Analysis of Current Therapy and Clinical Outcome in Childhood Pemphigus Vulgaris

Abstract:  Pemphigus vulgaris (PV) is a rare, potentially fatal chronic autoimmune disease of the skin and mucous membrane. The objective of this study was to analyze the clinical outcomes and side effects associated with treatment of childhood PV (CPV). A retrospective review of the English language literature was conducted through PUBMED using the words childhood pemphigus vulgaris, and treatment or clinical outcome. Only patients under 12 years of age were included. Thirty-three cases were found in 29 reports. Mean age at onset was 8.3 years (range 1.5–12 yrs). Mucosal involvement (97.0%) was more ...

Analysis of Current Therapy and Clinical Outcome in Childhood Pemphigus Vulgaris is a post from: Skincare

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Acute Effects of Fractional Laser on Photo-Aged Skin

Background

Nonablative fractional photothermolysis (FP) laser treatment has shown clinical efficacy on photo-aged skin. Few studies have examined the molecular responses to FP.



Objective

To characterize the dynamic alterations involved in dermal matrix remodeling after FP laser treatment.



Methods

A single multipass FP treatment was performed. Baseline, day 1, and day 7 biopsies were obtained. Biopsies were sectioned and stained for histology and immunofluorescence confocal microscopic. Heat shock protein-70 (HSP-70) and matrix metalloproteinase-1 (MMP-1) expression and extracellular matrix (ECM) autofluorescence were examined. Quantitative real-time polymerase chain reaction (qRT-PCR) experiments were performed probing for collagen 1A1 ...

Acute Effects of Fractional Laser on Photo-Aged Skin is a post from: Skincare

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From contact angle titration to chemical force microscopy: a new route to assess the pH-dependent character of the stratum corneum

Synopsis

Despite of its complex multicomponent organization and its compact architecture, the Stratum corneum (SC) is not completely impermeable to substances directly applied on the skin surface. A huge number of works have been dedicated to the understanding of the mechanisms involved in substance permeation by exploring deeper layers than the SC itself. Surprisingly, there is a poor interest in studies relating to interactions which may occur in the near-surface region (i.e. approximately 1 nm depth) of the SC. In this work, equilibrium proton-transfer reactions have been used as probes to define ...

From contact angle titration to chemical force microscopy: a new route to assess the pH-dependent character of the stratum corneum is a post from: Skincare

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Melanocytic naevi and basal cell carcinoma: is there an association?

Abstract

Background  Melanoma and basal cell carcinoma (BCC) affect similar body sites and share a complex relationship with sun exposure.


Objective  To establish the existence and magnitude of association between melanocytic naevi, the strongest predictors of melanoma, and BCC to give possible insights into shared pathways of solar ultraviolet tumourigenesis.


Methods  In a community-based longitudinal Australian study, detailed information was collected about sun sensitivity, and dermatologists assessed skin colour and counted naevi on the forearms (1986) and back (1992). The BCC frequency and sites were prospectively monitored until 2007. Multivariate logistic regression was ...

Melanocytic naevi and basal cell carcinoma: is there an association? is a post from: Skincare

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Female acne – a different subtype of teenager acne?

Abstract

Above all, acne is considered an adolescent affection. However, in literature as in daily life, female acne is becoming more and more common. According to the articles that cover this subject, the prevalence is estimated from 40% to 50%. The objective of our work was to make an overview of new data about female acne at the clinical and epidemiological level to be precise if female acne has to be considered as a subtype of acne different from teenager acne. This review shows that the most frequently recognized age when ...

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Prevalence and correlation of conventional and lupus-specific risk factors for cardiovascular disease in Chinese systemic lupus erythematosus patients

Abstract

Background  It has become clear that the morbidity and mortality of patients with lupus and cardiovascular disease (CVD) have substantially increased. Therefore, we designed a retrospective case–control study to assess the prevalence of traditional and lupus-specific risk factors for CVD in Chinese systemic lupus erythematosus (SLE) patients.


Objective  To identify the prevalence and correlation of conventional and lupus-specific risk factors for CVD in Chinese SLE patients.


Methods  One hundred and thirty-nine patients with SLE were enrolled in the study. They were compared with 139 age and gender-matched controls, who had no history ...

