Leptin, Obesity and Cutaneous Melanoma

Leptin, Obesity and Cutaneous Melanoma is a post from: Skincare

Leptin, Obesity and Cutaneous Melanoma is a post from: Skincare

Leptin, Obesity and Cutaneous Melanoma via BuzzBlazer.com

Clozapine-induced symmetrical drug-related intertriginous and flexural exanthema: first reported cases

Clozapine-induced symmetrical drug-related intertriginous and flexural exanthema: first reported cases is a post from: Skincare

Clozapine-induced symmetrical drug-related intertriginous and flexural exanthema: first reported cases is a post from: Skincare

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In vitro induction of apoptosis, necrosis and genotoxicity by cosmetic preservatives: application of flow cytometry as a complementary analysis by NRU

Synopsis

Preservatives are used in cosmetics to prevent microbial contamination; however, some preservatives are not free of allergenic and cytotoxic potential. Allergenicity and cytoxicity potentialvaluesare major aspects of preservative safety, which determine limitations and maximum concentration dose in a cosmetic product. The purpose of this study was to investigate and compare the in vitro apoptosis, necrosis and genotoxicity-inducing potential of five different types of preservatives: Phenoxyethanol (PE), Propylparaben (PP), Methylparaben (MP), Benzyl Alcohol (BA), and Ethylhexyl Glycerine (EG). In vitro experiments were carried out on human dermal fibroblasts by a quantitative ...

In vitro induction of apoptosis, necrosis and genotoxicity by cosmetic preservatives: application of flow cytometry as a complementary analysis by NRU is a post from: Skincare

In vitro induction of apoptosis, necrosis and genotoxicity by cosmetic preservatives: application of flow cytometry as a complementary analysis by NRU via BuzzBlazer.com

Sebaceous Nevus Syndrome, Central Nervous System Malformations, Aplasia Cutis Congenita, Limbal Dermoid, and Pigmented Nevus Syndrome

Abstract:  SCALP syndrome is an acronym describing the coincidence of sebaceous nevus syndrome, central nervous system malformations, aplasia cutis congenita, limbal dermoid, and pigmented nevus (giant congenital melanocytic nevus). We present a fourth case of this syndrome.

Sebaceous Nevus Syndrome, Central Nervous System Malformations, Aplasia Cutis Congenita, Limbal Dermoid, and Pigmented Nevus Syndrome is a post from: Skincare

Sebaceous Nevus Syndrome, Central Nervous System Malformations, Aplasia Cutis Congenita, Limbal Dermoid, and Pigmented Nevus Syndrome is a post from: Skincare

Sebaceous Nevus Syndrome, Central Nervous System Malformations, Aplasia Cutis Congenita, Limbal Dermoid, and Pigmented Nevus Syndrome via BuzzBlazer.com

Hereditary Mucoepithelial Dysplasia: Report of Two Sporadic Cases

Abstract:  Hereditary mucoepithelial dysplasia (HMD) is a rare genodermatosis characterized by nonscarring alopecia, fiery red gums, perineal erythema, and visual impairment. Histologically, dyskeratotic keratinocytes and a small number of desmosomes are the hallmark of the disease. We report on two unrelated patients who presented with typical clinical and histologic features of HMD along with other unreported clinical findings.

Hereditary Mucoepithelial Dysplasia: Report of Two Sporadic Cases is a post from: Skincare

Hereditary Mucoepithelial Dysplasia: Report of Two Sporadic Cases is a post from: Skincare

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Periorificial Dermatitis Due to Systemic Corticosteroids in Children: Report of Two Cases

Abstract:  Periorificial dermatitis is a common acneiform eruption that is thought to represent a variant of rosacea. These patients typically present with uniform erythematous papules most commonly located periorally but also occurring around the nose and eyelids. This eruption has been linked to topical corticosteroid use, with only a few reports in the literature associated with systemic steroid use in adults. Here, we report two cases of periorificial dermatitis occurring after systemic corticosteroid use in children.

Periorificial Dermatitis Due to Systemic Corticosteroids in Children: Report of Two Cases is a post ...

Periorificial Dermatitis Due to Systemic Corticosteroids in Children: Report of Two Cases is a post from: Skincare

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Transient Infantile Patterned Hyperpigmentation

Abstract:  Patterned transient pigmentation along lines of creases occurring in a newborn is rare. A case report of this entity is described, along with a review of all six cases described in the literature so far.

Transient Infantile Patterned Hyperpigmentation is a post from: Skincare

Transient Infantile Patterned Hyperpigmentation is a post from: Skincare

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Indolent Subcutaneous Panniculitis-Like T Cell Lymphoma in a 1-Year-Old Child

Abstract:  Subcutaneous panniculitis-like T-cell lymphoma is an uncommon form of CD8-positive cytotoxic T-cell lymphoma of the skin that predominantly affects the subcutaneous tissue and is extremely rare in early childhood (<3 yrs). Here, we present an early pediatric case with an indolent form of subcutaneous panniculitis-like T-cell lymphoma occurring at 12 months old. The subcutaneous nodules gradually disappeared spontaneously, and the girl showed excellent prognosis with no aggressive treatment.

Indolent Subcutaneous Panniculitis-Like T Cell Lymphoma in a 1-Year-Old Child is a post from: Skincare

Indolent Subcutaneous Panniculitis-Like T Cell Lymphoma in a 1-Year-Old Child is a post from: Skincare

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Fluorescent fibre-optic confocal imaging of lesional and non-lesional psoriatic skin compared with normal skin in vivo

Background/aims

Fibre-optic confocal imaging (FOCI) allows non-invasive visualization of live skin in vivo. A contrast agent, a fluorophore, is injected in the dermis. FOCI images are optical sections from a horizontal (en face) view. The aim was to study epidermis and the cellular structure of keratinocytes of psoriatic plaques and adjacent non-lesional with healthy skin as a reference.



Methods

Twelve patients with stable plaque psoriasis were studied and compared with a control group of eight healthy individuals. Fluorescein sodium was used as fluorophore. A hand held fibre-optic laser scanner (Stratum®; Optiscan Pty., Melbourne, ...

Fluorescent fibre-optic confocal imaging of lesional and non-lesional psoriatic skin compared with normal skin in vivo is a post from: Skincare

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7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology

Purpose

The aims of this study were to compare in vitro magnetic resonance imaging (MRI) characteristics of keratinocytic skin cancer assessed by a 7-tesla (T) MRI with histopathology, and to describe MRI features of skin tumors.



Methods

This prospective study included 30 skin tumors treated by surgery. MR images of skin samples were acquired on a 7-T MR scanner using a fast spin-echo T2-weighted and an isotropic 3D gradient-echo T1-weighted sequence. Length, width, Breslow index and margins of the lesions were measured. The presence or absence of the following was noted: healthy margins, ...

