Cellular Phone and Cellular Phone Accessory Dermatitis Due to Nickel Allergy: Report of Five Cases

Abstract:  Cellular phone dermatitis, also known as mobile phone dermatitis, is a recently recognized condition due to either nickel or chromate allergy. Cellular phone dermatitis has most often been reported in young adults and less commonly in adolescents. We describe five adolescents whose cellular phone dermatitis was caused by nickel allergy.

Cellular Phone and Cellular Phone Accessory Dermatitis Due to Nickel Allergy: Report of Five Cases is a post from: Skincare

Cellular Phone and Cellular Phone Accessory Dermatitis Due to Nickel Allergy: Report of Five Cases is a post from: Skincare

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“Hot Tub” Folliculitis from a NonChlorinated Children’s Pool

Abstract: Pseudomonas aeruginosa is common cause of folliculitis following contact with contaminated water. We report a case of pseudomonal folliculitis that occurred after swimming in a children’s pool filled with water from a well.

“Hot Tub” Folliculitis from a NonChlorinated Children’s Pool is a post from: Skincare

“Hot Tub” Folliculitis from a NonChlorinated Children’s Pool is a post from: Skincare

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Giannoti-Crosti Syndrome Associated With Type A Influenza

Abstract:  Gianotti-Crosti syndrome is an entity characterized by an acute papular eruption in children and has been associated with a multitude of viruses. This is the first case reported in association with type A influenza, a virus that usually has no dermatologic findings.

Giannoti-Crosti Syndrome Associated With Type A Influenza is a post from: Skincare

Giannoti-Crosti Syndrome Associated With Type A Influenza is a post from: Skincare

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Pediatric Dermatology Consultations: A Retrospective Analysis of Inpatient Consultations Referred to the Dermatology Service

Abstract:  To analyze the care provided by consultant dermatologists to hospitalized pediatric patients, we retrospectively studied the records of inpatient pediatric consultation requests received by a hospital dermatology department between 2000 and 2009. The diagnoses were recorded according to the International Classification of Diseases, Ninth Revision (ICD-9). In a high percentage of cases, the problem was addressed in a single visit, and few additional tests were ordered. The most common diagnostic groups were diseases of the skin and subcutaneous tissue (ICD-9: 680–709). The most frequent specific diagnosis was atopic dermatitis ...

Pediatric Dermatology Consultations: A Retrospective Analysis of Inpatient Consultations Referred to the Dermatology Service is a post from: Skincare

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PHACE without Face? Infantile Hemangiomas of the Upper Body Region with Minimal or Absent Facial Hemangiomas and Associated Structural Malformations

Abstract:  Infantile hemangiomas can be associated with congenital anomalies such as PHACE syndrome with facial hemangiomas and genitourinary and spinal anomalies in the setting of lower body hemangiomas. We describe five infants in whom segmental hemangiomas involving the upper torso and extremities with absent or small facial hemangiomas were associated with structural anomalies similar to those reported with PHACE syndrome, including three with structural arterial anomalies of the subclavian arteries, three with aortic arch anomalies (right sided or narrowed arch), two with congenital heart disease (atrial septal defect and ventricular ...

PHACE without Face? Infantile Hemangiomas of the Upper Body Region with Minimal or Absent Facial Hemangiomas and Associated Structural Malformations is a post from: Skincare

PHACE without Face? Infantile Hemangiomas of the Upper Body Region with Minimal or Absent Facial Hemangiomas and Associated Structural Malformations via BuzzBlazer.com

Skin Manifestations in Primary Immunodeficient Children

Abstract:  Skin manifestations are prevalent in primary immunodeficiency disorders (PID). In a large proportion of patients, they manifest as presenting signs and serve as important factors for the early diagnosis of PID. Only a few studies describing the spectrum of skin disorders in PID are available. The objective of the current study was to determine the prevalence and characteristics of skin manifestations in children with PID. Participants were 128 pediatric patients with PID (aged <16 years) registered prospectively over 6 years. Skin manifestations were observed in 61 patients (48%), and those manifestations ...

Skin Manifestations in Primary Immunodeficient Children is a post from: Skincare

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Scalp Discoloration from Selenium Sulfide Shampoo: A Case Series and Review of the Literature

Abstract:  We describe six patients who developed orange to red–brown scalp discoloration after application of selenium sulfide–containing shampoos. This phenomenon has been described only once previously. In all of the cases, the discoloration resolved shortly after discontinuing the selenium sulfide. Lightly swabbing with isopropyl alcohol facilitated removal of the discoloration. This simple technique serves as a painless diagnostic method, which may prevent unnecessary evaluation with a biopsy.

Scalp Discoloration from Selenium Sulfide Shampoo: A Case Series and Review of the Literature is a post from: Skincare

Scalp Discoloration from Selenium Sulfide Shampoo: A Case Series and Review of the Literature is a post from: Skincare

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Salicin regulates the expression of functional ‘youth gene clusters’ to reflect a more youthful gene expression profile

Synopsis

There are a variety of biological mechanisms that contribute to specific characteristics of ageing skin; for example, the loss of skin structure proteins, increased susceptibility to UV-induced pigmentation and/or loss of hydration. Each of these biological processes is influenced by specific groups of genes. In this research, we have identified groups of genes associated with specific clinical signs of skin ageing and refer to these as functional ‘youth gene clusters’. In this study, quantitative real-time polymerase chain reaction (qPCR) was used to investigate the effects of topical application of salicin ...

Salicin regulates the expression of functional ‘youth gene clusters’ to reflect a more youthful gene expression profile is a post from: Skincare

Salicin regulates the expression of functional ‘youth gene clusters’ to reflect a more youthful gene expression profile via BuzzBlazer.com

Influence of Aqueous Cream on corneocyte size, maturity, skin protease activity, protein content and Trans-Epidermal Water Loss

Summary

Background:  Aqueous cream B.P. is frequently prescribed for patients with eczema and is known to induce sensitivity in certain patients and also to decrease the thickness of the stratum corneum. We have previously reported methodology to quantify corneocyte maturity and size, protease activity and protein content within different levels of the stratum corneum.


Objectives:  The aim of the present study was to investigate changes in corneocyte size, corneocyte maturity, selected protease activities, protein content and Trans-epidermal water loss (TEWL) in normal skin after a 28-day application of Aqueous Cream B.P.


Methods:  The ...

Influence of Aqueous Cream on corneocyte size, maturity, skin protease activity, protein content and Trans-Epidermal Water Loss is a post from: Skincare

Influence of Aqueous Cream on corneocyte size, maturity, skin protease activity, protein content and Trans-Epidermal Water Loss via BuzzBlazer.com

Body site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice

Abstract

Background: Concern about skin cancer is a common reason for people from predominantly fair-skinned populations present to primary care doctors.


Objectives: To examine the frequency and body site distribution of malignant, pre-malignant and benign pigmented skin lesions excised in primary care.


