BRM and BRG1 subunits of the SWI/SNF chromatin-remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours

Abstract

Background  Non-melanoma skin cancer is caused by exposure to ultraviolet radiation within sunlight. Actinic keratoses (AK) are benign precursor lesions that can develop into invasive squamous cell carcinoma (SCC). Little is known about the molecular events that lead to human skin cancer progression from benign to invasive.


Objectives  To determine novel genes that may be involved in skin cancer progression based on data from an initial microarray screen of human skin cancers.


Methods  The SWI/SNF chromatin remodelling ATPase subunit BRM was identified as being downregulated in SCC but not AK compared to ...

BRM and BRG1 subunits of the SWI/SNF chromatin-remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours is a post from: Skincare

BRM and BRG1 subunits of the SWI/SNF chromatin-remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours via BuzzBlazer.com

Survival in cancer patients hospitalised for psoriasis: a population-based cohort study in Sweden

Abstract

Background:  Increased cancer risk after psoriasis has been observed in previous studies, whereas little is known about the prognosis in cancer patients with previously diagnosed psoriasis.


Objective:  We aimed at examining the cancer-specific and overall mortality among psoriatic cancer patients compared with the reference.


Methods:  The population-based Swedish registers were used to identify psoriatic cancer patients and cancer patients without psoriasis. We used Cox regression model to estimate hazard ratios (HRs), showing the probability of death between 2 groups.


Results:  A total of 1,746 psoriatic cancer patients and 1,011,757 other cancer patients were ...

Survival in cancer patients hospitalised for psoriasis: a population-based cohort study in Sweden is a post from: Skincare

Survival in cancer patients hospitalised for psoriasis: a population-based cohort study in Sweden via BuzzBlazer.com

Efficacious and safe management of moderate-to-severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomised, controlled study

Abstract

Background:  Topical antifungals and corticosteroids are mainstay of treatment for seborrhoeic dermatitis (SD). The short-contact clobetasol propionate 0.05% shampoo (CP) is an efficacious and safe once-daily treatment for scalp psoriasis.


Objective:  To evaluate the efficacy and safety of CP alone and combined with ketoconazole shampoo 2% (KC) in the treatment of moderate-to-severe scalp SD.


Methods:  This randomised and investigator-blinded study consisted of 3 phases, each lasting 4 weeks. During the treatment phase, subjects were randomised to receive KC twice weekly (K2), CP twice weekly (C2), CP twice weekly alternating with KC twice ...

Efficacious and safe management of moderate-to-severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomised, controlled study is a post from: Skincare

Efficacious and safe management of moderate-to-severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomised, controlled study via BuzzBlazer.com

Photodynamic therapy reduces the histologic features of actinic damage and the expression of early oncogenic markers.

Abstract

Photodynamic therapy (PDT) has been shown to be effective to treat non-melanoma skin cancer (NMSC), especially, actinic keratosis (AK). Moreover there is sufficient evidence of its effectiveness to prevent the appearance of premalignant and malignant lesions in organ transplant recipients.


The aim of this study is to describe the molecular and genetic changes underlying this preventive effect. Therefore 22 patients were treated with using methyl-aminolevulinate and red light. Biopsies were performed before and six weeks after the treatment. Conventional histopathology and immunohistochemistry were carried out.


Not only was a reduction in the ...

Photodynamic therapy reduces the histologic features of actinic damage and the expression of early oncogenic markers. is a post from: Skincare

Photodynamic therapy reduces the histologic features of actinic damage and the expression of early oncogenic markers. via BuzzBlazer.com

Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi?

Background  Psoriasis affects about 2-3% of Caucasian people. The psoriasis excessive growth and aberrant differentiation of keratinocytes is driven and maintained by multiple components of the immune system, including many immune-derived cytokines. It has been demonstrated that keratinocytes synthesize and secrete many cytokines; some of these interact with other skin cells like melanocytes and play a strong secretory activity, giving rise to chemical messengers that may control the proliferation and differentiation of melanocytes and the rate of melanin production. The main stimulating factors of melanogenesis are α-melanocyte stimulating hormone, ACTH ...

Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? is a post from: Skincare

Psoriasis and melanocytic naevi: does the first confer a protective role against melanocyte progression to naevi? via BuzzBlazer.com

Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden

Abstract

Background/Objectives:  Studies reporting the incidence of isolated cutaneous lupus erythematosus (CLE) are rare. This population-based cohort study examines the incidence of CLE and its subsets in Sweden. The short-time probability of receiving an additional diagnosis of systemic lupus erythematosus (SLE) is also assessed.


Methods:  A population-based open cohort study including all patients with CLE (International Classification of Disease (ICD) code; ICD-10: L93) in Sweden, 2005-2007. Patients (n=1088) were identified in the National Patient Register (NPR).


Results:  The incidence of CLE was 4.0/100,000; female to male ratio was 3:1. Mean age of disease ...

Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden is a post from: Skincare

Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden via BuzzBlazer.com

MELANOTAN ASSOCIATED MELANOMA

MELANOTAN ASSOCIATED MELANOMA is a post from: Skincare

MELANOTAN ASSOCIATED MELANOMA is a post from: Skincare

MELANOTAN ASSOCIATED MELANOMA via BuzzBlazer.com

Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care.

Abstract

Introduction:  Cellulitis is responsible for over 400 000 bed days/year in the English NHS at the cost of £ 96 million.


Methods:  This study transferred care of lower limb cellulitis managed in secondary care from general physicians to dermatologists.


Results:  33% of 635 cases referred with lower limb cellulitis had other diagnoses which did not require admission. 407/425 patients with cellulitis were managed entirely as outpatients, many at home. 28% of patients with cellulitis had an underlying skin disease identified and treated, which is likely to have reduced the risk of recurrent ...

Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. is a post from: Skincare

Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. via BuzzBlazer.com

Altered Expression of Co-stimulatory Molecules in Behçet’s Disease According to Clinical Activity

Abstract

Background:  The reduced expression of molecules limiting excessive immune responses has been considered a pathogenic mechanism associated with autoimmune diseases.


