Earlobe Keloids: Classification According to Gross Morphology Determines Proper Surgical Approach

Background

A previous study described the outcomes of a treatment protocol using a prospective design and identified three clinical risk factors for recurrent keloids.



Objective

To introduce a novel classification of earlobe keloids through a retrospective study and describe the appropriate surgical methods according to this new classification.



Methods

One thousand twenty-seven earlobe keloids were treated at Kangbuk Samsung Hospital from March 2001 to February 2011. All cases were studied retrospectively and classified.



Results

The earlobe keloids were classified into five groups. The frequency of earlobe keloids in descending order were a sessile type, single nodular pattern; ...

Earlobe Keloids: Classification According to Gross Morphology Determines Proper Surgical Approach is a post from: Skincare

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White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics

White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics is a post from: Skincare

White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics is a post from: Skincare

White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics via BuzzBlazer.com

Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation

Abstract

Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive hereditary disorder that is characterized by having both sensory neuropathy and anhidrosis. A 6-year-old Japanese boy presented with recurrent fever, lack of sweating, occult bone fractures and impaired pain sensation without mental retardation. Genetic analyses revealed compound heterozygous mutations in the NTRK1 gene that encodes TrkA, which is a receptor for nerve growth factor. While there were no apparent changes in the patient’s dermal eccrine glands, the quantitative sudomotor axon reflex test with acetylcholine chloride revealed a complete loss ...

Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation is a post from: Skincare

Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation via BuzzBlazer.com

An Ectodysplasin A receptor (EDAR) founder mutation results in a high frequency of the autosomal recessive form of Hypohidrotic Ectodermal Dysplasia in India

Abstract:

Background:  Hypohidrotic/anhydrotic ectodermal dysplasia (HED) is a rare mendelian disorder affecting ectodermal tissues. The disease is primarily caused by inactivation of any one of three genes viz. Ectodysplasin A1 (EDA-A1) which encodes a ligand belonging to the Tumor Necrosis Factor (TNF) super family; Ectodysplasin A receptor (EDAR) encoding the EDA-A1 receptor and Ectodysplasin A receptor associated death domain (EDARADD) encoding an adaptor protein. X-linked recessive (EDA-A1), the predominant form of HED, as well as autosomal recessive and dominant (EDAR and EDARADD) inheritance patterns have been identified in affected families.


Objectives:  To ...

An Ectodysplasin A receptor (EDAR) founder mutation results in a high frequency of the autosomal recessive form of Hypohidrotic Ectodermal Dysplasia in India is a post from: Skincare

An Ectodysplasin A receptor (EDAR) founder mutation results in a high frequency of the autosomal recessive form of Hypohidrotic Ectodermal Dysplasia in India via BuzzBlazer.com

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness

Summary

Background:  Male-pattern baldness (androgenetic alopecia, AGA) is the most common form of hair loss among humans. Research has shown that it is caused by genetic factors. Numerous studies have unequivocally identified two major genetic risk loci for AGA: the X-chromosomal AR/EDA2R-locus; and the PAX1/FOXA2-locus on chromosome 20.


Objectives:  To identify further candidate genes for AGA, and thus gain further insights into this phenotype.


Methods:  A German sample of 581 severely affected cases and 617 controls was used to perform a genome-wide association study. The identified associated locus was further analyzed by fine-mapping, ...

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness is a post from: Skincare

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness via BuzzBlazer.com

Halo nevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo

Abstract

Background:  Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and non-segmental vitiligo, has been rarely reported.


Objective:  The aim of this study was to search for factors associated with the generalization of vitiligo in patients with segmental vitiligo.


Patients and Methods:  This was a prospective observational study conducted in the vitiligo clinic of the department of dermatology of Bordeaux, France. The Vitiligo European Task Force questionnaire was informed for each patient attending the clinic with a confirmed diagnosis of segmental vitiligo after ...

Halo nevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo is a post from: Skincare

Halo nevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo via BuzzBlazer.com

Light Activated Tissue Bonding for Excisional Wound Closure: A Split-Lesion Clinical Trial

Summary

Background:  Apposition of wound edges by sutures provides a temporary scaffold and tension support for healing. We have developed a novel tissue sealing technology, photoactivated tissue bonding (PTB) that immediately cross-links proteins between tissue planes thereby sealing on a molecular scale.


