Associated comorbidities in psoriasis and inflammatory bowel disease

Abstract

Background  The association between psoriasis and inflammatory bowel disease (IBD) has been previously reported although a great deal remains unknown about associated comorbidities.


Objectives  The aim of this study was to examine comorbidities in individuals diagnosed with both psoriasis and IBD, and to compare those with individuals diagnosed with psoriasis-only. We also looked at differences within the IBD group by clearly defining that cohort.


Methods  We included 146 patients diagnosed with both psoriasis and IBD and 146 controls diagnosed of psoriasis-only without previous records of IBD, matched by gender, ethnicity and age ...

Associated comorbidities in psoriasis and inflammatory bowel disease is a post from: Skincare

Associated comorbidities in psoriasis and inflammatory bowel disease via BuzzBlazer.com

Sun behaviour patterns and perception of illness among melanoma patients

Abstract

Background  Melanoma is one of the most aggressive skin tumours for which the major risk factor is ultraviolet radiation. Sun protection is extremely important, especially for melanoma patients who, once diagnosed with melanoma, have 500 times greater chance of developing another melanoma than the general population.


Objective  In this study, we examined the perception of melanoma and attitudes towards sun protection among melanoma patients and compared their results with the patients suffering from other dermatological disorders.


Methods  In total, 240 participants were included in the study: 120 patients suffering from melanoma and ...

Sun behaviour patterns and perception of illness among melanoma patients is a post from: Skincare

Sun behaviour patterns and perception of illness among melanoma patients via BuzzBlazer.com

Airborne contact dermatitis to tetrazepam in geriatric nurses – a report of 10 cases

Abstract

Background  Tetrazepam, a benzodiazepine, is a frequently used muscle relaxant. The most common adverse reactions are neurological and gastrointestinal. Cutaneous reactions to tetrazepam are rare and occur predominantly after systemic administration.


Objective  To present 10 health care professionals who developed airborne contact dermatitis to tetrazepam due to occupational exposure to tetrazepam dusts.


Materials and methods  We report a series of 10 cases observed in our department between January 2006 and March 2011 where tetrazepam was identified to cause allergic airborne contact dermatitis. Affected individuals were employed as (geriatric) nursing staff, exposed to ...

Airborne contact dermatitis to tetrazepam in geriatric nurses – a report of 10 cases is a post from: Skincare

Airborne contact dermatitis to tetrazepam in geriatric nurses – a report of 10 cases via BuzzBlazer.com

The effectiveness of anticellulite treatment using tripolar radiofrequency monitored by classic and high-frequency ultrasound

Abstract

Background  Cellulite affects nearly 85% of the female population. Given the size of the phenomenon, we are continuously looking for effective ways to reduce cellulite. Reliable monitoring of anticellulite treatment remains a problem.


Objective  The main aim of the study was to evaluate the effectiveness of anticellulite treatment carried out using radiofrequency (RF), which was monitored by classical and high-frequency ultrasound.


Methods  Twenty-eight women underwent anticellulite treatment using RF, 17 women were in the placebo group. The therapy was monitored by classical and high-frequency ultrasound. The examinations evaluated the thickness of the ...

The effectiveness of anticellulite treatment using tripolar radiofrequency monitored by classic and high-frequency ultrasound is a post from: Skincare

The effectiveness of anticellulite treatment using tripolar radiofrequency monitored by classic and high-frequency ultrasound via BuzzBlazer.com

Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study

Abstract

Objective  We aimed to determine whether there was a difference between adult and paediatric alopecia areata patients with respect to the severity and pattern of the disease, nail changes and personal and family history of autoimmune diseases and also in comparison with controls.


Methods  Two groups were included: patients with onset of alopecia before the age of ≤18 years and >18 years. The total number of the patients were 124. The control group was comprised of 114 age- and gender-matched patients.


Results  There were 81 adults and 43 children. No statistically significant difference was ...

Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study is a post from: Skincare

Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study via BuzzBlazer.com

Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis

Abstract

Background  In analogy with melanoma-associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo.


Objective  The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo-like lesions develop directly linked to the halo phenomenon.


Methods  Forty-one patients with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions.


Results  We identified a subset of five halo naevi patients with additional subtle depigmentations. After ...

Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis is a post from: Skincare

Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis via BuzzBlazer.com

Corrective eyeglasses and medial canthal basal cell carcinoma: a case-control study

Abstract

Background  Corrective eyeglasses are frequently worn by adults, particularly at older ages. Their lenses and frames provide ultraviolet protection. Medial canthal basal cell carcinomas are infrequent (3–8%), and their relation with the use of corrective glasses was not yet investigated.


Objectives  To assess the prevalence of corrective eyeglasses use in individuals with medial canthal basal cell carcinoma.


Methods  Case-control study using two controls matched by age, gender, and ethnicity for each case. Cases were patients with medial canthal basal cell carcinoma, and controls were patients with basal cell carcinoma elsewhere on the ...

Corrective eyeglasses and medial canthal basal cell carcinoma: a case-control study is a post from: Skincare

Corrective eyeglasses and medial canthal basal cell carcinoma: a case-control study via BuzzBlazer.com

Erythroderma as a paraneoplastic cutaneous disorder in systemic anaplastic large cell lymphoma

Abstract

Background  Paraneoplastic cutaneous disorders (PCDs) or dermadromes are skin conditions that have an association with internal malignancies but are not themselves malignant. We report the first two cases of systemic anaplastic large cell lymphoma (s-ALCL) accompanied by erythroderma and multiple leg ulcers as PCDs.


Case 1.  A 52-year-old Japanese man presented with disseminated itchy papular erythemas which he had over his entire body for the preceding 5 years that later exacerbated to erythroderma. Multiple punched-out ulcers also developed on his lower legs. Superficial lymph nodes (LNs) were swollen, and a left axillary ...

Erythroderma as a paraneoplastic cutaneous disorder in systemic anaplastic large cell lymphoma is a post from: Skincare

Erythroderma as a paraneoplastic cutaneous disorder in systemic anaplastic large cell lymphoma via BuzzBlazer.com

Midfacial analysis and planning for midface augmentation with injectable filling materials: an anatomical approach

Abstract

Background  Midfacial augmentation improves the appearance of patients with flat or ptotic cheek.


Objectives  To develop a simple method of preoperative delineating the location of the ideal malar prominence and determining the best area to augment with injectable filling materials.


Methods  We used detailed analysis of the facial features of some Caucasian men and women as the basis for this study.


Results  We described a technique to locate the ideal malar prominence and proposed a classification of midfacial contour defects.


Conclusion  This method greatly simplifies the surgeon’s task of determining the area to be ...