Methods: This prospective study conducted in Queensland, Australia, included 154 primary care doctors. For all excised or biopsied lesions, doctors recorded the patient’s age and sex, body site, level of patient pressure to excise, and the clinical diagnosis. Histological confirmation was obtained through pathology laboratories.


Results: Of 9,650 skin lesions, 57.7% were ...

Body site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice is a post from: Skincare

Body site distribution of skin cancer, pre-malignant and common benign pigmented lesions excised in general practice via BuzzBlazer.com

High-Resolution Ultrasound Imaging to Demonstrate and Predict Efficacy of Carbon Dioxide Fractional Resurfacing Laser Treatment

BACKGROUND
Fractional resurfacing is a new laser treatment used mainly for treating photoaging and acne scars.


OBJECTIVE
To demonstrate the efficacy of carbon dioxide (CO2) fractional resurfacing laser treatment using high-resolution ultrasound imaging and to evaluate factors predictive of response to the treatment.


MATERIALS AND METHODS
A prospective observational study was undertaken from January 2007 to August 2009. Laser treatment was performed using a CO2 fractional resurfacing device. Patients were offered high-resolution ultrasound imaging to follow up their treatment. Dermal and subepidermal nonechogenic band (SENEB) thicknesses were measured.


RESULTS
Twenty-four consecutive patients were ...

High-Resolution Ultrasound Imaging to Demonstrate and Predict Efficacy of Carbon Dioxide Fractional Resurfacing Laser Treatment is a post from: Skincare

High-Resolution Ultrasound Imaging to Demonstrate and Predict Efficacy of Carbon Dioxide Fractional Resurfacing Laser Treatment via BuzzBlazer.com

Immunohistochemical Staining with Melan-A of Uninvolved Sun-Damaged Skin Shows Features Characteristic of Lentigo Maligna

BACKGROUND
The greater density and unusual patterning of melanocytes in chronically sun-exposed skin complicates interpretation of intraoperative Melan-A immunohistochemical stained margins during margin-controlled surgery for lentigo maligna (LM) and lentigo maligna melanoma (LMM).


OBJECTIVE
To identify the immunohistochemical similarities and differences in melanocyte distribution between LM and LMM and chronically sun-exposed skin.


METHODS
Retrospective review of Melan-A-stained original biopsy specimens of LM and LMM and uninvolved sun-damaged skin (negative controls), from 70 LM and LMM cases from the University of Utah in 2008.


RESULTS
Histologic features commonly associated with LM were common in ...

Immunohistochemical Staining with Melan-A of Uninvolved Sun-Damaged Skin Shows Features Characteristic of Lentigo Maligna is a post from: Skincare

Immunohistochemical Staining with Melan-A of Uninvolved Sun-Damaged Skin Shows Features Characteristic of Lentigo Maligna via BuzzBlazer.com

Atypical Fibroxanthoma in the Setting of Chronic Lymphocytic Leukemia and Other Non-Hodgkin Lymphomas

BACKGROUND
Atypical fibroxanthoma (AFX) is a rare cutaneous malignancy of older adults. Little is known about the behavior of AFX in the setting of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL).


OBJECTIVE
To further understand the development, characteristics, and behavior of AFX in the setting of concomitant CLL and other types of NHL.


METHODS AND MATERIALS
Study approval was obtained from the Mayo Clinic Institutional Review Board. The master diagnosis index was queried from January 1, 1980, through December 31, 2008, to identify patients with AFX and CLL or other types ...

Atypical Fibroxanthoma in the Setting of Chronic Lymphocytic Leukemia and Other Non-Hodgkin Lymphomas is a post from: Skincare

Atypical Fibroxanthoma in the Setting of Chronic Lymphocytic Leukemia and Other Non-Hodgkin Lymphomas via BuzzBlazer.com

Automatic detection of basal cell carcinoma using telangiectasia analysis in dermoscopy skin lesion images

Background: Telangiectasia, dilated blood vessels near the surface of the skin of small, varying diameter, are critical dermoscopy structures used in the detection of basal cell carcinoma (BCC). Distinguishing these vessels from other telangiectasia, that are commonly found in sun-damaged skin, is challenging.


Methods: Image analysis techniques are investigated to find vessels structures in BCC automatically. The primary screen for vessels uses an optimized local color drop technique. A noise filter is developed to eliminate false-positive structures, primarily bubbles, hair, and blotch and ulcer edges. From the telangiectasia mask ...

Automatic detection of basal cell carcinoma using telangiectasia analysis in dermoscopy skin lesion images is a post from: Skincare

Automatic detection of basal cell carcinoma using telangiectasia analysis in dermoscopy skin lesion images via BuzzBlazer.com

The influence of stratum corneum hydration on body fat determination by bioelectrical impedance analysis

Background/aims: Bioelectrical impedance analysis (BIA) is used for the estimation of the amount of body fat. We evaluated the influence of the stratum corneum hydration at the contact areas used for BIA on the body fat estimation.


Methods: Stratum corneum hydration was measured at the sole of the right foot and the palm of the right hand before and after contact with the Tanita Body Composition Analyzer TBF 410® and the Omron Body Fat Analyzer®, (n=128 females and 126 males), respectively. Changes in stratum corneum hydration during the contact ...

The influence of stratum corneum hydration on body fat determination by bioelectrical impedance analysis is a post from: Skincare

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Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy

Background: Confocal microscopy has been successfully applied both in oncologic and inflammatory diseases. In particular, it has been proved as a useful tool for the in vivo detection of microscopical changes occurring in allergic reactions.


Aims of the study: To evaluate microscopic changes occurring in positive patch test reactions.


Methods: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy.


Results: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in ...

Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy is a post from: Skincare

Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy via BuzzBlazer.com

Novel anti-wrinkle effect of cosmeceutical product with new retinyl retinoate microsphere using biodegradable polymer

Background: The novel hybrid retinoid, retinyl retinoate, is a synthetic material that was designed to reduce the side effects of retinoic acid and to increase the stability of retinol. The formulation of the retinyl retinoate, however, is required to enhance skin permeation, and thus to increase the anti-wrinkle effect.


Aim: To identify the efficacy of retinyl retinoate microsphere using biodegradable polymer as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles.


Methods: The retinyl retinoate microsphere was prepared using the biodegradable polymer; polylactic ...

Novel anti-wrinkle effect of cosmeceutical product with new retinyl retinoate microsphere using biodegradable polymer is a post from: Skincare

Novel anti-wrinkle effect of cosmeceutical product with new retinyl retinoate microsphere using biodegradable polymer via BuzzBlazer.com

Facing up to the imperceptible perspiration. Modulatory influences by diabetic neuropathy, physical exercise and antiperspirant

Background: Sweating is variably altered by physical exercise, diabetic neuropathy and antiperspirants.


Methods: Skin temperature, skin surface water loss (SSWL), the Corneometer® average capacitance (CMAC) and skin capacitance mapping (SCM) were measured before and after moderate physical exercise in 20 healthy subjects. The effect of 5% aluminium chloride hexahydrate (ACH) in a water solution was similarly tested. The same assessments were performed in 20 diabetic patients at rest.