Objectives:  To determine the effectiveness of PTB for superficial closure of skin excisions and to compare the results to standard epidermal suturing.


Methods:  A split-lesion, paired comparison study of 31 skin excisions was performed. Following deep closure with absorbable sutures, one-half of each wound was superficially closed with non-absorbable nylon sutures ...

Light Activated Tissue Bonding for Excisional Wound Closure: A Split-Lesion Clinical Trial is a post from: Skincare

Light Activated Tissue Bonding for Excisional Wound Closure: A Split-Lesion Clinical Trial via BuzzBlazer.com

An Exploratory 1H-NMR Metabolomics Study Reveals Altered Urine Spectral Profiles in Infants with Atopic Dermatitis

An Exploratory 1H-NMR Metabolomics Study Reveals Altered Urine Spectral Profiles in Infants with Atopic Dermatitis is a post from: Skincare

An Exploratory 1H-NMR Metabolomics Study Reveals Altered Urine Spectral Profiles in Infants with Atopic Dermatitis is a post from: Skincare

An Exploratory 1H-NMR Metabolomics Study Reveals Altered Urine Spectral Profiles in Infants with Atopic Dermatitis via BuzzBlazer.com

Efficacy and safety of adalimumab when added to inadequate therapy for the treatment of psoriasis: results of PRIDE, an open-label, multicentre, phase IIIb study

Abstract

Background  Adalimumab is an effective treatment for chronic plaque psoriasis.


Objective  To evaluate the safety and efficacy of adalimumab for psoriasis patients who did not adequately respond to prior psoriasis therapy.


Methods  PRIDE (an Open-Label Access PRogram to Evaluate the Safety and Effectiveness of Adalimumab When Added to InaDEquate Therapy for the Treatment of Psoriasis) was a multicentre, Phase IIIb study in Canada. Patients with active moderate-to-severe plaque psoriasis who failed to respond to, or were intolerant of, prior therapies received adalimumab 80 mg at Week 0 followed by adalimumab 40 mg every other ...

Efficacy and safety of adalimumab when added to inadequate therapy for the treatment of psoriasis: results of PRIDE, an open-label, multicentre, phase IIIb study is a post from: Skincare

Efficacy and safety of adalimumab when added to inadequate therapy for the treatment of psoriasis: results of PRIDE, an open-label, multicentre, phase IIIb study via BuzzBlazer.com

Dermatitis herpetiformis in China: a report of 22 cases

Abstract

Background  Although dermatitis herpetiformis (DH) is a relatively common disease in Caucasian populations, it is very rare in the Far East, including China.


Objectives  To investigate the clinical, histological and immunopathological characteristics of Chinese patients with DH.


Methods  The clinical data and serum samples of patients with DH diagnosed at Shandong Provincial Institute of Dermatology and Venereology from 2006 to 2010 were collected. Anti-endomysium antibodies (EMA) and anti-tissue transglutaminase (tTG) antibodies were tested using indirect immunofluorescence and enzyme-linked immunosorbent assay respectively. Biopsies of small intestine were performed in those patients who had ...

Dermatitis herpetiformis in China: a report of 22 cases is a post from: Skincare

Dermatitis herpetiformis in China: a report of 22 cases via BuzzBlazer.com

Cost-effectiveness evaluation of clobetasol propionate shampoo (CPS) maintenance in patients with moderate scalp psoriasis: a Pan-European analysis

Abstract

Background  Scalp psoriasis is a difficult to treat and usually chronic manifestation of psoriasis. The CalePso study showed that CPS (Clobex® Shampoo) in maintenance therapy of scalp psoriasis (twice weekly) significantly increases the probability of keeping patient under remission during 6 months, compared with vehicle (40.3% relapses vs. 11.6% relapses, ITT).


Objective  The objective of the study was to assess the cost-effectiveness of a maintenance therapy with CPS vs. its vehicle in nine European countries.


