Background. Interleukin (IL)-18 is a pleiotropic cytokine. Synergistically with IL-12, IL-18 promotes immune responses of the T helper type, by enhancing synthesis of interferon-γ and inhibiting IgE production. IL-18 can also enhance production of IL-4 and IL-13 production, and stimulate synthesis of IgE. Moreover, in the presence of IL-3, IL-18 can directly stimulate basophils and mast cells to produce their mediators in an IgE-independent manner. These results indicate a role for IL-18 in the pathogenesis of atopic dermatitis (AD).
Aim. To examine the association of serum IL-18 with IgE levels and ...
Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis is a post from: Skincare
Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis via BuzzBlazer.com
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