Results: Diabetic neuropathy appeared at rest as an increased (compensatory) SCM on the forearms without obvious modification on the hypohidrotic legs. ...

Facing up to the imperceptible perspiration. Modulatory influences by diabetic neuropathy, physical exercise and antiperspirant is a post from: Skincare

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Patterns of aluminum hydroxychloride deposition onto the skin

Background: Aluminum hydroxychloride (AlCl3) is an antiperspirant.


Aim: To revisit the AlCl3 deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS).


Methods: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl3 on the forearms. The AlCl3-coated skin, glass slides and CSSS were observed using two ultraviolet light-emitting CCD cameras in order to record changes in specular reflectance related to AlCl3 deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl3 irritation.


Results: AlCl3 ...

Patterns of aluminum hydroxychloride deposition onto the skin is a post from: Skincare

Patterns of aluminum hydroxychloride deposition onto the skin via BuzzBlazer.com

A Case of Sclerodermatous Graft-versus-Host Disease Responsive to Imatinib Therapy

Abstract:  Sclerodermatous graft-versus-host disease (sGVHD) is a rare, late complication of hematopoietic cell transplantation. Classified as a variant of chronic graft-versus-host disease, sGVHD is thought to be predominantly an immune-mediated response characterized by aberrant T-cell function and dysregulation of tyrosine kinase cascades. Recently, the profibrotic cytokine transforming growth factor B and stimulatory autoantibodies against the platelet-derived growth factor receptor have been implicated in the pathogenesis of sGVHD. Treatment of sGVHD remains disappointing and largely limited by systemic side effects. Imatinib mesylate is a small molecule tyrosine kinase inhibitor that has ...

A Case of Sclerodermatous Graft-versus-Host Disease Responsive to Imatinib Therapy is a post from: Skincare

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Acute Generalized Exanthematous Pustulosis and Coombs-Positive Hemolytic Anemia in a Child Following Loxosceles reclusa Envenomation

Abstract:  Previously reported cases of acute generalized exanthematous pustulosis secondary to brown recluse spider bite have been questioned due to lack of identification of the spider or because of the concomitant administration of antibiotics. We report a 9-year-old boy who arrived at the emergency department with a confirmed Loxosceles reclusa bite to the neck. On the third day of hospitalization, he developed hundreds of monomorphous, sterile pustules, initially in intertriginous areas. The eruption disseminated and was followed by pinpoint desquamation typical for acute generalized exanthematous pustulosis. During this he also ...

Acute Generalized Exanthematous Pustulosis and Coombs-Positive Hemolytic Anemia in a Child Following Loxosceles reclusa Envenomation is a post from: Skincare

Acute Generalized Exanthematous Pustulosis and Coombs-Positive Hemolytic Anemia in a Child Following Loxosceles reclusa Envenomation via BuzzBlazer.com

Childhood Tinea Incognito Caused by Trichophyton mentagrophytes var. interdigitale Mimicking Pustular Psoriasis

Abstract:  Tinea incognito refers to fungal infection whose clinical appearance is modified or aggravated by administration of systemic or topical corticosteroids. We report a case of pustular psoriasis-like tinea incognito caused by Trichophyton mentagrophytes var. interdigitale under topical corticosteroid therapy. Sequence analysis of the internal transcribed spacer 2 region, in addition to the D1D2 domain of the 26S ribosomal RNA gene, was helpful in identifying the fungal species.

Childhood Tinea Incognito Caused by Trichophyton mentagrophytes var. interdigitale Mimicking Pustular Psoriasis is a post from: Skincare

Childhood Tinea Incognito Caused by Trichophyton mentagrophytes var. interdigitale Mimicking Pustular Psoriasis is a post from: Skincare

Childhood Tinea Incognito Caused by Trichophyton mentagrophytes var. interdigitale Mimicking Pustular Psoriasis via BuzzBlazer.com

Satellite Lesions in Congenital Melanocytic Nevi—Time for a Change of Name

Abstract:  The term “satellite lesions” is used in many conditions in dermatology, generally to describe smaller lesions near the edges of a principal lesion. An online medical dictionary gives the definition “a smaller lesion accompanying a main one and situated nearby,” and this can apply both macroscopically and microscopically. The implication is that the smaller lesions have spread from the parent lesion. Given this definition and usual understanding of the term its use is not apt in the case of congenital melanocytic nevi (CMN). In the vast majority of cases ...

Satellite Lesions in Congenital Melanocytic Nevi—Time for a Change of Name is a post from: Skincare

Satellite Lesions in Congenital Melanocytic Nevi—Time for a Change of Name via BuzzBlazer.com

Annular Lipoatrophic Panniculitis of the Ankles

Abstract:  We report a girl with lipophagic lobular panniculitis of unknown origin located on her ankles leading to circumferential fat atrophy of the ankles, a condition usually referred to as “annular lipoatrophy of the ankles.” According to our patient’s features and five additional cases reported so far, we conclude that this condition is actually an end-stage manifestation of an idiopathic lobular panniculitis of children localized to the lower part of the lower limbs. An association with some autoimmune manifestations is highlighted.

Annular Lipoatrophic Panniculitis of the Ankles is a post from: ...

Annular Lipoatrophic Panniculitis of the Ankles is a post from: Skincare

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Is Langerhan Cell Histiocytosis Complicated with Hydrops Fetalis Exclusively Lethal in Premature Neonates?

Abstract:  Langerhans cell histiocytosis is a rare disease and is lethal in premature neonates. A male premature neonate born at gestational 33 weeks presented with generalized vesicles, hydrops fetalis with pleural effusion, bilateral cataracts, and severe respiratory distress syndrome complicated with persistent pulmonary hypertension. Skin biopsy confirmed the diagnosis of Langerhans cell histiocytosis.

Is Langerhan Cell Histiocytosis Complicated with Hydrops Fetalis Exclusively Lethal in Premature Neonates? is a post from: Skincare

Is Langerhan Cell Histiocytosis Complicated with Hydrops Fetalis Exclusively Lethal in Premature Neonates? is a post from: Skincare

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MRSA Blistering Distal Dactylitis and Review of Reported Cases

Abstract:  We describe a 6-month-old infant with blistering distal dactylitis. Bacterial culture from the skin lesion grew methicillin resistant Staphylococcus aureus. No carriage of this bacterial agent was identified in her family. She responded to vancomycin administration and incision and drainage of the lesion. This is the first reported case of methicillin resistant Staphylococcus aureus-associated blistering distal dactylitis in an infant.

MRSA Blistering Distal Dactylitis and Review of Reported Cases is a post from: Skincare

MRSA Blistering Distal Dactylitis and Review of Reported Cases is a post from: Skincare

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Symmetric Aplasia Cutis Congenita Associated with Fetus Papyraceus: Report of Two Cases

Abstract:  We present two cases of neonates born with symmetric aplasia cutis congenita associated with intrauterine fetal demise of cotwins during the early second trimester. Fetus papyraceus resulting in aplasia cutis congenita is a rare association with many clinical presentations, including extratruncal symmetric lesions and small linear, arcuate, and triangular lesions when twin intrauterine demise occurs after the first trimester.