Methods  A 24-week decision tree model was developed with 4-weekly time steps. The considered population has moderate scalp ...

Cost-effectiveness evaluation of clobetasol propionate shampoo (CPS) maintenance in patients with moderate scalp psoriasis: a Pan-European analysis is a post from: Skincare

Cost-effectiveness evaluation of clobetasol propionate shampoo (CPS) maintenance in patients with moderate scalp psoriasis: a Pan-European analysis via BuzzBlazer.com

Skin Benefits of a Myconoside-rich extract from resurrection plant Haberlea rhodopensis

Synopsis

Resurrection plant Haberlea rhodopensis develops molecules to survive drought stress. These molecules allow the plant to resurge from a desiccation state. We have extracted a specific fraction from the plant (Haberlea extract) and found it rich, among other molecules, of a caffeoyl phenylethanoid glycoside called myconoside, a molecule extremely abundant in the plant with a potential role in survival. Peroxide-stressed normal human dermal fibroblasts treated with the Haberlea extract, showed increased collagen VI (+822%), collagen XVI (+928%) and elastin (+144%) mRNA synthesis, measured by RT-qPCR. This effect was superior to ...

Skin Benefits of a Myconoside-rich extract from resurrection plant Haberlea rhodopensis is a post from: Skincare

Skin Benefits of a Myconoside-rich extract from resurrection plant Haberlea rhodopensis via BuzzBlazer.com

Determining the Safety of Office-Based Surgery: What 10 Years of Florida Data and 6 Years of Alabama Data Reveal

Background

This is a continued examination of 10 years of prospectively collected Florida in-office adverse event data and new comparable data from mandatory Alabama in-office adverse event data reporting.



Objective

To determine which office surgical procedures have resulted in reported complications.



Methods

This study is a compilation of mandatory reporting of office surgical complications by Florida and Alabama physicians to a central agency. Reports resulting in death or a hospital transfer were further investigated over the telephone or on-line to determine the reporting physician’s board certification status, hospital privilege status, and office accreditation status.



Results

In 10 years in ...

Determining the Safety of Office-Based Surgery: What 10 Years of Florida Data and 6 Years of Alabama Data Reveal is a post from: Skincare

Determining the Safety of Office-Based Surgery: What 10 Years of Florida Data and 6 Years of Alabama Data Reveal via BuzzBlazer.com

Double-Blind, Randomized, Controlled Clinical Trial to Compare Safety and Efficacy of a Metallic Cannula with that of a Standard Needle for Soft Tissue Augmentation of the Nasolabial Folds

Background

Injection-related side effects and complications are likely to occur during or after filler injections; they are mainly caused by the injection technique.



Objective

To assess safety and efficacy of a metallic cannula to inject hyaluronic acid (HA) filler in the nasolabial folds and to compare the safety of this cannula with that of a standard needle.



Methods

This was a prospective, randomized, phase II, double-blinded study that included 25 participants with Grade 2 to 3 for bilateral nasolabial folds according to the Modified Fitzpatrick Wrinkle Scale (MFWS). The side of the injection was randomized ...

Double-Blind, Randomized, Controlled Clinical Trial to Compare Safety and Efficacy of a Metallic Cannula with that of a Standard Needle for Soft Tissue Augmentation of the Nasolabial Folds is a post from: Skincare

Double-Blind, Randomized, Controlled Clinical Trial to Compare Safety and Efficacy of a Metallic Cannula with that of a Standard Needle for Soft Tissue Augmentation of the Nasolabial Folds via BuzzBlazer.com

Combined Treatment with a Nonablative Infrared Device and Hyaluronic Acid Filler Does Not Have Enhanced Efficacy in Treating Nasolabial Fold Wrinkles

Background

Although hyaluronic acid (HA) fillers are extensively used for the correction of facial wrinkles and folds, there is a limit to patient satisfaction, especially in patients with severe wrinkles.



Objective

To evaluate the potential for synergistic effects with combined treatment using a nonablative infrared (IR) device and HA filler in the treatment of nasolabial fold (NLF) wrinkles.