Prevalence and correlation of conventional and lupus-specific risk factors for cardiovascular disease in Chinese systemic lupus erythematosus patients is a post from: Skincare

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Acral lesions of vitiligo: why are they resistant to photochemotherapy?

Abstract

Background  Acral lesions of vitiligo are usually resistant to conventional lines of treatment as well as surgical interventions.


Objective  To clarify causes underlying resistance of acral lesions to pigmentation in vitiligo by studying some of the factors associated with mechanisms of repigmentation following photochemotherapy.


Methods  The study included twenty patients with active vitiligo. Skin biopsies were taken from lesional and perilesional skin of areas expected to respond (trunk and proximal limb) and skin of acral areas, before and after PUVA therapy. Sections were stained with H and E, Melan-A, MHCII, CD1a, SCF ...

Acral lesions of vitiligo: why are they resistant to photochemotherapy? is a post from: Skincare

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Serological screening for autoimmune polyendocrine syndromes in patients with vitiligo

Serological screening for autoimmune polyendocrine syndromes in patients with vitiligo is a post from: Skincare

Serological screening for autoimmune polyendocrine syndromes in patients with vitiligo is a post from: Skincare

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Twenty Years of Clinical Experience with a New Modality of Vascular-Targeted Photodynamic Therapy for Port Wine Stains

BACKGROUND
Port wine stains (PWS) are congenital capillary malformations of the skin and are difficult to treat without scarring. Since January 1991, our group has performed a new modality of vascular-targeted photodynamic therapy (PDT) for PWS treatment.


OBJECTIVE
To summarize our clinical experiences with vascular-targeted PDT for PWS at Chinese PLA General Hospital.


METHODS AND MATERIALS
Our group has collected and reviewed retrospective clinical research data of vascular-targeted PDT for treating PWS since January 1991.


RESULTS
Clinical studies showed that vascular-targeted PDT is an effective treatment for all types of PWS. Repetitive treatment ...

Twenty Years of Clinical Experience with a New Modality of Vascular-Targeted Photodynamic Therapy for Port Wine Stains is a post from: Skincare

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Endovenous 808-nm Diode Laser Occlusion of Perforating Veins and Varicose Collaterals: A Prospective Study of 482 Limbs

BACKGROUND
Endovenous laser ablation (EVLA) was performed in the treatment of great and small saphenous veins (GSVs, SSVs), perforating veins (PVs), and varicose collaterals (VCs).


OBJECTIVE
To verify the outcome in PVs and VCs.


MATERIALS AND METHODS
Four hundred eighty-two limbs of 306 patients were studied. EVLA was performed on 167 GSVs, 52 SSVs, and 534 PVs of 303 limbs and on VCs of 467 limbs; 133 GSVs were stripped, 300 of saphenofemoral junctions (SFJs) and 45 saphenopopliteal junctions (SPJs) were interrupted. Limbs were selected using duplex ultrasound examination and photographs; PVs-VCs ...

Endovenous 808-nm Diode Laser Occlusion of Perforating Veins and Varicose Collaterals: A Prospective Study of 482 Limbs is a post from: Skincare

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Fractional Rejuvenation Using a Novel Bipolar Radiofrequency System in Asian Skin

BACKGROUND
Fractional photothermolysis (FP) constitutes an effective modality of skin resurfacing by delivering thermal energy into multiple arrays of microscopic treatment zones. Radiofrequency (RF) can induce volumetric heating of dermis depending on electrical properties of target tissue.


OBJECTIVES
To evaluate the efficacy and safety of a novel bipolar RF-based fractional device for the treatment of photoaged Asian faces.


METHODS
Twenty-six Korean women (mean age 56, skin phototype III-IV) received three consecutive fractional RF treatments at 4- to 6-week intervals. Outcome assessments included standardized photography physician evaluation of fine lines, pores, smoothness and ...

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Identification of an emulsifier and conditions for preparing stable nanoemulsions containing the antioxidant astaxanthin

Synopsis

In this study, oil-in-water nanoemulsions of astaxanthin were prepared by high-pressure homogenization. The influence of emulsifying conditions including emulsifier type, concentration, passing time, astaxanthin concentration and coantioxidants were optimized. The stabilities of nanoemulsions were measured using zetasizer, FF-SEM, TEM, colorimeter and particle size analyzer. The mean diameter of the dispersed particles containing astaxanthin ranged from 160 to 190 nm. The size distribution was unimodal and extended from 100 to 200 nm. The nanoemulsions prepared with glyceryl citrate/lactate/linoleate/oleate (glyceryl ester) had smaller particle size and narrower size distribution than the emulsion prepared with ...