Midfacial analysis and planning for midface augmentation with injectable filling materials: an anatomical approach is a post from: Skincare

Midfacial analysis and planning for midface augmentation with injectable filling materials: an anatomical approach via BuzzBlazer.com

Basal cell carcinoma of the head region: therapeutical results of 350 lesions treated with Mohs micrographic surgery

Abstract

Background  Basal cell carcinoma (BCC) is a non-melanocytic skin tumour with a high risk of recurrence after incomplete treatment, especially the aggressive subtypes (basosquamous, micronodular and morphea BCC). The percentage of recurrence also depends on the anatomical site of the tumour. Nose–cheek fold, paranasal fold, retroauricular fold and internal canthus are considered to be critical sites.


Objective  The aim of this study was to report on recurrence rates for BCC treated with Mohs micrographic surgery (MMS).


Material and Methods  We retrospectively studied 350 BCCs of the head region treated with MMS. Results ...

Basal cell carcinoma of the head region: therapeutical results of 350 lesions treated with Mohs micrographic surgery is a post from: Skincare

Basal cell carcinoma of the head region: therapeutical results of 350 lesions treated with Mohs micrographic surgery via BuzzBlazer.com

Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment Improves Amiodarone-Induced Hyperpigmentation

The authors have indicated no significant interest with commercial supporters.

Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment Improves Amiodarone-Induced Hyperpigmentation is a post from: Skincare

Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment Improves Amiodarone-Induced Hyperpigmentation is a post from: Skincare

Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment Improves Amiodarone-Induced Hyperpigmentation via BuzzBlazer.com

Successful Treatment of Recurrent Digital Mucoid Cysts Using a 1,444-nm Neodymium-Doped Yttrium Aluminum Garnet Laser

The authors have indicated no significant interest with commercial supporters.

Successful Treatment of Recurrent Digital Mucoid Cysts Using a 1,444-nm Neodymium-Doped Yttrium Aluminum Garnet Laser is a post from: Skincare

Successful Treatment of Recurrent Digital Mucoid Cysts Using a 1,444-nm Neodymium-Doped Yttrium Aluminum Garnet Laser is a post from: Skincare

Successful Treatment of Recurrent Digital Mucoid Cysts Using a 1,444-nm Neodymium-Doped Yttrium Aluminum Garnet Laser via BuzzBlazer.com

A Novel Injection Technique for Horizontal Neck Lines Correction Using Calcium Hydroxylapatite

A Novel Injection Technique for Horizontal Neck Lines Correction Using Calcium Hydroxylapatite is a post from: Skincare

A Novel Injection Technique for Horizontal Neck Lines Correction Using Calcium Hydroxylapatite is a post from: Skincare

A Novel Injection Technique for Horizontal Neck Lines Correction Using Calcium Hydroxylapatite via BuzzBlazer.com

Effects of a new mild shampoo for preventing hair loss in Asian by a simple hand-held phototrichogram technique

Synopsis

This study was conducted to evaluate the effects of a commercially available shampoo in Korean subjects with alopecia using a simple hand-held phototrichogram technique. Forty-four subjects with alopecia were enrolled and forty subjects continued for 16 weeks. In the test group, total hair counts increased significantly at weeks 8 and 16, and the number of shedding hair significantly decreased at week 16. Terminal hair counts significantly increased at week 8. In the control group, hair thickness and the number of vellus hairs significantly decreased at week 16. The number of total ...

Effects of a new mild shampoo for preventing hair loss in Asian by a simple hand-held phototrichogram technique is a post from: Skincare

Effects of a new mild shampoo for preventing hair loss in Asian by a simple hand-held phototrichogram technique via BuzzBlazer.com

Surface distribution and depths profiling of particulate organic UV absorbers by Raman imaging and tape stripping

Synopsis

Tape stripping in conjunction with scanning Raman microscopy was used for assessing the lateral and vertical distribution of an organic particulate UV filter, methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT), in a sunscreen formulation. On the volar forearms of three volunteers, 1 mg cm−2 formulation containing 10% MBBT was applied, and the average amount of MBBT was measured by Raman scanning microscopy in 15 consecutive tape strippings. The recovery of MBBT was 91.1% with 30.2% localizing on the skin surface (first strip), 42.5% in the upper stratum corneum (strips 2–5) and from 3.6 down to ...

Surface distribution and depths profiling of particulate organic UV absorbers by Raman imaging and tape stripping is a post from: Skincare

Surface distribution and depths profiling of particulate organic UV absorbers by Raman imaging and tape stripping via BuzzBlazer.com

Preliminary evaluation of the genotoxic potential of a hydrophilic polymer with three preservation systems

Synopsis

This study compared the genotoxic potential of a polymeric associative thickener used in topically applied emulsions preserved with three different preservative systems. The method used for the assessment of genotoxicity is the in vitro micronucleus test [Organization for Economic Cooperation and Development (OECD) guideline number 487]. When changing an additive such as a preservation system in a raw material, it is crucial to re-evaluate its toxicity potential because this change may significantly alter its properties. This study shows that at the levels tested neither of the systems evaluated demonstrated any ...

Preliminary evaluation of the genotoxic potential of a hydrophilic polymer with three preservation systems is a post from: Skincare

Preliminary evaluation of the genotoxic potential of a hydrophilic polymer with three preservation systems via BuzzBlazer.com

Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function

Synopsis

The objectives of this study were to identify a plant extract that would improve stratum corneum functions and to elucidate the mechanism(s) involved. Based on the information that stratum corneum functions depend on the level of ceramide in the stratum corneum, we identified a Eucalyptus extract that was able to increase the level of ceramide in human keratinocytes in culture and in human stratum corneum and that improves the stratum corneum water holding and barrier functions. Addition of the Eucalyptus extract to human keratinocytes in culture increased the level of ...

Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function is a post from: Skincare

Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function via BuzzBlazer.com

Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin

Synopsis

Acute eczematous atopic dermatitis (AD) is associated with increases in stratum corneum (SC) serine protease activity. The purpose of this study was to examine whether the increased SC protease activities in acute eczematous atopic dermatitis were associated with increased mass levels of SC proteases. Six subjects with healthy skin and six patients with AD each with non-lesional skin or lesional acute eczematous skin had the mass levels of their extractable SC kallikreins (KLK), plasmin and urokinase quantified using Luminex multiplex bead-based assays from SC tape strippings. The mass levels of ...

Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin is a post from: Skincare

Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin via BuzzBlazer.com

The structural implications of water hardness metal uptake by human hair

Synopsis

Human hair can extract significant levels of calcium and magnesium, water hardness metals, from tap water immediately following chemical treatments and during hygiene practices. We have previously shown that this uptake is primarily a function of the condition of the hair. Depending on the extent of chemical damage, the hair can extract notable amounts of water hardness metals even from soft water. As water hardness metals concentrate primarily in the cuticle layers of the hair fibre, it is hypothesized that their presence will affect the structural properties that are chiefly ...

The structural implications of water hardness metal uptake by human hair is a post from: Skincare

The structural implications of water hardness metal uptake by human hair via BuzzBlazer.com

Treatment of alopecia areata: “What is new on the horizon?”