Objectives:  To understand the implications of co-stimulatory molecules in Behçet’s disease (BD), the expression of CTLA-4 and PD-1 on T cell subsets and of their ligands, CD80, CD86 and PD-L1 on antigen presenting cells (APCs) were investigated.


Methods:  The mononuclear blood cells of subjects (11 patients with active BD, 8 patients with inactive BD, 8 patients with recurrent aphthous ulcers and 10 healthy volunteers as healthy controls (HC)) were stimulated with PMA ...

Altered Expression of Co-stimulatory Molecules in Behçet’s Disease According to Clinical Activity is a post from: Skincare

Altered Expression of Co-stimulatory Molecules in Behçet’s Disease According to Clinical Activity via BuzzBlazer.com

Staphylococcus aureus endocarditis as a complication of acupuncture for eczema.

Staphylococcus aureus endocarditis as a complication of acupuncture for eczema. is a post from: Skincare

Staphylococcus aureus endocarditis as a complication of acupuncture for eczema. is a post from: Skincare

Staphylococcus aureus endocarditis as a complication of acupuncture for eczema. via BuzzBlazer.com

Relationship between clinical features of facial dry skin and biophysical parameters in Asians

Synopsis

There have been few reports classifying the biophysical characteristics of Korean women with healthy skin. Consequently, the aim of this study was to find the most useful parameters for categorizing skin types based on a clinical assessment. One hundred and three female volunteers, aged 20–59, participated in this study. We conducted a self-evaluation questionnaire, a clinical assessment of the facial skin, and non-invasive measurements on the cheek under controlled environmental conditions. The questionnaire survey indicated that 72% of respondents had dry skin. However, results of the clinical assessment focusing on ...

Relationship between clinical features of facial dry skin and biophysical parameters in Asians is a post from: Skincare

Relationship between clinical features of facial dry skin and biophysical parameters in Asians via BuzzBlazer.com

Grey hair: clinical investigation into changes in hair fibres with loss of pigmentation in a photoprotected population

Synopsis

Loss of pigmentation in hair fibres is one of the most obvious phenotypic changes with ageing and has been a topic of increasing interest in the study of follicle biology. The onset of greying brings cosmetic complaints that grey fibres are wild or difficult to manage. Of course, these perceptions may be the consequence of visual obviousness rather than underlying physical or chemical differences. Although several studies have compared pigmented and unpigmented fibres, few have tried to control genetic and ethnic difference as well as extrinsic factors such as photoexposure ...

Grey hair: clinical investigation into changes in hair fibres with loss of pigmentation in a photoprotected population is a post from: Skincare

Grey hair: clinical investigation into changes in hair fibres with loss of pigmentation in a photoprotected population via BuzzBlazer.com

Evaluation of antimicrobial effectiveness of C-8 xylitol monoester as an alternative preservative for cosmetic products

Synopsis

Xylitol is a natural sugar derived from plants, fruits and vegetables, whose antimicrobial properties are described in the literature. This study aimed to evaluate the antimicrobial effectiveness of C-8 xylitol monoester, for its use as a preservative in cosmetic formulations. The minimum inhibitory concentration (MIC) was determined by the broth macrodilution method, and the antimicrobial effectiveness of C-8 xylitol monoester was determined by using challenge test method. The results obtained in the determination of minimum inhibitory concentration are between 1.0% and 1.25% for Staphylococcus aureus, Escherichia coli and Candida albicans ...

Evaluation of antimicrobial effectiveness of C-8 xylitol monoester as an alternative preservative for cosmetic products is a post from: Skincare

Evaluation of antimicrobial effectiveness of C-8 xylitol monoester as an alternative preservative for cosmetic products via BuzzBlazer.com

Distribution of skin temperature in Mexican children

Background: Infrared thermography can be a valuable diagnostic tool in the evaluation and management of several pathologies; however, the temperature pattern of the healthy body should be known in order to perform a more precise clinical evaluation.


Methods: A total of 25 healthy children (10 female and 15 male) were examined with a thermographic camera. Eighty-four temperature points of the body were recorded, saved in a database, and analyzed.


Results: The measurements showed that the forehead, neck, and the cervical area have the highest average temperatures of the whole ...

Distribution of skin temperature in Mexican children is a post from: Skincare

Distribution of skin temperature in Mexican children via BuzzBlazer.com

Chromatic aberration correction: an enhancement to the calibration of low-cost digital dermoscopes

Background/purpose: We present a method for calibrating low-cost digital dermoscopes that corrects for color and inconsistent lighting and also corrects for chromatic aberration. Chromatic aberration is a form of radial distortion that often occurs in inexpensive digital dermoscopes and creates red and blue halo-like effects on edges. Being radial in nature, distortions due to chromatic aberration are not constant across the image, but rather vary in both magnitude and direction. As a result, distortions are not only visually distracting but could also mislead automated characterization techniques.


Methods: Two low-cost ...

Chromatic aberration correction: an enhancement to the calibration of low-cost digital dermoscopes is a post from: Skincare

Chromatic aberration correction: an enhancement to the calibration of low-cost digital dermoscopes via BuzzBlazer.com

Relationship between the echogenicity of subcutaneous tissue and the depth of forehead wrinkles

Background/purpose: Subcutaneous tissue is rarely studied in research on wrinkles. We used diagnostic ultrasonography to produce images of subcutaneous tissue of the forehead, one of the areas where age-related wrinkles form. We quantified the resulting echogenicity and investigated its relationship with wrinkle depth.


Methods: One hundred and seventy-three Japanese subjects were divided into four age groups (21–28 years, 35–41 years, 47–59 years, 65–75 years). Maximum wrinkle depth (Rmax) was measured in the forehead. On an ultrasound image, which was captured by scanning perpendicular to the deepest wrinkle, we set ...

Relationship between the echogenicity of subcutaneous tissue and the depth of forehead wrinkles is a post from: Skincare

Relationship between the echogenicity of subcutaneous tissue and the depth of forehead wrinkles via BuzzBlazer.com

Skin texture parameters of the dorsal hand in evaluating skin aging in China

Background/purpose: There are various non-invasive methods in skin morphology for assessing skin aging. The use of digital photography will make it easier and more convenient. In this study, we explored some skin texture parameters for evaluating skin aging using digital image processing.