Symmetric Aplasia Cutis Congenita Associated with Fetus Papyraceus: Report of Two Cases is a post from: Skincare

Symmetric Aplasia Cutis Congenita Associated with Fetus Papyraceus: Report of Two Cases is a post from: Skincare

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A Case of Congenital Pigmented Dermatofibrosarcoma Protuberans (Bednar Tumor) in a Patient with Fanconi Anemia

Abstract:  Bednar tumor is a rare pigmented variation of dermatofibrosarcoma protuberans, present in 1 to 5% of all patients with dermatofibrosarcoma protuberans. No significant clinicopathologic differences exist between Bednar tumor and conventional dermatofibrosarcoma protuberans apart from the presence of scattered nonneoplastic pigmented dendritic cells in the former. Although most dermatofibrosarcoma protuberans occur in adults, they may be rarely present at birth. Fanconi anemia is a genetically heterogeneous chromosomal instability syndrome, characterized by multiple congenital anomalies, progressive bone marrow failure, and a predisposition to malignancy. We describe here a patient with ...

A Case of Congenital Pigmented Dermatofibrosarcoma Protuberans (Bednar Tumor) in a Patient with Fanconi Anemia is a post from: Skincare

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Hybrid Follicular Cyst (Pilomatrical and Infundibular) Arising Within a Sebaceous Nevus

Abstract:  A 7-year-old girl presented with a 3-month history of a small blue–brown papule arising within a large sebaceous nevus on her temporal scalp. A punch excision was performed that demonstrated a hybrid follicular cyst. The majority of the cyst wall displayed pilomatrical differentiation consisting of basaloid matrical-type cells with luminal shadow cell keratinization. The matrical epithelium displayed strong membranous, cytoplasmic, and nuclear staining for β-catenin. Only a small component of the wall displayed infundibular differentiation. These findings were consistent with a hybrid follicular cyst predominantly displaying pilomatrical differentiation with ...

Hybrid Follicular Cyst (Pilomatrical and Infundibular) Arising Within a Sebaceous Nevus is a post from: Skincare

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Treatment of Syringoma Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser: A Prospective Analysis of 35 Patients

BACKGROUND
Treatment of syringoma aims to destroy the dermal tumor using methods that can include surgical excision, electrodessication, cryosurgery, chemical peeling, and laser ablation, but complete removal of syringomas is often unsuccessful, and recurrence occurs frequently.


OBJECTIVE
To investigate the therapeutic efficacy of an ablative 10,600-nm carbon dioxide fractional laser system (CO2 FS) for the treatment of periorbital syringomas.


METHODS
Thirty-five patients with periorbital syringomas were treated with two sessions of CO2 FS at 1-month intervals. Laser fluences were delivered in two or three passes over the lower eyelids, using a pulse ...

Treatment of Syringoma Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser: A Prospective Analysis of 35 Patients is a post from: Skincare

Treatment of Syringoma Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser: A Prospective Analysis of 35 Patients via BuzzBlazer.com

Skin Tightening of Aging Upper Arms Using an Infrared Light Device

BACKGROUND
Upper arm skin laxity is an important area of cosmetic concern. Recent studies using a noninvasive infrared device has demonstrated its efficacy in tightening skin in various body regions. The use of this device in upper arm loose skin has not been investigated.


OBJECTIVES
To determine the safety and efficacy of an infrared device to treat upper arm laxity in aged skin.


PATIENTS AND METHODS
Twenty women with mild to very loose aged upper arm skin underwent two treatments with an infrared device 1 month apart. Nineteen patients completed the study ...

Skin Tightening of Aging Upper Arms Using an Infrared Light Device is a post from: Skincare

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Reconstruction of a Multi-Subunit Nasal Defect

The authors have indicated no significant interest with commercial supporters.

Reconstruction of a Multi-Subunit Nasal Defect is a post from: Skincare

Reconstruction of a Multi-Subunit Nasal Defect is a post from: Skincare

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Lasers in the Treatment of Nonmelanoma Skin Cancer

BACKGROUND
Nonmelanoma skin cancers (NMSCs) constitute the largest proportion of cancers worldwide, especially in the Western population, making it essential to develop methods to manage these cancers. Ultraviolet (UV) light being the most significant culprit in the development of NMSCs makes the sun-exposed parts of the body, such as face and extremities, the most vulnerable to develop these tumors. Early diagnosis and emphasis on cosmesis are vital while treating them especially, in patients with multiple squamous and basal cell carcinomas. Lasers seem to be a useful therapeutic modality and are ...

Lasers in the Treatment of Nonmelanoma Skin Cancer is a post from: Skincare

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Liposome-Encapsulated 0.5% 5-Aminolevulinic Acid with Intense Pulsed Light for the Treatment of Inflammatory Facial Acne: A Pilot Study

BACKGROUND
Liposome used in spray form to encapsulate and deliver 5-aminolevulinic acid (5-ALA) into the pilosebaceous unit lowers the concentration of 5-ALA to 0.5% in photodynamic therapy (PDT) for acne, with low post-treatment photosensitivity.


OBJECTIVE
To investigate the clinical outcome and side effects of PDT using intense pulsed light (IPL) and 0.5% 5-ALA spray for inflammatory facial acne in Asian skin.


METHODS
Twelve subjects (skin types IV–V) with facial acne received full-face treatment at 3-week intervals with IPL 1 hour after being sprayed with 5-ALA. Lesion counts were assessed using serial standardized ...

Liposome-Encapsulated 0.5% 5-Aminolevulinic Acid with Intense Pulsed Light for the Treatment of Inflammatory Facial Acne: A Pilot Study is a post from: Skincare

Liposome-Encapsulated 0.5% 5-Aminolevulinic Acid with Intense Pulsed Light for the Treatment of Inflammatory Facial Acne: A Pilot Study via BuzzBlazer.com

Facial Blanching After Cutaneous Injections: Cannulation of Branches of the Ophthalmic Artery. Case Series and Review of the Literature

The authors have indicated no significant interest with commercial supporters.

Facial Blanching After Cutaneous Injections: Cannulation of Branches of the Ophthalmic Artery. Case Series and Review of the Literature is a post from: Skincare

Facial Blanching After Cutaneous Injections: Cannulation of Branches of the Ophthalmic Artery. Case Series and Review of the Literature is a post from: Skincare

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Negative Pressure Therapy Potential Enhancement with a Biointeractive Hyaluronan Acid Scaffold Interface: Case Report

The authors have indicated no significant interest with commercial supporters.

Negative Pressure Therapy Potential Enhancement with a Biointeractive Hyaluronan Acid Scaffold Interface: Case Report is a post from: Skincare

Negative Pressure Therapy Potential Enhancement with a Biointeractive Hyaluronan Acid Scaffold Interface: Case Report is a post from: Skincare

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Successful Treatment of Periungual Warts with Diluted Bleomycin Using Translesional Multipuncture Technique: A Pilot Prospective Study

BACKGROUND
The treatment of periungual warts is a therapeutic challenge. Various treatment modalities can be ineffective and may cause scarring and permanent nail changes.