ABSTRACT

New drug treatment opportunities based on the results of a genome-wide association study, which implicate T cell and natural killer (NK)-cell activation pathways, are leading to new approaches in future clinical trials of alopecia areata. Special attention is being given to the UL 16-binding protein (ULBP3) gene cluster on chromosome 6q25, as these genes make the NKG2D-activating ligand or signal that can trigger the NKG2D receptor, initiating an autoimmune response. A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active ...

Treatment of alopecia areata: “What is new on the horizon?” is a post from: Skincare

Treatment of alopecia areata: “What is new on the horizon?” via BuzzBlazer.com

Topical and intralesional therapies for alopecia areata

ABSTRACT

Alopecia areata is a common form of nonscarring alopecia. It affects males and females equally and has no racial predilection. It usually affects the scalp, but any hair-bearing area can be involved. It presents as patchy hair loss, loss of hair on the entire scalp (alopecia totalis), or the whole body (alopecia universalis). The histopathology varies according to the disease stage, but usually a perifollicular lymphocytic infiltrate is seen. The course of the disease and response to treatment are unpredictable. Various therapeutic modalities are used including topical, intralesional, and systemic ...

Topical and intralesional therapies for alopecia areata is a post from: Skincare

Topical and intralesional therapies for alopecia areata via BuzzBlazer.com

Alopecia areata: Clinical presentation, diagnosis, and unusual cases

ABSTRACT

Alopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable. However, early, long-lasting, and severe cases have a less ...

Alopecia areata: Clinical presentation, diagnosis, and unusual cases is a post from: Skincare

Alopecia areata: Clinical presentation, diagnosis, and unusual cases via BuzzBlazer.com

Etiopathogenesis of alopecia areata: Why do our patients get it?

ABSTRACT

Alopecia areata (AA) is a nonscarring, inflammatory skin disease that results in patchy hair loss. AA is unpredictable in its onset, severity, and duration making it potentially very stressful for affected individuals. Currently, the treatment options for AA are limited and the efficacy of these treatments varies from patient to patient. The exact etiology of AA is unknown. This article provides some insights into the etiopathogenesis of AA and why some people develop it. The current knowledge on the pathogenesis of AA is summarized and some of the recent hypotheses ...

Etiopathogenesis of alopecia areata: Why do our patients get it? is a post from: Skincare

Etiopathogenesis of alopecia areata: Why do our patients get it? via BuzzBlazer.com

The genetics of alopecia areata: What’s new and how will it help our patients?

ABSTRACT

In the United States, alopecia areata (AA) is the most prevalent autoimmune disease, affecting approximately 5.3 million people, including males and females of all ages and across all ethnic groups. AA affects more individuals than most other autoimmune diseases combined, and yet despite its prevalence, there is little information on the underlying pathogenesis and there are currently no evidence-based treatments available to treat or cure this disease. Genetics has provided a valuable tool for gaining insight into disease pathology. We recently completed the first genome-wide association study (GWAS) in AA ...

The genetics of alopecia areata: What’s new and how will it help our patients? is a post from: Skincare

The genetics of alopecia areata: What’s new and how will it help our patients? via BuzzBlazer.com

Systemic treatment for alopecia areata

ABSTRACT

Of the world population, 1.7% is suffering from alopecia areata at some point in their lives. The exact etiology of this disease is still unknown, and the course of the disease is unpredictable. Effective treatments, especially for severe multifocal alopecia areata, alopecia areata totalis, and alopecia areata universalis, are lacking. The present article will discuss side effects and relapse rates of different systemic agents for treatment of severe and rapid progressive alopecia areata.

Systemic treatment for alopecia areata is a post from: Skincare

Systemic treatment for alopecia areata is a post from: Skincare

Systemic treatment for alopecia areata via BuzzBlazer.com

Investigative guidelines for alopecia areata

ABSTRACT

The reported efficacy of various treatments for alopecia is difficult to compare based on a general lack of consideration in case reports/series and clinical trials of the spontaneous regrowth or baseline prognostic factors seen in alopecia areata and a general lack of quantification of hair growth. This report will give both the investigator and clinician guidelines for clinical trial design that will take into account variables known to effect efficacy results such as baseline severity, pattern, and duration of hair loss, age of the subject, and concomitant conditions that may ...

Investigative guidelines for alopecia areata is a post from: Skincare

Investigative guidelines for alopecia areata via BuzzBlazer.com

Camouflage technique for alopecia areata: What is a patient to do?

ABSTRACT

Alopecia areata is a devastating condition for any patient as hair is a prized component of human beauty. Poems and folktales have been written about long, luxuriant, female, golden, and chestnut hair, and even the Bible discusses the diminishment of male power when hair is lost. The question arises as to whether anyone can be beautiful without hair. The answer is a definite yes. No one can dispute the virility of a shaved male head, indicating the absence of hair can make a strikingly beautiful fashion statement. This is sadly ...

Camouflage technique for alopecia areata: What is a patient to do? is a post from: Skincare

Camouflage technique for alopecia areata: What is a patient to do? via BuzzBlazer.com

Alopecia areata: Support groups and meetings – how can it help your patient?

ABSTRACT

Many people with alopecia areata find the fellowship of the support groups provides them with the help they need to cope. They find that they are not alone, how others have coped, what doctors and treatments have been tried, and what the results have been. The National Alopecia Areata Foundation offers support groups throughout the world to refer patients.

Alopecia areata: Support groups and meetings – how can it help your patient? is a post from: Skincare

Alopecia areata: Support groups and meetings – how can it help your patient? is a post from: Skincare

Alopecia areata: Support groups and meetings – how can it help your patient? via BuzzBlazer.com

Dermatologic therapy: Alopecia areata update

Dermatologic therapy: Alopecia areata update is a post from: Skincare

Dermatologic therapy: Alopecia areata update is a post from: Skincare

Dermatologic therapy: Alopecia areata update via BuzzBlazer.com

Sensory irritation caused by two organic solvents–short-time single application and repeated occlusive test in stingers and non-stingers

Background. Neurosensory irritation is a subjective phenomenon induced by a number of chemicals.


Objectives. To investigate the sensory irritation induced by two organic solvents – n-octane and cumene – between two groups of volunteers, stingers and non-stingers, identified as such according to the results of a lactic acid stinging test (LAST).


Methods. The immediate effects of the solvents were directly compared in a single simultaneous application test. The reaction intensities over time were studied in a repetitive irritation test over 4 days. The volunteers graded the reaction intensities by the use of ...

Sensory irritation caused by two organic solvents–short-time single application and repeated occlusive test in stingers and non-stingers is a post from: Skincare

Sensory irritation caused by two organic solvents–short-time single application and repeated occlusive test in stingers and non-stingers via BuzzBlazer.com

The Burden of Childhood Psoriasis

Abstract:  A pilot study of the effect on quality of life of childhood psoriasis is presented. Of the children interviewed, 65% experienced stigmatization to a certain extent, 71% reported itching, and 43% complained about fatigue. Clinicians should pay attention to these items to initiate patient-tailored treatment.