Methods: Two hundred and twenty-eight subjects who lived in Sanya, China, were involved. Individual sun exposure history and other factors influencing skin aging were collected by a questionnaire. Meanwhile, we took photos of their dorsal hands. Skin images were graded according to the Beagley–Gibson system. These skin ...

Skin texture parameters of the dorsal hand in evaluating skin aging in China is a post from: Skincare

Skin texture parameters of the dorsal hand in evaluating skin aging in China via BuzzBlazer.com

A novel method to measure conspicuous facial pores using computer analysis of digital-camera-captured images: the effect of glycolic acid chemical peeling

Background/purpose: Chemical peeling is becoming increasingly popular for skin rejuvenation in dermatological esthetic surgery. Conspicuous facial pores are one of the most frequently encountered skin problems in women of all ages. This study was performed to analyze the effectiveness of reducing conspicuous facial pores using glycolic acid chemical peeling (GACP) based on a novel computer analysis of digital-camera-captured images.


Methods: GACP was performed a total of five times at 2-week intervals in 22 healthy women. Computerized image analysis of conspicuous, open, and darkened facial pores was performed using the ...

A novel method to measure conspicuous facial pores using computer analysis of digital-camera-captured images: the effect of glycolic acid chemical peeling is a post from: Skincare

A novel method to measure conspicuous facial pores using computer analysis of digital-camera-captured images: the effect of glycolic acid chemical peeling via BuzzBlazer.com

Influence of probe application pressure on in vitro and in vivo capacitance (Corneometer CM 825®) and conductance (Skicon 200 EX®) measurements

Background/purpose: The measuring probe of the electrical hydration instruments is equipped with a spring system to ensure a constant pressure of probe application on the skin surface. However, it is possible to trigger the measurement at, respectively, a low and a high force of probe application. It is the purpose of this paper to compare the in vitro and in vivo hydration values of the capacitance and conductance method at, respectively, low and high values of application pressure on the considered surface.


Methods: In vitro capacitance and conductance hydration measurements ...

Influence of probe application pressure on in vitro and in vivo capacitance (Corneometer CM 825®) and conductance (Skicon 200 EX®) measurements is a post from: Skincare

Influence of probe application pressure on in vitro and in vivo capacitance (Corneometer CM 825®) and conductance (Skicon 200 EX®) measurements via BuzzBlazer.com

Classification of Papulo-Squamous skin diseases using image analysis

Introduction: Papulo-squamous skin diseases are variable but are very close in their clinical features. They present with the same lesions, erythematous scaly lesions. Clinical evaluation of skin lesions is based on common sense and experience of the dermatologist to differentiate features of each disease.


Aim: To evaluate a computer-based image analysis system as a helping tool for classification of commonly encountered diseases.


Materials and Methods: The study included 50 selected images from each of psoriasis, lichen planus, atopic dermatitis, seborrheic dermatitis, pityrasis rosea, and pitryasis rubra pilaris with a ...

Classification of Papulo-Squamous skin diseases using image analysis is a post from: Skincare

Classification of Papulo-Squamous skin diseases using image analysis via BuzzBlazer.com

Quantitative evaluation of patch test reactions: a comparison between visual grading and erythema index image analysis

Background/aims: The interpretation of patch test reactions may vary between examiners. As test results are graded, an issue also arises when differing degrees of erythema are placed in the same grade. The purpose of this study was to quantitatively evaluate the degree of erythema in patch tests using image analysis and to study the usefulness of this method by comparing it with visual grading.


Methods: A total of 121 Japanese patients were patch tested with various materials. At 48 h, digital photographs of the patch test areas were taken, in ...

Quantitative evaluation of patch test reactions: a comparison between visual grading and erythema index image analysis is a post from: Skincare

Quantitative evaluation of patch test reactions: a comparison between visual grading and erythema index image analysis via BuzzBlazer.com

An improved method for measurement of change in skin roughness caused by cleansing products under mild application conditions

Background: The aim of this study was to develop a method for the evaluation of subtle change in skin roughness caused by cleansing products under mild application conditions using a non-invasive three-dimensional (3D) analysis system.


Methods: A double-blind comparative study of the modified soap chamber test was performed using two soap bars and a syndet bar. Skin changes were evaluated by visual scoring [mean cumulative irritation index (MCII)] and by bioengineering measurements [transepidermal water loss (TEWL), skin capacitance, and skin surface roughness].


Results: MCII of the syndet bar was ...

An improved method for measurement of change in skin roughness caused by cleansing products under mild application conditions is a post from: Skincare

An improved method for measurement of change in skin roughness caused by cleansing products under mild application conditions via BuzzBlazer.com

Relationship between the echogenicity of subcutaneous tissue and the depth of eye corner wrinkles

Background/purpose: A close relationship was found between the internal structure of subcutaneous tissue and wrinkle depth in our previous study of human forehead. The present study examined the relationship in the eye corner.


Methods: One hundred and seventy-three Japanese subjects were divided into four age groups (21–28 years, 35–41 years, 47–59 years and 65–75 years). The maximum wrinkle depth (Rmax) of an eye corner wrinkle was obtained. On an ultrasound image, which was captured by scanning perpendicular to the wrinkle, we set a 12.5-mm-wide region of interest (ROI) by ...

Relationship between the echogenicity of subcutaneous tissue and the depth of eye corner wrinkles is a post from: Skincare

Relationship between the echogenicity of subcutaneous tissue and the depth of eye corner wrinkles via BuzzBlazer.com

Photoaging under recreational sunbeds

Background: Artificial sources of restricted light wavelength, particularly tanning beds, are progressively gaining importance in photoaging.


Objective: To assess the kinetics and the long-term evolution of skin pigmentation and tensile functions in sunbed worshippers over a period of 8 years.


Methods: Photoaging was explored in women who were both sunshine and sunbed worshippers. A series of 65 phototype III women aged 31–46 years completed a 100-month survey. Quarterly assessments were performed on the forearms to measure (a) the skin color individual typology angle (ITA°), (b) the extent in mottled ...