7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology is a post from: Skincare

7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology via BuzzBlazer.com

How long does protection last? – In vivo fluorescence confocal laser scanning imaging for the evaluation of the kinetics of a topically applied lotion in an everyday setting

Background

Confocal laser scanning microscopic imaging is well established as a helpful diagnostic tool in dermatology. With a new generation of multi-wave laser confocal microscopes now, in addition to the reflection mode, examinations with fluorescent agents are possible in kursiv and ex vivo. Gathering details on the physical, chemical and kinetic features of different fluorophores in different vehicles in healthy skin in vivo will be of interest for therapeutic as well as cosmetic dermatology.



Objectives

Objective of this study was to determine the kinetics of the protective function of a topically applied, fluorescent-containing ...

How long does protection last? – In vivo fluorescence confocal laser scanning imaging for the evaluation of the kinetics of a topically applied lotion in an everyday setting is a post from: Skincare

How long does protection last? – In vivo fluorescence confocal laser scanning imaging for the evaluation of the kinetics of a topically applied lotion in an everyday setting via BuzzBlazer.com

The Prevalence of Pediculus humanus capitis and the Coexistence of Intestinal Parasites in Young Children in Boarding Schools in Sivas, Turkey

Abstract:  The aim of this study was to investigate the prevalence of Pediculus humanus capitis and the coexistence of intestinal parasites in boarding primary schools in Sivas, Turkey. Seven hundred seventy-two students (350 [45.3%] girls, 422 [54.7%] boys) were evaluated with combing for the presence of head lice, collection of fecal samples, and examination of the perianal region for intestinal parasites using the cellophane tape method. The overall infestation rate for head lice was 6% (n = 46). Nine children had evidence of nits only (1.2%), whereas living lice and nits or ...

The Prevalence of Pediculus humanus capitis and the Coexistence of Intestinal Parasites in Young Children in Boarding Schools in Sivas, Turkey is a post from: Skincare

The Prevalence of Pediculus humanus capitis and the Coexistence of Intestinal Parasites in Young Children in Boarding Schools in Sivas, Turkey via BuzzBlazer.com

Angiosarcoma-like presentation of pacemaker-related vascular proliferation

Summary

A 90-year-old man presented with a rapidly growing vascular lesion after a pacemaker generator change. The rapid growth suggested a possible angiosarcoma. A less dramatic presentation of vascular proliferation has been described as reticular telangiectatic erythema, which has been reporting following insertion of pacemakers, implantable cardioverter defibrillators, and drug-delivery devices. The onset of the disorder is described as weeks to years after implantation or generator change. It is a benign condition that generally remains static or regresses over time. The vascular proliferation noted in this case resolved almost completely over ...

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Field melanin mapping of the hairless scalp

Background

Mottled subclinical melanoderma (MSM) is frequently seen on facial skin using the ultraviolet light enhanced visualization (ULEV) method. The corresponding aspect on the hairless scalp remains unknown.



Objective

To explore the field distribution of melanin on the scalp of fair-skinned Caucasian subjects.



Method

The scalp was examined in 43 men with androgenic alopecia. The Visioscan® camera provided the ULEV pictures. Another optical (Visioface® Quick) device was used under white light illumination followed by colour contrast enhancement. This was reached after specific computer filtration of the cyan hue wavelengths.



Results

Under white light illumination, the scalp looked ...

Field melanin mapping of the hairless scalp is a post from: Skincare

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Noninvasive estimation of chronological and photoinduced skin damage using Raman spectroscopy and principal component analysis

Background

Skin aging can be attributed to endogenous and exogenous factors which modify the hydration and protein structure of the skin which can be measured using Raman spectroscopy.



Method

This study included 21 healthy adult volunteers, aged 32–81 years, Raman spectra were obtained from sun-protected and sun-exposed skin, also three millimeter punch biopsies of sun-exposed skin were collected and analyzed. The Raman spectra were analyzed using principal component analysis and the results were correlated with clinical and histological findings.



Results

The principal component analysis of the Raman spectra shows that the first principal component (PC1) obtained ...

Noninvasive estimation of chronological and photoinduced skin damage using Raman spectroscopy and principal component analysis is a post from: Skincare

Noninvasive estimation of chronological and photoinduced skin damage using Raman spectroscopy and principal component analysis via BuzzBlazer.com

Managing a basal cell carcinoma overlying a pacemaker

Managing a basal cell carcinoma overlying a pacemaker is a post from: Skincare

Managing a basal cell carcinoma overlying a pacemaker is a post from: Skincare

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Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents

Summary

Background.  Diverse options are available for the treatment of acne. Topical therapy is standard, especially in cases of mild to moderate acne, while the current treatments for acne vulgaris are topical keratolytics and topical antibiotics. Tolerability is a critical factor in patient compliance with topical acne therapies. The simultaneous use of more than one topical preparation with different active ingredients may cause increased irritation. However, the multifactorial aetiologies of acne, and the need to prevent development of bacterial resistance, require new acne-treatment combinations. Combining agents that target the different aetiological ...

Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents is a post from: Skincare

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Different patterns of dermatological presentations in patients co-infected with human immunodeficiency virus and hepatitis C virus (HCV), and those infected with HCV alone

Summary

Background.  Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) share the same transmission routes. About 30% of HIV-positive patients are co-infected with HCV. Of the various HCV-related extrahepatic events, those involving the skin may be the first sign of infection.


Aim.  To specify the skin presentations in patients co-infected with HIV and HCV (co-infected patients; CP) and compare them with those found in patients with HCV mono-infection (mono-infected patients; MP).


Methods.  This was a cross-sectional study, in which the studied population consisted of MP and CP from a tertiary hospital in ...

Different patterns of dermatological presentations in patients co-infected with human immunodeficiency virus and hepatitis C virus (HCV), and those infected with HCV alone is a post from: Skincare

Different patterns of dermatological presentations in patients co-infected with human immunodeficiency virus and hepatitis C virus (HCV), and those infected with HCV alone via BuzzBlazer.com

Progression of IgA gammopathy to myeloma following infliximab treatment for pyoderma gangrenosum

Summary

Pyoderma gangrenosum (PG) may be associated with inflammatory disorders and haematological conditions such as monoclonal gammopathy of uncertain significance (MGUS). We report the case of a 53-year old man who had PG and MGUS. After treatment with infliximab for the PG, he developed myeloma. The course of events in this case suggests that infliximab facilitated the progression from MGUS to myeloma.

Progression of IgA gammopathy to myeloma following infliximab treatment for pyoderma gangrenosum is a post from: Skincare

Progression of IgA gammopathy to myeloma following infliximab treatment for pyoderma gangrenosum is a post from: Skincare

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Q-switched ruby laser therapy and long-term follow-up evaluation of small to medium-sized congenital melanocytic naevi

Q-switched ruby laser therapy and long-term follow-up evaluation of small to medium-sized congenital melanocytic naevi is a post from: Skincare

Q-switched ruby laser therapy and long-term follow-up evaluation of small to medium-sized congenital melanocytic naevi is a post from: Skincare

Q-switched ruby laser therapy and long-term follow-up evaluation of small to medium-sized congenital melanocytic naevi via BuzzBlazer.com

Pulmonary, rhino-orbital and cutaneous mucormycosis caused by Rhizomucor pusillus in an immunocompromised patient

Summary

The number of patients with haematopoietic malignancies receiving chemotherapy and stem-cell transplantation has increased the incidence of severe opportunistic infections. Systemic fungal infections are of major concern in immunocompromised patients, as these infections are often fatal. We report a case of a patient with acute myeloid leukaemia who developed multiple cutaneous plaques and necrotizing infiltrates in the lungs during chemotherapy. Using real-time PCR on a wax-embedded tissue sample, Rhizomucor pusillus was identified. We provide an overview of the literature on cutaneous mucormycosis and its diagnosis by PCR.