The Burden of Childhood Psoriasis is a post from: Skincare

The Burden of Childhood Psoriasis is a post from: Skincare

The Burden of Childhood Psoriasis via BuzzBlazer.com

A Congenital Case of Circumscribed Acral Hypokeratosis

Abstract:  Circumscribed acral hypokeratosis is a disorder characterized by areas of erythematous depressed skin with distinct histopathological findings typically found on the palmar and plantar surfaces. Most patients are middle-aged women who report a multiyear history. We present an 10-year-old African American boy who had an asymptomatic, irregularly shaped erythematous lesion on his left medial foot that had been present since birth. A biopsy showed an abrupt, well-demarcated decrease in the thickness of the stratum corneum layer, with no parakeratosis, that was consistent with a diagnosis of circumscribed hypokeratosis. This ...

A Congenital Case of Circumscribed Acral Hypokeratosis is a post from: Skincare

A Congenital Case of Circumscribed Acral Hypokeratosis via BuzzBlazer.com

Efficacy of Oral Prednisolone Use in the Treatment of Infantile Hemangiomas in Indian Children

Abstract:  Approximately 10% to 15% of patients with infantile hemangioma (IH) require treatment that needs to be individualized according to the size, location, and type of IH. Oral corticosteroids [CS] have been the mainstay of therapy, but dose and duration of therapy have been variably reported in literature. The possible side effects with high dose CS is a constant deterrant. Twenty infants with IH requiring therapy were treated with prednisolone at a dose of 3 to 4 mg/kg/day. Response to therapy, adverse effects, and risk of rebound growth were monitored. All ...

Efficacy of Oral Prednisolone Use in the Treatment of Infantile Hemangiomas in Indian Children is a post from: Skincare

Efficacy of Oral Prednisolone Use in the Treatment of Infantile Hemangiomas in Indian Children via BuzzBlazer.com

Ectodermal Abnormalities in Patients with Kabuki Syndrome

Abstract:  Kabuki syndrome (KS) is extensively described in the literature and characterized by a typical facial gestalt in combination with postnatal short stature, hypotonia, joint laxity, developmental delay, persistent fetal fingertip pads, and an ever-growing group of congenital abnormalities. In this study, we focus on some ectodermal manifestations that we have observed. We studied seven patients who fulfilled the clinical criteria for KS and undertook a detailed clinical, dental, cytogenetic, and immunoglobulin assessments. In addition, microscopic hair examinations were performed on all patients and compared with matched control patients. All ...

Ectodermal Abnormalities in Patients with Kabuki Syndrome is a post from: Skincare

Ectodermal Abnormalities in Patients with Kabuki Syndrome via BuzzBlazer.com

Onychophagia-Induced Longitudinal Melanonychia

Abstract:  An otherwise-healthy 13-year-old girl with previously normal nails developed longitudinal pigmented bands on multiple fingernails. Physical examination revealed faintly pigmented bands on multiple fingernails and on the left fifth toenail. We believed that the cause of the pigmented bands was onychophagia-induced longitudinal melanonychia, a rare phenomenon, which emphasizes the need for dermatologists to question patients with melanonychia about their nail biting habits because they may not be forthcoming with this information.

Onychophagia-Induced Longitudinal Melanonychia is a post from: Skincare

Onychophagia-Induced Longitudinal Melanonychia is a post from: Skincare

Onychophagia-Induced Longitudinal Melanonychia via BuzzBlazer.com

Childhood Erythema Nodosum Associated with Kerion Celsi: A Case Report and Review of Literature

Abstract:  Erythema nodosum (EN) in association with kerion celsi is a rare condition in children, with only 11 cases having been reported in the English literature. We describe a new case in a 7-year-old boy in whom the disorder had begun 2 months before. He had many inflamed, boggy, suppurative nodules over the left occipitoparietal area of the scalp and, 2 weeks later, developed multiple painful, erythematous subcutaneous nodules of the shins, thighs, and upper limbs. EN was confirmed by histologic examination. Our review of the literature of all cases of EN ...

Childhood Erythema Nodosum Associated with Kerion Celsi: A Case Report and Review of Literature is a post from: Skincare

Childhood Erythema Nodosum Associated with Kerion Celsi: A Case Report and Review of Literature via BuzzBlazer.com

Accessory Scrotum Attached to a Peduncular Perineal Lipoma

Abstract:  In this study, we report on the case of a newborn boy diagnosed after birth with an accessory scrotum attached to a peduncular type of perineal lipoma without any other associated congenital anomalies. The neonate underwent a simple surgical excision of the lipoma and accessory scrotum in the first month of life, and his postoperative course was uneventful. Histologic examination revealed normal scrotal skin and adipose tissue. Accessory scrotum has a high incidence of association with perineal lipoma (83% of reported cases) and other urogenital and anorectal anomalies, but ...

Accessory Scrotum Attached to a Peduncular Perineal Lipoma is a post from: Skincare

Accessory Scrotum Attached to a Peduncular Perineal Lipoma via BuzzBlazer.com

A New SPINK5 Mutation in a Patient with Netherton Syndrome: A Case Report

Abstract:  We report on a case of Netherton syndrome showing a new SPINK5 mutation (c.957_960dupTGGT duplication in exon 11), associated with partial defect of biotinidase.

A New SPINK5 Mutation in a Patient with Netherton Syndrome: A Case Report is a post from: Skincare

A New SPINK5 Mutation in a Patient with Netherton Syndrome: A Case Report is a post from: Skincare

A New SPINK5 Mutation in a Patient with Netherton Syndrome: A Case Report via BuzzBlazer.com

Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products

Background. The risk of sensitization cannot be derived from the frequency of sensitization to allergens alone, but exposure should be considered.


Objective. To estimate the risk of sensitization to selected preservatives.


Methods. The occurrence of preservatives in 3541 leave-on products based on the labelling of the ingredients was documented. Frequency of sensitization to preservatives was analysed on the basis of Information Network of Departments of Dermatology data for 2006–2009. As an estimate of sensitization risk, the sensitization exposure quotient (SEQ) was calculated as the quotient of the relative frequency of sensitization and ...

Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products is a post from: Skincare

Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products via BuzzBlazer.com

A functional promoter polymorphism of the human IL-18 gene is associated with aspirin-induced urticaria

Abstract

Background:  Urticaria is the commonest cutaneous reaction caused by aspirin or other NSAIDs. The pathogenesis of aspirin-induced urticaria (AIU) is not fully understood, but appears to involve mast cell activation and neutrophil infiltration.


Objectives:  To investigate the genetic contribution of interleukin-18 (IL-18), which can amplify acute inflammation by promoting mast cell activation, neutrophil migration, and cytokine production, to the pathogenesis of AIU.


Methods:  A case–control association study was performed using 247 patients with AIU and 196 normal healthy controls in a Korean population. Two promoter polymorphisms of the IL-18 gene (–607A/C and ...