Photoaging under recreational sunbeds is a post from: Skincare

Photoaging under recreational sunbeds via BuzzBlazer.com

Using human hair follicle-derived keratinocytes and melanocytes for constructing pigmented tissue-engineered skin

Background: Traditional tissue-engineered skin does not produce a satisfactory long-term result because it lacks natural skin pigmentation and leads to discolored cosmetically unpleasing skin that only functions to cover the body of patients. Additionally, the cell sources for tissue-engineered skin are generally derived from normal skin, which is often limited in patients with skin defects.


Methods: In this study, hair follicle melanocytes and keratinocytes were isolated from human scalp. The melanocytes were co-cultured with keratinocytes until the second passage and then purified. Purified melanocytes and keratinocytes were seeded onto ...

Using human hair follicle-derived keratinocytes and melanocytes for constructing pigmented tissue-engineered skin is a post from: Skincare

Using human hair follicle-derived keratinocytes and melanocytes for constructing pigmented tissue-engineered skin via BuzzBlazer.com

Histological classification of melasma with reflectance confocal microscopy: a pilot study in Chinese patients

Objective: To investigate the histological classification of melasma with reflectance confocal microscopy (RCM) in vivo.


Methods: Two hundred and ten cases with facial melasma lesions were enrolled. After informed consent, the target melasma lesion of 10 patients were imaged with RCM and then biopsied as well. Under the RCM scanning, the distribution of the melanin determined the histological types, and then, the results of RCM images were compared with those of the histopathology. The other 200 cases were tested only with RCM.


Results: For the 10 cases imaged and ...

Histological classification of melasma with reflectance confocal microscopy: a pilot study in Chinese patients is a post from: Skincare

Histological classification of melasma with reflectance confocal microscopy: a pilot study in Chinese patients via BuzzBlazer.com

Imaging of the skin and subcutaneous tissue using classical and high-frequency ultrasonographies in anti-cellulite therapy

Background: The development of ultrasonography allowed for skin imaging used in dermatology and esthetic medicine. By means of classic and high-frequency ultrasonographies, changes within the dermis and subcutaneous tissue can be presented.


Objective: The aim of this study was to show the possibilities of applying classic and high-frequency ultrasonographies in esthetic dermatology based on monitoring various types of anti-cellulite therapies.


Methods: Sixty-one women with cellulite were assigned to two smaller groups. One group was using anti-cellulite cream and the second group was a placebo group. The ultrasound examination was ...

Imaging of the skin and subcutaneous tissue using classical and high-frequency ultrasonographies in anti-cellulite therapy is a post from: Skincare

Imaging of the skin and subcutaneous tissue using classical and high-frequency ultrasonographies in anti-cellulite therapy via BuzzBlazer.com

Quality of life and sexual health in patients with genital psoriasis

Abstract

Background:  Knowledge with respect to quality of life and sexual health in patients with genital psoriasis is limited.


Objectives:  We studied the quality of life and sexual function in a large group of patients with genital psoriasis by means of validated questionnaires. In addition, we evaluated whether there is sufficient attention for sexual problems among medical professionals according to psoriatic patients.


Methods:  A self-administered questionnaire was sent to 1579 members of the Dutch Psoriasis Association. Sociodemographic patient characteristics, medical data and scores of several validated questionnaires regarding quality of life (Dermatology Life ...

Quality of life and sexual health in patients with genital psoriasis is a post from: Skincare

Quality of life and sexual health in patients with genital psoriasis via BuzzBlazer.com

Systemic anti-psoriatic therapy may reverse endothelial dysfunction

Systemic anti-psoriatic therapy may reverse endothelial dysfunction is a post from: Skincare

Systemic anti-psoriatic therapy may reverse endothelial dysfunction is a post from: Skincare

Systemic anti-psoriatic therapy may reverse endothelial dysfunction via BuzzBlazer.com

Systemic anti-psoriatic therapy may reverse endothelial dysfunction: Reply from authors

Systemic anti-psoriatic therapy may reverse endothelial dysfunction: Reply from authors is a post from: Skincare

Systemic anti-psoriatic therapy may reverse endothelial dysfunction: Reply from authors is a post from: Skincare

Systemic anti-psoriatic therapy may reverse endothelial dysfunction: Reply from authors via BuzzBlazer.com

An exceptional mutational event leading to Chanarin Dorfman syndrome in a large consanguineous family

An exceptional mutational event leading to Chanarin Dorfman syndrome in a large consanguineous family is a post from: Skincare

An exceptional mutational event leading to Chanarin Dorfman syndrome in a large consanguineous family is a post from: Skincare

An exceptional mutational event leading to Chanarin Dorfman syndrome in a large consanguineous family via BuzzBlazer.com

Contact allergy to preservatives. Analysis of IVDK data 1996 – 2009

Abstract

Objective:  To examine the frequency of sensitization to preservatives, including time trends.


Methods:  Retrospective analysis of data on patch testing preservatives contained in the standard series and special series collected by the IVDK 1996-2009.


Results:  Some 120,000 and 80,000 patients were tested with the baseline and the preservative series, respectively. Sensitization frequencies of the standard series allergens all ranged above 1%: Methyldibromo glutaronitrile (MDBGN) 2.36 – 4.5%, methyl(chloro)isothiazolinone (MCI/MI) 2.22%, formaldehyde 1.54%, paraben mix 1.33% and Bronopol ™ 1.25%. Regarding the special preservative series, 1.54% reacted positive to methylisothiazolinone (MI), and less ...

Contact allergy to preservatives. Analysis of IVDK data 1996 – 2009 is a post from: Skincare

Contact allergy to preservatives. Analysis of IVDK data 1996 – 2009 via BuzzBlazer.com

Elevated levels of TNF-α, IL-1β and IL-10 in hidradenitis suppurativa skin; a rationale for targeting TNF-α and IL-1β

Summary

Background:  The pathogenesis of hidradenitis suppurativa (HS) is largely unknown and the disease is difficult to treat. Patients are in high need of an effective treatment. Although it is not known whether the levels of TNF-α are aberrant in HS skin, anti-TNF-α biologics are used, with variable clinical efficacy.


Objectives:  To determine the cytokine profile in lesional and perilesional HS skin.