Pulmonary, rhino-orbital and cutaneous ...

Pulmonary, rhino-orbital and cutaneous mucormycosis caused by Rhizomucor pusillus in an immunocompromised patient is a post from: Skincare

Pulmonary, rhino-orbital and cutaneous mucormycosis caused by Rhizomucor pusillus in an immunocompromised patient via BuzzBlazer.com

Mesna-induced photodistributed dermatosis

Summary

We present the case of a 41-year-old man who developed a photodistributed eruption 1 month after being started on 2-mercaptoethane sulfonate sodium (mesna) for treatment of cyclophosphamide-induced haemorrhagic cystitis. The patient had a background history of Wegener granulomatosis, and had been taking cyclophosphamide at a stable dose of 150 mg daily for the previous 3 years. Complete resolution of the rash occurred within 8 weeks of cessation of mesna. This is the first reported case, to our knowledge, of mesna-induced photodistributed dermatosis. Early recognition of this condition will ensure prompt cessation of the culprit ...

Mesna-induced photodistributed dermatosis is a post from: Skincare

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Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease

Summary

Background.  Numerous molecular events have been associated with the development of malignant melanoma (MM). The cellular FLICE-like inhibitory protein (c-FLIP) was originally identified as an inhibitor of death-receptor signalling through competition with FADD-like interleukin-1β-converting enzyme (FLICE; also known as caspase-8) for recruitment to the FAS-associated death domain (FADD), and it has been suggested recently that c-FLIP is required for the survival and proliferation of various cell types.


Aim.  To investigate the relationship of c-FLIP expression with the clinicopathological features of MM.


Methods.  Immunohistochemical staining with anti-c-FLIP antibody was performed on tissue samples ...

Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease is a post from: Skincare

Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease via BuzzBlazer.com

Primary Cutaneous Ewing’s Sarcoma: A Systematic Review Focused on Treatment and Outcome

Summary

Background:  Despite intensive treatment, the overall prognosis of Ewing’s sarcoma of the bone remains poor. Primary cutaneous Ewing’s sarcoma very rarely occurs and the prognosis has been reported to be better in some small series. All cases of Ewing’s sarcoma are currently treated in the same way, regardless of their location.


Objectives:  To determine whether Ewing’s sarcoma of the bone and primary cutaneous Ewing’s sarcoma were different in terms of epidemiology and prognosis.


Methods:  A systematic review of the literature was carried out using the keywords “cutaneous Ewing’s sarcoma,”“primary Ewing’s sarcoma of ...

Primary Cutaneous Ewing’s Sarcoma: A Systematic Review Focused on Treatment and Outcome is a post from: Skincare

Primary Cutaneous Ewing’s Sarcoma: A Systematic Review Focused on Treatment and Outcome via BuzzBlazer.com

Dermatological Phenotype in Costello Syndrome: Consequences of Ras Dysregulation in Development

Abstract

Background:  The RASopathies are a class of human genetic syndromes caused by germline mutations in genes that encode protein components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Costello syndrome (CS) is a RASopathy caused by mutations in the HRAS gene, a key regulator of signal transduction.


Objective:  To quantify the specific cutaneous phenotype observed in 46 individuals with Costello syndrome with confirmed HRAS mutations.


Methods:  This was a cross-sectional study. Dermatologic surveys were designed by the authors and were completed by parents of mutation-positive CS individuals at the Costello Syndrome Family Network ...

Dermatological Phenotype in Costello Syndrome: Consequences of Ras Dysregulation in Development is a post from: Skincare

Dermatological Phenotype in Costello Syndrome: Consequences of Ras Dysregulation in Development via BuzzBlazer.com

Pachyonychia congenita patients with mutations in K6a have more extensive disease compared to patients with mutations in K16

Abstract

Background:  Pachyonychia Congenita (PC) is an autosomal dominant, very rare keratin disorder caused by mutations in any of at least four genes (KRT6A, KRT6B, KRT16, or KRT17) which can lead to hypertrophic nail dystrophy and palmoplantar keratoderma, among other manifestations. Classically, patients with mutations in K6a and K16 have been grouped to the PC-1 subtype (Jadassohn-Lewandowski type) and K6b and K17 to PC-2 (Jackson-Lawler type).


Objectives:  To describe clinical heterogeneity among PC patients with genetic mutations in K6a and K16.


Methods:  In 2004, the Pachyonychia Congenita Project established the International PC Research ...

Pachyonychia congenita patients with mutations in K6a have more extensive disease compared to patients with mutations in K16 is a post from: Skincare

Pachyonychia congenita patients with mutations in K6a have more extensive disease compared to patients with mutations in K16 via BuzzBlazer.com

Demodex–associated bacterial proteins induce neutrophil activation

Background:  Patients with rosacea demonstrate a higher density of Demodex mites in their skin than controls. A bacterium isolated from a Demodex mite from a patient with papulopustular rosacea (PPR) was previously shown to provoke an immune response in patients with PPR or ocular rosacea thus suggesting a possible role for bacterial proteins in the etiology of this condition.


Objectives:  To examine the response of neutrophils to proteins derived from a bacterium isolated from a Demodex mite.


Methods:  Bacterial cells were lysed and proteins were partially purified by AKTA-FPLC. Isolated neutrophils were ...

Demodex–associated bacterial proteins induce neutrophil activation is a post from: Skincare

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Bacteriology of hidradenitis suppurativa exacerbations. Deep tissue cultures obtained during carbon dioxide laser treatment

Summary

Background:  Previous studies have shown different bacteria in hidradenitis suppurativa (HS) lesions, but the literature regarding bacteria in acute exacerbation of HS is sparse.


Objectives:  The aim of the study was to determine the type of bacteria isolated from HS lesions during exacerbation of the disease.


Methods:  HS patients with acute nodules or abscesses were examined and treated by carbon dioxide laser vaporisation. Bacterial samples for aerobic and anaerobic cultures were taken from the skin surface (before surgery) and then from the deeper layer (during surgery) of the lesions. At each level ...