A functional promoter polymorphism of the human IL-18 gene is associated with aspirin-induced urticaria is a post from: Skincare

A functional promoter polymorphism of the human IL-18 gene is associated with aspirin-induced urticaria via BuzzBlazer.com

Cross-reactivity among some metals in a murine metal-allergy model

Summary

Background:  Information concerning cross-reactivity among metal-allergens is scarce. We previously devised a murine metal-allergy model using lipopolysaccharide (LPS) as an adjuvant. LPS reduces the minimum allergy-inducing concentration (MAIC) of metals at both the sensitization and elicitation steps.


Objectives:  Here, we examined allergic cross-reactivity among some metals in this murine model, and compared the effects of ultra-pure (99.99% or more) and low-purity (93-99%) metal salts.


Methods:  A mixture of a metal salt and E. coli LPS was injected intraperitoneally into BALB/c mice (0.25 mL/mouse). Ten days later, metal salts (with or without LPS) ...

Cross-reactivity among some metals in a murine metal-allergy model is a post from: Skincare

Cross-reactivity among some metals in a murine metal-allergy model via BuzzBlazer.com

Patient-reported outcomes in psoriasis research and practice

Patient-reported outcomes in psoriasis research and practice is a post from: Skincare

Patient-reported outcomes in psoriasis research and practice is a post from: Skincare

Patient-reported outcomes in psoriasis research and practice via BuzzBlazer.com

Costs and cost-effectiveness analysis of treatment in children with eczema by nurse practitioner versus dermatologist: results of a randomized controlled trial and a review of international costs

Abstract

Background:  In a randomized controlled trial (RCT) on childhood eczema we reported that substituting dermatologists with nurse practitioners (NPs) resulted in similar outcomes of eczema severity and in the quality of life and higher patient satisfaction.


Objectives:  To determine costs and cost-effectiveness of care provided by NPs versus dermatologists and to compare our results with those in studies from other countries.


Patients/Methods:  We estimated the health care costs, the family costs and the costs in other sectors alongside the RCT. All the costs were linked to the quality of life (Infants’ Dermatitis ...

Costs and cost-effectiveness analysis of treatment in children with eczema by nurse practitioner versus dermatologist: results of a randomized controlled trial and a review of international costs is a post from: Skincare

Costs and cost-effectiveness analysis of treatment in children with eczema by nurse practitioner versus dermatologist: results of a randomized controlled trial and a review of international costs via BuzzBlazer.com

A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex : A pilot study of 9 Japanese TSC patients with different disease severity

Abstract

Background:  Dysregulation of mTOR signaling by mutations in tuberin and/or hamartin leads to the formation of tuberous sclerosis complex (TSC). Trials to treat TSC using mTOR inhibitors, including rapamycin, have been performed. Although rapamycin improves many TSC lesions, significant side effects appear after systemic administration. Topical administration has been recommended.


Objectives:  The efficacy of rapamycin-tacrolimus ointment was examined for TSC-related angiofibroma.


Methods:  Left-right comparisons of the tacrolimus ointments with/without 0.2% rapamycin was conducted in symmetrical facial angiofibromas in 9 definitive TSC patients. After the 3-month treatment, a cumulative score for redness, flatness, ...

A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex : A pilot study of 9 Japanese TSC patients with different disease severity is a post from: Skincare

A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex : A pilot study of 9 Japanese TSC patients with different disease severity via BuzzBlazer.com

A comparative split-face study of photodynamic therapy with indocyanine green (ICG) and indole-3-acetic acid (IAA) for the treatment of acne vulgaris

Abstract

Background:  Recently, photodynamic therapy (PDT) using a variety of light sources and photosensitizers has been used for the treatment of acne vulgaris. PDT with aminolevulinic or methylaminolevulinic acid has also been used in clinical trials as a treatment for acne, but adverse effects such as pain, erythema, and pustular eruption are common. Indocyanine green (ICG) and indole-3-acetic acid (IAA), newer photosensitizers, are known to have minimal adverse effects.


Objectives:  This study was designed to compare the safety and efficacy of PDT using ICG and IAA in the treatment of mild to ...

A comparative split-face study of photodynamic therapy with indocyanine green (ICG) and indole-3-acetic acid (IAA) for the treatment of acne vulgaris is a post from: Skincare

A comparative split-face study of photodynamic therapy with indocyanine green (ICG) and indole-3-acetic acid (IAA) for the treatment of acne vulgaris via BuzzBlazer.com

Effective and evidence-based management strategies for rosacea: summary of a Cochrane systematic review

Structured abstract/Summary

Background:  Rosacea is a common chronic skin disease affecting the face. There are numerous treatment options, but it is unclear which are the most effective.


Objective:  To assess the evidence for the efficacy and safety of treatments for rosacea.


Methods:  Searches included the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE, EMBASE, Science Citation Index, and Ongoing Trials Registers (updated February 2011). Randomized controlled trials in people with moderate to severe rosacea were included.


Results:  Fifty-eight trials, including 27 from the original review, ...

Effective and evidence-based management strategies for rosacea: summary of a Cochrane systematic review is a post from: Skincare

Effective and evidence-based management strategies for rosacea: summary of a Cochrane systematic review via BuzzBlazer.com

IF serration pattern analysis as a diagnostic criterion in anti-laminin-332 mucous membrane pemphigoid – immunopathological findings and clinical experience in 10 Dutch patients

Abstract

Background:  Anti-laminin-332 mucous membrane pemphigoid (anti-LN-332 MMP) is a chronic subepidermal blistering disease characterized by IgG anti-epidermal basement membrane zone (BMZ) autoantibodies against laminin-332 (LN-332). Patients with anti-LN-332 MMP have an increased relative risk of malignancy. For diagnosis of anti-LN-332 MMP difficult to obtain laboratory techniques are needed.


Objectives:  To incorporate direct immunofluorescence (DIF) serration pattern analysis of IgG depositions in the diagnostic criteria of anti-LN-332 MMP.


Patients/Methods:  Patients that met our revised inclusion criteria for anti-LN-332 MMP were selected from our biobank over the period 1997-2009. Inclusion criteria were clinical symptoms, ...

IF serration pattern analysis as a diagnostic criterion in anti-laminin-332 mucous membrane pemphigoid – immunopathological findings and clinical experience in 10 Dutch patients is a post from: Skincare

IF serration pattern analysis as a diagnostic criterion in anti-laminin-332 mucous membrane pemphigoid – immunopathological findings and clinical experience in 10 Dutch patients via BuzzBlazer.com

Novel filaggrin mutation but no other loss-of-function variants found in ethiopian atopic-dermatitis patients

Abstract

Background:  Filaggrin is a key protein involved in maintaining skin barrier function and hydration. Mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) and are a major predisposing factor for atopic dermatitis (AD) in individuals of European and Asian descent. It has been proposed that FLG mutations are population-specific and a difference in the spectra of mutations between different ancestral groups has been described. However, it is unknown whether FLG mutations in the African population are a causative genetic factor for IV and predispose to AD, or whether other ...