Methods:  We cultured 20 lesional, 10 normal appearing perilesional HS skin samples, 7 psoriasis and 6 healthy control skin samples in a transwell culture system. Two distinct cytokine bead arrays were ...

Elevated levels of TNF-α, IL-1β and IL-10 in hidradenitis suppurativa skin; a rationale for targeting TNF-α and IL-1β is a post from: Skincare

Elevated levels of TNF-α, IL-1β and IL-10 in hidradenitis suppurativa skin; a rationale for targeting TNF-α and IL-1β via BuzzBlazer.com

An extraordinary “sunburn” in a black patient

An extraordinary “sunburn” in a black patient is a post from: Skincare

An extraordinary “sunburn” in a black patient is a post from: Skincare

An extraordinary “sunburn” in a black patient via BuzzBlazer.com

A novel technique for chitosan microparticle preparation using a water/silicone emulsion: green tea model

Synopsis

Many effective methods such as spray drying, coacervation, ionic gelation, solvent evaporation and sieving have been suggested for entrapping bioactive compounds into micro- or nanoparticles. However, those methods still have some limitations owing to high temperature requirement, difficulty in particle harvesting or low entrapment for uncharged molecules. In this study, a novel chitosan microparticle preparation method was developed using water-in-silicone emulsion technique with green tea extract as a model active compound. Chitosan microparticles of diameter <5 μm were obtained from 2% chitosan solution with tripolyphosphate (TPP) solution as the hardening agent. ...

A novel technique for chitosan microparticle preparation using a water/silicone emulsion: green tea model is a post from: Skincare

A novel technique for chitosan microparticle preparation using a water/silicone emulsion: green tea model via BuzzBlazer.com

Unilateral livedo reticularis after kidney graft embolization with polyvinyl alcohol microspheres.

Unilateral livedo reticularis after kidney graft embolization with polyvinyl alcohol microspheres. is a post from: Skincare

Unilateral livedo reticularis after kidney graft embolization with polyvinyl alcohol microspheres. is a post from: Skincare

Unilateral livedo reticularis after kidney graft embolization with polyvinyl alcohol microspheres. via BuzzBlazer.com

Cardiovascular safety of ustekinumab in patients with moderate-to-severe psoriasis: Results of integrated analyses of data from phase II and III clinical studies

Abstract

Background:  Psoriasis patients are believed to be at an increased risk of cardiovascular (CV) morbidity, and the effect of biological agents on CV safety is not fully understood.


Objective:  To evaluate the effect of ustekinumab on CV events using detailed analyses of pooled data from the phase II/III clinical studies of its use in moderate-to-severe psoriasis.


Methods:  The incidence of major adverse CV events (MACE; myocardial infarction [MI], stroke, or CV death) is reported. Meta-analyses using risk difference and odds ratio (OR) estimates are presented based on data collected during the placebo-controlled ...

Cardiovascular safety of ustekinumab in patients with moderate-to-severe psoriasis: Results of integrated analyses of data from phase II and III clinical studies is a post from: Skincare

Cardiovascular safety of ustekinumab in patients with moderate-to-severe psoriasis: Results of integrated analyses of data from phase II and III clinical studies via BuzzBlazer.com

Role of interleukin-17 in the pathogenesis of vitiligo

Summary

Background.  Skewing of the immune response towards T helper (Th)1 or Th17 and away from regulatory T cells (Tregs) and Th2 cells may be responsible for the development and progression of autoimmune disease. An autoimmune theory has been proposed in the pathogenesis of vitiligo. No previous reports have investigated alterations in IL-17 produced by Th17 cells in lesional skin in vitiligo.


Aim.  To investigate the role of IL-17 in the pathogenesis of vitiligo by assessing its levels in lesional skin and serum of patients with vitiligo compared with controls.


Methods.  In total, ...

Role of interleukin-17 in the pathogenesis of vitiligo is a post from: Skincare

Role of interleukin-17 in the pathogenesis of vitiligo via BuzzBlazer.com

Evidence for the absence of mutations at GJB3, GJB4 and LOR in progressive symmetrical erythrokeratodermia

Summary

Background.  Progressive symmetrical erythrokeratodermia (PSEK) is a rare inherited cornification disorder characterized by symmetrical erythematous hyperkeratotic plaques. The genetic basis for PSEK is not clear. PSEK shares many clinical features with erythrokeratodermia variabilis (EKV), which is associated with mutations in genes coding for gap junction beta (GJB) 3 and 4. A mutation in the loricrin gene (LOR) was found in patients with PSEK, who were members of a family with Vohwinkel syndrome. It would therefore be of interest to determine if PSEK is also caused by mutations in these genes.


Aim.  ...

Evidence for the absence of mutations at GJB3, GJB4 and LOR in progressive symmetrical erythrokeratodermia is a post from: Skincare

Evidence for the absence of mutations at GJB3, GJB4 and LOR in progressive symmetrical erythrokeratodermia via BuzzBlazer.com

New homozygous SPINK5 mutation, p.Gln333X, in a Turkish pedigree with Netherton syndrome

Summary

Netherton syndrome (NS) is a rare autosomal recessive genodermatosis caused by loss-of-function mutations in the SPINK5 gene. The clinical features include congenital ichthyosis, trichorrhexis invaginata and atopy. In this study, we report a new homozygous SPINK5 mutation, p.Gln333X, responsible for NS in affected members of two closely related Turkish families, and provide an overview of the genotype–phenotype correlation in this condition.

New homozygous SPINK5 mutation, p.Gln333X, in a Turkish pedigree with Netherton syndrome is a post from: Skincare

New homozygous SPINK5 mutation, p.Gln333X, in a Turkish pedigree with Netherton syndrome is a post from: Skincare

New homozygous SPINK5 mutation, p.Gln333X, in a Turkish pedigree with Netherton syndrome via BuzzBlazer.com

Unusual presentation of onychomycosis caused by Exophiala (Wangiella) dermatitidis

Unusual presentation of onychomycosis caused by Exophiala (Wangiella) dermatitidis is a post from: Skincare

Unusual presentation of onychomycosis caused by Exophiala (Wangiella) dermatitidis is a post from: Skincare

Unusual presentation of onychomycosis caused by Exophiala (Wangiella) dermatitidis via BuzzBlazer.com

Local complications of erysipelas: a study of associated risk factors

Summary

Background.  Local complications of erysipelas include haemorrhagic, bullous, abscessing and necrotic lesions. The risk factors predisposing patients to local complications are not fully known.