Materials and Methods

This was a split-face randomized study in which 12 Korean patients were treated with HA filler on both NLFs and with a nonablative IR device on the experimental side of the face. Clinical evaluations ...

Combined Treatment with a Nonablative Infrared Device and Hyaluronic Acid Filler Does Not Have Enhanced Efficacy in Treating Nasolabial Fold Wrinkles is a post from: Skincare

Combined Treatment with a Nonablative Infrared Device and Hyaluronic Acid Filler Does Not Have Enhanced Efficacy in Treating Nasolabial Fold Wrinkles via BuzzBlazer.com

Laser-Assisted Lipolysis: A Review

Background

In the United States, liposuction is the most commonly performed cosmetic surgical procedure. Laser lipolysis is the latest adjunct to liposuction. This technique employs laser energy to induce lipolysis and hemostasis and stimulate neocollagenesis. Multiple laser systems have been studied.



Methods

PubMed literature search with the key words laser lipolysis and laser assisted liposuction. Original articles that studied the internal application of laser energy to adipose tissue were reviewed and included.



Results

Nineteen manuscripts were reviewed. One double-blind randomized controlled trial compared laser liposuction with tumescent liposuction. Several authors claimed that laser lipolysis offers ...

Laser-Assisted Lipolysis: A Review is a post from: Skincare

Laser-Assisted Lipolysis: A Review via BuzzBlazer.com

Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease

Abstract

Background  Oral lichen planus (OLP) is a chronic inflammatory disease for which the pathogenesis is not fully understood. OLP has autoimmune features and auto immunity has been suggested as a potential cause, whereas WHO has classified OLP as a premalignant condition. Association between chronic inflammation and cancer is known and chronic inflammation is one of the characteristics of OLP. A protein connected to inflammation and suggested to be involved in cancer development is cyclooxygenase-2 (COX-2) which can be inhibited by microRNA-26b (miR-26b).


Objective  The aim was to map levels of COX-2 ...

Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease is a post from: Skincare

Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease via BuzzBlazer.com

Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link

Abstract

Papulopustular rosacea (PPR) is a common facial skin disease, characterized by erythema, telangiectasia, papules and pustules. Its physiopathology is still being discussed, but recently several molecular features of its inflammatory process have been identified: an overproduction of Toll-Like receptors 2, of a serine protease, and of abnormal forms of cathelicidin.


The two factors which stimulate the Toll-like receptors to induce cathelicidin expression are skin infection and cutaneous barrier disruption: these two conditions are, at least theoretically, fulfilled by Demodex, which is present in high density in PPR and creates epithelial breaches ...

Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link is a post from: Skincare

Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link via BuzzBlazer.com

Routine FDG PET-CT in patients with a high-risk localized melanoma has a high predictive positive value for nodal disease and high negative predictive value for the presence of distant metastases

Abstract

Background  FDG PET-CT is the superior imaging modality for the detection of visceral metastases (M+) in patients with melanoma. Conflicting evidence exists regarding its role for the initial staging of patients with high risk localized melanoma (large Breslow Thickness (BT) and/or ulceration).


Objective  To assess the role of routine staging with FDG PET-CT in melanoma patients with localized high risk melanoma.


Methods  Forty-eight consecutive patients with 1 < BT < 4 mm with ulceration and with BT ≥ 4 mm were staged with PET-CT. PET-CT procedures were performed on a GE Discovery ST® scanner. PET-CT findings for regional nodal status ...

Routine FDG PET-CT in patients with a high-risk localized melanoma has a high predictive positive value for nodal disease and high negative predictive value for the presence of distant metastases is a post from: Skincare

Routine FDG PET-CT in patients with a high-risk localized melanoma has a high predictive positive value for nodal disease and high negative predictive value for the presence of distant metastases via BuzzBlazer.com

Cutaneous adverse drug reactions to allopurinol: 10 year observational survey of the dermatology department – cagliari university (Italy)

Abstract

Background  Allopurinol is extensively prescribed for conditions associated with urate excess, despite being responsible for severe cutaneous adverse drug reactions (ADR).


Objective  A cross-sectional survey of allopurinol cases observed at the main Dermatology Department with inpatients facilities in southern Sardinia. (approx 560 836 inhabitants).