OBJECTIVES
A prospective pilot study to investigate the efficacy and safety of a low concentration (0.1 U/mL) of bleomycin in the treatment of periungual warts.


METHODS
Periungual warts were injected with bleomycin (0.1 U/mL) every 4 weeks until elimination of the lesions or until the injections were discontinued because of adverse effects. Bleomycin was administered using the translesional multipuncture technique.


RESULTS
We recruited 15 patients with periungual warts from March 2007 ...

Successful Treatment of Periungual Warts with Diluted Bleomycin Using Translesional Multipuncture Technique: A Pilot Prospective Study is a post from: Skincare

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Decorin Expression with Stump Recurrence and Neovascularization after Varicose Vein Surgery—a Pilot Study

BACKGROUND
An evaluation of the reason for saphenofemoral recurrence (SFR, technical error vs neovascularization) after surgery is necessary to improve the method or find purchase for new therapies. Currently, differentiation by the surgeon or ultrasound are unsatisfying; histology depends mainly on the physician’s experience. Decorin, an extracellular matrix component, is up-regulated in angiogenesis with antiangiogenetic effects on neovascularization.


OBJECTIVE
To determine whether decorin is a reliable marker to distinguish neovascularization and stump recurrence.


METHODS
Twenty specimens obtained in re-operation of patients with duplex-detected SFR were stained with hematoxylin and eosin, Elastica van ...

Decorin Expression with Stump Recurrence and Neovascularization after Varicose Vein Surgery—a Pilot Study is a post from: Skincare

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Subcision for Depressed Facial Scars Made Easy Using a Simple Modification

The authors have indicated no significant interest with commercial supporters.

Subcision for Depressed Facial Scars Made Easy Using a Simple Modification is a post from: Skincare

Subcision for Depressed Facial Scars Made Easy Using a Simple Modification is a post from: Skincare

Subcision for Depressed Facial Scars Made Easy Using a Simple Modification via BuzzBlazer.com

Efficacy of blue light vs. red light in the treatment of psoriasis: a double-blind, randomized comparative study

Abstract

Background  Protoporphyrin IX is present in psoriatic skin without the preceding application of aminolevulinic acid. Therefore, endogenous photosensitizers in psoriasis are a potential target for photodynamic treatment with high-dose visible light.


Objectives  In the present pilot study, treatment with high-dose blue and red light in psoriasis were analysed with respect to clinical improvement and potential side-effects.


Methods  In 20 patients, two stable psoriatic plaques were treated with either blue or red light, three times weekly for four consecutive weeks. To remove scaling that could potentially interfere with penetration of the light into ...

Efficacy of blue light vs. red light in the treatment of psoriasis: a double-blind, randomized comparative study is a post from: Skincare

Efficacy of blue light vs. red light in the treatment of psoriasis: a double-blind, randomized comparative study via BuzzBlazer.com

Thyroid autoimmunity associated with recurrent aphthous stomatitis

Abstract

Background  Recurrent aphthous stomatitis (RAS) is an autoimmune disorder characterized by the periodic appearance of aphthous lesions on the oral mucosa. TH1 cytokines plays a key role in the aetiopathogenesis. Autoimmune thyroid disease (ATD) is the most common autoimmune disease and is frequently accompanied by various other autoimmune diseases.


Objective  To investigate the frequency of ATD which has not been studied in the patients with RAS.


Methods  Ninety patients and 30 healthy volunteers were included into the study. The serum samples were assayed for thyroid stimulant hormone (TSH), free and total triiodothyronine ...

Thyroid autoimmunity associated with recurrent aphthous stomatitis is a post from: Skincare

Thyroid autoimmunity associated with recurrent aphthous stomatitis via BuzzBlazer.com

Safety of treatment with biologics for psoriasis in daily practice: 5-year data

Abstract

Background  The cumulative exposition to biologics is increasing with prolonged treatment with a certain biologic or consecutive biological treatment. However, long-term safety data are limited available.


Objectives  The aim of this study was to prospectively evaluate the 5-year safety of biological treatment for psoriasis in daily practice.


Methods  A cohort of 173 psoriasis patients on biologics was prospectively followed for 5 years. All adverse events reported were documented and analysed. Primary endpoint was the percentage of patients reporting at least one serious adverse event. The rate of malignancies, serious infections and serious cardiovascular ...

Safety of treatment with biologics for psoriasis in daily practice: 5-year data is a post from: Skincare

Safety of treatment with biologics for psoriasis in daily practice: 5-year data via BuzzBlazer.com

Multiple familial and pigmented basal cell carcinomas in early childhood – Bazex–Dupré–Christol syndrome

Abstract

Background  Bazex–Dupré–Christol syndrome (BDCS) is an X-linked dominantly inherited disorder affecting hair follicle structures. Currently, hypotrichosis, follicular atrophoderma and basal cell carcinomas are considered frequent symptoms of the disorder whereas milia are supposed to reflect infrequent clinical signs. Usually, basal cell carcinomas in this disease manifest from the second decade of life onwards.


Case report  Here, we studied a novel multigeneration family of German origin with BDCS. Interestingly, two family members developed pigmented basal cell carcinomas in early childhood, at the age of 3 and 5 years, respectively. The differentiation from other ...

Multiple familial and pigmented basal cell carcinomas in early childhood – Bazex–Dupré–Christol syndrome is a post from: Skincare

Multiple familial and pigmented basal cell carcinomas in early childhood – Bazex–Dupré–Christol syndrome via BuzzBlazer.com

Phacomatosis spilorosea with oligodontia, scoliosis and fibrous cortical defects

Phacomatosis spilorosea with oligodontia, scoliosis and fibrous cortical defects is a post from: Skincare

Phacomatosis spilorosea with oligodontia, scoliosis and fibrous cortical defects is a post from: Skincare

Phacomatosis spilorosea with oligodontia, scoliosis and fibrous cortical defects via BuzzBlazer.com

Improvement of a three-dimensional measurement system for the evaluation of foot edema

Background/aims: This study investigated the accuracy and usefulness of a newly improved three-dimensional measurement system for measuring the volume and circumference at the foot as well as at the calf and ankle.


Methods: Regarding the newly improved device, halogen light was projected from four directions instead of the conventional two directions. The circumference and volume were measured in the morning and evening with and without elastic stockings in 23 healthy subjects.


Results: The average circumference at the foot calculated using the ‘average method’, in which the circumference of the ...

