White Gel Pen Easily Marks a Port-Wine Stain Margin During Pulsed Dye Laser Therapy is a post from: Skincare
White Gel Pen Easily Marks a Port-Wine Stain Margin During Pulsed Dye Laser Therapy via BuzzBlazer.com
Friday, September 30, 2011
White Gel Pen Easily Marks a Port-Wine Stain Margin During Pulsed Dye Laser Therapy
White Gel Pen Easily Marks a Port-Wine Stain Margin During Pulsed Dye Laser Therapy is a post from: Skincare
White Gel Pen Easily Marks a Port-Wine Stain Margin During Pulsed Dye Laser Therapy via BuzzBlazer.com
White Gel Pen Easily Marks a Port-Wine Stain Margin During Pulsed Dye Laser Therapy via BuzzBlazer.com
Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature
Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature is a post from: Skincare
Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature via BuzzBlazer.com
Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature is a post from: Skincare
Management of Pilomatrix Carcinoma: A Case Report of Successful Treatment with Mohs Micrographic Surgery and Review of the Literature via BuzzBlazer.com
Lateral Longitudinal Excision of the Nail Unit
Lateral Longitudinal Excision of the Nail Unit is a post from: Skincare
Lateral Longitudinal Excision of the Nail Unit via BuzzBlazer.com
Lateral Longitudinal Excision of the Nail Unit is a post from: Skincare
Lateral Longitudinal Excision of the Nail Unit via BuzzBlazer.com
Characterization of Clinical Response in Patients with Vitiligo Undergoing Autologous Epidermal Punch Grafting
Background
Punch grafting is a well-established treatment for vitiligo, but predictive factors for outcomes are not well established.
Objective
To determine the characteristics of responses to punch grafting performed in patients with vitiligo.
Methods and Materials
Retrospective, single-center chart review. Response rates were assessed using photographs taken before and after grafting using a 1.5-mm punch instrument. Effectiveness of repigmentation was assessed using the following scale: worse, no improvement, 0% to 25% improvement, 25% to 50% improvement, 50% to 75% improvement, and 75% to 100% improvement. Repigmentation rates were correlated with patient demographics.
Results
Thirty-seven charts were reviewed, ...
Characterization of Clinical Response in Patients with Vitiligo Undergoing Autologous Epidermal Punch Grafting is a post from: Skincare
Characterization of Clinical Response in Patients with Vitiligo Undergoing Autologous Epidermal Punch Grafting via BuzzBlazer.com
Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi
Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi is a post from: Skincare
Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi via BuzzBlazer.com
Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi is a post from: Skincare
Basal Cell Carcinoma, Syringocystadenoma Papilliferum, Trichilemmoma, and Sebaceoma Arising Within a Nevus Sebaceus Associated with Pigmented Nevi via BuzzBlazer.com
Comparison of the Efficacy of Intralesional Triamcinolone Acetonide and 5-Fluorouracil Tattooing for the Treatment of Keloids
Background
Hypertrophic scars and keloids may complicate wound healing secondary to trauma or surgery. A variety of treatment regimens have been used for treatment of keloids.
Objective
To compare 5-fluorouracil (5-FU) tattooing and intralesional steroid for treatment of keloids.
Methods
In this 44-week, double-blind, clinical trial, 40 patients were randomized into two study groups. Patients in group 1 were given intralesional triamcinolone acetonide (TAC), and patients in group 2 were treated with 5-FU tattooing; both groups received treatment every 4 weeks for 12 weeks. Lesions were assessed for erythema, pruritus, height, surface, and induration at baseline (initiation ...
Comparison of the Efficacy of Intralesional Triamcinolone Acetonide and 5-Fluorouracil Tattooing for the Treatment of Keloids is a post from: Skincare
Comparison of the Efficacy of Intralesional Triamcinolone Acetonide and 5-Fluorouracil Tattooing for the Treatment of Keloids via BuzzBlazer.com
Thursday, September 29, 2011
The Euromelanoma skin cancer prevention campaign in Europe: characteristics and results of 2009 and 2010
Abstract
Background Euromelanoma is a skin cancer education and prevention campaign that started in 1999 in Belgium as ‘Melanoma day’. Since 2000, it is active in a large and growing number of European countries under the name Euromelanoma.
Objective To evaluate results of Euromelanoma in 2009 and 2010 in 20 countries, describing characteristics of screenees, rates of clinically suspicious lesions for skin cancer and detection rates of melanomas.
Methods Euromelanoma questionnaires were used by 20 countries providing their data in a standardized database (Belgium, Croatia, Cyprus, Czech Republic, FYRO Macedonia, Germany, Greece, Hungary, ...
The Euromelanoma skin cancer prevention campaign in Europe: characteristics and results of 2009 and 2010 via BuzzBlazer.com
Background Euromelanoma is a skin cancer education and prevention campaign that started in 1999 in Belgium as ‘Melanoma day’. Since 2000, it is active in a large and growing number of European countries under the name Euromelanoma.
Objective To evaluate results of Euromelanoma in 2009 and 2010 in 20 countries, describing characteristics of screenees, rates of clinically suspicious lesions for skin cancer and detection rates of melanomas.
Methods Euromelanoma questionnaires were used by 20 countries providing their data in a standardized database (Belgium, Croatia, Cyprus, Czech Republic, FYRO Macedonia, Germany, Greece, Hungary, ...
The Euromelanoma skin cancer prevention campaign in Europe: characteristics and results of 2009 and 2010 is a post from: Skincare
The Euromelanoma skin cancer prevention campaign in Europe: characteristics and results of 2009 and 2010 via BuzzBlazer.com
A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population
Abstract
Background Vitiligo has been found to be associated with different HLA antigens in different ethnic groups. In our previous genome-wide association study (GWAS), we identified independent association signal of rs9468925 (P = 2.21 × 10−33, OR = 0.74) within HLA-C-HLA-B region.
Objectives To explore the association between rs9468925 polymorphism within MHC and the clinical features of generalized vitiligo.
Methods The study, using 5566 cases and 6462 controls from previous GWA study investigated the single and combined (GA + GG) genotypic distribution of rs9468925 in subsets of vitiligo patients having different clinical features. We performed a QTL analysis (quantitative trait locus) ...
A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population via BuzzBlazer.com
Background Vitiligo has been found to be associated with different HLA antigens in different ethnic groups. In our previous genome-wide association study (GWAS), we identified independent association signal of rs9468925 (P = 2.21 × 10−33, OR = 0.74) within HLA-C-HLA-B region.
Objectives To explore the association between rs9468925 polymorphism within MHC and the clinical features of generalized vitiligo.
Methods The study, using 5566 cases and 6462 controls from previous GWA study investigated the single and combined (GA + GG) genotypic distribution of rs9468925 in subsets of vitiligo patients having different clinical features. We performed a QTL analysis (quantitative trait locus) ...
A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population is a post from: Skincare
A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population via BuzzBlazer.com
Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration
Abstract
Background Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation.
Objectives The aim of this study was to investigate apoptosis process in RAU using immunohistochemistry.
Methods We studied the expression and location of p53, bcl-2 and bax in ulcerated lesions clinically diagnosed as RAU (n = 12) and compared it with that of oral clinically normal mucosa (n = 6) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; n = 18).
Results Significant statistically differences (n < 0.05) in ...
Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration via BuzzBlazer.com
Background Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation.
Objectives The aim of this study was to investigate apoptosis process in RAU using immunohistochemistry.
Methods We studied the expression and location of p53, bcl-2 and bax in ulcerated lesions clinically diagnosed as RAU (n = 12) and compared it with that of oral clinically normal mucosa (n = 6) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; n = 18).
Results Significant statistically differences (n < 0.05) in ...
Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration is a post from: Skincare
Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration via BuzzBlazer.com
The importance of stressful family events in psoriatic patients: a retrospective study
Abstract
Background Psychosomatic stress events are believed to play an important role in psoriasis either by inducing or worsening the disease.
Objective In this article, we compared the role of family stress events against other types of stress events on the psychological well being of patients and on their skin disease. We used our sample of psoriasis patients with said stress events.
Method Patients underwent a dermatological examination which was evaluated through the PASI index. Simultaneously, they underwent interviews for psychological evaluations. The Hamilton scales were administered to assess anxiety and depression (Ham-A ...
The importance of stressful family events in psoriatic patients: a retrospective study via BuzzBlazer.com
Background Psychosomatic stress events are believed to play an important role in psoriasis either by inducing or worsening the disease.
Objective In this article, we compared the role of family stress events against other types of stress events on the psychological well being of patients and on their skin disease. We used our sample of psoriasis patients with said stress events.
Method Patients underwent a dermatological examination which was evaluated through the PASI index. Simultaneously, they underwent interviews for psychological evaluations. The Hamilton scales were administered to assess anxiety and depression (Ham-A ...
The importance of stressful family events in psoriatic patients: a retrospective study is a post from: Skincare
The importance of stressful family events in psoriatic patients: a retrospective study via BuzzBlazer.com
Associations between eNOS polymorphisms and susceptibility to Behcet’s disease: a meta-analysis
Abstract
Objective To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet’s disease (BD).
Methods A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model.
Results A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one ...
Associations between eNOS polymorphisms and susceptibility to Behcet’s disease: a meta-analysis via BuzzBlazer.com
Objective To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet’s disease (BD).
Methods A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model.
Results A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one ...
Associations between eNOS polymorphisms and susceptibility to Behcet’s disease: a meta-analysis is a post from: Skincare
Associations between eNOS polymorphisms and susceptibility to Behcet’s disease: a meta-analysis via BuzzBlazer.com
Chronic cutaneous leishmaniasis, a great mimicker with various clinical presentations: 12 years experience from Aleppo
Abstract
Background Cutaneous leishmaniasis (CL) has been an endemic disease in Aleppo, Syria for many decades. During the past 12 years, there was a clear increase in the overall incidence of the disease in the region. Treatment using intralesional method of antimonial compounds became ineffective in a considerable proportion of cases and more patients developed the chronic form of the disease.