Material and methods  Data collection of all consecutive patients referred for ADR between 2001 and 2010. Causality assessment followed the WHO Collaborating Centre for Drug Monitoring criteria; illness severity score was adopted for toxic epidermal necrolysis (SCORTEN).


Results  Allopurinol was the culprit drug in 84 of 780 cutaneous ADR cases ...

Cutaneous adverse drug reactions to allopurinol: 10 year observational survey of the dermatology department – cagliari university (Italy) is a post from: Skincare

Cutaneous adverse drug reactions to allopurinol: 10 year observational survey of the dermatology department – cagliari university (Italy) via BuzzBlazer.com

Skin surface hydration decreases rapidly during long distance flights

Introduction

Dehydration of the stratum corneum leads to sensations and symptoms of ‘dry skin’ such as skin tightness and itchiness. As these complaints are frequently experienced by airline travellers, the aim of this study was to investigate the changes in skin surface hydration during long distance flights.



Methods

The study was performed on four healthy Caucasian, and on four Japanese women aged 29–39 years, travelling on long distance flights. They had stopped using skin care products at least 12 h before, and did not apply them during the flights. The air temperature and relative ...

Skin surface hydration decreases rapidly during long distance flights is a post from: Skincare

Skin surface hydration decreases rapidly during long distance flights via BuzzBlazer.com

A small suberythemal UVB dose every second week is sufficient to maintain summer vitamin D levels: a randomized controlled trial.

Abstract

Background:  It is known that ultraviolet-B (UVB) radiation increases serum vitamin D level (25-hydroxyvitamin D3 (25(OH)D)). However, there is uncertainty about the relationship between the maintenance of vitamin D status and UVB.


Objective:  To define the frequency of UVB exposure necessary for maintaining summer 25(OH)D levels during the winter.


Patients/Methods:  A total of 60 participants were included from October 2008 to February 2009 (16 weeks) and randomized for UVB exposure of 1 standard erythema dose (SED) to ∼88% body area once a week (n = 15 completed), every second week (n = ...

A small suberythemal UVB dose every second week is sufficient to maintain summer vitamin D levels: a randomized controlled trial. is a post from: Skincare

A small suberythemal UVB dose every second week is sufficient to maintain summer vitamin D levels: a randomized controlled trial. via BuzzBlazer.com

Adalimumab (anti-TNF-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study

Summary

Background:  Hidradenitis suppurativa (HS) is a difficult to manage disease. Randomized controlled trials with anti-TNF-α biologics have been conducted and in most studies disease activity was reduced. However, the mechanism of action in HS skin is so far unknown.


Objectives:  To assess whether anti-TNF-α treatment affects in situ cytokine production and frequency of inflammatory cell populations in HS lesional skin.


Methods:  Nine HS patients, participating in a larger placebo-controlled, double-blind phase IIb clinical trial on the efficacy and safety of adalimumab in patients with moderate to severe HS (M10-467), were randomized and ...

Adalimumab (anti-TNF-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study is a post from: Skincare

Adalimumab (anti-TNF-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study via BuzzBlazer.com

Vitamin D status in patients with chronic plaque psoriasis

Abstract

Background:  Vitamin D could have important immuno-modulatory effects in psoriasis.


Objective:  Measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features.


Methods:  A cross-sectional study conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, co-morbidities, disease severity and exposure time to sunlight which was derived by questionnaire, were collected.


Results:  The prevalence of vitamin D ...

Vitamin D status in patients with chronic plaque psoriasis is a post from: Skincare

Vitamin D status in patients with chronic plaque psoriasis via BuzzBlazer.com

Factors influencing quality of life of inherited ichthyosis : a qualitative study in adult using focus groups

Summary

Background:  There is limited information regarding quality of life in inherited ichthyosis.


Objectives:  To identify factors influencing quality of life in inherited ichthyosis.


Methods:  The study used focus groups and involved adult patients suffering from inherited ichthyosis from three French hospital centers. Group discussions were conducted by two facilitators and were continued until data saturation was reached. The verbatim transcripts were analyzed independently by two investigators. Categories considered as key factors in the modulation of quality of life were negotiated until agreement was obtained.