Improvement of a three-dimensional measurement system for the evaluation of foot edema is a post from: Skincare

Improvement of a three-dimensional measurement system for the evaluation of foot edema via BuzzBlazer.com

In vivo reflectance confocal microscopy imaging of vitiligo, nevus depigmentosus and nevus anemicus

Background/purpose: Hypopigmentary skin disorders such as vitiligo, nevus depigmentosus and nevus anemicus are common diseases in clinic. The lesions of these diseases could be similar to some extent, although each of them has its own characteristic clinical appearance and histological features. Clinically, the atypical lesions are often difficult to be differentiated. In vivo reflectance confocal microscopy (RCM) is a non-invasive, repetitive imaging tool that provides real-time images at a nearly cellular histological resolution. Our aim was to investigate the RCM features of vitiligo, nevus depigmentosus and nevus anemicus.


Subjects and ...

In vivo reflectance confocal microscopy imaging of vitiligo, nevus depigmentosus and nevus anemicus is a post from: Skincare

In vivo reflectance confocal microscopy imaging of vitiligo, nevus depigmentosus and nevus anemicus via BuzzBlazer.com

Blood vessel characterization in human dermal wound repair and scarring

Blood vessel characterization in human dermal wound repair and scarring is a post from: Skincare

Blood vessel characterization in human dermal wound repair and scarring is a post from: Skincare

Blood vessel characterization in human dermal wound repair and scarring via BuzzBlazer.com

Extracellular Cellular Matrix Protein 1 (ECM1) Autoantibodies in Male Genital Lichen Sclerosus (MGLSc).

Extracellular Cellular Matrix Protein 1 (ECM1) Autoantibodies in Male Genital Lichen Sclerosus (MGLSc). is a post from: Skincare

Extracellular Cellular Matrix Protein 1 (ECM1) Autoantibodies in Male Genital Lichen Sclerosus (MGLSc). is a post from: Skincare

Extracellular Cellular Matrix Protein 1 (ECM1) Autoantibodies in Male Genital Lichen Sclerosus (MGLSc). via BuzzBlazer.com

New onset polyarthritis during successful treatment of hidradenitis suppurativa with infliximab

Abstract

Background:  Hidradenitis suppurativa (HS) can be associated with several forms of arthritis, usually considered as reactive arthritis. A new observation is that some HS patients develop arthritis after treatment with infliximab (anti-TNF-alpha).


Objectives:  A retrospective study was performed to establish the frequency and clinical presentation of new onset arthritis during infliximab treatment.


Methods:  Between 2005 and 2009, 27 individuals with severe HS were treated with infliximab and followed-up closely. Laboratory parameters and side-effects were recorded. The frequency of arthritis was compared to control groups consisting of 227 HS patients not treated with ...

New onset polyarthritis during successful treatment of hidradenitis suppurativa with infliximab is a post from: Skincare

New onset polyarthritis during successful treatment of hidradenitis suppurativa with infliximab via BuzzBlazer.com

CCL13 serum levels in systemic sclerosis patients and controls

CCL13 serum levels in systemic sclerosis patients and controls is a post from: Skincare

CCL13 serum levels in systemic sclerosis patients and controls is a post from: Skincare

CCL13 serum levels in systemic sclerosis patients and controls via BuzzBlazer.com

Relevance of laboratory investigations in monitoring patients with psoriasis on etanercept or adalimumab.

Abstract

Background:  Guidelines concerning biological treatment of patients with psoriasis recommend different pre-treatment and monitoring laboratory panels in variable frequencies to monitor treatment.


Objectives:  To investigate the relevance of laboratory investigations in monitoring patients with psoriasis on etanercept or adalimumab.


Methods:  A prospective cohort study during 5 years was conducted in all consecutive patients with psoriasis on etanercept or adalimumab. All laboratory investigations performed for monitoring treatment were analysed. Laboratory abnormalities were graded according to the Common Terminology Criteria for Adverse Events v4.03. Primary endpoint was the percentage of patients having a grade ...

Relevance of laboratory investigations in monitoring patients with psoriasis on etanercept or adalimumab. is a post from: Skincare

Relevance of laboratory investigations in monitoring patients with psoriasis on etanercept or adalimumab. via BuzzBlazer.com

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

Abstract

Null mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) and predispose to atopic dermatitis (AD). Cohort studies in Europe and Japan have reported a FLG mutation carrier frequency between 14 and 56%, but the prevalent European FLG mutations are rare or absent in Chinese patients with IV and AD. To further investigate the spectrum of FLG-null mutations in Chinese patients and compare it with other populations, we conducted comprehensive FLG genetic analysis in a discovery cohort of 92 Singaporean Chinese individuals with IV and/or moderate-to-severe AD. All detected ...

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations is a post from: Skincare

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations via BuzzBlazer.com

Cortexolone 17α-propionate 1% cream, a new potent anti-androgen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study versus placebo and tretinoin (Retin-A® 0.05% cream).

Abstract

Background:  Acne vulgaris is a disorder of the pilo-sebaceous unit in which the androgens contribute to its onset and persistence. The use of anti-androgens is therefore potentially effective, however anti-androgens for topical use are not available in the market. Cortexolone 17α-propionate (CB-03-01) is a new potent topical anti-androgen potentially useful in acne vulgaris.


Objectives:  To evaluate the safety and the topical efficacy of cortexolone 17α-propionate 1% cream in acne vulgaris as compared to placebo and to tretinoin (Retin-A® 0.05% cream).


Patients/Methods:  Seventy-seven adult males with facial acne scored 2-3 according to Investigator’s ...

Cortexolone 17α-propionate 1% cream, a new potent anti-androgen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study versus placebo and tretinoin (Retin-A® 0.05% cream). is a post from: Skincare

Cortexolone 17α-propionate 1% cream, a new potent anti-androgen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study versus placebo and tretinoin (Retin-A® 0.05% cream). via BuzzBlazer.com

Randomized double-blinded placebo-controlled intra-individual trial on 1,25-(OH)2 vitamin D3 analogue in polymorphic light eruption

Summary

Background:  Polymorphic light eruption (PLE) is very frequent photodermatosis whose pathogenesis may involve resistance to UV-induced immune suppression. Similar to UV radiation, calcitriol (1,25-(OH) vitamin D3) and its analogues such as calcipotriol have been shown to exhibit immunosuppressive properties.


Methods:  We performed a randomized double-blinded placebo-controlled intra-individual half-body trial (NCT00871052) to investigate the preventive effect of a calcipotriol-containing cream in PLE. Thirteen PLE patients (10 women, 3 men; mean age, 37 years) pre-treated their skin on two symmetrically located test fields with calcipotriol or placebo cream twice daily for seven days ...

Randomized double-blinded placebo-controlled intra-individual trial on 1,25-(OH)2 vitamin D3 analogue in polymorphic light eruption is a post from: Skincare

Randomized double-blinded placebo-controlled intra-individual trial on 1,25-(OH)2 vitamin D3 analogue in polymorphic light eruption via BuzzBlazer.com

Hereditary tumour syndromes featuring basal cell carcinomas

Abstract

Basal cell carcinoma (BCC) is the most frequent cutaneous malignancy worldwide. This skin tumour is characterised by a broad phenotypic variability and distinct histopathological subtypes. It shows slow, locally invasive growth and only rarely metastasises. BCCs can occur either sporadically or in the context of genetic syndromes, including Gorlin syndrome, Bazex-Dupré-Christol syndrome (BDCS), Rombo syndrome, Oley syndrome, and Xeroderma pigmentosum (XP). To date, different genes and signalling routes have been shown to play an important role in the development and growth of these tumours, including the hedgehog and Wnt/beta-catenin pathway. ...