Objectives To categorize chronic cutaneous leishmaniasis (CCL) into different subtypes that mimic a wide spectrum of skin diseases, and to analyse the cause of this increase in the incidence of the disease ...
Chronic cutaneous leishmaniasis, a great mimicker with various clinical presentations: 12 years experience from Aleppo via BuzzBlazer.com
Background Cutaneous leishmaniasis (CL) has been an endemic disease in Aleppo, Syria for many decades. During the past 12 years, there was a clear increase in the overall incidence of the disease in the region. Treatment using intralesional method of antimonial compounds became ineffective in a considerable proportion of cases and more patients developed the chronic form of the disease.
Objectives To categorize chronic cutaneous leishmaniasis (CCL) into different subtypes that mimic a wide spectrum of skin diseases, and to analyse the cause of this increase in the incidence of the disease ...
Chronic cutaneous leishmaniasis, a great mimicker with various clinical presentations: 12 years experience from Aleppo is a post from: Skincare
Chronic cutaneous leishmaniasis, a great mimicker with various clinical presentations: 12 years experience from Aleppo via BuzzBlazer.com
Life quality of Chinese patients with chronic urticaria as assessed by the dermatology life quality index
Abstract
Background No report focused on the life quality of Chinese patients with chronic urticaria (CU). It was also due to lack of data to assess the usage of the Dermatology Life Quality Index (DLQI) in Chinese patients.
Objectives We explored the quality of life (QoL) of Chinese patients with CU and assessed the factor structure and reliability of the Chinese version of the DLQI.
Methods The DLQI scores were recorded to evaluate the life quality of out-patients with CU. The reliability and the factor structure of the DLQI were assessed using reliability ...
Life quality of Chinese patients with chronic urticaria as assessed by the dermatology life quality index via BuzzBlazer.com
Background No report focused on the life quality of Chinese patients with chronic urticaria (CU). It was also due to lack of data to assess the usage of the Dermatology Life Quality Index (DLQI) in Chinese patients.
Objectives We explored the quality of life (QoL) of Chinese patients with CU and assessed the factor structure and reliability of the Chinese version of the DLQI.
Methods The DLQI scores were recorded to evaluate the life quality of out-patients with CU. The reliability and the factor structure of the DLQI were assessed using reliability ...
Life quality of Chinese patients with chronic urticaria as assessed by the dermatology life quality index is a post from: Skincare
Life quality of Chinese patients with chronic urticaria as assessed by the dermatology life quality index via BuzzBlazer.com
Pilot study on reflectance confocal microscopy imaging of lichen planus: a real-time, non-invasive aid for clinical diagnosis
Abstract
Background Lichen planus (LP) represents a relatively common skin inflammatory entity included in the major group of interface dermatitis. In recent years, reflectance confocal microscopy has demonstrated to be a valuable tool for the ‘in vivo’ characterization of various skin diseases with cellular level resolution. No data are currently available that uses reflectance confocal microscopy to study LP.
Observations In this study, we have investigated the clinical and confocal features of five cases of histopathologically proven LP, and we have correlated the observed features with histopathological findings. The most characteristic criterion ...
Pilot study on reflectance confocal microscopy imaging of lichen planus: a real-time, non-invasive aid for clinical diagnosis via BuzzBlazer.com
Background Lichen planus (LP) represents a relatively common skin inflammatory entity included in the major group of interface dermatitis. In recent years, reflectance confocal microscopy has demonstrated to be a valuable tool for the ‘in vivo’ characterization of various skin diseases with cellular level resolution. No data are currently available that uses reflectance confocal microscopy to study LP.
Observations In this study, we have investigated the clinical and confocal features of five cases of histopathologically proven LP, and we have correlated the observed features with histopathological findings. The most characteristic criterion ...
Pilot study on reflectance confocal microscopy imaging of lichen planus: a real-time, non-invasive aid for clinical diagnosis is a post from: Skincare
Pilot study on reflectance confocal microscopy imaging of lichen planus: a real-time, non-invasive aid for clinical diagnosis via BuzzBlazer.com
Pulsed dye laser as an excellent choice of treatment for lupus tumidus: a prospective study
Abstract
Background Clinical manifestations of cutaneous lupus erythematosus (CLE) vary widely, and different subtypes of this autoimmune disease exist. Tumidus subtype (LT) has been recently separated from the chronic subtypes and is now considered an independent entity due to its particular clinical and histological features. Different treatments are usually prescribed for CLE. Our group has experience of CLE effectively treated with pulsed dye laser (PDL). It was our impression that better responses were achieved in the LT subtype, but no controlled prospective studies with PDL have been specifically performed.
Materials and methods ...
Pulsed dye laser as an excellent choice of treatment for lupus tumidus: a prospective study via BuzzBlazer.com
Background Clinical manifestations of cutaneous lupus erythematosus (CLE) vary widely, and different subtypes of this autoimmune disease exist. Tumidus subtype (LT) has been recently separated from the chronic subtypes and is now considered an independent entity due to its particular clinical and histological features. Different treatments are usually prescribed for CLE. Our group has experience of CLE effectively treated with pulsed dye laser (PDL). It was our impression that better responses were achieved in the LT subtype, but no controlled prospective studies with PDL have been specifically performed.
Materials and methods ...
Pulsed dye laser as an excellent choice of treatment for lupus tumidus: a prospective study is a post from: Skincare
Pulsed dye laser as an excellent choice of treatment for lupus tumidus: a prospective study via BuzzBlazer.com
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells
Abstract
Background Microphthalmia associated transcription factor (Mitf) is a key regulatory transcriptional factor of pigmentation-related genes including tyrosinase. Inhibition of tyrosinase transcription by blocking the binding of Mitf with its promoter E-box DNA can control the pigmentation. However, no such chemicals were reported so far.
Objective To discover and evaluate the small molecule inhibitors of Mitf-E-box DNA.
Methods Candidate chemicals were screened by virtual screening from pharmacophore data followed by Mitf E-box DNA protein chip. After selecting the chemical, its inhibitory activity on binding interaction between Mitf and E-box DNA, electrophoretic mobility shift ...
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells via BuzzBlazer.com
Background Microphthalmia associated transcription factor (Mitf) is a key regulatory transcriptional factor of pigmentation-related genes including tyrosinase. Inhibition of tyrosinase transcription by blocking the binding of Mitf with its promoter E-box DNA can control the pigmentation. However, no such chemicals were reported so far.
Objective To discover and evaluate the small molecule inhibitors of Mitf-E-box DNA.
Methods Candidate chemicals were screened by virtual screening from pharmacophore data followed by Mitf E-box DNA protein chip. After selecting the chemical, its inhibitory activity on binding interaction between Mitf and E-box DNA, electrophoretic mobility shift ...
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells is a post from: Skincare
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells via BuzzBlazer.com
Penetration Pattern of Rhodamine Dyes into Enamel and Dentin: Confocal Laser Microscopy Observation
Synopsis
Enamel and dentin are susceptible to extrinsic and intrinsic stains. The purpose of this study was to determine the penetration pattern of Rhodamine B and dextran-conjugated Rhodamine B into the enamel and dentin as observed by confocal laser microscopy and relate it to the penetration pattern of hydrogen peroxide commonly used as an active ingredient in tooth whitening agents and high molecular weight staining molecules. Eighteen recently extracted human maxillary anterior teeth were used. Teeth were cleaned and painted with nail varnish except for the crown area above the cemento-enamel ...
Penetration Pattern of Rhodamine Dyes into Enamel and Dentin: Confocal Laser Microscopy Observation via BuzzBlazer.com
Enamel and dentin are susceptible to extrinsic and intrinsic stains. The purpose of this study was to determine the penetration pattern of Rhodamine B and dextran-conjugated Rhodamine B into the enamel and dentin as observed by confocal laser microscopy and relate it to the penetration pattern of hydrogen peroxide commonly used as an active ingredient in tooth whitening agents and high molecular weight staining molecules. Eighteen recently extracted human maxillary anterior teeth were used. Teeth were cleaned and painted with nail varnish except for the crown area above the cemento-enamel ...
Penetration Pattern of Rhodamine Dyes into Enamel and Dentin: Confocal Laser Microscopy Observation is a post from: Skincare
Penetration Pattern of Rhodamine Dyes into Enamel and Dentin: Confocal Laser Microscopy Observation via BuzzBlazer.com
Wednesday, September 28, 2011
Safety and efficacy of sunscreens: demystifying the debate
Safety and efficacy of sunscreens: demystifying the debate is a post from: Skincare
Safety and efficacy of sunscreens: demystifying the debate via BuzzBlazer.com
Safety and efficacy of sunscreens: demystifying the debate is a post from: Skincare
Safety and efficacy of sunscreens: demystifying the debate via BuzzBlazer.com
The D-batable safety of sunscreens
The D-batable safety of sunscreens is a post from: Skincare
The D-batable safety of sunscreens via BuzzBlazer.com
The D-batable safety of sunscreens is a post from: Skincare
The D-batable safety of sunscreens via BuzzBlazer.com
Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy
Leishmaniasis is a protozoan infectious disease that often affects the skin and may acquire a chronic and difficult to treat course. Topical photodynamic therapy (PDT) is a novel treatment which involves the selective uptake of a photosensitizing agent. Exposure to an appropriate light source in the presence of oxygen leads to formation of reactive oxygen species and destruction of the target cells. We report on the successful treatment of a 69-year-old patient with a relapse of long-standing cutaneous leishmaniasis using intralesional aminolevulinic acid-PDT.
Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic ...
Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy is a post from: Skincare
Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy via BuzzBlazer.com
Localized bullous pemphigoid induced by photodynamic therapy
Topical photodynamic therapy (PDT) causes localized phototoxicity and has been shown both in vitro and in humans to have immunomodulatory and immunosuppressive effects. We report a case of localized bullous pemphigoid (BP) developing after PDT. Although BP has been reported to develop following cutaneous insults such as surgery, radiotherapy, psoralen ultraviolet A (PUVA) and ultraviolet B phototherapy, PDT has not previously been reported as a trigger. Possible mechanisms include direct mechanical injury to the basement membrane and subsequent autoantibody formation, an indirect immunomodulatory effect of PDT, or most likely, precipitation ...
Localized bullous pemphigoid induced by photodynamic therapy is a post from: Skincare
Localized bullous pemphigoid induced by photodynamic therapy via BuzzBlazer.com
Successful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp
Narrow-band ultraviolet B (NB-UVB) therapy is widely used for refractory skin diseases. Targeted phototherapy is now being used to reduce the number of sessions and to avoid exposing normal skin. We developed a targeted NB-UVB therapy using a flat-type lamp emitting a wavelength similar to that of the TL-01 fluorescent lamp. Six Japanese patients with psoriasis were recruited and treated with the flat-type NB-UVB device with an initial dose of 70% of the minimal erythema dose, with a 20% increase at each subsequent session. The plaque severity score was determined. ...
Successful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp is a post from: Skincare
Successful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp via BuzzBlazer.com
Systemic photosensitivity due to Goji berries
Systemic photosensitivity due to the intake of plants or herbal compounds is a rare phenomenon. Goji berries are widely used as a well-being and anti-aging remedy. In spite of this, only a few adverse reactions and no cases of photosensitivity have been reported to date. A 53-year-old male consulted due to a pruriginous eruption located on sun-exposed areas of 2 weeks of duration. He had been taking Goji berries and infusions of cat’s claw herb for 5 and 3 months, respectively. Minimal erythema dose for UVB (MED-UVB) was diminished when ...
Systemic photosensitivity due to Goji berries is a post from: Skincare
Systemic photosensitivity due to Goji berries via BuzzBlazer.com
The solar ultraviolet B radiation protection provided by shading devices with regard to its diffuse component
Background: The composition of the incident solar global ultraviolet B (UVB) radiation with regard to its beam and diffuse radiation fractions is highly relevant with regard to outdoor sun protection. This is especially true with respect to sun protection during leisure-time outdoor sun exposure at the shore and pools, where people tend to escape the sun under shade trees or different types of shading devices, e.g., umbrellas, overhangs, etc., believing they offer protection from the erythemal solar radiation. The degree of sun protection offered by such devices is directly ...
The solar ultraviolet B radiation protection provided by shading devices with regard to its diffuse component is a post from: Skincare
The solar ultraviolet B radiation protection provided by shading devices with regard to its diffuse component via BuzzBlazer.com
Protection against ultraviolet A-induced oxidative damage in normal human epidermal keratinocytes under post-menopausal conditions by an ultraviolet A-activated caged-iron chelator: a pilot study
Background/purpose: Human skin is constantly exposed to ultraviolet A (UVA), which can generate reactive oxygen species and cause iron release from ferritin, leading to oxidative damage in biomolecules. This is particularly true in post-menopausal skin due to an increase in iron as a result of menopause. As iron is generally released through desquamation, the skin becomes a main portal for the release of excess iron in this age group. In the present study, we examined a strategy for controlling UVA- and iron-induced oxidative stress in skin using a keratinocyte ...
Protection against ultraviolet A-induced oxidative damage in normal human epidermal keratinocytes under post-menopausal conditions by an ultraviolet A-activated caged-iron chelator: a pilot study is a post from: Skincare
Protection against ultraviolet A-induced oxidative damage in normal human epidermal keratinocytes under post-menopausal conditions by an ultraviolet A-activated caged-iron chelator: a pilot study via BuzzBlazer.com
The influence of psoriatic plaques pretreatment with crude coal tar vs. petrolatum on the efficacy of narrow-band ultraviolet B: a half-vs.-half intra-individual double-blinded comparative study
Background/purpose: The value of psoriatic plaques pretreatment with specific topical preparations in the setting of NB-ultraviolet-B (UVB) therapy is debatable. It may be clarified through a comparative assessment between crude coal tar and petrolatum as pretreatment candidates.
Methods: A prospective study included 40 patients with plaque psoriasis undergoing NB-UVB therapy. We compared among three treatment regimens: NB-UVB alone (control group; n=20) as well as NB-UVB preceded by crude coal tar 3% on one side and petrolatum on the other side (cases group I and II; n=20). Tar and petrolatum ...
The influence of psoriatic plaques pretreatment with crude coal tar vs. petrolatum on the efficacy of narrow-band ultraviolet B: a half-vs.-half intra-individual double-blinded comparative study is a post from: Skincare
The influence of psoriatic plaques pretreatment with crude coal tar vs. petrolatum on the efficacy of narrow-band ultraviolet B: a half-vs.-half intra-individual double-blinded comparative study via BuzzBlazer.com
HIGHLIGHTS FOR OCTOBER
HIGHLIGHTS FOR OCTOBER is a post from: Skincare
HIGHLIGHTS FOR OCTOBER via BuzzBlazer.com
HIGHLIGHTS FOR OCTOBER is a post from: Skincare
HIGHLIGHTS FOR OCTOBER via BuzzBlazer.com
Tuesday, September 27, 2011
Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata
Summary
Background: Alopecia areata (AA) is a hair loss disease caused by T cell-mediated autoimmune reactions against anagen stage hair follicles. Although the exact etiology is poorly understood, there is evidence to suggest that both genetic and environmental factors are involved in AA pathogenesis.
Objectives: To analyze DNA methylation and histone modification patterns in peripheral blood mononuclear cells (PBMCs) of patients with AA.
Methods: PBMC samples were obtained from 25 patients with AA and 20 healthy controls. Global DNA methylcytosine levels, as well as histone acetylation and methylation levels were measured by enzyme-linked ...
Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata via BuzzBlazer.com
Background: Alopecia areata (AA) is a hair loss disease caused by T cell-mediated autoimmune reactions against anagen stage hair follicles. Although the exact etiology is poorly understood, there is evidence to suggest that both genetic and environmental factors are involved in AA pathogenesis.
Objectives: To analyze DNA methylation and histone modification patterns in peripheral blood mononuclear cells (PBMCs) of patients with AA.
Methods: PBMC samples were obtained from 25 patients with AA and 20 healthy controls. Global DNA methylcytosine levels, as well as histone acetylation and methylation levels were measured by enzyme-linked ...
Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata is a post from: Skincare
Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata via BuzzBlazer.com
IL-17 expression in neutrophils and Th17 cells in Cutaneous T Cells Lymphoma associated with neutrophilic infiltrate of the skin
IL-17 expression in neutrophils and Th17 cells in Cutaneous T Cells Lymphoma associated with neutrophilic infiltrate of the skin is a post from: Skincare
IL-17 expression in neutrophils and Th17 cells in Cutaneous T Cells Lymphoma associated with neutrophilic infiltrate of the skin via BuzzBlazer.com
IL-17 expression in neutrophils and Th17 cells in Cutaneous T Cells Lymphoma associated with neutrophilic infiltrate of the skin is a post from: Skincare
IL-17 expression in neutrophils and Th17 cells in Cutaneous T Cells Lymphoma associated with neutrophilic infiltrate of the skin via BuzzBlazer.com
Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis
Abstract
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by keratinocyte apoptosis and necrosis, resulting in epidermal detachment. Although monocytes abundantly infiltrate the epidermis in SJS/TEN skin lesions, the properties and functions of these cells have not been fully examined.
Objectives: To determine the properties of monocytes infiltrating into the epidermis in SJS/TEN.
Methods: Immunostaining of skin sections was performed to examine the membrane markers of monocytes infiltrating into skin lesions.
Results: Immunostaining of cryo-sections from 11 SJS/TEN skin lesions revealed numerous CD14+ monocytes located along the dermo-epidermal junction and throughout ...
Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis via BuzzBlazer.com
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by keratinocyte apoptosis and necrosis, resulting in epidermal detachment. Although monocytes abundantly infiltrate the epidermis in SJS/TEN skin lesions, the properties and functions of these cells have not been fully examined.
Objectives: To determine the properties of monocytes infiltrating into the epidermis in SJS/TEN.
Methods: Immunostaining of skin sections was performed to examine the membrane markers of monocytes infiltrating into skin lesions.
Results: Immunostaining of cryo-sections from 11 SJS/TEN skin lesions revealed numerous CD14+ monocytes located along the dermo-epidermal junction and throughout ...
Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis is a post from: Skincare
Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis via BuzzBlazer.com
Pendulous melanocytes: a characteristic feature of melasma and how it occurred
Pendulous melanocytes: a characteristic feature of melasma and how it occurred is a post from: Skincare
Pendulous melanocytes: a characteristic feature of melasma and how it occurred via BuzzBlazer.com
Pendulous melanocytes: a characteristic feature of melasma and how it occurred is a post from: Skincare
Pendulous melanocytes: a characteristic feature of melasma and how it occurred via BuzzBlazer.com
Frontal Fibrosing Alopecia in a Patient with Common Variable Immunodeficiency
Abstract
Frontal fibrosing alopecia is a clinically distinct variant of lichen planopilaris. It has been associated with immune-mediated disorders and dermatologic disorders, such as vitiligo. We present a patient with a longstanding history of common variable immunodeficiency who developed frontal fibrosing alopecia. Increased research into the pathophysiologic mechanisms of associated immune-mediated conditions can shed light into the etiology of FFA.
Frontal Fibrosing Alopecia in a Patient with Common Variable Immunodeficiency is a post from: Skincare
Frontal Fibrosing Alopecia in a Patient with Common Variable Immunodeficiency via BuzzBlazer.com
Frontal fibrosing alopecia is a clinically distinct variant of lichen planopilaris. It has been associated with immune-mediated disorders and dermatologic disorders, such as vitiligo. We present a patient with a longstanding history of common variable immunodeficiency who developed frontal fibrosing alopecia. Increased research into the pathophysiologic mechanisms of associated immune-mediated conditions can shed light into the etiology of FFA.
