few cases of MMP with widespread blisters have been reported. Serologically, IgA and IgG class autoantibodies directed against COL17 or IgG autoantibodies directed against laminin-332 in patients with MMP have been well documented. MMP cases in which IgA reacts with laminin-332, however, are extremely rare. We report a case of MMP in a 67-year-old man. Clinical examination revealed extensive ...

Mucous membrane pemphigoid with generalized blisters: IgA and IgG autoantibodies target both laminin-332 and type XVII collagen is a post from: Skincare

Mucous membrane pemphigoid with generalized blisters: IgA and IgG autoantibodies target both laminin-332 and type XVII collagen via BuzzBlazer.com

Asteatotic eczema (“eczema craquelé”) with histopathological interface dermatitis: a new cutaneous reaction following pemetrexed

Asteatotic eczema (“eczema craquelé”) with histopathological interface dermatitis: a new cutaneous reaction following pemetrexed is a post from: Skincare

Asteatotic eczema (“eczema craquelé”) with histopathological interface dermatitis: a new cutaneous reaction following pemetrexed is a post from: Skincare

Asteatotic eczema (“eczema craquelé”) with histopathological interface dermatitis: a new cutaneous reaction following pemetrexed via BuzzBlazer.com

Analysis of Three Outcome Measures in Moderate to Severe Psoriasis –A Registry Based Study of 2.450 Patients

Abstract

Background:  As moderate to severe psoriasis is a systemic disease with large effects on health related quality of life (HRQOL) generic measures that include overall health, not only skin involvement, are necessary. The knowledge about the relationship between the generic preference-based EQ-5D and dermatology-specific measures in psoriasis is limited.


Objective:  The objective was to analyse EQ-5D, the Dermatology Life Quality Index (DLQI) and Psoriasis Area and Severity Index (PASI) in patients with moderate to severe psoriasis in Swedish clinical practice by demographic characteristics, to compare EQ-5D among patients to Swedish population ...

Analysis of Three Outcome Measures in Moderate to Severe Psoriasis –A Registry Based Study of 2.450 Patients is a post from: Skincare

Analysis of Three Outcome Measures in Moderate to Severe Psoriasis –A Registry Based Study of 2.450 Patients via BuzzBlazer.com

Autologous Plasma and Serum Skin Test in Chronic Urticaria

Autologous Plasma and Serum Skin Test in Chronic Urticaria is a post from: Skincare

Autologous Plasma and Serum Skin Test in Chronic Urticaria is a post from: Skincare

Autologous Plasma and Serum Skin Test in Chronic Urticaria via BuzzBlazer.com

Autologous plasma and serum skin test in chronic urticaria – reply from authors

Autologous plasma and serum skin test in chronic urticaria – reply from authors is a post from: Skincare

Autologous plasma and serum skin test in chronic urticaria – reply from authors is a post from: Skincare

Autologous plasma and serum skin test in chronic urticaria – reply from authors via BuzzBlazer.com

Concentration variability of potent allergens of p-tert-Butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR

Abstract:

Background:  p-tert-Butylphenol-formaldehyde resin (PTBP-FR) is a common component of glues used in the manufacturing of many plastic, electronic, rubber, wood, and leather products. Two main allergens of PTBP-FR have been described.


Objectives:  The objective of this study is to determine the concentrations of the two main allergens of PTBP-FR in diagnostic patch testing preparations and PTBP-FR available to glue and adhesive manufacturers.


Methods:  Nuclear magnetic resonance spectrometry (NMR) was used to confirm identity and determine the purity of reference materials. High-pressure liquid chromatography (HPLC) was used to analyse patch test preparations and ...

Concentration variability of potent allergens of p-tert-Butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR is a post from: Skincare

Concentration variability of potent allergens of p-tert-Butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR via BuzzBlazer.com

NIR and skin impedance spectroscopic measurements for studying the effect of coffee and alcohol on skin, and dysplastic naevi

Background/purpose

Near infrared and impedance spectroscopy can be used for clinical skin measurements and need to be evaluated for possible confounding factors; (i) are skin conditions of the patient and the subsequent skin measurements influenced by alcohol and/or coffee consumption and (ii) are measurements of dysplastic naevi (DN) reproducible over time and significantly different compared to reference skin.



Methods

Near infrared and skin impedance spectroscopic data were analysed multivariately. In the first study, the skin characteristics of 15 healthy individuals were examined related to body location, gender, individual differences, and consumption of coffee ...