Novel filaggrin mutation but no other loss-of-function variants found in ethiopian atopic-dermatitis patients is a post from: Skincare

Novel filaggrin mutation but no other loss-of-function variants found in ethiopian atopic-dermatitis patients via BuzzBlazer.com

Treatment of Facial Angiofibromas with Topical Application of Oral Rapamycin Solution (1 mg/mL) in Two Patients with Tuberous Sclerosis

Treatment of Facial Angiofibromas with Topical Application of Oral Rapamycin Solution (1 mg/mL) in Two Patients with Tuberous Sclerosis is a post from: Skincare

Treatment of Facial Angiofibromas with Topical Application of Oral Rapamycin Solution (1 mg/mL) in Two Patients with Tuberous Sclerosis is a post from: Skincare

Treatment of Facial Angiofibromas with Topical Application of Oral Rapamycin Solution (1 mg/mL) in Two Patients with Tuberous Sclerosis via BuzzBlazer.com

Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast?

Summary

There is a histopathological similarity between cutaneous apocrine carcinoma (CAC) and breast carcinoma. Cutaneous histiocytoid or signet-ring cell (SRC) carcinoma is a rare neoplasm, which usually occurs on the eyelid, and less commonly on the axilla. The precise histogenesis of this carcinoma remains controversial. We report the case of a man with a cutaneous histiocytoid SRC carcinoma of the axilla having histopathological and immunohistochemical features that were quite similar to histiocytoid lobular carcinoma (histiocytoid LC) of the breast, which is a subtype of classic invasive lobular carcinoma of the breast ...

Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast? is a post from: Skincare

Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast? via BuzzBlazer.com

Annular elastolytic giant cell granuloma associated with prostate carcinoma: demonstration of human metalloelastase-12 expression

Annular elastolytic giant cell granuloma associated with prostate carcinoma: demonstration of human metalloelastase-12 expression is a post from: Skincare

Annular elastolytic giant cell granuloma associated with prostate carcinoma: demonstration of human metalloelastase-12 expression is a post from: Skincare

Annular elastolytic giant cell granuloma associated with prostate carcinoma: demonstration of human metalloelastase-12 expression via BuzzBlazer.com

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis

Summary

Background.  Interleukin (IL)-18 is a pleiotropic cytokine. Synergistically with IL-12, IL-18 promotes immune responses of the T helper type, by enhancing synthesis of interferon-γ and inhibiting IgE production. IL-18 can also enhance production of IL-4 and IL-13 production, and stimulate synthesis of IgE. Moreover, in the presence of IL-3, IL-18 can directly stimulate basophils and mast cells to produce their mediators in an IgE-independent manner. These results indicate a role for IL-18 in the pathogenesis of atopic dermatitis (AD).


Aim.  To examine the association of serum IL-18 with IgE levels and ...

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis is a post from: Skincare

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis via BuzzBlazer.com

Cutaneous larva migrans induced by swallowing live pond loaches

Summary

Freshwater fish, specifically loaches, are potential hosts of Gnathostoma species. Consumption of uncooked freshwater loaches may result in cutaneous larva migrans. We report the case of a 70-year-old Taiwanese man who presented with a serpiginous skin rash on his abdomen. He had eaten live loaches intermittently (sometimes daily) for 5 months before his presentation. On histopathological examination, a transected parasite body and a headbulb were found in the mid-dermis. The parasite was confirmed as belonging to the genus Gnathostoma, most likely Gnathostoma doloresi. The patient recovered uneventfully without treatment, and had ...

Cutaneous larva migrans induced by swallowing live pond loaches is a post from: Skincare

Cutaneous larva migrans induced by swallowing live pond loaches via BuzzBlazer.com

Donepezil-induced linear IgA disease

Donepezil-induced linear IgA disease is a post from: Skincare

Donepezil-induced linear IgA disease is a post from: Skincare

Donepezil-induced linear IgA disease via BuzzBlazer.com

Specular light reflectance of flakes in seborrhoeic dermatitis of the scalp: a pilot study

Summary

Seborrhoeic dermatitis and dandruff are common scalp conditions. In this study, we set out to explore a new method for rating both the severity of the scalp condition and the efficacy of scalp-care compounds. Scalp flakiness was sampled for 40 volunteers using adhesive-coated clear discs, with image analysis used to quantify the specular light reflectance (SLR) of the flakes Two ultraviolet (UV)-emitting charge-coupled device cameras (Visioscan VC98 and Visiopor PP34) were used. SLR clearly highlighted the flakiness with high contrast against a black background, and the recorded appearance could be ...

Specular light reflectance of flakes in seborrhoeic dermatitis of the scalp: a pilot study is a post from: Skincare

Specular light reflectance of flakes in seborrhoeic dermatitis of the scalp: a pilot study via BuzzBlazer.com

Treatment of alopecia areata: “What is new on the horizon?”

ABSTRACT

New drug treatment opportunities based on the results of a genome-wide association study, which implicate T cell and natural killer (NK)-cell activation pathways, are leading to new approaches in future clinical trials of alopecia areata. Special attention is being given to the UL 16-binding protein (ULBP3) gene cluster on chromosome 6q25, as these genes make the NKG2D-activating ligand or signal that can trigger the NKG2D receptor, initiating an autoimmune response. A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active ...

Treatment of alopecia areata: “What is new on the horizon?” is a post from: Skincare

Treatment of alopecia areata: “What is new on the horizon?” via BuzzBlazer.com

Topical and intralesional therapies for alopecia areata

ABSTRACT

Alopecia areata is a common form of nonscarring alopecia. It affects males and females equally and has no racial predilection. It usually affects the scalp, but any hair-bearing area can be involved. It presents as patchy hair loss, loss of hair on the entire scalp (alopecia totalis), or the whole body (alopecia universalis). The histopathology varies according to the disease stage, but usually a perifollicular lymphocytic infiltrate is seen. The course of the disease and response to treatment are unpredictable. Various therapeutic modalities are used including topical, intralesional, and systemic ...

Topical and intralesional therapies for alopecia areata is a post from: Skincare

Topical and intralesional therapies for alopecia areata via BuzzBlazer.com

Alopecia areata: Clinical presentation, diagnosis, and unusual cases

ABSTRACT

Alopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable. However, early, long-lasting, and severe cases have a less ...

Alopecia areata: Clinical presentation, diagnosis, and unusual cases is a post from: Skincare

Alopecia areata: Clinical presentation, diagnosis, and unusual cases via BuzzBlazer.com

Etiopathogenesis of alopecia areata: Why do our patients get it?

ABSTRACT

Alopecia areata (AA) is a nonscarring, inflammatory skin disease that results in patchy hair loss. AA is unpredictable in its onset, severity, and duration making it potentially very stressful for affected individuals. Currently, the treatment options for AA are limited and the efficacy of these treatments varies from patient to patient. The exact etiology of AA is unknown. This article provides some insights into the etiopathogenesis of AA and why some people develop it. The current knowledge on the pathogenesis of AA is summarized and some of the recent hypotheses ...