Aim.  To examine local complications of erysipelas and to identify possible risk factors predisposing to their appearance.


Methods.  Medical records from all patients hospitalized with complications of erysipelas (purpura, bullae, abscesses and necrosis), admitted to the University Hospital of Heraklion between 1994 and 2002, were retrospectively studied. Clinical and laboratory data were compared with those from patients with erysipelas without local complications.


Results.  In total, 145 patients were analysed, ...

Local complications of erysipelas: a study of associated risk factors is a post from: Skincare

Local complications of erysipelas: a study of associated risk factors via BuzzBlazer.com

Autoimmune progesterone dermatitis: a diagnosis easily missed

Summary

Autoimmune progesterone dermatitis (AIPD) is a rare, poorly characterized dermatosis, with about 60 previously reported cases. It typically undergoes cyclical flares relating to the menstrual cycle, especially the luteal phase, when levels of progesterone are at their highest. We report the case of a 34-year-old woman with an 8-year history of a profoundly pruritic eruption, associated with her menstrual cycle, in whom the diagnosis had proved elusive. Buserelin nasal spray resulted in complete clearance. AIPD is a diagnosis to consider in intractable eruptions in women, particularly if there is cyclical ...

Autoimmune progesterone dermatitis: a diagnosis easily missed is a post from: Skincare

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Estimation of (IgA) anti-gliadin, anti-endomysium and tissue transglutaminase in the serum of patients with psoriasis

Summary

Studies have indicated an association between psoriasis and coeliac disease (CD), an immune-mediated gluten-dependent enteropathy; however, the precise relationship between psoriasis and CD remains controversial. We aimed to assess the prevalence of the CD-associated IgA antibodies antigliadin antibody (AGA), tissue transglutaminase (tTG) and antiendomysium antibody (EMA) in patients with psoriasis. In total, 41 patients with psoriasis and 41 healthy controls were enrolled in this study. Blood samples were taken from all participants, and screened for AGA, tTG and EMA. We found a significantly higher level of AGA in patients with ...

Estimation of (IgA) anti-gliadin, anti-endomysium and tissue transglutaminase in the serum of patients with psoriasis is a post from: Skincare

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Immunofluorescence of the outer root sheath: an aid to diagnosis in pemphigus

Summary

Background.  The direct immunofluorescence (DIF) pattern of the outer root sheath (ORS) of the hair follicle in patients with pemphigus resembles that of perilesional skin. We performed DIF on anagen and telogen hair ORS from patients with pemphigus and compared the findings with those of perilesional skin.


Aim.  To assess the sensitivity of DIF in the ORS of anagen and telogen hair in patients with pemphigus with positive DIF results in perilesional skin.


Methods.  In total, 50 patients with active pemphigus and positive DIF findings in perilesional skin were selected for the ...

Immunofluorescence of the outer root sheath: an aid to diagnosis in pemphigus is a post from: Skincare

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A Japanese-specific recurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa

Summary

Background.  Herlitz junctional epidermolysis bullosa (H-JEB) is an extremely rare genodermatosis characterized by lethality owing to severe blister formation. We report two unrelated Japanese patients with H-JEB. Genetic analyses detected a single nonsense mutation on the LAMC2 gene in these two patients.


Aim.  To identify the mutation involved and describe the first reported Japanese recurrent mutation in the LAMC2 gene.


Methods.  Direct sequencing was performed of DNA from either peripheral blood or fetal cells in amniotic fluid. Reverse transcriptase PCR was used to confirm that an aberrant transcript resulted from the splice ...

A Japanese-specific recurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa is a post from: Skincare

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Effects of p-coumaric acid on erythema and pigmentation of human skin exposed to ultraviolet radiation

Summary

Background.  It has been recently recognized that p-coumaric acid (PCA) is a strong inhibitor of cellular melanogenesis.


Aim.  To evaluate the erythema-suppressive and skin-lightening effects of PCA after topical application to human skin.


Methods.  The control and PCA cream products were applied twice daily to the skin of the forearm of 21 subjects before and after ultraviolet (UV) irradiation to determine whether they could prevent erythema formation and pigmentation. The cream products were also applied to different areas only after the induction of erythema or pigmentation to determine whether they could have ...

Effects of p-coumaric acid on erythema and pigmentation of human skin exposed to ultraviolet radiation is a post from: Skincare

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Non-Invasive Genomic Detection of Melanoma

Summary

Background:  Early detection and treatment of melanoma is important for optimal clinical outcome, leading to biopsy of pigmented lesions deemed suspicious for the disease. The vast majority of such lesions are benign. Thus, a more objective and accurate means for detection of melanoma is needed to identify lesions for excision.


Objective:  The goal of this study is to provide proof-of-principal that epidermal genetic information retrieval (EGIRTM), a method that non-invasively samples cells from stratum corneum by means of adhesive tape stripping, can be used to discern melanomas from nevi.


Methods:  Skin overlying ...

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A retrospective study of patch tests in Chongqing, China from 2004 to 2009

Background. There has been no previous report on allergens responsible for dermatitis in southwest China.


Objective. To investigate the prevalence of contact allergy in southwest China, we retrospectively analysed the patch testing results in our department from 2004 to 2009.


Methods. A total of 2758 patients were patch tested with the Chinese baseline series of contact allergens (Beijing Medical University), the most common baseline series used in China. The results from patch tests were collected, analysed, and compared with clinical findings.


Results. Of 2758 patients tested, 1826 (66.2%) were allergic to one or ...

A retrospective study of patch tests in Chongqing, China from 2004 to 2009 is a post from: Skincare

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Textile allergy – the Melbourne experience

Background. Textile allergy is a well-established entity, but there are relatively few Australian reports in this area.


Objectives. To report the combined experience of textile contact dermatitis from the general and occupational contact dermatitis clinics at the Skin and Cancer Foundation, Melbourne, Victoria, Australia.