Identification of an emulsifier and conditions for preparing stable nanoemulsions containing the antioxidant astaxanthin is a post from: Skincare

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Hair shedding in women

Hair shedding in women is a post from: Skincare

Hair shedding in women is a post from: Skincare

Hair shedding in women via BuzzBlazer.com

Ultraviolet B radiation to the eye induces pigmentation in the epidermis via the activation of the subunit gp91 phox of reduced nicotinamide adenine dinucleotide phosphate oxidase

Summary

Irradiation by ultraviolet (UV)B is known to increase the number of dopamine (Dopa)-positive melanocytes in the skin. In this study, a 2.5-kJ/m2 dose of UVB radiation was delivered by a sunlamp to the ear or the eye of wild-type C57BL/6j mice and of gp91 phox−/− C57BL/6j mice that had a knockout mutation of the gp91 phox subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase (NADPH). The degree of change in the Dopa-positive melanocyte expression in was reduced in gp91 phox−/− mice given UVB irradiation to the eye, but not in ...

Ultraviolet B radiation to the eye induces pigmentation in the epidermis via the activation of the subunit gp91 phox of reduced nicotinamide adenine dinucleotide phosphate oxidase is a post from: Skincare

Ultraviolet B radiation to the eye induces pigmentation in the epidermis via the activation of the subunit gp91 phox of reduced nicotinamide adenine dinucleotide phosphate oxidase via BuzzBlazer.com

Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-γ and tumour necrosis factor-α

Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-γ and tumour necrosis factor-α is a post from: Skincare

Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-γ and tumour necrosis factor-α is a post from: Skincare

Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-γ and tumour necrosis factor-α via BuzzBlazer.com

Antioxidant status in patients with lichen planus

Summary

Background.  Lichen planus (LP) is an autoimmune inflammatory disease of the mucocutaneous tissue, whose exact pathological course is not yet understood. Many studies have implicated the role of reactive oxygen species (ROS) and the protective role of antioxidants in several autoimmune skin disorders. In this study, serum levels of antioxidants in patients with LP were determined and compared with those of healthy controls.


Methods.  In total, 30 patients with LP (mean ± SD age 41.63 ± 13.03), who had never received treatment for their disease, were enrolled; 30 healthy people (aged 41.17 ± 13.24) were recruited as ...

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Analysis of ATP2C1 gene mutations in Chinese patients with Hailey–Hailey disease

Analysis of ATP2C1 gene mutations in Chinese patients with Hailey–Hailey disease is a post from: Skincare

Analysis of ATP2C1 gene mutations in Chinese patients with Hailey–Hailey disease is a post from: Skincare

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Analysis of the differentially expressed genes in Microsporum canis in inducing smooth skin and scalp tissue conditions

Summary

Microsporum canis is a common zoophilic dermatophyte, which causes a range of infections. To explore the pathogenic mechanism of tinea capitis, we used the suppression subtractive hybridization (SSH) technique to investigate the differences in gene expression between different cultures of Microsporum canis incubated on three different types of mineral media containing child glabrous skin, child scalp tissue and adult scalp tissue. Using dot-blot hybridization and real-time PCR technique, we successfully screened and identified a pair of genes that had expression levels 44.6 and 117 times higher in culture 1 (M. canis ...

Analysis of the differentially expressed genes in Microsporum canis in inducing smooth skin and scalp tissue conditions is a post from: Skincare

Analysis of the differentially expressed genes in Microsporum canis in inducing smooth skin and scalp tissue conditions via BuzzBlazer.com

Circulating miR-142-3p levels in patients with systemic sclerosis

Summary

Background.  Recently, increased evidence has shown that serum micro (mi)RNA levels are a useful biomarker for the diagnosis, prognosis and therapeutic value of various diseases. However, serum miRNA has not been investigated in patients with systemic sclerosis (SSc), to our knowledge.