Results:  Data saturation was reached after the 5th group. ...

Factors influencing quality of life of inherited ichthyosis : a qualitative study in adult using focus groups is a post from: Skincare

Factors influencing quality of life of inherited ichthyosis : a qualitative study in adult using focus groups via BuzzBlazer.com

Association analysis of Estrogen Receptor Beta gene (ESR2) polymorphisms with female pattern hair loss

Association analysis of Estrogen Receptor Beta gene (ESR2) polymorphisms with female pattern hair loss is a post from: Skincare

Association analysis of Estrogen Receptor Beta gene (ESR2) polymorphisms with female pattern hair loss is a post from: Skincare

Association analysis of Estrogen Receptor Beta gene (ESR2) polymorphisms with female pattern hair loss via BuzzBlazer.com

Acute phototoxicity induced by methylene blue-assisted parathyroidectomy: an unreported risk of a common procedure

Acute phototoxicity induced by methylene blue-assisted parathyroidectomy: an unreported risk of a common procedure is a post from: Skincare

Acute phototoxicity induced by methylene blue-assisted parathyroidectomy: an unreported risk of a common procedure is a post from: Skincare

Acute phototoxicity induced by methylene blue-assisted parathyroidectomy: an unreported risk of a common procedure via BuzzBlazer.com

Prevalence of Chlamydial Infection in a Series of 108 Primary Cutaneous Lymphomas

Prevalence of Chlamydial Infection in a Series of 108 Primary Cutaneous Lymphomas is a post from: Skincare

Prevalence of Chlamydial Infection in a Series of 108 Primary Cutaneous Lymphomas is a post from: Skincare

Prevalence of Chlamydial Infection in a Series of 108 Primary Cutaneous Lymphomas via BuzzBlazer.com

Photochemical interaction of ascorbic acid with riboflavin, nicotinamide and alpha-tocopherol in cream formulations

Synopsis

The present work is based on a study of the effect of some vitamins such as riboflavin (RF), nicotinamide (NA) and alpha-tocopherol (TP) on the photodegradation of ascorbic acid (vitamin C) (AH2) in oil-in-water cream formulations using a UV irradiation source. A UV spectrophotometric and the official iodimetric methods have been used for the assay of AH2 in cream formulations. These methods have been validated in the presence of RF, NA and TP before their application to the creams. The recoveries of AH2 in the creams are in the range ...

Photochemical interaction of ascorbic acid with riboflavin, nicotinamide and alpha-tocopherol in cream formulations is a post from: Skincare

Photochemical interaction of ascorbic acid with riboflavin, nicotinamide and alpha-tocopherol in cream formulations via BuzzBlazer.com

Age-dependent changes in eumelanin composition in hairs of various ethnic origins

Synopsis

Hair pigmentation is one of the most conspicuous phenotypes of humans. From a chemical point of view, however, data remain scarce regarding human hair pigmentation characteristics. To determine melanin content and composition in human eumelanic hair from individuals of different ethnic origins and at different ages, we collected hair from 56 subjects with eumelanic hair from each group of African-American, East Asian, and Caucasian origin. The 56 subjects consist of 14, 7 each of males and females, each from 4 age classes of younger than 11, between 12 and 19, ...

Age-dependent changes in eumelanin composition in hairs of various ethnic origins is a post from: Skincare

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Sweet’s Syndrome with Postinflammatory Elastolysis and Takayasu Arteritis in a Child: A Case Report and Literature Review

Abstract:  Sweet’s syndrome (SS) is an uncommon condition characterized by recurrent painful cutaneous inflammatory eruptions. It is rare in childhood and has a broad range of extracutaneous manifestations. We describe a child presenting with SS and postinflammatory elastolysis who subsequently developed aortitis complicated by aortic dilatation requiring surgical intervention. Histologic features of the aorta were consistent with Takayasu arteritis (TA). Our case and previously reported cases of pediatric SS complicated by aortitis all demonstrate striking clinical similarities in that all have been associated with postinflammatory elastolysis of involved skin and ...