Frontal Fibrosing Alopecia in a Patient with Common Variable Immunodeficiency is a post from: Skincare
Frontal Fibrosing Alopecia in a Patient with Common Variable Immunodeficiency is a post from: Skincare
Frontal Fibrosing Alopecia in a Patient with Common Variable Immunodeficiency via BuzzBlazer.com
New insights in segmental vitiligo: case report and review of theories
Summary
Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The etiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other auto-immune diseases as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune mediated overlap between the two subtypes.
In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo nevus. To our knowledge, this is the ...
New insights in segmental vitiligo: case report and review of theories via BuzzBlazer.com
Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The etiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other auto-immune diseases as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune mediated overlap between the two subtypes.
In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo nevus. To our knowledge, this is the ...
New insights in segmental vitiligo: case report and review of theories is a post from: Skincare
New insights in segmental vitiligo: case report and review of theories via BuzzBlazer.com
The Development of Two Different Malignancies in a Patient with Large Congenital Melanocytic Nevus
Abstract: Patients with large congenital melanocytic nevus (LCMN) have a high risk of developing malignant melanoma (MM) and other malignancies. We report a case of a mesenchymal malignancy that best fit the diagnosis of a malignant peripheral nerve sheath tumor and subsequent development of a MM developing from a LCMN. There are no previous reports of a second primary malignant neoplasm arising from a LCMN.
The Development of Two Different Malignancies in a Patient with Large Congenital Melanocytic Nevus is a post from: Skincare
The Development of Two Different Malignancies in a Patient with Large Congenital Melanocytic Nevus is a post from: Skincare
The Development of Two Different Malignancies in a Patient with Large Congenital Melanocytic Nevus via BuzzBlazer.com
Failure to Thrive in Infants with Complicated Facial Hemangiomas
Abstract: We have observed that some children with facial hemangiomas of infancy have feeding difficulties coincident with periods of failure to thrive. We evaluated the early oral sensory and feeding experiences of four children with facial hemangiomas through medical record review and parental surveys to investigate their contribution to the patients’ failure to thrive. All children with feeding irregularities experienced some degree of oral sensory impairment and required early oral sensory intervention, but there were varying reports of difficulty or delay in the development of oral feeding. The nature of ...
Failure to Thrive in Infants with Complicated Facial Hemangiomas is a post from: Skincare
Failure to Thrive in Infants with Complicated Facial Hemangiomas via BuzzBlazer.com
Multiple Nuchal Fibromas in a 2-Year-Old Without Gardner Syndrome
Abstract: Nuchal fibromas, uncommon benign soft tissue tumors typically arising along the posterior neck, are often associated with Gardner syndrome (GS). These tumors have rarely been reported in association with scleroderma or as secondary to trauma and diabetes. Nuchal fibromas not associated with GS have been described predominantly in men aged 30 to 50. We report a 2-year-old African American girl with multiple nuchal fibromas along the posterior aspect of her neck and upper back. Retinal examination showed no signs of congenital hypertrophy of the retinal pigment epithelium, and genetic ...
Multiple Nuchal Fibromas in a 2-Year-Old Without Gardner Syndrome is a post from: Skincare
Multiple Nuchal Fibromas in a 2-Year-Old Without Gardner Syndrome via BuzzBlazer.com
Sunday, September 25, 2011
Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive
Background. Fragrance ingredients are a frequent cause of allergic contact dermatitis. The EU Cosmetics Directive states that 26 specific fragrance ingredients, known to cause allergic contact dermatitis, must be declared on the ingredient lists of cosmetic products.
Objectives. To investigate frequencies of sensitization to the 26 individual fragrances and evaluate their importance as screening markers of fragrance allergy.
Method. This was a retrospective study based on data from the Department of Dermato-Allergology, Copenhagen University Hospital Gentofte. Eczema patients (n = 1508) were patch tested (January 2008 to July 2010) with the 26 ...
Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive is a post from: Skincare
Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive via BuzzBlazer.com
Non-fragrance allergens in specific cosmetic products
Objectives. Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce.
Methods. Between January 2000 and December 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form.
Results. Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to ...
Non-fragrance allergens in specific cosmetic products is a post from: Skincare
Non-fragrance allergens in specific cosmetic products via BuzzBlazer.com
On the lookout for precursor lesions: where does dry skin end and slight hand eczema begin?
Background. The prognosis of occupational hand eczema is strongly associated with its duration, severity, and the onset of treatment.
Objectives. The study was aimed at characterizing skin eruptions that might be potential precursors of occupational hand eczema, their pattern, and typical sites in a population at moderate risk of hand eczema.
Patients/Materials/Methods. Eight hundred German male metal workers took part in a structured interview focused on their medical history combined with a dermatological examination of their hands, by use of the quantitative Hand Eczema Score for Occupational Screenings, with follow-up 1 year ...
On the lookout for precursor lesions: where does dry skin end and slight hand eczema begin? is a post from: Skincare
On the lookout for precursor lesions: where does dry skin end and slight hand eczema begin? via BuzzBlazer.com
Saturday, September 24, 2011
Relationships Between Hair Growth Rate and Morphological Parameters of Human Straight Hair: A Same Law Above Ethnical Origins?
Abstract
After measurement of individual growth rates, natural hair fibers from Asian and Caucasian subjects were analyzed using Scanning Electron Microscopy. In total, more than 1000 hairs were analyzed. Measurements of diameter, medulla and inter-scale distance (average distance between two successive cuticle scales) show these parameters strongly correlated with hair growth rate. A thicker hair fiber, corresponds to a faster growth rate, a shorter inter-scale distance and greater probability to have a medulla; and vice versa, a thin hair fiber shows slower growth rate, a larger inter-scale distance and a lower ...
Relationships Between Hair Growth Rate and Morphological Parameters of Human Straight Hair: A Same Law Above Ethnical Origins? via BuzzBlazer.com
After measurement of individual growth rates, natural hair fibers from Asian and Caucasian subjects were analyzed using Scanning Electron Microscopy. In total, more than 1000 hairs were analyzed. Measurements of diameter, medulla and inter-scale distance (average distance between two successive cuticle scales) show these parameters strongly correlated with hair growth rate. A thicker hair fiber, corresponds to a faster growth rate, a shorter inter-scale distance and greater probability to have a medulla; and vice versa, a thin hair fiber shows slower growth rate, a larger inter-scale distance and a lower ...
Relationships Between Hair Growth Rate and Morphological Parameters of Human Straight Hair: A Same Law Above Ethnical Origins? is a post from: Skincare
Relationships Between Hair Growth Rate and Morphological Parameters of Human Straight Hair: A Same Law Above Ethnical Origins? via BuzzBlazer.com
Thursday, September 22, 2011
A split axilla comparison study of axillary hair removal with low fluence high repetition rate 810 nm diode laser vs. high fluence low repetition rate 1064 nm Nd:YAG laser
Abstract
Background A low fluence, high repetition rate 810 nm diode laser using constant motion technique has been recently introduced with advantages of less treatment discomfort and fewer side effects compared with traditional laser hair removal.
Objective To compare hair reduction and side effects of low fluence high repetition rate 810 nm diode with high fluence low repetition rate 1064 nm Nd:YAG lasers.
Methods Forty-nine subjects were randomly received five monthly treatments with diode laser on one side of their axilla and long-pulsed Nd:YAG laser on the other side. Hair count was recorded at baseline, 1- ...
A split axilla comparison study of axillary hair removal with low fluence high repetition rate 810 nm diode laser vs. high fluence low repetition rate 1064 nm Nd:YAG laser via BuzzBlazer.com
Background A low fluence, high repetition rate 810 nm diode laser using constant motion technique has been recently introduced with advantages of less treatment discomfort and fewer side effects compared with traditional laser hair removal.
Objective To compare hair reduction and side effects of low fluence high repetition rate 810 nm diode with high fluence low repetition rate 1064 nm Nd:YAG lasers.
Methods Forty-nine subjects were randomly received five monthly treatments with diode laser on one side of their axilla and long-pulsed Nd:YAG laser on the other side. Hair count was recorded at baseline, 1- ...
A split axilla comparison study of axillary hair removal with low fluence high repetition rate 810 nm diode laser vs. high fluence low repetition rate 1064 nm Nd:YAG laser is a post from: Skincare
A split axilla comparison study of axillary hair removal with low fluence high repetition rate 810 nm diode laser vs. high fluence low repetition rate 1064 nm Nd:YAG laser via BuzzBlazer.com
Epigenetics and psoriasis
Abstract
Increasing evidence indicates that epigenetic mechanisms are involved in the pathogenesis of autoimmune rheumatic diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The pathogenesis of the organ-specific autoimmune disease psoriasis, however, remains poorly understood. Recent studies have shown that aberrant epigenetic patterns are present in patients with psoriasis, suggesting that epigenetic mechanisms may also be involved in this disease. Herein, we review relevant epigenetic findings associated with psoriasis, and provide clues and directions for further studies in this field.
Epigenetics and psoriasis is a post from: Skincare
Epigenetics and psoriasis via BuzzBlazer.com
Increasing evidence indicates that epigenetic mechanisms are involved in the pathogenesis of autoimmune rheumatic diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The pathogenesis of the organ-specific autoimmune disease psoriasis, however, remains poorly understood. Recent studies have shown that aberrant epigenetic patterns are present in patients with psoriasis, suggesting that epigenetic mechanisms may also be involved in this disease. Herein, we review relevant epigenetic findings associated with psoriasis, and provide clues and directions for further studies in this field.
