Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products

Background. The risk of sensitization cannot be derived from the frequency of sensitization to allergens alone, but exposure should be considered.


Objective. To estimate the risk of sensitization to selected preservatives.


Methods. The occurrence of preservatives in 3541 leave-on products based on the labelling of the ingredients was documented. Frequency of sensitization to preservatives was analysed on the basis of Information Network of Departments of Dermatology data for 2006–2009. As an estimate of sensitization risk, the sensitization exposure quotient (SEQ) was calculated as the quotient of the relative frequency of sensitization and ...

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