Etiopathogenesis of alopecia areata: Why do our patients get it? is a post from: Skincare

Etiopathogenesis of alopecia areata: Why do our patients get it? via BuzzBlazer.com

The genetics of alopecia areata: What’s new and how will it help our patients?

ABSTRACT

In the United States, alopecia areata (AA) is the most prevalent autoimmune disease, affecting approximately 5.3 million people, including males and females of all ages and across all ethnic groups. AA affects more individuals than most other autoimmune diseases combined, and yet despite its prevalence, there is little information on the underlying pathogenesis and there are currently no evidence-based treatments available to treat or cure this disease. Genetics has provided a valuable tool for gaining insight into disease pathology. We recently completed the first genome-wide association study (GWAS) in AA ...

The genetics of alopecia areata: What’s new and how will it help our patients? is a post from: Skincare

The genetics of alopecia areata: What’s new and how will it help our patients? via BuzzBlazer.com

Systemic treatment for alopecia areata

ABSTRACT

Of the world population, 1.7% is suffering from alopecia areata at some point in their lives. The exact etiology of this disease is still unknown, and the course of the disease is unpredictable. Effective treatments, especially for severe multifocal alopecia areata, alopecia areata totalis, and alopecia areata universalis, are lacking. The present article will discuss side effects and relapse rates of different systemic agents for treatment of severe and rapid progressive alopecia areata.

Systemic treatment for alopecia areata is a post from: Skincare

Systemic treatment for alopecia areata is a post from: Skincare

Systemic treatment for alopecia areata via BuzzBlazer.com

Investigative guidelines for alopecia areata

ABSTRACT

The reported efficacy of various treatments for alopecia is difficult to compare based on a general lack of consideration in case reports/series and clinical trials of the spontaneous regrowth or baseline prognostic factors seen in alopecia areata and a general lack of quantification of hair growth. This report will give both the investigator and clinician guidelines for clinical trial design that will take into account variables known to effect efficacy results such as baseline severity, pattern, and duration of hair loss, age of the subject, and concomitant conditions that may ...

Investigative guidelines for alopecia areata is a post from: Skincare

Investigative guidelines for alopecia areata via BuzzBlazer.com

Camouflage technique for alopecia areata: What is a patient to do?

ABSTRACT

Alopecia areata is a devastating condition for any patient as hair is a prized component of human beauty. Poems and folktales have been written about long, luxuriant, female, golden, and chestnut hair, and even the Bible discusses the diminishment of male power when hair is lost. The question arises as to whether anyone can be beautiful without hair. The answer is a definite yes. No one can dispute the virility of a shaved male head, indicating the absence of hair can make a strikingly beautiful fashion statement. This is sadly ...

Camouflage technique for alopecia areata: What is a patient to do? is a post from: Skincare

Camouflage technique for alopecia areata: What is a patient to do? via BuzzBlazer.com

Alopecia areata: Support groups and meetings – how can it help your patient?

ABSTRACT

Many people with alopecia areata find the fellowship of the support groups provides them with the help they need to cope. They find that they are not alone, how others have coped, what doctors and treatments have been tried, and what the results have been. The National Alopecia Areata Foundation offers support groups throughout the world to refer patients.

Alopecia areata: Support groups and meetings – how can it help your patient? is a post from: Skincare

Alopecia areata: Support groups and meetings – how can it help your patient? is a post from: Skincare

Alopecia areata: Support groups and meetings – how can it help your patient? via BuzzBlazer.com

Dermatologic therapy: Alopecia areata update

Dermatologic therapy: Alopecia areata update is a post from: Skincare

Dermatologic therapy: Alopecia areata update is a post from: Skincare

Dermatologic therapy: Alopecia areata update via BuzzBlazer.com

Efficacy of oral hyposensitization in allergic contact dermatitis caused by nickel

Background. Nickel contact allergy remains common in Western countries, and the dermatitis may require prolonged treatment. The development of new strategies aimed at improving the quality of life of affected individuals is needed.


Objectives. To investigate the efficacy of oral hyposensitization in nickel-allergic individuals and how this affects in vitro T cell responsiveness to the metal.


Methods. Twenty-eight nickel-allergic patients received a daily dose of 50 µg of elemental nickel (given as NiSO4·6H2O) in cellulose capsules for 3 months. Severity of clinical manifestations, in vivo nickel responsiveness and in vitro T cell ...

Efficacy of oral hyposensitization in allergic contact dermatitis caused by nickel is a post from: Skincare

Efficacy of oral hyposensitization in allergic contact dermatitis caused by nickel via BuzzBlazer.com

Value of patch tests in clindamycin-related drug eruptions

Background. Patch tests help to confirm the aetiology of the cutaneous adverse drug reactions involving delayed hypersensitivity mechanisms, but the results vary with the pattern of skin reaction and the culprit drug.


Objectives. To analyse the results of patch tests in patients with cutaneous adverse drug reactions imputable to clindamycin and assess their contribution to the diagnosis.


Patients and methods. Between 2005 and 2009, we studied patients with delayed cutaneous adverse drug reactions following administration of clindamycin, usually associated with other drugs. After resolution of the cutaneous adverse drug reaction, patch tests ...

Value of patch tests in clindamycin-related drug eruptions is a post from: Skincare

Value of patch tests in clindamycin-related drug eruptions via BuzzBlazer.com

Toxic epidermal necrolysis and Stevens-Johnson syndrome at the Prague Burn Centre 1998–2008

Abstract

Background  Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are skin disorders characterized by extensive necrosis of the mucous membranes and the epidermis caused by an autoimmune response.


Objectives  To present experience of treating TEN and SJS at the Prague Burn Centre (PBC) 1998–2008.


Methods  22 patients with the diagnosis TEN or SJS were enrolled. We collected data including the extent of the skin involvement, the ratio of men : women, the average age, the mortality rate, presence of comorbidities, the length of hospital stay, the period from the first symptoms to the admission ...

Toxic epidermal necrolysis and Stevens-Johnson syndrome at the Prague Burn Centre 1998–2008 is a post from: Skincare

Toxic epidermal necrolysis and Stevens-Johnson syndrome at the Prague Burn Centre 1998–2008 via BuzzBlazer.com

Assessing quality of life in patients with psoriasis and its improvement with treatment

Assessing quality of life in patients with psoriasis and its improvement with treatment is a post from: Skincare

Assessing quality of life in patients with psoriasis and its improvement with treatment is a post from: Skincare

Assessing quality of life in patients with psoriasis and its improvement with treatment via BuzzBlazer.com

Specifically requesting surgical tattoo removal: are deep personal motivations involved?

Abstract

Background  Motivations for tattoo removal include employment reasons, stigmata, changes in lifestyles or partners, incompatibility with present attitudes and values and clothing problems. Most studies on the motivations for tattoo removal have focused on patients seeking laser therapy. We hypothesized that patients seeking surgical tattoo removal would present with different motivations.