Aim.  To investigate the possibility that serum levels of Homo sapiens miR-142 stem-loop (hsa-miR-142-3p), one of the miRNAs regulating the expression of integrin αV, could be a specific disease marker for SSc.


Methods.  Serum samples were obtained from 61 patients with SSc and 20 healthy controls. Patients with systemic lupus erythematosus ...

Circulating miR-142-3p levels in patients with systemic sclerosis is a post from: Skincare

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Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum

Summary

Background.  Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells.


Aim.  To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD.


Methods.  Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA.


Results.  Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin ...

Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum is a post from: Skincare

Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum via BuzzBlazer.com

Epidermotropic CD8+ cytotoxic T-cell lymphoma exhibiting a transition from the indolent to the aggressive phase, accompanied by emergence of CD7+ cells and formation of neutrophilic pustules

Summary

A 47-year-old-man presented with rashes on his trunk and limbs, and a diagnosis of parapsoriasis was made. Ten years later, the rashes had progressed gradually to form plaques and tumours. Gene rearrangement studies revealed monoclonality of the T-cell receptor β-chain (TCR-Jβ)1 gene, and results of flow cytometry and immunohistochemical examination confirmed a diagnosis of epidermotropic CD8+ cytotoxic T-cell lymphoma. The clinical course of the disease remained indolent for some time, but about 2 years later, neutrophilic pustules formed on the surface of the skin lesions, and tumours developed in the patient’s ...

Epidermotropic CD8+ cytotoxic T-cell lymphoma exhibiting a transition from the indolent to the aggressive phase, accompanied by emergence of CD7+ cells and formation of neutrophilic pustules is a post from: Skincare

Epidermotropic CD8+ cytotoxic T-cell lymphoma exhibiting a transition from the indolent to the aggressive phase, accompanied by emergence of CD7+ cells and formation of neutrophilic pustules via BuzzBlazer.com

Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two

Summary

Background:  Exclusive breastfeeding for at least 4 months is recommended by many governments and allergy organizations to prevent allergic disease.


Objectives:  To investigate whether exclusive breastfeeding protects against childhood eczema.


Methods:  Study subjects comprised 51 119 randomly selected 8- to 12-year-old schoolchildren in 21 countries. Information on eczema and breastfeeding was gathered by parental questionnaire. Children were also examined for flexural eczema and underwent skin prick testing. Odds ratios (ORs) were calculated for each study centre and then pooled across populations.


Results:  There was a small increase in the risk of reported ‘eczema ever’ ...

Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two is a post from: Skincare

Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two via BuzzBlazer.com

Hydration measurements of the stratum corneum: comparison between the capacitance method (digital version of the Corneometer CM 825®) and the impedance method (Skicon-200EX®)

Background

Measurement of stratum corneum (SC) hydration often involves the use of commercial instruments. The aim of this study was to compare and validate two recent instruments: the Corneometer 825® (digital probe) and the Skicon-200 EX®.



Methods

In vitro calibration was carried out on filter pads using different solvents, measurements over different layers of plastic foils, and evaluation of desorption kinetics. In vivo measurements were carried out on skin sites covering a range of very dry to well-hydrated skin areas.



Results

Conductance measurements are influenced by electrolytes while capacitance measurements are not. Dielectric constant of ...

Hydration measurements of the stratum corneum: comparison between the capacitance method (digital version of the Corneometer CM 825®) and the impedance method (Skicon-200EX®) is a post from: Skincare

Hydration measurements of the stratum corneum: comparison between the capacitance method (digital version of the Corneometer CM 825®) and the impedance method (Skicon-200EX®) via BuzzBlazer.com

Assessment of melanocytic skin lesions with a high-definition laser Doppler imaging system

Background

Early detection is a major goal in the management of malignant melanoma. Besides clinical assessment many noninvasive technologies such as dermoscopy, digital dermoscopy and in vivo laser scanner microscopy are used as additional methods. Herein we tested a system to assess lesional perfusion as a tool for early melanoma detection.



Methods

Laser Doppler flow (FluxExplorer) and mole analyser (MA) score (FotoFinder) were applied to histologically verified melanocytic nevi (33) and malignant melanomas (12).



Results

Mean perfusion and MA scores were significantly increased in melanoma compared to nevi. However, applying an empirically determined threshold of ...