NIR and skin impedance spectroscopic measurements for studying the effect of coffee and alcohol on skin, and dysplastic naevi is a post from: Skincare

NIR and skin impedance spectroscopic measurements for studying the effect of coffee and alcohol on skin, and dysplastic naevi via BuzzBlazer.com

A novel method to investigate the relationship between facial movements and wrinkle formation using particle image velocimetry

Background

The possible relationship between the direction of wrinkles and the movement of facial skin has not previously been reported. Therefore, we characterized that relationship using particle image velocimetry (PIV) analysis.



Method

Twenty-one healthy Japanese women aged in their 20s (n = 7) or 50s (n = 14) were recruited for this study. Moving images of facial skin motions (closing the eyes tightly, raising the eyebrows) were captured using a single infrared camera under infrared ray irradiation of the skin. PIV analysis was then carried out using Flow-Vec32™ software to determine the velocity and the direction of ...

A novel method to investigate the relationship between facial movements and wrinkle formation using particle image velocimetry is a post from: Skincare

A novel method to investigate the relationship between facial movements and wrinkle formation using particle image velocimetry via BuzzBlazer.com

Emerging applications of nanomedicine in dermatology

Background

Nanotechnology is a new branch of engineering consisting of the usage of nanoscale particles (100 nm and smaller). Nanomedicine is the application of nanoscale technologies for diagnostic and therapeutic purposes in medicine. Nanodermatology, nanotechnology applied to dermatology, represents one of the most advanced field for which an increasing interest, both economic and scientific, is rising.


 The skin is the first point of contact for a whole host of nanomaterials, ranging from topical preparations, articles of clothing and household products, to sporting goods and industrial manufactured goods.


 Applications of nanomedicine in dermatology include new ...

Emerging applications of nanomedicine in dermatology is a post from: Skincare

Emerging applications of nanomedicine in dermatology via BuzzBlazer.com

Association of psoriasis with the VEGF gene polymorphism in the northern Polish population

Abstract

Background  Neovascularization plays an important role in pathogenesis of psoriasis and vascular endothelial growth factor (VEGF) seems to be the main angiogenic factor involved in this disease. Published studies which analysed the role of VEGF gene polymorphism in psoriasis were limited and they received controversial results.


Objective The aim of our study was to evaluate the association between −1154 G/A, −460 T/C and +405 G/C polymorphisms and the psoriasis susceptibility and to determine whether this genetic variation influence levels of VEGF protein expression.


Materials and methods  One hundred and eighty-nine patients with psoriasis ...

Association of psoriasis with the VEGF gene polymorphism in the northern Polish population is a post from: Skincare

Association of psoriasis with the VEGF gene polymorphism in the northern Polish population via BuzzBlazer.com

Childhood mycosis fungoides: a report of 20 cases from Turkey

Abstract

Background  Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphomas in adults. In the recent past, several reports have focused on an increased prevalence of MF in children.


Objective  The present study was aimed to evaluate the clinical characteristics, treatment modalities and disease progression in childhood MF patients from Turkey.


Methods  In a retrospective analysis of 368 MF patients in a referral center at Istanbul, Turkey, 20 patients were diagnosed before the age of 18 years and were included in the study.


Results  Childhood cases constituted 5.4% of all MF ...

Childhood mycosis fungoides: a report of 20 cases from Turkey is a post from: Skincare

Childhood mycosis fungoides: a report of 20 cases from Turkey via BuzzBlazer.com

Long standing scientist and ICS editorial board member passes away

Long standing scientist and ICS editorial board member passes away is a post from: Skincare

Long standing scientist and ICS editorial board member passes away is a post from: Skincare

Long standing scientist and ICS editorial board member passes away via BuzzBlazer.com

A secretion of the mollusk Cryptomphalus aspersa promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts in vitro

Synopsis

Regenerative properties of skin decrease with age and, thus, the search for substances that minimize cutaneous aging has increased in the last few years. The secretion of the mollusk Cryptomphalus Aspersa (SCA) is a natural product that bears regenerative properties when applied topically.


Objectives:  To study the in vitro effects of SCA on cell proliferation and migration, as well as on cell-cell (E-Cadherin, β-catenin) and cell-substrate (vinculin, β1-integrin) adhesion proteins expression.


Methods:  We have used a human keratinocyte cell line (HaCaT cells) and primary dermal fibroblasts (HF). To test cells proliferation, a ...

A secretion of the mollusk Cryptomphalus aspersa promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts in vitro is a post from: Skincare

A secretion of the mollusk Cryptomphalus aspersa promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts in vitro via BuzzBlazer.com

Recommendations for the treatment of nail psoriasis in patients with moderate to severe psoriasis: a dermatology expert group consensus

Abstract

Background  Nail involvement is common in psoriasis patients and is often associated with severe disease. Patients with nail psoriasis experience pain, functional impairment and social stigma, with significant restriction of daily activities and quality of life. However, nail psoriasis often goes untreated, as many physicians believe it is difficult to treat, despite the availability of effective treatment options. Clinical data and guidelines for managing and treating psoriasis patients with both skin and nail symptoms are limited.