Epigenetics and psoriasis is a post from: Skincare
Epigenetics and psoriasis is a post from: Skincare
Epigenetics and psoriasis via BuzzBlazer.com
Preoperative skin tumours thickness determination by high-frequency ultrasound on head and neck region
Abstract
Background High-frequency ultrasound is non-invasive imaging method for examination of skin tumours.
Objective The aim of our study was to examine validity of 20-MHz ultrasound in preoperative determination of skin tumour thickness localized on head and neck region as a potentially useful tool for planning of the surgical intervention.
Methods Seventy-three different skin tumours were preoperatively examined using Dermascan C (Cortex Technology, Denmark) 20-MHz ultrasound equipment. Maximal vertical thickness of tumours was preoperatively determined by ultrasound, and after surgical excision of tumours, on pathohistological preparations using Nippon–Kogaku ocular micrometre. All patohistological specimens ...
Preoperative skin tumours thickness determination by high-frequency ultrasound on head and neck region via BuzzBlazer.com
Background High-frequency ultrasound is non-invasive imaging method for examination of skin tumours.
Objective The aim of our study was to examine validity of 20-MHz ultrasound in preoperative determination of skin tumour thickness localized on head and neck region as a potentially useful tool for planning of the surgical intervention.
Methods Seventy-three different skin tumours were preoperatively examined using Dermascan C (Cortex Technology, Denmark) 20-MHz ultrasound equipment. Maximal vertical thickness of tumours was preoperatively determined by ultrasound, and after surgical excision of tumours, on pathohistological preparations using Nippon–Kogaku ocular micrometre. All patohistological specimens ...
Preoperative skin tumours thickness determination by high-frequency ultrasound on head and neck region is a post from: Skincare
Preoperative skin tumours thickness determination by high-frequency ultrasound on head and neck region via BuzzBlazer.com
Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence
Abstract
Background Some of chronic hyperpigmentary diseases, such as melasma, induced by multiple factors including chronic sunlight exposure, can recur even after chemical epidermal removal. Dermal factors may be involved in the pathogenesis of melasma. Changes in dermal fibroblasts resulting from chronic sun exposure might cause melanocytes to synthesize melanin in the epidermis.
Objective This study aimed at determining the effects of repetitive ultraviolet (UV) radiation on cultured fibroblasts and the secretion of melanogenic factors.
Methods Cultured human fibroblasts were exposed to ultraviolet A (UVA) or ultraviolet B (UVB) for five consecutive days. ...
Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence via BuzzBlazer.com
Background Some of chronic hyperpigmentary diseases, such as melasma, induced by multiple factors including chronic sunlight exposure, can recur even after chemical epidermal removal. Dermal factors may be involved in the pathogenesis of melasma. Changes in dermal fibroblasts resulting from chronic sun exposure might cause melanocytes to synthesize melanin in the epidermis.
Objective This study aimed at determining the effects of repetitive ultraviolet (UV) radiation on cultured fibroblasts and the secretion of melanogenic factors.
Methods Cultured human fibroblasts were exposed to ultraviolet A (UVA) or ultraviolet B (UVB) for five consecutive days. ...
Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence is a post from: Skincare
Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence via BuzzBlazer.com
Contact hypersensitivity in rosacea – a study in 82 patients
Contact hypersensitivity in rosacea – a study in 82 patients is a post from: Skincare
Contact hypersensitivity in rosacea – a study in 82 patients via BuzzBlazer.com
Contact hypersensitivity in rosacea – a study in 82 patients is a post from: Skincare
Contact hypersensitivity in rosacea – a study in 82 patients via BuzzBlazer.com
Prurigo pigmentosa: a clinicopathologic study of 16 cases
Abstract
Background Prurigo pigmentosa is a rare inflammatory disease of unknown origin. It is characterized by the sudden onset of pruritic erythematous papules, usually involving the trunk and neck, which coalesce to form reticulated, mottled patches.
Methods We studied 16 patients with prurigo pigmentosa. The patients were selected from those attending the outpatient Department of Dermatology at the Kyung Hee University Hospital from January 2002 to January 2010. All clinical information was retrospectively collected from medical records. The serum concentrations of ketones (acetoacetic acid, 3-hydroxybutyrate acid [3-OHBA]) were examined in four patients, ...
Prurigo pigmentosa: a clinicopathologic study of 16 cases via BuzzBlazer.com
Background Prurigo pigmentosa is a rare inflammatory disease of unknown origin. It is characterized by the sudden onset of pruritic erythematous papules, usually involving the trunk and neck, which coalesce to form reticulated, mottled patches.
Methods We studied 16 patients with prurigo pigmentosa. The patients were selected from those attending the outpatient Department of Dermatology at the Kyung Hee University Hospital from January 2002 to January 2010. All clinical information was retrospectively collected from medical records. The serum concentrations of ketones (acetoacetic acid, 3-hydroxybutyrate acid [3-OHBA]) were examined in four patients, ...
Prurigo pigmentosa: a clinicopathologic study of 16 cases is a post from: Skincare
Prurigo pigmentosa: a clinicopathologic study of 16 cases via BuzzBlazer.com
Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure?
Abstract
Background Cutaneous granulomas after a soft filler injection represent one of the worst scenarios for both patient and injector.
Objectives To present clinical and histopathological features of granulomatous nodular reactions induced by a new alginate-based dermal filler (Novabel®), and put it in context of the process of injectable soft tissue fillers approval and promotion in the EU.
Methods A case series of four patients injected with Novabel® for volume restoration of the face and hands, who developed severe foreign body reactions.
Results Four patients injected with Novabel® into tear troughs and/or dorsa of ...
Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure? via BuzzBlazer.com
Background Cutaneous granulomas after a soft filler injection represent one of the worst scenarios for both patient and injector.
Objectives To present clinical and histopathological features of granulomatous nodular reactions induced by a new alginate-based dermal filler (Novabel®), and put it in context of the process of injectable soft tissue fillers approval and promotion in the EU.
Methods A case series of four patients injected with Novabel® for volume restoration of the face and hands, who developed severe foreign body reactions.
Results Four patients injected with Novabel® into tear troughs and/or dorsa of ...
Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure? is a post from: Skincare
Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure? via BuzzBlazer.com
Skin manifestations of obesity: a comparative study
Abstract
Background Obesity is one of the world’s biggest health problems nowadays. Little research has been done on the skin diseases that affect obese patients.
Objective To study the prevalence of skin manifestations in obese patients compared with a control group of normal-weight patients.
Methods A total of 76 obese patients [body mass index (BMI) ≥30 kg/m2] and 73 with normal-weight volunteers (BMI 18.5–24.9 kg/m2) were included in the study and had their complete medical history and skin examination evaluated by the same examiner. All patients were investigated for the presence of metabolic syndrome.
Results The ...
Skin manifestations of obesity: a comparative study via BuzzBlazer.com
Background Obesity is one of the world’s biggest health problems nowadays. Little research has been done on the skin diseases that affect obese patients.
Objective To study the prevalence of skin manifestations in obese patients compared with a control group of normal-weight patients.
Methods A total of 76 obese patients [body mass index (BMI) ≥30 kg/m2] and 73 with normal-weight volunteers (BMI 18.5–24.9 kg/m2) were included in the study and had their complete medical history and skin examination evaluated by the same examiner. All patients were investigated for the presence of metabolic syndrome.
Results The ...
Skin manifestations of obesity: a comparative study is a post from: Skincare
Skin manifestations of obesity: a comparative study via BuzzBlazer.com
Sentinel lymph node biopsy for melanoma is becoming a consensus: a national survey of French centres involved in melanoma care in 2008
Abstract
Background The role of sentinel lymph node (SLN) biopsy in melanoma care remains controversial and is not included in most guidelines for the management of melanoma in Europe.
Objective To evaluate the practice of SLN biopsy for melanoma.
Methods In 2008, a self-administered questionnaire was mailed to physicians in 49 hospitals in France.
Results Questionnaires were returned by 34 (69.3%). A median number of 90 new cases of melanoma were treated each year per centre. SLN biopsy was performed routinely in 21 (61.7%) centres. The practice of SLN biopsy for melanoma was recommended ...
Sentinel lymph node biopsy for melanoma is becoming a consensus: a national survey of French centres involved in melanoma care in 2008 via BuzzBlazer.com
Background The role of sentinel lymph node (SLN) biopsy in melanoma care remains controversial and is not included in most guidelines for the management of melanoma in Europe.
Objective To evaluate the practice of SLN biopsy for melanoma.
Methods In 2008, a self-administered questionnaire was mailed to physicians in 49 hospitals in France.
Results Questionnaires were returned by 34 (69.3%). A median number of 90 new cases of melanoma were treated each year per centre. SLN biopsy was performed routinely in 21 (61.7%) centres. The practice of SLN biopsy for melanoma was recommended ...
Sentinel lymph node biopsy for melanoma is becoming a consensus: a national survey of French centres involved in melanoma care in 2008 is a post from: Skincare
Sentinel lymph node biopsy for melanoma is becoming a consensus: a national survey of French centres involved in melanoma care in 2008 via BuzzBlazer.com
Porokeratosis: present concepts
Abstract
Porokeratosis represents a group of disorders of epidermal keratinization which are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The aetiology of porokeratosis is still unclear. This review summarizes the currently available data on the pathophysiology of this condition and discusses the clinical variants and the currently available therapies.
Porokeratosis: present concepts is a post from: Skincare
Porokeratosis: present concepts via BuzzBlazer.com
Porokeratosis represents a group of disorders of epidermal keratinization which are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The aetiology of porokeratosis is still unclear. This review summarizes the currently available data on the pathophysiology of this condition and discusses the clinical variants and the currently available therapies.
Porokeratosis: present concepts is a post from: Skincare
Porokeratosis: present concepts is a post from: Skincare
Porokeratosis: present concepts via BuzzBlazer.com
Tuesday, September 20, 2011
Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A2α
Abstract
Background: Irritant contact dermatitis is a frequent and often underrated problem for which the major efficacious therapy is still local glucocorticoids, although they have the known adverse effects due to their wide spectrum of action.