Assessment of melanocytic skin lesions with a high-definition laser Doppler imaging system is a post from: Skincare

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Analysis of human perception of facial skin radiance by means of image histogram parameters of surface and subsurface reflections from the skin

Background

The appearance of the skin is the result of complicated light–skin interactions involving surface and subsurface reflections. Radiant skin is a complicated attribute but is important for skin beauty. The aim of the present study was to achieve an understanding of the association between human perceptions of skin radiance and image histogram parameters from technically recorded images of surface and subsurface reflections.



Methods

Facial images of 45 subjects were evaluated visually by 30 respondents and were also computer analyzed in terms of their image histogram parameters. A partial least squares regression model ...

Analysis of human perception of facial skin radiance by means of image histogram parameters of surface and subsurface reflections from the skin is a post from: Skincare

Analysis of human perception of facial skin radiance by means of image histogram parameters of surface and subsurface reflections from the skin via BuzzBlazer.com

Cutaneous resonance running time is decreased in psoriatic lesions

Background/aims

Psoriasis is characterized by lower stratum corneum (SC) hydration and dermal inflammation. Both SC hydration and cutaneous inflammation influence cutaneous resonance running time (CRRT). However, the characteristics of CRRT in psoriatic lesions are largely unknown. In the present study, we assessed whether changes in CRRT occur in psoriatic lesions in Chinese.



Methods

A Reviscometer RVM600 and Corneometer CM 825 were used to measure CRRTs and SC hydration, respectively, in psoriatic lesions (psoriasis vulgaris) on the extensor of forearm in 111 subjects (58 men, 53 women), aged 23–80 years (50.42 ± 1.23 years). The contralateral uninvolved sites ...

Cutaneous resonance running time is decreased in psoriatic lesions is a post from: Skincare

Cutaneous resonance running time is decreased in psoriatic lesions via BuzzBlazer.com

Effects of adhesive dressings on stratum corneum conductance

Background

Stratum corneum is a fundamental layer of epidermis. It acts as a barrier, with antimicrobial features, regulating skin permeability and integrity as well. Adhesive dressings and their removal could alter this layer, affecting cutaneous water balance and lipid composition of stratum corneum. These changes could be monitored by measurement of cutaneous hydration.



Methods

Ninety-two patients affected by wounds dressed with adhesive tapes or plasters have been studied. Measurement of skin conductance under tape/plaster and in the surrounding healthy skin, immediately after removal of dressing has been performed. Dressing age, wound localization, and ...

Effects of adhesive dressings on stratum corneum conductance is a post from: Skincare

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Computer-aided pattern classification system for dermoscopy images

Background

Computer-aided pattern classification of melanoma and other pigmented skin lesions is one of the most important tasks for clinical diagnosis. To differentiate between benign and malignant lesions, the extraction of color, architectural order, symmetry of pattern and homogeneity (CASH) is a challenging task.



Methods

In this article, a novel pattern classification system (PCS) based on the clinical CASH rule is presented to classify among six classes of patterns. The PCS system consists of the following five steps: transformation to the CIEL*a*b* color space, pre-processing to enhance the tumor region and removal of ...

Computer-aided pattern classification system for dermoscopy images is a post from: Skincare

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Two-dimensional dielectric imaging for dermatologic screening: a feasibility study

Background/purpose

The diagnosis of skin neoplasia can be very challenging, given the low sensitivity and specificity of traditional methods of diagnosis which are based on visual appearance. Techniques which are based on the dielectric properties of cells can improve the diagnostic accuracy of screening techniques; as an example, point-contact coaxial probes for dielectric measurement can improve diagnostic accuracy. Unfortunately, these probes are not well suited for two-dimensional spatial imaging of the skin surface, given that they must be manually scanned over the skin surface.



Methods/Results

An electronic scanning probe was developed and fabricated ...

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The Dermoscopic Features in Infantile Hemangioma

Abstract:  Dermoscopy is useful for evaluating the precise vascular structure. We recently applied dermoscopy to infantile hemangiomas without proliferation and showed polymorphous vascular structures. We now demonstrate two typical dermoscopic figures of proliferative infantile hemangiomas. One was a superficial hemangioma which showed polymorphous vascular structure without obvious red linear vessels and red dilated vessels. The other was a thicker hemangioma with a deeper component. This hemangioma had polymorphous vascular structures with red linear and red dilated vessels. These observations indicates the usefulness of dermoscopy for subclassifying infantile hemangioma.