Hereditary tumour syndromes featuring basal cell carcinomas is a post from: Skincare

Hereditary tumour syndromes featuring basal cell carcinomas via BuzzBlazer.com

Evidence of iIncreased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

Evidence of iIncreased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia is a post from: Skincare

Evidence of iIncreased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia is a post from: Skincare

Evidence of iIncreased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia via BuzzBlazer.com

Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trial

Background: All-trans-retinoic acid (RA) and all-trans-retinol (ROL) are not widely used as anti-wrinkle agents due to their irritancy and photo-stability, respectively. Therefore, the safety and photo-stability in the development of RA or ROL derivatives have been an important issue.


Aim: To identify the efficacy of retinyl retinoate as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles.


Methods: The clinical study was a prospective, double-blind, randomized, and controlled study with a total of 11 Korean women. At every 4 weeks, the effectiveness was ...

Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trial is a post from: Skincare

Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trial via BuzzBlazer.com

Comparison of topical 3% diclofenac sodium gel and 5% imiquimod cream for the treatment of actinic keratoses

Summary

Background.  There is a wide spectrum of treatments available for actinic keratosis (AK). Topical diclofenac sodium and imiquimod are two topical treatments, which are noninvasive, easily applied, well-tolerated and effective.


Aim.  To compare the effects of topical 3% diclofenac sodium plus hyaluranon (DFS) gel, 5% imiquimod (IMQ) cream, and base cream (BC) in patients with AK.


Methods.  In total, 61 patients, diagnosed clinically and histopathologically as having AK, were randomized into three treatment groups to receive topical treatment with either DFS (twice daily for 12 weeks), IMQ (twice per week for 16 weeks) or ...

Comparison of topical 3% diclofenac sodium gel and 5% imiquimod cream for the treatment of actinic keratoses is a post from: Skincare

Comparison of topical 3% diclofenac sodium gel and 5% imiquimod cream for the treatment of actinic keratoses via BuzzBlazer.com

Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms

Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms is a post from: Skincare

Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms is a post from: Skincare

Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms via BuzzBlazer.com

Viral oncogenesis and its role in nonmelanoma skin cancer

Summary

In recent years, the contribution of viruses to cutaneous oncogenesis has steadily gained recognition. The archetype is human herpesvirus 8, which is well established as the causative agent in Kaposi sarcoma. Other viruses believed to play a role in nonmelanoma skin cancer include human papillomavirus and the recently described Merkel cell polyomavirus. We review the mechanisms by which these three viruses interact with the host cell, ultraviolet radiation and immunosuppression to result in carcinogenesis.

Viral oncogenesis and its role in nonmelanoma skin cancer is a post from: Skincare

Viral oncogenesis and its role in nonmelanoma skin cancer is a post from: Skincare

Viral oncogenesis and its role in nonmelanoma skin cancer via BuzzBlazer.com

Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan

Summary

Background.  Autosomal recessive hypotrichosis/woolly hair is a rare genetic hair loss disorder characterized by sparse scalp hair/woolly hair, sparse to absent eyebrows and eyelashes, sparse axillary and body hair in affected individuals. This form of hair loss results from mutations in either LPAR6 or LIPH gene.


Aim.  To identify mutations in LPAR6 and LIPH genes in 17 consanguineous Pakistani families showing features of hypotrichosis/woolly hair.


Methods.  Genotyping in 17 families was carried out using polymorphic microsatellite markers linked to genes causing autosomal recessive hypotrichosis/woolly hair phenotype. To screen for mutations in LPAR6 ...

Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan is a post from: Skincare

Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan via BuzzBlazer.com

tert-Butyl hydroperoxide, an organic peroxide, causes temporary delay in hair growth in a neonatal rat model

Summary

tert-Butyl hydroperoxide (tBHP), an organic peroxide, has been shown to cause irreversible damage to keratinocytes in vitro with prolonged administration at high concentrations, and reversible damage with short-term administration at low concentrations. To investigate the effects of tBHP on keratinocytes in vivo, we analysed hair growth in tBHP-treated neonatal rats. Sprague–Dawley and Long–Evans rat pups were injected subcutaneously with tBHP or vehicle once daily for 6 days, and hair growth was monitored. The tBHP-treated rats had a significant delay in hair growth. However, this delay reversed within days, and the hair ...

tert-Butyl hydroperoxide, an organic peroxide, causes temporary delay in hair growth in a neonatal rat model is a post from: Skincare

tert-Butyl hydroperoxide, an organic peroxide, causes temporary delay in hair growth in a neonatal rat model via BuzzBlazer.com

Ability to self-detect malignant melanoma decreases with age

Summary

The prognosis of malignant melanoma depends on the thickness of the tumour. In this study, we analysed the trends in Breslow thickness in 63 patients referred to our institution, a tertiary dermatology referral centre. The mean thickness of melanoma was 0.31 mm, which was lower than the national average of 1.10 mm. There was a significant trend towards increased melanoma thickness with increasing age, with a rate of 0.24 mm (95% CI 0.12–0.37) for each additional 10 years of age above the age of 20 years. This trend was only apparent in cases of self-diagnosed ...

Ability to self-detect malignant melanoma decreases with age is a post from: Skincare

Ability to self-detect malignant melanoma decreases with age via BuzzBlazer.com

Sunnier European countries have lower melanoma mortality

Summary

Doubt has been cast on sunlight as the major causative factor for malignant melanoma. We performed statistical analysis of the average annual sunlight hours in 36 European capital cities compared with the country’s melanoma mortality rate. A significant inverse proportionality was identified in both men and women, indicating that sun exposure is unlikely to be the strongest factor affecting mortality from malignant melanoma.

Sunnier European countries have lower melanoma mortality is a post from: Skincare

Sunnier European countries have lower melanoma mortality is a post from: Skincare

Sunnier European countries have lower melanoma mortality via BuzzBlazer.com

Lichen nitidus and lichen spinulosus or spinous follicular lichen nitidus? A second case

Lichen nitidus and lichen spinulosus or spinous follicular lichen nitidus? A second case is a post from: Skincare

Lichen nitidus and lichen spinulosus or spinous follicular lichen nitidus? A second case is a post from: Skincare

Lichen nitidus and lichen spinulosus or spinous follicular lichen nitidus? A second case via BuzzBlazer.com

Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group

Abstract

Background  Actinic keratoses (AK) are carcinomata in situ with the potential to develop into invasive carcinoma. Several studies have demonstrated that 3% diclofenac in 2.5% hyaluronic acid gel (HA) is effective and well tolerated in the treatment of AK. To date there are no large randomized multicentre trials with treatment durations longer than 90 days and histopathological control of treatment outcome.