Bacteriology of hidradenitis suppurativa exacerbations. Deep tissue cultures obtained during carbon dioxide laser treatment is a post from: Skincare

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Successful management of severe infant bullous pemphigoid with omalizumab

Successful management of severe infant bullous pemphigoid with omalizumab is a post from: Skincare

Successful management of severe infant bullous pemphigoid with omalizumab is a post from: Skincare

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Botulinum A toxin and brachioradial pruritus

Botulinum A toxin and brachioradial pruritus is a post from: Skincare

Botulinum A toxin and brachioradial pruritus is a post from: Skincare

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Protease-antiprotease imbalance may be linked to potential defects in profilaggrin proteolysis in atopic dermatitis

Protease-antiprotease imbalance may be linked to potential defects in profilaggrin proteolysis in atopic dermatitis is a post from: Skincare

Protease-antiprotease imbalance may be linked to potential defects in profilaggrin proteolysis in atopic dermatitis is a post from: Skincare

Protease-antiprotease imbalance may be linked to potential defects in profilaggrin proteolysis in atopic dermatitis via BuzzBlazer.com

Successful treatment of cutaneous venous malformations in a blue rubber bleb nevus syndrome patient by Nd:YAG laser

Abstract

Background:  Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare mucocutaneous disorder which is characterized by multiple venous malformations in the skin and the gastrointestinal tract.


Objective:  We present a case of an 18 year old patient who presented with mucocutaneous as well as gastrointestinal lesions. We firstly describe the successful treatment of mucocutaneous lesions of a patient suffering from BRBNS by Nd:YAG laser.


Method:  One case is reported, and literature is reviewed.


Result:  All treated lesions virtually disappeared. Big, eruptive lesions needed multiple treatments. Side effects were not observed.


Conclusion:  Nd:YAG laser therapy ...

Successful treatment of cutaneous venous malformations in a blue rubber bleb nevus syndrome patient by Nd:YAG laser is a post from: Skincare

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Obesity and Melanoma

Obesity and Melanoma is a post from: Skincare

Obesity and Melanoma is a post from: Skincare

Obesity and Melanoma via BuzzBlazer.com

Anti-oxidant defence mechanism in vitiliginous skin increases with skin type

Abstract

Background  Vitiligo skin shows different burning capacity in people with different phototype. In normal skin antioxidant status is correlated to skin phototype, but unexpectedly it appears that there is a gradual decrease in burning susceptibility of depigmented skin of individuals with increasing phototype (II→VI).


Objective  To assess if the antioxidant response in the lesional vitiligo skin is involved in those protection mechanisms. Moreover, a possible correlation between cutaneous and systemic endogenous antioxidants in vitiligo patients has been investigated.


Methods  We enrolled in the study 29 patients with active vitiligo, divided into five ...

Anti-oxidant defence mechanism in vitiliginous skin increases with skin type is a post from: Skincare

Anti-oxidant defence mechanism in vitiliginous skin increases with skin type via BuzzBlazer.com

Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata

Abstract

Background  Former studies have shown that Propionibacterium acnes may stimulate expression of toll-like receptor 4 (TLR4) in keratinocytes of patients with acne vulgaris.


Objective  To investigate the impact of single nucleotide polumorphisms (SNPs) of the TLR4 gene in acne vulgaris.


Methods  Genomic DNA was isolated from 191 patients with acne vulgaris and 75 healthy controls. Asp299Gly and Thr399Ile SNPs were defined after cutting of the PCR products by restriction enzymes. Sebum of lesions was cultured for P. acnes.


Results  No differences in SNP allele frequencies were found between patients and healthy controls. 46.5% ...

Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata is a post from: Skincare

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Public awareness and attitudes towards cutaneous leishmaniasis in an endemic region in Saudi Arabia

Abstract

Background and Aims  One of the priorities in public health policy for the control of Cutaneous Leishmaniasis (CL) is to investigate associations between disease distribution, socio-demographical and environmental risk factors, so that rational prevention and control strategies can be developed. Assessment of baseline awareness of the disease amongst the endemic population would be one of the first steps in this direction. This study aims to provide qualitative information on lay perceptions of CL in an endemic area in Saudi Arabia. We also attempted to correlate these perceptions with associated socio-demographical ...

Public awareness and attitudes towards cutaneous leishmaniasis in an endemic region in Saudi Arabia is a post from: Skincare

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Diffuse cutaneous mastocytosis: analysis of 10 cases and a brief review of the literature

Abstract

Background  Diffuse cutaneous mastocytosis (DCM) is an extremely rare disease characterized by mast cell (MCs) infiltration of the entire skin. Little is known about the natural course of DCM.


Objectives  We decided to characterize clinical manifestations, the frequency of MCs mediator-related symptoms and anaphylaxis, risk of systemic mastocytosis (SM) and prognosis, based on 10 cases of DCM, the largest series published to date.


Methods  Diffuse cutaneous mastocytosis, DCM was confirmed by histopathological examination of skin samples in all cases. SCORing Mastocytosis (SCORMA) Index was used to assess the intensity of DCM. The ...

Diffuse cutaneous mastocytosis: analysis of 10 cases and a brief review of the literature is a post from: Skincare

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A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance

Synopsis

In order to formulate a consumer-acceptable cosmetic product numerous demands have to be fulfilled, as the most important, efficacy (both real and perceived) and adequate aesthetic (visual perception) and all sensorial characteristics have to be achieved. In the present study four model water-in-oil creams intended for hand care, varying in one emollient component, were submitted to rheological, sensory and textural characterization and their efficacy was evaluated in in vivo study on human volunteers. Our results indicate that certain alteration restricted to the oil phase induced a change in all investigated ...

A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance is a post from: Skincare

A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance via BuzzBlazer.com

Antimelanoma, Tyrosinase Inhibitory and Antimicrobial Activities of Gold Nanoparticles Synthesized from Aqueous Leaf extracts of Teraxacum officinale

Synopsis

There has been a tenacious search for pharmaceuticals of natural origin, since they are cost effective and are noted for having little or no side effects. The rate at which diseases are developing resistance to synthetic drugs is quite alarming and the side effects of these drugs remain an excruciating agony to the pharmaceutical industry. Gold nanoparticles (AuNPs) have wide applications in current technology. However, their use in medicine has not been adequately explored. Chemical methods for the synthesis are associated with environmental benignity and tissue toxicity on in vivo ...

Antimelanoma, Tyrosinase Inhibitory and Antimicrobial Activities of Gold Nanoparticles Synthesized from Aqueous Leaf extracts of Teraxacum officinale is a post from: Skincare

Antimelanoma, Tyrosinase Inhibitory and Antimicrobial Activities of Gold Nanoparticles Synthesized from Aqueous Leaf extracts of Teraxacum officinale via BuzzBlazer.com

Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation in the CCL-110 skin fibroblast cell line

Synopsis

Coenzyme Q10 (CoQ10) is a major ingredient in skin care products due to its anti-wrinkle effects, although it has some side-effects especially at higher amounts. In this study we compare the anti-wrinkle related properties of CoQ10 and a proprietary Commiphora mukul gum resin (guggul) and triheptanoin preparation (GU-TC7). GU-TC7 is prepared with a supercritical CO2- co-solvent extraction with ethanol, standardized to 2% guggulsterones and triheptanoin, a triglyceride composed of three 7-carbon fatty acids. Treatment of CCL-110 skin fibroblasts with GU-TC7 demonstrates a mild proliferative effect compared to CoQ10 and increased ...

Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation in the CCL-110 skin fibroblast cell line is a post from: Skincare

Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation in the CCL-110 skin fibroblast cell line via BuzzBlazer.com

Population genetic segmentation of MHC correlated perfume preferences

Abstract:

It has become difficult to find a matching perfume. An overwhelming number of 300 new perfumes launch each year and marketing campaigns target pre-defined groups based on gender, age or income rather than individual preferences. Recent evidence for a genetic basis of perfume preferences, however, could be the starting point for a novel population genetic approach to better match perfumes with people’s preferences. With a total of 116 participants genotyped for alleles of three loci of the Major Histocompatibility Complex (MHC), the aim of this study was to test, whether ...

Population genetic segmentation of MHC correlated perfume preferences is a post from: Skincare

Population genetic segmentation of MHC correlated perfume preferences via BuzzBlazer.com

Separation of Sunscreens in Skincare Creams Using Greener High Temperature Liquid Chromatography and Subcritical Water Chromatography

Abstract

In this study, high temperature liquid chromatographic (HTLC) and subcritical water chromatographic (SBWC) separations of sunscreens contained in skincare creams were achieved at temperatures ranging from 90 to 250 °C. The columns employed in this work include a ZirChrom-DiamondBond-C18, a XTerra MS C18, and a XBridge C18 column. The quantity of methanol consumed by the greener HTLC sunscreen methods developed in this project is significantly reduced although the HTLC separation at this stage is not as efficient as that achieved by traditional HPLC. SBWC separation of sunscreens was also achieved ...

Separation of Sunscreens in Skincare Creams Using Greener High Temperature Liquid Chromatography and Subcritical Water Chromatography is a post from: Skincare

Separation of Sunscreens in Skincare Creams Using Greener High Temperature Liquid Chromatography and Subcritical Water Chromatography via BuzzBlazer.com

Vitamin D serum level changes in psoriatic patients treated with narrowband ultraviolet B phototherapy are related to the season of the irradiation

Summary

Background

Vitamin D is produced in the human skin by short wavelength (290–315 nm) ultraviolet (UV) radiation.



Purpose

The aim of the study was to investigate how outdoor conditions may influence the serum levels of 25(OH) vitamin D in psoriasis patients under narrowband ultraviolet B (UVB) phototherapy.



Methods

The winter and summer groups of patients received almost the same narrowband UV (nUVB) doses during whole-body phototherapy. The 25(OH)D serum concentration was measured before and after two series of 10 exposures. The cabinet doses were compared with potentially available cumulative solar doses. The solar doses (unweighted UVB ...

Vitamin D serum level changes in psoriatic patients treated with narrowband ultraviolet B phototherapy are related to the season of the irradiation is a post from: Skincare

Vitamin D serum level changes in psoriatic patients treated with narrowband ultraviolet B phototherapy are related to the season of the irradiation via BuzzBlazer.com

Effects of ultraviolet radiation exposure on FOXP3+ infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma

Summary

Purpose

To analyze the prevalence and significance of FOXP3+ infiltration into (pre)malignant skin carcinomas following ultraviolet radiation (UVR) exposure. The possible pathways that UVR impacts on FOXP3 are to be discussed.



Background

FOXP3+ regulatory T cells (FOXP3+ Tregs) are correlated to cutaneous squamous tumor progression. However, there is no information describing the prevalence of FOXP3+ infiltration in cutaneous premalignant and malignant squamous carcinomas with UVR exposure.



Methods

We investigated the prevalence of FOXP3+ infiltration in 14 patients with Bowen’s disease, 40 squamous cell carcinoma SCC patients and 21 patients with basal cell carcinoma (BCC) by ...

Effects of ultraviolet radiation exposure on FOXP3+ infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma is a post from: Skincare

Effects of ultraviolet radiation exposure on FOXP3+ infiltration in cutaneous squamous cell carcinoma and basal cell carcinoma via BuzzBlazer.com

Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study

Summary

Background

Combination of topical methoxsalen and narrowband ultraviolet B (NBUVB) was shown to be more effective than NBUVB alone in treating plaque-type psoriasis.



Objective

To find out whether topical methoxsalen and NBUVB had any benefit in induction of remission on treatment-resistant plaques of psoriasis on the legs in comparison with NBUVB alone.



Methods

Ten patients were included. Two symmetric lesions with similar Psoriasis Severity Index score on the lower legs were randomly assigned to be treated with cold cream as placebo or 0.1% 8-methoxypsoralen (8MOP) cream 15 min before phototherapy with NBUVB. Phototherapy was given three ...

Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study is a post from: Skincare

Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study via BuzzBlazer.com

Compliance with age and skin type restrictions following the introduction of indoor tanning legislation in Melbourne, Australia

Summary

Background/Purpose

The study aimed to establish compliance of indoor tanning businesses with 2009 legislation, particularly with requirements to provide information on skin cancer and exclude people under 18 or with fair skin.



Methods

Compliance was tested through surveys and in-person visits to 30 businesses in Melbourne, Australia. Research assistants presented as potential customers with different profiles: young adults eligible to use a sunbed, young adults with fair skin, under age customers who prompted with their age and under age customers who concealed their age and claimed to be 18 if asked.



Results

Communicating the risks ...

Compliance with age and skin type restrictions following the introduction of indoor tanning legislation in Melbourne, Australia is a post from: Skincare

Compliance with age and skin type restrictions following the introduction of indoor tanning legislation in Melbourne, Australia via BuzzBlazer.com

Continuous ultra-low-intensity artificial daylight is not as effective as red LED light in photodynamic therapy of multiple actinic keratoses

Summary

Background/Purpose

Daylight-mediated photodynamic therapy (PDT) is a simple and tolerable treatment of nonmelanoma skin cancer. It is of interest which light intensity is sufficient to prevent accumulation of protoporphyrin IX (PpIX) and effectively treat actinic keratoses (AKs). We compared the efficacy of PDT with light-emitting diode (LED) to daylight-mediated PDT with very low-intensity artificial daylight (‘daylight’) in the treatment of multiple AKs in the face or scalp.



Methods

Twenty patients were treated with conventional methyl aminolevulinate (MAL) PDT in one area. Another area was, after half an hour of occlusive treatment with MAL, ...