The Dermoscopic Features ...

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Severe Atopic Dermatitis and Transient Hypogammaglobulinemia in Children

Abstract:  We sought to describe the clinical outcomes of eight pediatric patients diagnosed with atopic dermatitis (AD) and hypogammaglobulinemia through retrospective review of medical records. All patients presented with severe facial AD. The mean and median ages of diagnosis of hypogammaglobulinemia were 6.2 months and 6.5 months, respectively, with a mean immunoglobulin G (IgG) level of 156 mg/dL. Seven of the eight patients identified in our search demonstrated simultaneous improvement in AD and serum IgG levels within 2 years of initial presentation, suggesting a diagnosis of transient hypogammaglobulinemia. The remaining patient demonstrated normalization by ...

Severe Atopic Dermatitis and Transient Hypogammaglobulinemia in Children is a post from: Skincare

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Vitiligo in Children: A Clinical-Epidemiologic Study in Jordan

Abstract:  Two thousand consecutive children were analyzed in a 2-year period to establish a clinical and epidemiologic profile of vitiligo in Jordan; 71 had vitiligo, with the prevalence increasing with age (0.45% <1 yr, 1% aged 1–5 yrs, 2.1% aged 5–12 yrs). Nonsegmental-type vitiligo was seen in 67 of the patients (92.9%).

Vitiligo in Children: A Clinical-Epidemiologic Study in Jordan is a post from: Skincare

Vitiligo in Children: A Clinical-Epidemiologic Study in Jordan is a post from: Skincare

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Diffuse Cutaneous Mastocytosis Masquerading as Epidermolysis Bullosa

Abstract:  A 10-month-old boy presented with a history of a generalized cutaneous bullous eruption since 3 months of age. Emesis, flush, pruritus, and fatigue had accompanied relapsing episodes of sometimes extensive blistering. Histopathology showed dense dermal infiltrates of mast cells on hematoxylin and eosin and corroborating immunohistochemical staining. Laboratory examination revealed a markedly high level of serum tryptase. Based on these results and after consecutive staging, the patient was diagnosed with diffuse cutaneous bullous mastocytosis (BM). Mutation analysis detected a deletion mutation (del419) in C-Kit by direct exon sequencing. This rare ...

Diffuse Cutaneous Mastocytosis Masquerading as Epidermolysis Bullosa is a post from: Skincare

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Local Vaccine Site Reactions and Contact Allergy to Aluminum

Abstract:  Childhood vaccines are a routine part of pediatric care in the United States; clinicians must be able to recognize and interpret associated localized adverse reactions. Redness and induration at the site of injection are commonly reported and are considered to be the result of local inflammation or hematoma formation, although other atypical reactions can occur. We report the case of a 6-month-old infant who developed subcutaneous nodules at the sites of his 4- and 6-month Pentacel (DTaP/Hib/IPV, diphtheria, tetanus, acellular pertussis, Haemophilus b conjugate, and inactivated poliovirus vaccine) and ...

Local Vaccine Site Reactions and Contact Allergy to Aluminum is a post from: Skincare

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Delineating Capillary Malformations in the Operating Suite Using White Eyeliner Pencil

Abstract:  Delineating the extent of capillary malformations in the operating suite can be challenging because of a variety of physiologic modifiers, including vasodilatation induced by anesthesia, reactive erythema, and filtering of colors with protective laser eyewear. The use of traditional surgical pens to mark the treatment field has limitations; we have found the use of a white eyeliner pencil to delineate lesions a contemporary technique that assists in identifying the target tissue intraoperatively.

Delineating Capillary Malformations in the Operating Suite Using White Eyeliner Pencil is a post from: Skincare

Delineating Capillary Malformations in the Operating Suite Using White Eyeliner Pencil is a post from: Skincare

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Early and Successful Enzymatıc Debridement Via Collagenase Application to Pinna in a Preterm Neonate

Abstract:  We report early and successful enzymatic debridement using collagenase application to pinna in a preterm neonate. Collagenase clostridiopeptidase A should be kept in mind not only for the removal of eschar but also for avoidance of the progression of necrotic tissue in neonates.