Objective  The aim of this study was to investigate whether a prolonged treatment with diclofenac in HA of 6 vs. 3 months adds to the efficacy in treatment for AK and if ...

Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group is a post from: Skincare

Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group via BuzzBlazer.com

Confocal Microscopy of Recurrent Naevi and Recurrent Melanomas: a Retrospective MORPHOLOGIC Study

Abstract

Background:  re-pigmentation within a scar after different procedures (shaving, partial excision, cryotherapy, laser) is a challenging diagnostic situation.


Objectives:  to determine distinct dermoscopic and confocal microscopic features in a series of histopathologically-proved melanocytic proliferations within a scar.


Methods:  clinical, dermoscopic and confocal microscopic images have been acquired before surgical excision in seven cases of re-pigmentation within a scar. The evaluation of the dermoscopic and confocal features was performed in blind to the final histopathologic diagnosis that was obtained in all cases.


Results:  Dermoscopically, the re-pigmentation in recurrent nevi (3 cases) were confined within ...

Confocal Microscopy of Recurrent Naevi and Recurrent Melanomas: a Retrospective MORPHOLOGIC Study is a post from: Skincare

Confocal Microscopy of Recurrent Naevi and Recurrent Melanomas: a Retrospective MORPHOLOGIC Study via BuzzBlazer.com

Multivariate analysis of factors associated with early onset segmental and non-segmental Vitiligo: a prospective observational study of 213 patients

Abstract

Background:  Although mixed forms have been recently described, segmental (SV) and nonsegmental vitiligo (NSV) are considered as clinically distinct. However, limited epidemiological data is available to help distinguishing associated factors, and recent genomewide association studies have been restricted to NSV. The higher prevalence of SV in children is convenient to compare the two major presentations of the disease.


Objective:  To compare factors associated with segmental and non-segmental vitiligo, especially for markers of autoimmunity or autoinflammation..


Patients and methods:  We conducted a single-center prospective observational study in patients aged 17 and less with ...

Multivariate analysis of factors associated with early onset segmental and non-segmental Vitiligo: a prospective observational study of 213 patients is a post from: Skincare

Multivariate analysis of factors associated with early onset segmental and non-segmental Vitiligo: a prospective observational study of 213 patients via BuzzBlazer.com

Scoring of hand eczema: Good agreement between patients and dermatological staff

Abstract

Introduction:  Assessment of hand eczema in a clinical study has been achieved using a scoring system which documents extent of eczema on different areas of the hand.


Objective:  To investigate whether the same scoring system could be used by patients to communicate actual status of hand eczema.


Method:  In a study of 62 patients (36 females 26 males, age 18-75), the patient’s own assessment was compared to the assessment by a dermatologist and a dermatological nurse. Standardized information was given to the patient and the form was filled in independently by the ...

Scoring of hand eczema: Good agreement between patients and dermatological staff is a post from: Skincare

Scoring of hand eczema: Good agreement between patients and dermatological staff via BuzzBlazer.com

The effect of ageing on phenotype and function of monocyte derived Langerhans’ cells

Summary

Background  With increasing age the immune system shows functional decline. In the skin this is associated with an increased incidence of epidermal malignancies and infections. Epidermal Langerhans’ cells (LC) act as sentinels of the immune system recognising, processing and presenting antigen and inducing T cell responses. Previous investigations have demonstrated a reduction in the number of epidermal LC in elderly subjects. Moreover, the ability of LC to migrate in response to tumour necrosis factor (TNF)-α, but not interleukin (IL)-1β, is significantly impaired in the elderly.


Objectives  To characterise further the changes ...

The effect of ageing on phenotype and function of monocyte derived Langerhans’ cells is a post from: Skincare

The effect of ageing on phenotype and function of monocyte derived Langerhans’ cells via BuzzBlazer.com

Comparative analysis of immunohistochemistry, PCR, and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis

Abstract

Background:  The incidence of syphilis is increasing in many parts of the world including a re-emerge in Western Europe and North America. Depending on the disease stage direct detection of T. pallidum in mucocutaneous lesions of syphilis may be difficult and histopathological findings are not always straightforward. Thus, the correct histological diagnosis may be challenging.


Objectives:  To comparatively evaluate the evidence for infection with T. pallidum by immunohistochemistry (IHC), polymerase chain reaction (PCR) and focus-floating microscopy (FFM).


Methods:  A series of 86 paraffin-embedded skin biopsy samples from patients with primary, secondary or ...

Comparative analysis of immunohistochemistry, PCR, and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis is a post from: Skincare

Comparative analysis of immunohistochemistry, PCR, and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis via BuzzBlazer.com

Varicella zoster virus immunity in dermatological patients on systemic immunosuppressant treatment

Abstract

Background:  Primary varicella infection is caused by varicella zoster virus (VZV), a herpesviridiae. It is a common childhood infection, which is usually benign but can occasionally cause morbidity and mortality. In immunosuppressed adults, atypical presentation and disseminated disease can occur with significant morbidity and mortality. A VZV vaccine is available.


Objectives:  This study was designed to measure the prevalence of immunity to VZV and to determine the predictive value of a self-reported history of varicella infection in a population of dermatological patients receiving systemic immunosuppressant therapy. We sought to assess the ...

Varicella zoster virus immunity in dermatological patients on systemic immunosuppressant treatment is a post from: Skincare

Varicella zoster virus immunity in dermatological patients on systemic immunosuppressant treatment via BuzzBlazer.com

Efficacy of icatibant treatment in patients with hereditary angioedema type I resistant to treatment with C1 inhibitor concentrate

Efficacy of icatibant treatment in patients with hereditary angioedema type I resistant to treatment with C1 inhibitor concentrate is a post from: Skincare

Efficacy of icatibant treatment in patients with hereditary angioedema type I resistant to treatment with C1 inhibitor concentrate is a post from: Skincare

Efficacy of icatibant treatment in patients with hereditary angioedema type I resistant to treatment with C1 inhibitor concentrate via BuzzBlazer.com

Vörner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation

Vörner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation is a post from: Skincare

Vörner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation is a post from: Skincare

Vörner type palmoplantar keratoderma: novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation via BuzzBlazer.com

Contagious Itch in Humans. A Study of Visual “Transmission” of Itch in Atopic Dermatitis and Healthy Subjects.

Abstract.

Anecdotal evidence suggests “contagious” itch occurs in daily life when we see other people itch and scratch. This phenomenon has not been systematically studied previously, and factors which can amplify itch perception were unknown. We investigated whether exposure to visual cues of itch can induce or intensify itch in healthy and atopic dermatitis subjects. Participants received histamine or a saline control delivered to the forearm and were asked to watch short video clips of people scratching. Spontaneous scratching induced by visual cues was monitored and analyzed. Atopic dermatitis patients reported ...

Contagious Itch in Humans. A Study of Visual “Transmission” of Itch in Atopic Dermatitis and Healthy Subjects. is a post from: Skincare

Contagious Itch in Humans. A Study of Visual “Transmission” of Itch in Atopic Dermatitis and Healthy Subjects. via BuzzBlazer.com