Patients/Methods. On the basis of the clinical suspicion of textile allergy, 2069 patients were tested with a textile series.


Results. One hundred and fifty-seven (7.6%) patients reacted to any of the textile-related allergens. The most common allergen was Basic Red 46 (20.2% of the positive reactions), followed by Disperse ...

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The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials

Background. Diazolidinyl urea is a formaldehyde-releasing compound that releases formaldehyde through its decomposition. However, there have been few reports about the decomposition properties of diazolidinyl urea in cosmetics and patch test materials.


Objectives. The aim of this study was to show how diazolidinyl urea decomposes in cosmetics and patch test vehicles, and to determine which cosmetic compounds should be evaluated in patch test studies of diazolidinyl urea.


Method. We fractionated diazolidinyl urea-dissolving buffers or diazolidinyl urea-containing cosmetics with high-performance liquid chromatography–photodiode array detector (HPLC-PDA), and characterized them in liquid chromatography–mass spectrometry (LC-MS) ...

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Influence of Notch System In The Therapeutic Response Of American Tegumentary Leishmaniasis

Abstract

Background:  American Tegumentary Leishmaniasis (ATL) evolution and therapeutic outcome depend upon many factors, including the balance between Th1 and Th2 cytokines to control parasite multiplication and the lesion extension. Other cytokines known for their role in inflammatory processes such as IL-17 or IL-18 as well as factors controlling keratinocyte differentiation and the inflammatory process in the skin, like Notch system, could also be involved in the disease outcome. Notch receptors are a group of transmembrane proteins that regulate cell fate decisions during development and adulthood in many tissues, including keratinocyte ...

Influence of Notch System In The Therapeutic Response Of American Tegumentary Leishmaniasis is a post from: Skincare

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Expression of tachykinins and their receptors in plaque psoriasis with pruritus

Summary

Background  Various mediators of pruritus have been suggested to be responsible for the mechanism of pruritus in psoriasis.


Objectives  The aim was to study the expression of members within the tachykinin family, substance P and neurokinin (NK) A and their receptors (R), NK-1 and NK-2 in psoriasis and to correlate their expression to the intensity of pruritus. A possible correlation with chronic stress and depression was also evaluated.


Methods  Biopsies were obtained from 28 patients with chronic plaque psoriasis, the majority having pruritus. The samples were taken from the lesional and non-lesional ...

Expression of tachykinins and their receptors in plaque psoriasis with pruritus is a post from: Skincare

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Reflectance Confocal Microscopy can differentiate dermoscopic white dots of the scalp between sweat glands ducts or follicular infundibulum

Reflectance Confocal Microscopy can differentiate dermoscopic white dots of the scalp between sweat glands ducts or follicular infundibulum is a post from: Skincare

Reflectance Confocal Microscopy can differentiate dermoscopic white dots of the scalp between sweat glands ducts or follicular infundibulum is a post from: Skincare

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A case of taxane-induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis

A case of taxane-induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis is a post from: Skincare

A case of taxane-induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis is a post from: Skincare

A case of taxane-induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis via BuzzBlazer.com

The N-terminal amino acid of apolipoprotein D is putatively covalently bound to 3-hydroxy-3-methyl hexanoic acid, a key odour compound in axillary sweat

Synopsis

Axillary sweat is odourless when freshly collected at the surface of human skin, but it contains non-odoriferous precursors, which can be transformed into odorous substances by bacteria. E-3-methyl-2-hexanoic acid (3M2H) is one of the key odorous substances, but there are two contradictory reports about its precursor form. One report states that 3M2H linked non-covalently to apolipoprotein D (apoD) is the precursor, while a second report states that 3M2H–Gln identified in human axillary sweat is the precursor. Recently, 3-hydroxy-3-methyl hexanoic acid (HMHA) and 3-methyl-3-sulfanylhexane-1-ol (3M3T) have also been identified and reported ...

The N-terminal amino acid of apolipoprotein D is putatively covalently bound to 3-hydroxy-3-methyl hexanoic acid, a key odour compound in axillary sweat is a post from: Skincare

The N-terminal amino acid of apolipoprotein D is putatively covalently bound to 3-hydroxy-3-methyl hexanoic acid, a key odour compound in axillary sweat via BuzzBlazer.com

Age-related changes in skin mechanical properties: a quantitative evaluation of 120 female subjects

Background/purpose: The most commonly used method to determine the mechanical ability of skin is the creep test using suction chamber devices. Until now, there is no scientific consensus upon which skin deformation parameters and which body sites are particularly suitable to describe age-related changes in human skin mechanics. The aim of this study was to find those mechanical skin parameters best representing influence of aging at five different body sites.


Methods: A total of 120 healthy women aged 18–65, divided into four similar age groups, were included in this ...

Age-related changes in skin mechanical properties: a quantitative evaluation of 120 female subjects is a post from: Skincare

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A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21

Summary

Background  Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression.


Objectives  The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis.


Methods  Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom® MassArray™ iPLEX Gold platform.


Results  We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3.3 x 10−4; rs2069778 genotypic P = 7.86 x ...

A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21 is a post from: Skincare

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Geographical, urban/rural and socio-economic variations in nonmelanoma skin cancer incidence: a population-based study in Ireland

Summary

Background  Nonmelanoma skin cancer (NMSC) is the most common cancer in white populations worldwide. International comparisons in incidence are limited because few registries collect comprehensive population-based data.


Objectives  We describe spatial, urban/rural and socio-economic variations in NMSC incidence in Ireland, overall and for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) separately.


Methods  NMSC cases (n = 47 347) diagnosed during 1994–2003 were extracted from the National Cancer Registry. Each case was allocated to a small area (electoral district, ED) based on address at diagnosis. Standardized incidence ratios (SIRs) were calculated and ...

Geographical, urban/rural and socio-economic variations in nonmelanoma skin cancer incidence: a population-based study in Ireland is a post from: Skincare

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Efficacy of high doses of Botulinum toxin A for treating provoked vestibulodynia

Summary

Background:  Provoked vestibulodynia is difficult to treat. The beneficial effects of botulinum toxin are being considered due to the muscular anomalies observed in this pathology.