Objective  To prepare recommendations for the management and treatment of patients with moderate to severe ...

Recommendations for the treatment of nail psoriasis in patients with moderate to severe psoriasis: a dermatology expert group consensus is a post from: Skincare

Recommendations for the treatment of nail psoriasis in patients with moderate to severe psoriasis: a dermatology expert group consensus via BuzzBlazer.com

Photodynamic therapy for actinic keratosis in organ transplant patients

Abstract

Background  The incidence of actinic keratoses (AK) and non-melanoma skin cancer (NMSC) in organ transplant recipients (OTRs) is significantly higher than in immunocompetent patients. Rates of progression and recurrence following treatment are higher too, in part due to the effects of the immunosuppressant drugs. Conventional therapies for AK, using curettage, cryotherapy, surgical excision, topical therapies and photodynamic therapy (PDT), are often less effective, and may be inappropriate, for treating the greater numbers and extent of lesions in OTRs. Moreover, there are no specific protocols for treating this patient population that ...

Photodynamic therapy for actinic keratosis in organ transplant patients is a post from: Skincare

Photodynamic therapy for actinic keratosis in organ transplant patients via BuzzBlazer.com

Familial Eruptive Vellus Hair Cysts

Abstract:  Eruptive vellus hairs cysts are benign papules consisting of small cysts containing multiple vellus hairs. An eruption commonly develops on the chest and sometimes the upper extremities. These papules are asymptomatic or rarely pruritic. Only a few cases of familial association have been described. We report the development of eruptive vellus hair cysts on the trunk of an 8- and 12-year-old sister and brother.

Familial Eruptive Vellus Hair Cysts is a post from: Skincare

Familial Eruptive Vellus Hair Cysts is a post from: Skincare

Familial Eruptive Vellus Hair Cysts via BuzzBlazer.com

Lipodystrophia Centrifugalis Abdominalis Infantilis: Report of four cases

Abstract:  Lipodystrophia centrifugalis abdominalis infantilis (LCAI) is a rare lipodystrophic disorder mainly affecting Eastern Asian children. We report the clinicopathologic findings of four Taiwanese children with LCAI in which local induration or ecchymotic changes preceded the skin depressions on the groin or abdomen.

Lipodystrophia Centrifugalis Abdominalis Infantilis: Report of four cases is a post from: Skincare

Lipodystrophia Centrifugalis Abdominalis Infantilis: Report of four cases is a post from: Skincare

Lipodystrophia Centrifugalis Abdominalis Infantilis: Report of four cases via BuzzBlazer.com

Intralesional Phosphatidylcholine and Sodium Deoxycholate: A Possible Treatment Option for Nevus Lipomatosus Superficialis

Abstract:  Treatment options are limited for classic nevus lipomatosus superficialis, in which clustered lesions present over a large area. We present a case of nevus lipomatosus superficialis that showed clinical and histological improvement after treatment with intralesional phosphatidylcholine and sodium deoxy-cholate.

Intralesional Phosphatidylcholine and Sodium Deoxycholate: A Possible Treatment Option for Nevus Lipomatosus Superficialis is a post from: Skincare

Intralesional Phosphatidylcholine and Sodium Deoxycholate: A Possible Treatment Option for Nevus Lipomatosus Superficialis is a post from: Skincare

Intralesional Phosphatidylcholine and Sodium Deoxycholate: A Possible Treatment Option for Nevus Lipomatosus Superficialis via BuzzBlazer.com

“Cauliflower Ear” in a Teenager: A Possible Sign of Child Abuse

Abstract:  “Cauliflower ear” is a perichondritis of the auricular pavilion, usually caused by infection or repeated trauma. In children, this entity is considered infrequent. We present the case of a 10-year-old girl living in a child care institution with “cauliflower ear” that was interpreted as a possible sign of child abuse.

“Cauliflower Ear” in a Teenager: A Possible Sign of Child Abuse is a post from: Skincare

“Cauliflower Ear” in a Teenager: A Possible Sign of Child Abuse is a post from: Skincare

“Cauliflower Ear” in a Teenager: A Possible Sign of Child Abuse via BuzzBlazer.com

Buschke-Ollendorff Syndrome and Bilateral Cutaneous Syndactyly

Abstract:  A 3-year-old boy presented with asymptomatic elastomas on the posterior trunk. Radiographic studies revealed osteopoikilosis, confirming the diagnosis of Buschke-Ollendorff syndrome. The patient had a history of bilateral simple cutaneous syndactyly, which has not been previously reported with this condition. Buschke-Ollendorff syndrome is a rare autosomal-dominant disorder characterized by connective tissue nevi and osteopoikilosis. Several associated systemic abnormalities have been reported, but morbidity and mortality are generally not affected.