A more focussed therapeutic strategy would be the inhibition of a key enzyme for biosynthesis of the lipid mediators, cytosolic phospholipase A2α (cPLA2α) in irritant contact dermatitis. We are analysing the pharmacological and biological effects of selective cPLA2α inhibitors.
Objective: To examine the usefulness of the potent and selective cPLA2α inhibitor 3-(5-carboxypentanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid (compound 1) for therapy ...
Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A2α via BuzzBlazer.com
Background: Irritant contact dermatitis is a frequent and often underrated problem for which the major efficacious therapy is still local glucocorticoids, although they have the known adverse effects due to their wide spectrum of action.
A more focussed therapeutic strategy would be the inhibition of a key enzyme for biosynthesis of the lipid mediators, cytosolic phospholipase A2α (cPLA2α) in irritant contact dermatitis. We are analysing the pharmacological and biological effects of selective cPLA2α inhibitors.
Objective: To examine the usefulness of the potent and selective cPLA2α inhibitor 3-(5-carboxypentanoyl)-1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid (compound 1) for therapy ...
Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A2α is a post from: Skincare
Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A2α via BuzzBlazer.com
Practical experience of Ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland
Summary
Background: There are limited data on the use of ustekinumab outside of clinical trials.
Objectives: To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 Dermatology Centres in the UK and Ireland.
Methods: A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab.
Results: Baseline Psoriasis Area and Severity Index (PASI) was 22.9 ± 10.1 (mean ± SD). After 16 weeks’ treatment with ustekinumab PASI 75 (75% reduction in PASI) was observed in 63.0% (n=80/127) of patients, although 4 patients required concomitant therapy at the 16 ...
Practical experience of Ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland via BuzzBlazer.com
Background: There are limited data on the use of ustekinumab outside of clinical trials.
Objectives: To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 Dermatology Centres in the UK and Ireland.
Methods: A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab.
Results: Baseline Psoriasis Area and Severity Index (PASI) was 22.9 ± 10.1 (mean ± SD). After 16 weeks’ treatment with ustekinumab PASI 75 (75% reduction in PASI) was observed in 63.0% (n=80/127) of patients, although 4 patients required concomitant therapy at the 16 ...
Practical experience of Ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland is a post from: Skincare
Practical experience of Ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland via BuzzBlazer.com
Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation
Abstract
Ichthyosis with confetti (IWC) was first described as ichthyosis en confettis in 19841 and subsequently as congenital reticular ichthyosiform erythroderma (CRIE)2, also according to the new classification.3 Patients with IWC suffer from erythroderma, prominent scaling, and palmoplantar keratoderma. Because of the development of hundreds to thousands of pale, normal appearing confetti-like spots during childhood, the disease was named IWC.1,4 Our female index patient was described in 1990 as the 4th patient reported worldwide; at that time she did not show any confetti-like spots.5 So far only 3 further IWC patients ...
Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation via BuzzBlazer.com
Ichthyosis with confetti (IWC) was first described as ichthyosis en confettis in 19841 and subsequently as congenital reticular ichthyosiform erythroderma (CRIE)2, also according to the new classification.3 Patients with IWC suffer from erythroderma, prominent scaling, and palmoplantar keratoderma. Because of the development of hundreds to thousands of pale, normal appearing confetti-like spots during childhood, the disease was named IWC.1,4 Our female index patient was described in 1990 as the 4th patient reported worldwide; at that time she did not show any confetti-like spots.5 So far only 3 further IWC patients ...
Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation is a post from: Skincare
Description of the natural course and clinical manifestations of ichthyosis with confetti caused by a novel KRT10 mutation via BuzzBlazer.com
Desmosomal genodermatoses
Abstract
Desmosomes are intercellular junctions that contribute to cell-cell adhesion, signalling, development and differentiation in various tissues, including the skin. Composed of a network of transmembranous and intracellular plaque proteins, pathogenic autosomal dominant or recessive mutations have been reported in 10 different desmosomal genes, resulting in a spectrum of phenotypes variably affecting skin, hair and heart. This review summarises the molecular pathology and phenotypes that predominantly affect the skin/hair. Recent desmosomal genodermatoses described include lethal congenital epidermolysis bullosa (plakoglobin), cardiomyopathy with alopecia and palmoplantar keratoderma (plakoglobin), hypotrichosis with scalp vesicles (desmocollin ...
Desmosomal genodermatoses via BuzzBlazer.com
Desmosomes are intercellular junctions that contribute to cell-cell adhesion, signalling, development and differentiation in various tissues, including the skin. Composed of a network of transmembranous and intracellular plaque proteins, pathogenic autosomal dominant or recessive mutations have been reported in 10 different desmosomal genes, resulting in a spectrum of phenotypes variably affecting skin, hair and heart. This review summarises the molecular pathology and phenotypes that predominantly affect the skin/hair. Recent desmosomal genodermatoses described include lethal congenital epidermolysis bullosa (plakoglobin), cardiomyopathy with alopecia and palmoplantar keratoderma (plakoglobin), hypotrichosis with scalp vesicles (desmocollin ...
Desmosomal genodermatoses is a post from: Skincare
Desmosomal genodermatoses via BuzzBlazer.com
Both bullous pemphigoid antigens are expressed in the central nervous system
Both bullous pemphigoid antigens are expressed in the central nervous system is a post from: Skincare
Both bullous pemphigoid antigens are expressed in the central nervous system via BuzzBlazer.com
Both bullous pemphigoid antigens are expressed in the central nervous system is a post from: Skincare
Both bullous pemphigoid antigens are expressed in the central nervous system via BuzzBlazer.com
Comprehensive cytochrome P450 CYP1A2 gene analysis in French Caucasian familial and sporadic porphyria cutanea tarda patients
Summary
Background: Porphyria cutanea tarda (PCT), the most frequent type of porphyria, results from decreased uroporphyrinogen decarboxylase (UROD) activity. Two forms of PCT are described: a familial form (fPCT) characterized by inherited decrease of UROD activity in all tissues and a sporadic form (sPCT) characterized by decreased UROD activity in the liver. Cytochrome P450 (CYP1A2) plays a major role in triggering experimental uroporphyria in rodents. It has been suggested that the highly inducible -163A/A genotype of the CYP1A2 gene could confer a heightened risk of porphyria cutanea tarda in patients.
Objectives: To ...
Comprehensive cytochrome P450 CYP1A2 gene analysis in French Caucasian familial and sporadic porphyria cutanea tarda patients via BuzzBlazer.com
Background: Porphyria cutanea tarda (PCT), the most frequent type of porphyria, results from decreased uroporphyrinogen decarboxylase (UROD) activity. Two forms of PCT are described: a familial form (fPCT) characterized by inherited decrease of UROD activity in all tissues and a sporadic form (sPCT) characterized by decreased UROD activity in the liver. Cytochrome P450 (CYP1A2) plays a major role in triggering experimental uroporphyria in rodents. It has been suggested that the highly inducible -163A/A genotype of the CYP1A2 gene could confer a heightened risk of porphyria cutanea tarda in patients.
Objectives: To ...
Comprehensive cytochrome P450 CYP1A2 gene analysis in French Caucasian familial and sporadic porphyria cutanea tarda patients is a post from: Skincare
Comprehensive cytochrome P450 CYP1A2 gene analysis in French Caucasian familial and sporadic porphyria cutanea tarda patients via BuzzBlazer.com
Alterations in leucocyte subsets and histomorphology in normal appearing perilesional skin, early, and chronic hidradenitis suppurativa lesions
Summary
Background: The current insight into the histopathological course of events during disease progression in hidradenitis suppurativa is fragmentary.
Objectives: To identify histological alterations and leucocyte subsets in normal appearing perilesional, early, and chronic HS skins.
Methods: In this observational study we examined skin samples from 8 perilesional, 6 early and 10 chronic prototypic HS lesions, as well as 4 healthy donors by using in situ immunostaining.
Results: Perilesional skin showed mild psoriasiform hyperplasia and follicular plugging as well as a low-grade influx of tryptase+ mast cells, CD3+ T cells, CD138+ plasma cells and ...
Alterations in leucocyte subsets and histomorphology in normal appearing perilesional skin, early, and chronic hidradenitis suppurativa lesions via BuzzBlazer.com
Background: The current insight into the histopathological course of events during disease progression in hidradenitis suppurativa is fragmentary.
Objectives: To identify histological alterations and leucocyte subsets in normal appearing perilesional, early, and chronic HS skins.
Methods: In this observational study we examined skin samples from 8 perilesional, 6 early and 10 chronic prototypic HS lesions, as well as 4 healthy donors by using in situ immunostaining.
Results: Perilesional skin showed mild psoriasiform hyperplasia and follicular plugging as well as a low-grade influx of tryptase+ mast cells, CD3+ T cells, CD138+ plasma cells and ...
Alterations in leucocyte subsets and histomorphology in normal appearing perilesional skin, early, and chronic hidradenitis suppurativa lesions is a post from: Skincare
Alterations in leucocyte subsets and histomorphology in normal appearing perilesional skin, early, and chronic hidradenitis suppurativa lesions via BuzzBlazer.com
Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects
Summary
Background: Nickel is a frequent allergen throghout the world. However, it has been unclear the extent to which nickel is relevant as an occupational contact allergen as opposed to simply being a reflection of jewellery exposure. Some thresholds for cutaneous nickel exposure to induce a dermatitis reaction in nickel-allergic individuals have been defined. Over recent years it has become possible to accurately meaure the quantity of nickel on the skin of individuals in a number of occupations.
Objectives: In this study we aimed to measure the quantities of nickel on the ...
Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects via BuzzBlazer.com
Background: Nickel is a frequent allergen throghout the world. However, it has been unclear the extent to which nickel is relevant as an occupational contact allergen as opposed to simply being a reflection of jewellery exposure. Some thresholds for cutaneous nickel exposure to induce a dermatitis reaction in nickel-allergic individuals have been defined. Over recent years it has become possible to accurately meaure the quantity of nickel on the skin of individuals in a number of occupations.
Objectives: In this study we aimed to measure the quantities of nickel on the ...
Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects is a post from: Skincare
Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects via BuzzBlazer.com
In vivo detection of Demodex folliculorum by means of confocal microscopy
In vivo detection of Demodex folliculorum by means of confocal microscopy is a post from: Skincare
In vivo detection of Demodex folliculorum by means of confocal microscopy via BuzzBlazer.com
In vivo detection of Demodex folliculorum by means of confocal microscopy is a post from: Skincare
In vivo detection of Demodex folliculorum by means of confocal microscopy via BuzzBlazer.com
No impairment of monocyte-derived Langerhans cell phenotype or function in early-onset psoriasis
Summary
Background. Migration of epidermal Langerhans cells (LCs) in response to the cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α is impaired in uninvolved skin of patients with early-onset psoriasis.
Aim. To investigate whether this impairment is a reflection of a systemic defect in dendritic cells (DCs), using an established model of monocyte-derived LC-like cells (mLCs).
Methods. CD14+ monocytes isolated from both patients with psoriasis and healthy control volunteers were cultured in a cytokine cocktail for 5 days to promote their differentiation into mLCs, then stimulated for 24 h with TNF-α, IL-1β (both 100 ng/mL) or medium ...
No impairment of monocyte-derived Langerhans cell phenotype or function in early-onset psoriasis via BuzzBlazer.com
Background. Migration of epidermal Langerhans cells (LCs) in response to the cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α is impaired in uninvolved skin of patients with early-onset psoriasis.
Aim. To investigate whether this impairment is a reflection of a systemic defect in dendritic cells (DCs), using an established model of monocyte-derived LC-like cells (mLCs).
Methods. CD14+ monocytes isolated from both patients with psoriasis and healthy control volunteers were cultured in a cytokine cocktail for 5 days to promote their differentiation into mLCs, then stimulated for 24 h with TNF-α, IL-1β (both 100 ng/mL) or medium ...
No impairment of monocyte-derived Langerhans cell phenotype or function in early-onset psoriasis is a post from: Skincare
No impairment of monocyte-derived Langerhans cell phenotype or function in early-onset psoriasis via BuzzBlazer.com
Sunday, September 18, 2011
The EDAR370A allele attenuates the severity of Hypohidrotic Ectodermal Dysplasia caused by EDA1 Gene Mutation
The EDAR370A allele attenuates the severity of Hypohidrotic Ectodermal Dysplasia caused by EDA1 Gene Mutation is a post from: Skincare
The EDAR370A allele attenuates the severity of Hypohidrotic Ectodermal Dysplasia caused by EDA1 Gene Mutation via BuzzBlazer.com
The EDAR370A allele attenuates the severity of Hypohidrotic Ectodermal Dysplasia caused by EDA1 Gene Mutation is a post from: Skincare
The EDAR370A allele attenuates the severity of Hypohidrotic Ectodermal Dysplasia caused by EDA1 Gene Mutation via BuzzBlazer.com
Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma
Abstract
Background: Dermoscopy improves melanoma recognition, but most criteria were described in the context of superficial spreading melanoma.
Objectives: To test whether pigmented nodular melanoma could be recognized dermoscopically by the presence of a combination of blue and black color within the lesion.
Methods: Dermoscopic images of histopathologically diagnosed pigmented nodular tumors with no (or only minimal) flat component were evaluated for the presence of standard melanoma criteria and for the presence of a new feature named blue-black (BB) color. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for standard ...
Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma via BuzzBlazer.com
Background: Dermoscopy improves melanoma recognition, but most criteria were described in the context of superficial spreading melanoma.
Objectives: To test whether pigmented nodular melanoma could be recognized dermoscopically by the presence of a combination of blue and black color within the lesion.
Methods: Dermoscopic images of histopathologically diagnosed pigmented nodular tumors with no (or only minimal) flat component were evaluated for the presence of standard melanoma criteria and for the presence of a new feature named blue-black (BB) color. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for standard ...
Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma is a post from: Skincare
Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma via BuzzBlazer.com
Calcium homeostasis and body composition in patients with the psoriasis variant palmoplantar pustulosis: a case-control study
Abstract
Background: Palmoplantar pustulosis (PPP) is a common disease strongly associated with smoking, autoimmune co-morbidities and a deranged calcium homeostasis. It is unclear whether these changes in calcium homeostasis are a consequence of vitamin D status, abnormal dermal vitamin D synthesis or whether it is substantiated in effects on bone mineral density (BMD).
Objectives: To study the vitamin D status and BMD in PPP patients.
Methods: In comparisons by two sets of controls (n=101 for serum analyses and n=5123 for BMD analyses), we therefore aimed to investigate whether PPP (59 cases) was associated ...
Calcium homeostasis and body composition in patients with the psoriasis variant palmoplantar pustulosis: a case-control study via BuzzBlazer.com
Background: Palmoplantar pustulosis (PPP) is a common disease strongly associated with smoking, autoimmune co-morbidities and a deranged calcium homeostasis. It is unclear whether these changes in calcium homeostasis are a consequence of vitamin D status, abnormal dermal vitamin D synthesis or whether it is substantiated in effects on bone mineral density (BMD).
Objectives: To study the vitamin D status and BMD in PPP patients.
Methods: In comparisons by two sets of controls (n=101 for serum analyses and n=5123 for BMD analyses), we therefore aimed to investigate whether PPP (59 cases) was associated ...
Calcium homeostasis and body composition in patients with the psoriasis variant palmoplantar pustulosis: a case-control study is a post from: Skincare
Calcium homeostasis and body composition in patients with the psoriasis variant palmoplantar pustulosis: a case-control study via BuzzBlazer.com
Is drug allergy less prevalent than previously assumed? A 5-year analysis
Abstract
Background: Rashes are a frequent conundrum in clinical practice since they may be reactive, drug-induced or disease-specific. Identification of the culprit drug is important since re-exposure may be harmful or even life-threatening and unnecessary avoidance of ‘innocent’ drugs leads to limitations of treatment options.
Objective: To objectify the cause of suspected cutaneous drug reactions in a larger patient population.
Method: Over the past 5 years, 612 patients with suspected cutaneous drug reactions were evaluated. Histology was assessed as indicated. About 200 patients were invited for complete work-up with skin tests (prick/intracutaneous testing ...
Is drug allergy less prevalent than previously assumed? A 5-year analysis via BuzzBlazer.com
Background: Rashes are a frequent conundrum in clinical practice since they may be reactive, drug-induced or disease-specific. Identification of the culprit drug is important since re-exposure may be harmful or even life-threatening and unnecessary avoidance of ‘innocent’ drugs leads to limitations of treatment options.
Objective: To objectify the cause of suspected cutaneous drug reactions in a larger patient population.
Method: Over the past 5 years, 612 patients with suspected cutaneous drug reactions were evaluated. Histology was assessed as indicated. About 200 patients were invited for complete work-up with skin tests (prick/intracutaneous testing ...
Is drug allergy less prevalent than previously assumed? A 5-year analysis is a post from: Skincare
Is drug allergy less prevalent than previously assumed? A 5-year analysis via BuzzBlazer.com
Determinants of Disability, Quality of Life and Depression in Dermatological Patients with Systemic Scleroderma
Abstract
Background: Systemic Scleroderma (SSc) is a rare disease with still limited knowledge about the relationship between clinical signs, disability, quality of life and depressive symptoms. Although SSc-patients are frequently treated by dermatologists, the vast majority of published evidence is based on rheumatological samples.
Objectives: To identify determinants of disability, decreased quality of life, and depression in a dermatological sample of SSc-patients.
Methods: Cross-sectional study on consecutive SSc-patients attending one specialist dermatological centre between April 2008 and November 2009. Validated questionnaires such as Health Assessment Questionnaire (HAQ), EuroQOL (EQ-5D) and Center for Epidemiologic ...
Determinants of Disability, Quality of Life and Depression in Dermatological Patients with Systemic Scleroderma via BuzzBlazer.com
Background: Systemic Scleroderma (SSc) is a rare disease with still limited knowledge about the relationship between clinical signs, disability, quality of life and depressive symptoms. Although SSc-patients are frequently treated by dermatologists, the vast majority of published evidence is based on rheumatological samples.
Objectives: To identify determinants of disability, decreased quality of life, and depression in a dermatological sample of SSc-patients.
Methods: Cross-sectional study on consecutive SSc-patients attending one specialist dermatological centre between April 2008 and November 2009. Validated questionnaires such as Health Assessment Questionnaire (HAQ), EuroQOL (EQ-5D) and Center for Epidemiologic ...
Determinants of Disability, Quality of Life and Depression in Dermatological Patients with Systemic Scleroderma is a post from: Skincare
Determinants of Disability, Quality of Life and Depression in Dermatological Patients with Systemic Scleroderma via BuzzBlazer.com
Hair greying is associated with active hair growth
Summary
Background: Hair greying is an obvious sign of aging in humans. White (non-pigmented) hair is thicker than black (pigmented) hair. The growth rate of white hair is also significantly higher than that of black hair. However, the mechanism underlying this is largely unknown.
Objectives: To examine the association between hair greying and hair growth patterns by evaluating expression of the genes or proteins related to hair growth in white and black hairs.
Methods: Morphological characteristics were observed in the eyebrow and scalp hairs. Differential expression of genes was analyzed in the black ...
Hair greying is associated with active hair growth via BuzzBlazer.com
Background: Hair greying is an obvious sign of aging in humans. White (non-pigmented) hair is thicker than black (pigmented) hair. The growth rate of white hair is also significantly higher than that of black hair. However, the mechanism underlying this is largely unknown.