Objective:  We aim to evaluate the efficacy of botulinum toxin A in the treatment of provoked vestibulodynia.


Methods:  Patients aged between 18 and 60 presenting with provoked vestibulodynia (according to the 2003 ISSVD classification) received 50 units of botulinum toxin A bilaterally in the bulbospongiosus muscle under electromyographic monitoring. Pain was evaluated by a visual analogue scale, quality of life was evaluated by the Dermatology Life Quality ...

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Item of correspondence

Item of correspondence is a post from: Skincare

Item of correspondence is a post from: Skincare

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Benefit of a topical slimming cream in conjunction with dietary advice

Synopsis

The aim of this study was to determine how worthwhile it would be to combine a newly developed topical slimming product with customized dietary habits not based on calorie restriction, so as to improve the cellulite appearance of the skin. At the beginning of the study, a nutritionist recorded the dietary habits of each participant and gave recommendations to each of them according to their food consumption. The chosen methodology was a right/left comparison, one thigh and hip being treated with the new topical slimming product and the other one ...

Benefit of a topical slimming cream in conjunction with dietary advice is a post from: Skincare

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Relation between facial morphology, personality and the functions of facial make-up in women

Synopsis

Our external appearance plays a key role in everyday life’s social interactions. Hence, taking care of our appearance allows us to adjust and protect ourselves, as well as communicate emotional disposition (i.e. sympathy or aversion) and social information (i.e. values, status). However, some discrete body parts or characteristics appear to be more salient than others in contributing to global body image. For example, authors showed that facial attractiveness is one of the best predictors of overall physical attractiveness and represent one of the primary factors influencing global self-esteem. Make-up is ...

Relation between facial morphology, personality and the functions of facial make-up in women is a post from: Skincare

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Sex difference in human fingertip recognition of micron-level randomness as unpleasant

Synopsis

We investigated sex difference in evaluation, using the human fingertip, of the tactile impressions of three different micron-scale patterns laser-engraved on plastic plates. There were two ordered (periodical) patterns consisting of ripples on a scale of a few micrometres and one pseudo-random (non-periodical) pattern; these patterns were considered to mimic the surface geometry of healthy and damaged human hair, respectively. In the first experiment, 10 women and 10 men ran a fingertip over each surface and determined which of the three plates felt most unpleasant. All 10 female participants reported ...

Sex difference in human fingertip recognition of micron-level randomness as unpleasant is a post from: Skincare

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Standardized extract of Syzygium aqueum: a safe cosmetic ingredient

Synopsis

Syzygium aqueum, a species in the Myrtaceae family, commonly called the water jambu is native to Malaysia and Indonesia. It is well documented as a medicinal plant, and various parts of the tree have been used in traditional medicine, for instance as an antibiotic. In this study, we show S. aqueum leaf extracts to have a significant composition of phenolic compounds, protective activity against free radicals as well as low pro-oxidant capability. Its ethanolic extract, in particular, is characterized by its excellent radical scavenging activity of EC50 of 133 μg mL−1 1,1-diphenyl-2-picryl-hydrazyl (DPPH), ...

Standardized extract of Syzygium aqueum: a safe cosmetic ingredient is a post from: Skincare

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Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone-3

Synopsis

Nanostructured lipid carriers (NLCs) are potential active delivery systems based on mixtures of solid lipids and liquid oil. In this paper, aqueous dispersions of NLCs were prepared by a hot high-pressure homogenization technique using carnauba wax as the solid lipid and isodecyl oleate as the liquid oil. The preparation and stability parameters of benzophenone-3-loaded NLCs have been investigated concerning particle size, zeta potential and loading capacity to encapsulate benzophenone-3, a molecular sunscreen. The current investigation illustrates the effect of the composition of the lipid mixture on the entrapment efficiency, in ...

Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone-3 is a post from: Skincare

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Characterizing the composition of underarm and forearm skin using confocal raman spectrscopy

Synopsis

Many studies have reported differences in skin composition as a function of body site and age. However, rarely has axilla (underarm) skin been included in these studies. This report highlights the results of a clinical study where confocal Raman spectroscopy was used to assess the differences between underarm and volar forearm skin. In the reported study, the concentration of natural moisturizing factor (NMF), urea, lactic acid, cholesterol, trans urocanic acid (t-UCA) and ceramide 3 (N-octadecanoyl-phytosphingosine) was evaluated as a function of depth, body site (underarm vs. forearm) and age. Two ...

Characterizing the composition of underarm and forearm skin using confocal raman spectrscopy is a post from: Skincare

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ESR study of photoinduced free radicals by visible light in hair and the effects of ascorbic acid (vitamin C)

Synopsis

The ESR spectra of melanin’s free radicals in natural black and red hair have been investigated. It is shown that the ESR spectrum of black hair is slightly asymmetric singlet with g = 2.0037 and ΔH = 0.5 mTl. The ESR spectrum of red hair with g = 2.0053 differs from the spectrum of black hair. Using the method of saturation was shown that ESR spectrum of red hair represents a superposition of two signals: a singlet, relating to the black hair, and a triplet from red hair’s pheomelanin. Under the influence of visible light (blue with ...

ESR study of photoinduced free radicals by visible light in hair and the effects of ascorbic acid (vitamin C) is a post from: Skincare

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Lifting properties of the alkamide fraction from the fruit husks of Zanthoxylum bungeanum

Synopsis

The fruits of various Zanthoxylum species are used as a spice in the Chinese and Japanese cuisine because of their delicate flavour and tingling properties. The lipophilic hydroxyalkamides hydroxy α- and β-sanshools (1a,b) have been identified as the tingling principles of these plants, and previous studies have validated a sanshool-rich lipophilic extract from the fruit husks of Z. bungeanum Maxim. (Zanthalene®) as an anti-itching cosmetic ingredient. Because tingling is a sort of ‘paralytic pungency’, and Zanthalene® potently inhibits synaptic transmission, we have investigated its capacity to relax subcutaneous muscles and act ...

Lifting properties of the alkamide fraction from the fruit husks of Zanthoxylum bungeanum is a post from: Skincare

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