Buschke-Ollendorff Syndrome and Bilateral Cutaneous Syndactyly is a post from: Skincare

Buschke-Ollendorff Syndrome and Bilateral Cutaneous Syndactyly is a post from: Skincare

Buschke-Ollendorff Syndrome and Bilateral Cutaneous Syndactyly via BuzzBlazer.com

Wells’ Syndrome Associated with Parvovirus in a 5-Year Old Boy

Abstract:  Wells’ syndrome, otherwise known as eosinophilic cellulitis, is a rare dermatosis seen more commonly in adults than in children. In this article, we present a 5-year-old Caucasian boy who initially presented with pruritic, erythematous macules and papules evolving to bullae formation. Subsequent histology confirmed diagnosis of Wells’ syndrome, and additional blood work also demonstrated positive immunoglobulin (Ig)M and IgG for parvovirus. In many instances, the direct etiology of Wells’ syndrome is unclear, but the link between parvoviral infection and development of Wells’ syndrome could further support an additional cause.

Wells’ ...

Wells’ Syndrome Associated with Parvovirus in a 5-Year Old Boy is a post from: Skincare

Wells’ Syndrome Associated with Parvovirus in a 5-Year Old Boy via BuzzBlazer.com

Treatment Outcomes of Secondarily Impetiginized Pediatric Atopic Dermatitis Lesions and the Role of Oral Antibiotics

Abstract:  Patients with atopic dermatitis (AD) are predisposed to infection with Staphylococcus aureus, which worsens their skin disease; it has been postulated that the lack of antimicrobial peptides due to aberrant allergic inflammation in skin with AD could mediate this enhanced bacterial susceptibility. We sought to characterize the amounts of S. aureus and biological products found in infected AD lesions and whether treatment with topical corticosteroids and oral cephalexin as the only antimicrobial improved outcomes. Fifty-nine children with clinically and S. aureus–positive impetiginized lesions of AD were enrolled in this study. A ...

Treatment Outcomes of Secondarily Impetiginized Pediatric Atopic Dermatitis Lesions and the Role of Oral Antibiotics is a post from: Skincare

Treatment Outcomes of Secondarily Impetiginized Pediatric Atopic Dermatitis Lesions and the Role of Oral Antibiotics via BuzzBlazer.com

Timolol Maleate 0.5% or 0.1% Gel-Forming Solution for Infantile Hemangiomas: A Retrospective, Multicenter, Cohort Study

Abstract:  Therapeutic options for superficial infantile hemangiomas (IH) are limited. Recently, timolol maleate gel, a topical nonselective beta-blocker, has been reported as a potentially effective treatment for superficial IH. This study is an extension of a previously published pilot study designed to further investigate the efficacy and safety and to identify predictors of good response of topical 0.5% or 0.1% timolol maleate gel-forming solution. This was a retrospective cohort study including patients enrolled from five centers. Patients were included if they were treated with timolol maleate 0.1% or 0.5% gel-forming ...

Timolol Maleate 0.5% or 0.1% Gel-Forming Solution for Infantile Hemangiomas: A Retrospective, Multicenter, Cohort Study is a post from: Skincare

Timolol Maleate 0.5% or 0.1% Gel-Forming Solution for Infantile Hemangiomas: A Retrospective, Multicenter, Cohort Study via BuzzBlazer.com

Skin hardening effect in patients with polymorphic light eruption: Comparison of UVB hardening in hospital with a novel home UV-hardening device

Abstract

Background  An effective prophylactic treatment of patients with polymorphic light eruption (PLE) consists of repeated low, gradually increasing exposures to UVB radiation. This so-called UV(B) hardening induces better tolerance of the skin to sunlight.


Objective  SunshowerMedical company (Amsterdam) has developed an UV (B) source that can be used during taking shower. The low UV fluence of this apparatus makes it an interesting device for UV hardening. In a group of PLE patients, we compared the effectiveness of the irradiation with SunshowerMedical at home with that of the UVB treatment in the ...

Skin hardening effect in patients with polymorphic light eruption: Comparison of UVB hardening in hospital with a novel home UV-hardening device is a post from: Skincare

Skin hardening effect in patients with polymorphic light eruption: Comparison of UVB hardening in hospital with a novel home UV-hardening device via BuzzBlazer.com