Objective  We analysed the characteristics and motivations of patients specifically requesting surgical tattoo removal.


Methods  We retrospectively reviewed the medical records of 16 patients in Helsinki, Finland, from 2005 to 2011. Demographic, clinical data, number of tattoos, location and size, time ...

Specifically requesting surgical tattoo removal: are deep personal motivations involved? is a post from: Skincare

Specifically requesting surgical tattoo removal: are deep personal motivations involved? via BuzzBlazer.com

Treatment of Acne Scarring Using a Dual-Spot-Size Ablative Fractionated Carbon Dioxide Laser: Review of the Literature

BACKGROUND
Fractional photothermolysis has been reported in the literature to improve pigmentary and textural changes associated with acne scarring.


OBJECTIVE
To review the literature for the treatment of acne scarring using nonablative fractional laser (NAFL) and ablative fractional laser (AFL) resurfacing.


METHODS
Review of the Medline literature evaluating NAFL and AFL for acne scarring.


RESULTS
NAFL and AFL are safe and effective treatments for acne scarring. It is likely that the controlled, limited dermal heating of fractional resurfacing initiates a cascade of events in which normalization of the collagenesis–collagenolysis cycle occurs. We present ...

Treatment of Acne Scarring Using a Dual-Spot-Size Ablative Fractionated Carbon Dioxide Laser: Review of the Literature is a post from: Skincare

Treatment of Acne Scarring Using a Dual-Spot-Size Ablative Fractionated Carbon Dioxide Laser: Review of the Literature via BuzzBlazer.com

Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification

BACKGROUND
Periorbital hyperpigmentation (POH) presents with a dark area surrounding the eyelids. It is an ill-defined condition, and the pathogenesis can be multifactorial.


OBJECTIVE
This epidemiologic study was conducted to assess the prevalence of periorbital hyperpigmentation in Singapore in an attempt to propose a classification.


MATERIALS AND METHODS
One thousand consecutive patients attending the general dermatology clinic at the National Skin Center were enrolled in the study to assess for POH, of whom 200 with POH were examined and investigated to define the cause of POH. The possible causes were determined according ...

Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification is a post from: Skincare

Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification via BuzzBlazer.com

A Better Way to Repair Torn Earlobes Using a Modified Z-Plasty

The authors have indicated no significant interest with commercial supporters.

A Better Way to Repair Torn Earlobes Using a Modified Z-Plasty is a post from: Skincare

A Better Way to Repair Torn Earlobes Using a Modified Z-Plasty is a post from: Skincare

A Better Way to Repair Torn Earlobes Using a Modified Z-Plasty via BuzzBlazer.com

Topical corticosteroid phobia in atopic dermatitis: a study of its nature, origins and frequency

Abstract

Background  Topical corticosteroids remain the mainstay of atopic dermatitis therapy. Many atopic dermatitis therapeutic failures appear to be attributable to poor adherence to treatment due to topical corticosteroid phobia.


Objectives  This study was undertaken to assess the facets, origins and frequency of fear of topical corticosteroid use among atopic dermatitis patients.


Methods  A questionnaire comprising 69 items, generated from information gathered during interviews with 21 patients and 15 health professionals, was given to consecutive patients consulting at the outpatient dermatology departments of five regional university hospitals or with 53 dermatologists in private ...

Topical corticosteroid phobia in atopic dermatitis: a study of its nature, origins and frequency is a post from: Skincare

Topical corticosteroid phobia in atopic dermatitis: a study of its nature, origins and frequency via BuzzBlazer.com

Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen?

Background. Isopropyl alcohol is a secondary alcohol, a structural isomer of propanol, that is widely used as an industrial solvent and as a preservative and antiseptic in the clinical environment. It is known to be a mild irritant for the eyes and mucous membranes, but is considered to be a weak and infrequent sensitizer.


Objectives. To show that isopropyl alcohol should be considered as a potential allergen in patients with eczema who have contact with this substance.


Materials and methods. We present a series of 1450 patients patch tested with isopropyl alcohol ...

Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen? is a post from: Skincare

Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen? via BuzzBlazer.com

Contact allergy in the cleaning industry: analysis of contact allergy surveillance data of the Information Network of Departments of Dermatology

Background. Occupational contact allergy is a common problem in the cleaning industry.


Objectives. To identify the most frequent occupation-associated allergens and time trends in contact allergy in female cleaners.


Methods. We analysed the patch test data concerning 803 female cleaners, who were evaluated for occupational contact dermatitis in 45 dermatological departments contributing to the Information Network of Departments of Dermatology (IVDK) from 1996 to 2009. Female patients, except cleaners, with occupational dermatitis (n = 14494) and female controls without occupational dermatitis (n = 64736) patch tested during this time period formed the ...

Contact allergy in the cleaning industry: analysis of contact allergy surveillance data of the Information Network of Departments of Dermatology is a post from: Skincare

Contact allergy in the cleaning industry: analysis of contact allergy surveillance data of the Information Network of Departments of Dermatology via BuzzBlazer.com

Single Follicular Unit Hair Transplantation to Restore Eyebrows

The authors have indicated no significant interest with commercial supporters.

Single Follicular Unit Hair Transplantation to Restore Eyebrows is a post from: Skincare

Single Follicular Unit Hair Transplantation to Restore Eyebrows is a post from: Skincare

Single Follicular Unit Hair Transplantation to Restore Eyebrows via BuzzBlazer.com

Correlation Between Preoperative Magnetic Resonance Imaging and Surgical Margins with Modified Mohs for Dermatofibrosarcoma Protuberans

BACKGROUND
Dermatofibrosarcoma protuberans (DFSP) is characterized by asymmetrical and poorly defined growth. Magnetic resonance imaging (MRI) has been proposed for the delimitation of this tumor.


OBJECTIVES
To study the utility of MRI in evaluating the depth of infiltration in DFSP and to compare the efficiency of clinical palpation with that of MRI in delimiting the invasiveness of DFSP.


METHODS
Observational, prospective study of DFSP cases. The MRI scans for all cases were compared with the exact histological infiltration plane obtained using modified Mohs micrographic surgery (MMS).


RESULTS
Forty-three DFSPs were included: 22 primary, ...

Correlation Between Preoperative Magnetic Resonance Imaging and Surgical Margins with Modified Mohs for Dermatofibrosarcoma Protuberans is a post from: Skincare

Correlation Between Preoperative Magnetic Resonance Imaging and Surgical Margins with Modified Mohs for Dermatofibrosarcoma Protuberans via BuzzBlazer.com

Primary Great Saphenous Vein Aneurysm

The authors have indicated no significant interest with commercial supporters.

Primary Great Saphenous Vein Aneurysm is a post from: Skincare

Primary Great Saphenous Vein Aneurysm is a post from: Skincare

Primary Great Saphenous Vein Aneurysm via BuzzBlazer.com