Early and Successful Enzymatıc Debridement Via Collagenase Application to Pinna in a Preterm Neonate is a post from: Skincare

Early and Successful Enzymatıc Debridement Via Collagenase Application to Pinna in a Preterm Neonate is a post from: Skincare

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Propranolol for Recalcitrant Ulcerated Hemangioma of Infancy

Abstract:  Hemangioma of infancy (HOI) is a common, self-resolving, benign tumor that frequently requires no intervention. Ulceration is one of the main complications of HOI, and active treatment is usually required to manage pain, potential scarring, and occasionally bleeding and infection. Since the discovery that oral propranolol is an effective treatment for complicated HOI, it has been replacing systemic corticosteroids as first-line therapy, and early recommendations for treatment protocols have been devised. We report the successful treatment of six children with recalcitrant ulcerated HOI using propranolol. In all cases, complete, ...

Propranolol for Recalcitrant Ulcerated Hemangioma of Infancy is a post from: Skincare

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Postvaccination Morphea Profunda in a Child

Abstract:  We report a new case of postvaccination morphea profunda (MP) in a child and discuss its different clinical presentations, prognosis, and therapy and its relationship with “solitary morphea profunda.” A 2-year-old healthy girl presented with an induration of the anterior aspect of the left thigh of 9 months duration. The lesion had appeared 3 months after a third dose of diphtheria-tetanus-pertussis vaccine. Cutaneous examination showed an induration of 7 × 7 cm with an “orange peel” texture after pinching the skin. Histologic examination confirmed the diagnosis of MP. Systemic steroids (1 mg/kg/day) led ...

Postvaccination Morphea Profunda in a Child is a post from: Skincare

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Sole Dermatitis in Children: Patch Testing Revisited

Abstract:  Although dermatoses affecting the soles of the feet in children are regularly encountered in dermatology clinics, the relationship with allergic contact dermatitis affecting this part of the foot is not well established. The aim of this study was to evaluate the relevance of patch testing children with sole dermatoses. We reviewed the results of all patch tests performed in children (<18 years) presenting with dermatoses involving the soles between 1997 and 2009 from our departmental patch test database. Forty-one children were identified: 27 children with an inflammatory dermatitis affecting the ...

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Contact allergy and allergic contact dermatitis in children – a review of current data

Allergic contact dermatitis (ACD) in children was previously considered to be a rare occurrence. However, the growing number of case reports and cross-sectional studies through the past three decades indicate that ACD is, in fact, a highly relevant diagnosis in children. Furthermore, the frequency of ACD in children seems to be increasing. In 1999, a review of the literature reported prevalence rates of 14.5–70% in selected paediatric populations. The current paper reviews the studies on the prevalence of positive patch test reactions and ACD in the paediatric population during the ...

Contact allergy and allergic contact dermatitis in children – a review of current data is a post from: Skincare

Contact allergy and allergic contact dermatitis in children – a review of current data via BuzzBlazer.com

Involvement of upper cheek sagging in nasolabial fold formation

Background:

Nasolabial folds are a well-known feature of aging, but the mechanism of their formation remains unclear.



Objectives:

To clarify the mechanism of nasolabial fold formation, we established grading criteria for severity and explored the influence of dermal elasticity and subcutaneous adipose mass. We also investigated the involvement of facial morphological changes, such as wrinkling and sagging.



Methods:

Faces of 108 healthy Japanese female volunteers (age range: 20–60) were photographed at the angle of 45°, and a six-grade photograph-based grading scheme for nasolabial fold severity was established and evaluated. In 70 Japanese female volunteers (middle-aged: ...

Involvement of upper cheek sagging in nasolabial fold formation is a post from: Skincare

Involvement of upper cheek sagging in nasolabial fold formation via BuzzBlazer.com

Surgical scar remodelling after photodynamic therapy using Aminolevulinic-acid (ALA) or methyl-ester of ALA: a retrospective, blinded study of patients with field cancerization

SUMMARY

Background:  Photodynamic therapy (PDT) is a non-surgical alternative to conventional tumour excision for non-melanoma skin cancers (NMSC).