Continuous ultra-low-intensity artificial daylight is not as effective as red LED light in photodynamic therapy of multiple actinic keratoses is a post from: Skincare

Continuous ultra-low-intensity artificial daylight is not as effective as red LED light in photodynamic therapy of multiple actinic keratoses via BuzzBlazer.com

Highlights for December

Highlights for December is a post from: Skincare

Highlights for December is a post from: Skincare

Highlights for December via BuzzBlazer.com

Light Microscopic Hair Shaft Analysis in Ectodermal Dysplasia Syndromes

Abstract:  The objective of the study was to catalog hair shaft abnormalities in individuals with ectodermal dysplasia (ED) syndromes using light microscopy and to compare findings with those in unaffected controls. Light microscopy was performed in a nonblinded manner on hair shafts from 65 participants with seven types of ED (hypohidrotic ED, ED–ectrodactyly–cleft lip or palate, ankyloblepharon–ectodermal defects–cleft lip and palate, Clouston syndrome, Goltz syndrome, Schopf-Schulz Passarge syndrome, and oculodentodigital dysplasia) and 41 unaffected controls. Hair donations were collected at the 28th Annual National Family Conference held by the National ...

Light Microscopic Hair Shaft Analysis in Ectodermal Dysplasia Syndromes is a post from: Skincare

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Cutaneous type adult T-cell leukaemia/lymphoma successfully treated with narrowband ultraviolet B phototherapy

Cutaneous type adult T-cell leukaemia/lymphoma successfully treated with narrowband ultraviolet B phototherapy is a post from: Skincare

Cutaneous type adult T-cell leukaemia/lymphoma successfully treated with narrowband ultraviolet B phototherapy is a post from: Skincare

Cutaneous type adult T-cell leukaemia/lymphoma successfully treated with narrowband ultraviolet B phototherapy via BuzzBlazer.com

Ulcerated Lupus Vulgaris at the Site of Bacille Calmette-Guérin Vaccination

Abstract:  We report a case of ulcerated lupus vulgaris occurring in 1.5-year-old boy at the Bacille Calmette-Guérin vaccination site within 6 months, which was diagnosed using histology and polymerase chain reaction. The lesion resolved with isoniazid and rifampicin therapy.

Ulcerated Lupus Vulgaris at the Site of Bacille Calmette-Guérin Vaccination is a post from: Skincare

Ulcerated Lupus Vulgaris at the Site of Bacille Calmette-Guérin Vaccination is a post from: Skincare

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Febrile Ulceronecrotic Mucha-Habermann Disease (Pityriasis Lichenoides et Varioliformis Acuta Fulminans) Presenting as Stevens-Johnson Syndrome

Abstract:  We present two pediatric patients with pityriasis lichenoides et varioliformis acuta fulminans whose admitting diagnosis was Stevens Johnson Syndrome. The patients were successfully treated with methotrexate and prednisone. These cases highlight the importance of early recognition and treatment of this disease to prevent further morbidity and a potentially fatal prognosis.

Febrile Ulceronecrotic Mucha-Habermann Disease (Pityriasis Lichenoides et Varioliformis Acuta Fulminans) Presenting as Stevens-Johnson Syndrome is a post from: Skincare

Febrile Ulceronecrotic Mucha-Habermann Disease (Pityriasis Lichenoides et Varioliformis Acuta Fulminans) Presenting as Stevens-Johnson Syndrome is a post from: Skincare

Febrile Ulceronecrotic Mucha-Habermann Disease (Pityriasis Lichenoides et Varioliformis Acuta Fulminans) Presenting as Stevens-Johnson Syndrome via BuzzBlazer.com

Efficacy of Acitretin for Porokeratosis in a Child with Chronic Cutaneous Graft Versus Host Disease

Abstract:  Porokeratosis is a rare disorder of epidermal keratinization that is regarded as a precancerous. Recipients of hematopoietic stem cell transplantation (HSCT) have a greater risk of skin cancer; chronic graft versus host disease (GVHD) is an additional risk factor. A 16-year-old boy who had received HSCT for acute myelogenous leukemia was referred to us for sclerodermoid chronic cutaneous GVHD. Two years later, he developed disseminated porokeratosis with a few atypical lesions. Despite cryotherapy, numerous lesions of porokeratosis recurred rapidly. Acitretin resulted in good clinical response and reduced the rate ...

Efficacy of Acitretin for Porokeratosis in a Child with Chronic Cutaneous Graft Versus Host Disease is a post from: Skincare

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An Unusual Presentation of Subcutaneous Granuloma Annulare in Association with Juvenile-Onset Diabetes: Case Report and Literature Review

Abstract:  Subcutaneous granuloma annulare (SGA) is a rarely reported subtype of granuloma annulare that occurs almost exclusively in children. The etiology of these lesions is unknown, although a possible relationship to insulin-dependent diabetes mellitus (IDDM) has been proposed in the literature. Here we present an unusual case of SGA on the right forearm in a 3-year-old girl. Unlike the typical lesions noted on the extremities, on magnetic resonance imaging her lesions involved the subcutaneous tissue and adjacent muscles in multiple locations. Histopathologically, the case was consistent with SGA but was ...

An Unusual Presentation of Subcutaneous Granuloma Annulare in Association with Juvenile-Onset Diabetes: Case Report and Literature Review is a post from: Skincare

An Unusual Presentation of Subcutaneous Granuloma Annulare in Association with Juvenile-Onset Diabetes: Case Report and Literature Review via BuzzBlazer.com

Intravenous Immunoglobulin to Treat Severe Atopic Dermatitis in Children: A Case Series

Abstract:  Severe cases of atopic dermatitis (AD) may require systemic immunosuppression to achieve disease control. Unfortunately, some cases continue to be refractory to management or develop unacceptable adverse effects. There are limited reports of the use of intravenous immunoglobulin (IVIg) in the treatment of severe AD, but results are inconsistent. In a retrospective study, we report 10 children with severe AD refractory to systemic immunosuppression and maximal topical therapy who were treated using IVIg. The children received monthly IVIg for an average of 24 months. This resulted in a significant improvement ...

Intravenous Immunoglobulin to Treat Severe Atopic Dermatitis in Children: A Case Series is a post from: Skincare

Intravenous Immunoglobulin to Treat Severe Atopic Dermatitis in Children: A Case Series via BuzzBlazer.com

Fractionated 1550-nm Erbium-Doped Fiber Laser for the Treatment of Periorbital Hyperpigmentation

Fractionated 1550-nm Erbium-Doped Fiber Laser for the Treatment of Periorbital Hyperpigmentation is a post from: Skincare

Fractionated 1550-nm Erbium-Doped Fiber Laser for the Treatment of Periorbital Hyperpigmentation is a post from: Skincare

Fractionated 1550-nm Erbium-Doped Fiber Laser for the Treatment of Periorbital Hyperpigmentation via BuzzBlazer.com

Hypersensitivity Reaction to Chromated Glycerin

Hypersensitivity Reaction to Chromated Glycerin is a post from: Skincare

Hypersensitivity Reaction to Chromated Glycerin is a post from: Skincare

Hypersensitivity Reaction to Chromated Glycerin via BuzzBlazer.com

Granulomatous Reaction to Hyaluronic Acid: A Case Series and Review of the Literature

Granulomatous Reaction to Hyaluronic Acid: A Case Series and Review of the Literature is a post from: Skincare

Granulomatous Reaction to Hyaluronic Acid: A Case Series and Review of the Literature is a post from: Skincare

Granulomatous Reaction to Hyaluronic Acid: A Case Series and Review of the Literature via BuzzBlazer.com

Efficacy of Pulsed Electromagnetic Energy in Postoperative Recovery from Blepharoplasty

Background

A novel medical device that has been approved by the Food and Drug Administration is available for treatment of postsurgical edema. The device emits a low-level, pulsed electromagnetic energy field, which modulates resting cell membrane potential, allowing a return to physiologic resting membrane potential.