Objectives: To examine the association between hair greying and hair growth patterns by evaluating expression of the genes or proteins related to hair growth in white and black hairs.
Methods: Morphological characteristics were observed in the eyebrow and scalp hairs. Differential expression of genes was analyzed in the black ...
Hair greying is associated with active hair growth is a post from: Skincare
Hair greying is associated with active hair growth via BuzzBlazer.com
Porokeratosis palmaris, plantaris et disseminata versus porokeratosis of Mibelli
Porokeratosis palmaris, plantaris et disseminata versus porokeratosis of Mibelli is a post from: Skincare
Porokeratosis palmaris, plantaris et disseminata versus porokeratosis of Mibelli via BuzzBlazer.com
Porokeratosis palmaris, plantaris et disseminata versus porokeratosis of Mibelli is a post from: Skincare
Porokeratosis palmaris, plantaris et disseminata versus porokeratosis of Mibelli via BuzzBlazer.com
Skin Melanoma Sentinel Lymph Node Biopsy Using Real Time Fluorescence Navigation With Indocyanine Green and Indocyanine Green With Human Serum Albumin
Skin Melanoma Sentinel Lymph Node Biopsy Using Real Time Fluorescence Navigation With Indocyanine Green and Indocyanine Green With Human Serum Albumin is a post from: Skincare
Skin Melanoma Sentinel Lymph Node Biopsy Using Real Time Fluorescence Navigation With Indocyanine Green and Indocyanine Green With Human Serum Albumin via BuzzBlazer.com
Skin Melanoma Sentinel Lymph Node Biopsy Using Real Time Fluorescence Navigation With Indocyanine Green and Indocyanine Green With Human Serum Albumin is a post from: Skincare
Skin Melanoma Sentinel Lymph Node Biopsy Using Real Time Fluorescence Navigation With Indocyanine Green and Indocyanine Green With Human Serum Albumin via BuzzBlazer.com
Multiple melanoma susceptibility factors function in a UVR response pathway in skin
Abstract
Exposure to ultraviolet radiation (UVR) and the familial melanoma susceptibility gene p16INK4A are among the major risk factors which have been identified to contribute to the development of melanoma, and also significantly contribute to squamous cell carcinoma. Previously, we have shown that UVR induces p16INK4A the expression in melanoma and keratinocyte cell lines and human skin, but the regulatory mechanisms controlling this expression was unknown. Here we show that UVR induced ERK signalling, mediated by BRAF, regulates p16INK4A expression at the transcriptional, and possibly translational level. This study demonstrates the ...
Multiple melanoma susceptibility factors function in a UVR response pathway in skin via BuzzBlazer.com
Exposure to ultraviolet radiation (UVR) and the familial melanoma susceptibility gene p16INK4A are among the major risk factors which have been identified to contribute to the development of melanoma, and also significantly contribute to squamous cell carcinoma. Previously, we have shown that UVR induces p16INK4A the expression in melanoma and keratinocyte cell lines and human skin, but the regulatory mechanisms controlling this expression was unknown. Here we show that UVR induced ERK signalling, mediated by BRAF, regulates p16INK4A expression at the transcriptional, and possibly translational level. This study demonstrates the ...
Multiple melanoma susceptibility factors function in a UVR response pathway in skin is a post from: Skincare
Multiple melanoma susceptibility factors function in a UVR response pathway in skin via BuzzBlazer.com
Clinical Characteristics and Risk of Melanoma Development from Giant Congenital Melanocytic Naevi in Korea: A Nationwide Retrospective Study
Abstract
Background: Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated.
Objectives: To evaluate the clinical characteristics and risk of melanoma development from GCMN in Koreans, we performed a nationwide retrospective cohort study in Korea. GCMN were defined as those comprising ≥ 5% body surface area in children or measuring ≥ 20 cm in adults.
Methods: A total of 131 patients with GCMN were enrolled, and they had a mean age of 10.3 years (range, birth to 70 years).
Results: The ...
Clinical Characteristics and Risk of Melanoma Development from Giant Congenital Melanocytic Naevi in Korea: A Nationwide Retrospective Study via BuzzBlazer.com
Background: Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated.
Objectives: To evaluate the clinical characteristics and risk of melanoma development from GCMN in Koreans, we performed a nationwide retrospective cohort study in Korea. GCMN were defined as those comprising ≥ 5% body surface area in children or measuring ≥ 20 cm in adults.
Methods: A total of 131 patients with GCMN were enrolled, and they had a mean age of 10.3 years (range, birth to 70 years).
Results: The ...
Clinical Characteristics and Risk of Melanoma Development from Giant Congenital Melanocytic Naevi in Korea: A Nationwide Retrospective Study is a post from: Skincare
Clinical Characteristics and Risk of Melanoma Development from Giant Congenital Melanocytic Naevi in Korea: A Nationwide Retrospective Study via BuzzBlazer.com
Saturday, September 17, 2011
Using optical coherence tomography for the longitudinal non-invasive evaluation of epidermal thickness in a murine model of chronic skin inflammation
Background
Non-invasive methods are desirable for longitudinal studies examining drug efficacy and disease resolution defined as decreases in epidermal thickness in mouse models of psoriasiform skin disease. This would eliminate the need for either sacrificing animals or collecting serial skin biopsies to evaluate changes in disease progression during an individual study. The quantitation of epidermal thickness using optical coherence tomography (OCT) provides an alternative to traditional histology techniques.
Methods
Using the KC-Tie2 doxycycline-repressible psoriasiform skin disease mouse model, OCT imaging was completed on diseased back skin of adult KC-Tie2 (n = 3–4) and control (n = 3–4) ...
Using optical coherence tomography for the longitudinal non-invasive evaluation of epidermal thickness in a murine model of chronic skin inflammation is a post from: Skincare
Using optical coherence tomography for the longitudinal non-invasive evaluation of epidermal thickness in a murine model of chronic skin inflammation via BuzzBlazer.com
Skin hydration and cooling effect produced by the Voltaren® vehicle gel
Background
Voltaren vehicle gel is the carrier substance of the topical Voltaren products. This vehicle gel is especially formulated to be easily applied on the skin, while providing some sensory benefits. The present study aims to substantiate the widely perceived hydrating and cooling effect of Voltaren vehicle gel.
Methods
Volar forearm skin hydration and transepidermal water loss (TEWL) were measured and user satisfaction was evaluated by questionnaires, after application in 31 healthy, female volunteers. The cooling effect was investigated for 40 min with thermal imaging on 12 forearm sites of six healthy subjects.
Results
Voltaren vehicle ...
Skin hydration and cooling effect produced by the Voltaren® vehicle gel is a post from: Skincare
Skin hydration and cooling effect produced by the Voltaren® vehicle gel via BuzzBlazer.com
Friday, September 16, 2011
Duplication of the Great Saphenous Vein: A Definition Problem and Implications for Ther
Background
In the literature there is a range from 1% to 20 % of duplication (up to 20%) of the great saphenous vein (GSV) reported, because there is a lack of an accurate definition of the GSV and objective parameters for an anatomical identification.
Objective
To investigate the frequency of true duplications of the GSV.
Materials and Methods
A systematic review of the literature, a retrospective analysis of duplex examinations, and a prospective study of duplex examinations to investigate the frequency of true duplications of the GSV.
Results
In the literature review, a great variety of definitions ...
Duplication of the Great Saphenous Vein: A Definition Problem and Implications for Ther is a post from: Skincare
Duplication of the Great Saphenous Vein: A Definition Problem and Implications for Ther via BuzzBlazer.com
Postradiation Chronic Scalp Ulcer: A Challenge for Wound Healing Experts
Postradiation Chronic Scalp Ulcer: A Challenge for Wound Healing Experts is a post from: Skincare
Postradiation Chronic Scalp Ulcer: A Challenge for Wound Healing Experts via BuzzBlazer.com
Postradiation Chronic Scalp Ulcer: A Challenge for Wound Healing Experts is a post from: Skincare
Postradiation Chronic Scalp Ulcer: A Challenge for Wound Healing Experts via BuzzBlazer.com
Management of Severe Anogenital Acne Inversa (Hidradenitis Suppurativa)
Background
Severe anogenital acne inversa (AI) is a debilitating chronic inflammatory disease with a major negative effect on quality of life.
Objectives
To evaluate the role of surgery in the treatment of severe anogenital AI.
Methods
We analyzed the records of patients with anogenital AI from 2000 to 2010. Assessment was done using the Hidradenitis Suppurativa Lesion, Area, and Severity Index (HS-LASI), pain visual analogue scale, physician global assessment (PhGA), and patient global assessment (PaGA). Comorbidities and adverse events were analyzed.
Results
Sixty-seven patients with a Hurley score of 3 were identified. Mean follow-up was 56.9 ± 41.3 months. A ...
Management of Severe Anogenital Acne Inversa (Hidradenitis Suppurativa) is a post from: Skincare
Management of Severe Anogenital Acne Inversa (Hidradenitis Suppurativa) via BuzzBlazer.com
Multiple Pass Ultrasound Tightening of Skin Laxity of the Lower Face and Neck
Background
Skin laxity is a common complaint of patients who request skin rejuvenation. Radiofrequency and infrared light are widely used for nonablative treatment of skin laxity. Intense focused ultrasound (IFUS) has been investigated as a tool for the treatment of solid benign and malignant tumors for many decades but is only now beginning to emerge as a potential noninvasive alternative to conventional nonablative therapy.
Objectives
To evaluate the efficacy of IFUS for the treatment of face and neck laxity.
Methods
Twelve female volunteers were enrolled in the study, and 10 were ultimately evaluated. The device ...
Multiple Pass Ultrasound Tightening of Skin Laxity of the Lower Face and Neck is a post from: Skincare
Multiple Pass Ultrasound Tightening of Skin Laxity of the Lower Face and Neck via BuzzBlazer.com
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