Objective:  We evaluated whether patients with field cancerization (multiple NMSC) treated with aminolevulinic acid (ALA) or methyl-ester of ALA (MAL) for that indication had PDT-induced changes in surgical scars in the treatment field.


Patients/Methods:  Six adult patients with multiple NMSC and a total of 21scars from previous excisions were studied in a retrospective blinded evaluation from clinical photographs of scar response to ALA/MAL-PDT. After a 3 hour application of topical 20% ALA or 16.8% MAL ...

Surgical scar remodelling after photodynamic therapy using Aminolevulinic-acid (ALA) or methyl-ester of ALA: a retrospective, blinded study of patients with field cancerization is a post from: Skincare

Surgical scar remodelling after photodynamic therapy using Aminolevulinic-acid (ALA) or methyl-ester of ALA: a retrospective, blinded study of patients with field cancerization via BuzzBlazer.com

KID Syndrome: Histopathological, immunohistochemical and molecular analysis of precancerous and cancerous skin lesions

KID Syndrome: Histopathological, immunohistochemical and molecular analysis of precancerous and cancerous skin lesions is a post from: Skincare

KID Syndrome: Histopathological, immunohistochemical and molecular analysis of precancerous and cancerous skin lesions is a post from: Skincare

KID Syndrome: Histopathological, immunohistochemical and molecular analysis of precancerous and cancerous skin lesions via BuzzBlazer.com

The “eyes” or “goggles” as a clue to the histopathologic diagnosis of primary lymphocytic cicatricial alopecia

The “eyes” or “goggles” as a clue to the histopathologic diagnosis of primary lymphocytic cicatricial alopecia is a post from: Skincare

The “eyes” or “goggles” as a clue to the histopathologic diagnosis of primary lymphocytic cicatricial alopecia is a post from: Skincare

The “eyes” or “goggles” as a clue to the histopathologic diagnosis of primary lymphocytic cicatricial alopecia via BuzzBlazer.com

Vessel Resistance To Blood Flow In The Nailfold In Patients With Psoriasis: A Prospective Case-Control Echo Doppler-Based Study

ABSTRACT

Background:  Psoriasis is a disease in which endothelial cells seem to play an important pathogenic role. No report published to date has examined of nail vascularity in psoriasis patients


Objetive:  Evaluate the vascularity in the nails of patients with psoriasis treated with classic and biologic therapies for comparison to disease-free controls. Furthermore, we evaluated whether there were differences in nail vascularity among patients with and without nail involvement


Methods:  We performed a prospective study with 2 cohorts comprising 23 patients with moderate-severe psoriasis and 23 controls without psoriasis. We measured the nailfold ...

Vessel Resistance To Blood Flow In The Nailfold In Patients With Psoriasis: A Prospective Case-Control Echo Doppler-Based Study is a post from: Skincare

Vessel Resistance To Blood Flow In The Nailfold In Patients With Psoriasis: A Prospective Case-Control Echo Doppler-Based Study via BuzzBlazer.com

Pretibial myxedema with autoimmunity and hyperplasia is cured by glucocorticoid and surgery

Pretibial myxedema with autoimmunity and hyperplasia is cured by glucocorticoid and surgery is a post from: Skincare

Pretibial myxedema with autoimmunity and hyperplasia is cured by glucocorticoid and surgery is a post from: Skincare

Pretibial myxedema with autoimmunity and hyperplasia is cured by glucocorticoid and surgery via BuzzBlazer.com

Effects of bosentan on non-digital ulcers in patients with systemic sclerosis

Abstract

Background:  Bosentan is an oral dual endothelin receptor antagonist, which has been proven to be efficacious for preventing new digital ulcers in patients with systemic sclerosis (SSc) by two high quality randomized controlled trials. However, its efficacy for non-digital ulcers in SSc has still remained unknown.


Objective:  To evaluate the efficacy of bosentan on non-digital ulcers in patients with SSc.


Methods:  Bosentan was administered against 5 SSc patients with pulmonary arterial hypertension, who also had non-digital ulcers refractory to conventional treatments. The efficacy of bosentan on non-digital ulcers and its association with ...

Effects of bosentan on non-digital ulcers in patients with systemic sclerosis is a post from: Skincare

Effects of bosentan on non-digital ulcers in patients with systemic sclerosis via BuzzBlazer.com