Objective

To investigate the benefits of electromagnetic energy in eyelid wound healing.



Methods

Fifty-seven individuals participated in this randomized, double-blinded study. All patients underwent upper blepharoplasty. At the postoperative visit, patients rated pain, edema, and ecchymosis, and the physician rated edema, ecchymosis, and erythema.



Results

There was no difference (p = .76) in patient ...

Efficacy of Pulsed Electromagnetic Energy in Postoperative Recovery from Blepharoplasty is a post from: Skincare

Efficacy of Pulsed Electromagnetic Energy in Postoperative Recovery from Blepharoplasty via BuzzBlazer.com

p-Phenylenediamine and other hair dye sensitizers in Spain

Background. Oxidative hair dyes are important skin sensitizers, causing contact allergy and dermatitis in hairdressers and consumers.


Objectives. To study the prevalence of hair dye substances, categorized as potent skin sensitizers, in consumer-available oxidative hair dye products on the market of a southern European country and to compare it with that in Sweden.


Methods. Ingredient labels of 105 oxidative hair dye products from 19 brands were studied, and the prevalence and use pattern of hair dye substances, categorized as potent skin sensitizers, was assessed. Network diagrams were used to display results.


Results. According ...

p-Phenylenediamine and other hair dye sensitizers in Spain is a post from: Skincare

p-Phenylenediamine and other hair dye sensitizers in Spain via BuzzBlazer.com

Dermal uptake study with 4,4′-diphenylmethane diisocyanate led to active sensitization

Background. To investigate the dermal uptake of 4,4′-diphenylmethane diisocyanate (4,4′-MDI), a study was performed in which 2 female volunteers were exposed to 10 and 25 mg, respectively, of 4,4′-MDI by applying 2.0% 4,4′-MDI in petrolatum over areas where the surface concentration corresponded to 800 µg/cm2. Ten days later, they developed eczematous dermatitis at the area of application.


Objectives. To investigate whether the dermal application caused active sensitization to 4,4′-MDI.


Methods. Chemical analysis of the 4,4′-MDI preparation used in the application and the amount of 4,4′-MDI not absorbed by the skin was performed ...

Dermal uptake study with 4,4′-diphenylmethane diisocyanate led to active sensitization is a post from: Skincare

Dermal uptake study with 4,4′-diphenylmethane diisocyanate led to active sensitization via BuzzBlazer.com

Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement

Background. Orthopaedic implants and osteosynthesis materials are increasingly being used. Complications include mainly physical–mechanical problems and infections. Uncommonly, an allergic reaction towards an alloy metal or a bone cement component has been implicated. Potential bone cement allergens include acrylates, benzoyl peroxide, N,N-dimethyl-p-toluidine, and gentamicin. Typical symptoms are pain, swelling, inflammatory skin reactions, implant loosening, and fistula formation.


Objectives. To report on 5 patients with complications from a knee or a shoulder joint implant in whom a relevant sensitization to benzoyl peroxide was shown.


Methods. Patch tests were performed with the European baseline ...

Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement is a post from: Skincare

Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement via BuzzBlazer.com

Do hairdressers in Denmark have their hand eczema reported as an occupational disease? Results from a register-based questionnaire study

Background. Occupational hand eczema is common in hairdressers, owing to wet work and chemicals.


Objectives. To estimate whether hairdressers in Denmark have their hand eczema reported as an occupational disease and to clarify the reasons for not reporting.


Methods. A register-based study was performed, comprising trained hairdressers (n = 7840), using a self-administered postal questionnaire including questions on hand eczema and it being reported as an occupational disease. A response rate of 67.9% (n = 5324) was obtained.


Results. Overall, 2186 respondents ever had hand eczema; 71.3% were apprentices at the time of ...

Do hairdressers in Denmark have their hand eczema reported as an occupational disease? Results from a register-based questionnaire study is a post from: Skincare

Do hairdressers in Denmark have their hand eczema reported as an occupational disease? Results from a register-based questionnaire study via BuzzBlazer.com

Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers

Abstract

Background  In Hong Kong, at the time of the study, compression treatment was not considered usual care for venous leg ulcer patients.


Aim  This randomized controlled trial compared quality of life (QOL) aspects in venous leg ulcer patients of over 55-years of age, of short-stretch compression (SSB), four-layer compression bandaging (4LB) and usual care (UC) (moist wound healing dressing, no compression).


Method  Study period was 24-weeks, the primary outcome was the patient functional status, disease-specific and generic health-related QOL measures and ulcer healing rates, comparing week 1 vs. week 24 (end) results. ...

Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers is a post from: Skincare

Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers via BuzzBlazer.com

Methods for evaluation of cosmetic antioxidant capacity

The skin as the largest part of human body is one of the main targets for ultraviolet radiation, environmental pollution, toxic chemicals and some metal ions, which share responsibility for the formation of free radicals. The resulting free radicals, both oxygen and nitrogen species are one of the main causes of aging due to impaired regulation of cell respiratory metabolism involving incomplete oxygen reduction in mitochondria and production a superoxide anion, hydroxyl radicals et al. In modern cosmetology to minimize the adverse effects of free radicals, antioxidants, which inhibit free radical ...

Methods for evaluation of cosmetic antioxidant capacity is a post from: Skincare

Methods for evaluation of cosmetic antioxidant capacity via BuzzBlazer.com

Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial

Abstract

Background  There is a need for the development of novel non-steroidal topical drugs for the treatment of psoriasis.


Objective  To assess the efficacy and safety of topical 1.0% WBI-1001 in patients with mild to moderate plaque psoriasis.


Methods  A total of 61 patients with 1–10% body surface area (BSA) covered with plaque psoriasis and a physician’s global assessment score (PGA) of 2–4 were randomized (2 : 1) to receive either 1% WBI-1001 in a cream formulation or placebo, applied twice daily for 12 weeks. Efficacy was evaluated using PGA, BSA and Psoriasis Area and Severity ...

Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial is a post from: Skincare

Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial via BuzzBlazer.com

Defective barrier function in melasma skin

Abstract

Background  Melasma is characterized by increased pigmentation and photodamaged features, which include solar elastosis. Recently, we detected the downregulation of the genes most associated with lipid metabolism using microarray analysis in melasma. These findings suggested that lesional skin may have different biophysical characteristics, and, in particular, an altered skin barrier function.


Objective  To determine the cutaneous biophysical characteristics of melasma.


Methods  The melanin index, erythema index, stratum corneum hydration, sebum content and transepidermal water loss (TEWL) were measured for lesional and perilesional normal skin of 16 melasma patients and then compared. In ...

Defective barrier function in melasma skin is a post from: Skincare

Defective barrier function in melasma skin via BuzzBlazer.com

Ustekinumab in clinical practice: response depends on dose and previous treatment

Abstract

Objectives  To evaluate the efficacy of ustekinumab in a series of patients with moderate to severe psoriasis treated according to the European Medicines Agency (EMA) label and to identify factors such as dose, baseline PASI or previous treatment potentially related to therapeutic outcome.


Methods  Retrospective review of the clinical records from 36 consecutive patients treated with ustekinumab during at least 36 weeks at a single referral center. Candidates for treatment had a PASI ≥ 10 or a BSA ≥ 10 and either failure to respond to, or a contraindication to, or intolerance to some systemic ...

Ustekinumab in clinical practice: response depends on dose and previous treatment is a post from: Skincare

Ustekinumab in clinical practice: response depends on dose and previous treatment via BuzzBlazer.com

Serum soluble CD26 levels: diagnostic efficiency for atopic dermatitis, cutaneous T-cell lymphoma and psoriasis in combination with serum thymus and activation-regulated chemokine levels

Abstract

Background  CD26 is a multifunctional type II transmembrane glycoprotein, which also exists as a secreted isoform, soluble CD26 (sCD26). The CD26 expression on circulating T cells is decreased in some skin diseases such as cutaneous T-cell lymphoma (CTCL) and psoriasis. It remains to be determined whether sCD26 can be used as a marker of skin diseases or not.


Objective  To investigate utility of sCD26 as a diagnostic marker of skin diseases in combination with thymus and activation-regulated chemokine (TARC).


Methods  Serum sCD26 levels were measured using enzyme-linked immunosorbent assay in 130 participants ...

Serum soluble CD26 levels: diagnostic efficiency for atopic dermatitis, cutaneous T-cell lymphoma and psoriasis in combination with serum thymus and activation-regulated chemokine levels is a post from: Skincare

Serum soluble CD26 levels: diagnostic efficiency for atopic dermatitis, cutaneous T-cell lymphoma and psoriasis in combination with serum thymus and activation-regulated chemokine levels via BuzzBlazer.com

Surgical Treatment of Nail Apparatus Melanoma in situ: The Use of Artificial Dermis in Reconstruction

Surgical Treatment of Nail Apparatus Melanoma in situ: The Use of Artificial Dermis in Reconstruction is a post from: Skincare

Surgical Treatment of Nail Apparatus Melanoma in situ: The Use of Artificial Dermis in Reconstruction is a post from: Skincare

Surgical Treatment of Nail Apparatus Melanoma in situ: The Use of Artificial Dermis in Reconstruction via BuzzBlazer.com

In vivo reflectance confocal microscopy for varicella prompt diagnosis and treatment in a severely immunosuppressed patient

In vivo reflectance confocal microscopy for varicella prompt diagnosis and treatment in a severely immunosuppressed patient is a post from: Skincare

In vivo reflectance confocal microscopy for varicella prompt diagnosis and treatment in a severely immunosuppressed patient is a post from: Skincare

In vivo reflectance confocal microscopy for varicella prompt diagnosis and treatment in a severely immunosuppressed patient via BuzzBlazer.com

Reactions of non-immunologic contact urticaria on scalp, face, and back

Background

This study compared the reactivity of scalp, face, and back to nonimmunologic contact urticants (NICU) to ascertain relative responsiveness.



Methods

Model urticants, benzoic acid (BA) and hexyl nicotinate (HN) with 3 concentrations of each were applied to marked skin of 10 bald males during 6 weeks. One urticant was applied to one side of nasolabial fold, back, and scalp and the other applied to the contralateral side. Reactivity was assessed by visual scores (VS) and biophysical instruments. Subjects ranked skin sensation with a 10-point visual analogue scale.



Results

With 0.25% HN application, upper back ...

Reactions of non-immunologic contact urticaria on scalp, face, and back is a post from: Skincare

Reactions of non-immunologic contact urticaria on scalp, face, and back via BuzzBlazer.com

Increasing place of Trichophyton tonsurans in Paris, France: A 15-year retrospective study

Increasing place of Trichophyton tonsurans in Paris, France: A 15-year retrospective study is a post from: Skincare

Increasing place of Trichophyton tonsurans in Paris, France: A 15-year retrospective study is a post from: Skincare

Increasing place of Trichophyton tonsurans in Paris, France: A 15-year retrospective study via BuzzBlazer.com

Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern

Abstract

Background:  Interstitial granulomatous dermatitis (IGD) is a rare disease for which a clinical-pathological correlation is essential to establish diagnosis.


Objective and Methods:  We describe the histological and clinical features of patients with IGD seen in our department from 2004 to 2010. Moreover, all cases retrieved through a literature search were critically analyzed.


Results:  Twelve adult patients (9 females and 3 males; mean age, 58.5 years; range 32-73) with IGD were enrolled. Lesions consisted of asymptomatic erythematous papules and plaques, symmetrically distributed on the trunk and the proximal limbs. Two patients had skin-coloured ...

Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern is a post from: Skincare

Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern via BuzzBlazer.com

Radiation therapy in the management of unilesional primary cutaneous T-cell lymphomas.

Abstract

Background:  Unilesional presentations of mycosis fungoides (MF)-type cutaneous T-cell lymphoma (CTCL) may offer opportunities for definitive treatment with intent to cure, as opposed to more advanced disease involving multiple body areas, where remissions are not expected to be long term.


Objective:  To determine the disease-free survival for patients with unilesional or clustered oligolesional cutaneous T-cell lymphoma treated with radiation therapy.


Methods:  We reviewed the records of all patients brought before the Multidisciplinary Cutaneous Oncology Tumor Board at University Hospitals Case Medical Center from 1997 to 2010. A total of 10 patients diagnosed ...

Radiation therapy in the management of unilesional primary cutaneous T-cell lymphomas. is a post from: Skincare

Radiation therapy in the management of unilesional primary cutaneous T-cell lymphomas. via BuzzBlazer.com

Erythrocyte sedimentation rate as an independent prognostic factor in Mycosis fungoides

Erythrocyte sedimentation rate as an independent prognostic factor in Mycosis fungoides is a post from: Skincare

Erythrocyte sedimentation rate as an independent prognostic factor in Mycosis fungoides is a post from: Skincare

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Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

Abstract

Background:  Nail disorders can be diagnostically challenging to the dermatologist. Non-invasive methods might help to avoid nail biopsies. More knowledge of the typical features of healthy nails with these techniques is needed for comparison with nail diseases.


Objectives:  Objectives were to describe the typical morphology of healthy nails in optical coherence tomography (OCT) and confocal laser scanning microscopy (CLSM) and to examine the influence of exposure to water on OCT features, nail-thickness as well as on the transonychial water loss before and after a hand bath.


Material and Methods:  In the first ...

Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails is a post from: Skincare

Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails via BuzzBlazer.com