Sweet’s Syndrome with Postinflammatory Elastolysis and Takayasu Arteritis in a Child: A Case Report and Literature Review is a post from: Skincare

Sweet’s Syndrome with Postinflammatory Elastolysis and Takayasu Arteritis in a Child: A Case Report and Literature Review via BuzzBlazer.com

Comma Hairs in Tinea Capitis: A Useful Dermatoscopic Sign for Diagnosis of Tinea Capitis

Abstract:  Diagnosis of tinea capitis (TC) can be challenging for dermatologists, especially in noninflammatory TC caused by anthropophilic dermatophytes and in black patients, in whom erythema of the scalp is difficult to appreciate. The finding of a typical TC dermoscopic pattern may lead more quickly to a correct diagnosis.

Comma Hairs in Tinea Capitis: A Useful Dermatoscopic Sign for Diagnosis of Tinea Capitis is a post from: Skincare

Comma Hairs in Tinea Capitis: A Useful Dermatoscopic Sign for Diagnosis of Tinea Capitis is a post from: Skincare

Comma Hairs in Tinea Capitis: A Useful Dermatoscopic Sign for Diagnosis of Tinea Capitis via BuzzBlazer.com

GENETIC SKIN DISORDERS

GENETIC SKIN DISORDERS is a post from: Skincare

GENETIC SKIN DISORDERS is a post from: Skincare

GENETIC SKIN DISORDERS via BuzzBlazer.com

Skin improvement with two different oestroprogestins in patients affected by acne and polycystic ovary syndrome: clinical and instrumental evaluation

Abstract

Background  Despite it is accepted that acne is mostly caused by an hyper-responsiveness of the pilo-sebaceous unit to normal circulating androgen hormones, in a few patients, especially women, acneic lesions can be associated with increased serum androgen levels (hyperandrogenism), of which polycystic ovary syndrome (PCOS) is the most common cause. In women with acne and proven PCOS therapy with estroprogestins (EPs) can be an excellent option.


Objective  The aim of the study was to assess the effects of two estroprogestins (EPs), ethinyl-estradiol (EE) 30 mcg/drospirenone (DRSP) 3 mg, and ethinyl-estradiol (EE) ...

Skin improvement with two different oestroprogestins in patients affected by acne and polycystic ovary syndrome: clinical and instrumental evaluation is a post from: Skincare

Skin improvement with two different oestroprogestins in patients affected by acne and polycystic ovary syndrome: clinical and instrumental evaluation via BuzzBlazer.com

Leflunomide is a possible deactivator for vitiligo, a pilot study

Leflunomide is a possible deactivator for vitiligo, a pilot study is a post from: Skincare

Leflunomide is a possible deactivator for vitiligo, a pilot study is a post from: Skincare

Leflunomide is a possible deactivator for vitiligo, a pilot study via BuzzBlazer.com

A scientometric analysis of dermoscopy literature over the past 25 years

Abstract

Background  Dermoscopy is a useful method allowing the non-invasive visualization of dermal and epidermal structures.


Objective  To determine the scientific output in dermoscopy between 1985 and 2009 using ISI Web of Knowledge.


Methods  The ISI Web of Knowledge was searched for articles on dermoscopy published between 1985 and 2009 using appropriate terms. Articles were characterized each year by publication type and journal type.


Results  The search yielded 1490 dermoscopy publications, of which 1198 (80%) appeared in dermatology journals. A cubic increase in the number of publications over time was observed (R2 = 95.3%, P < 0.0001). Most ...

A scientometric analysis of dermoscopy literature over the past 25 years is a post from: Skincare

A scientometric analysis of dermoscopy literature over the past 25 years via BuzzBlazer.com

UV Absorption & Scattering Properties of Inorganic Based Sun Screens

Synopsis

This paper first introduces the concepts which underlie calculations of scattering and absorption of light by small particles. Results of Mie theory calculations of light-scattering and light-absorption by 20, 50 and 100 nm TiO2 and ZnO particles are then presented. Since the attenuation, or extinction, by these particles is the sum of the scattering and absorption, the attenuation can then be calculated for wavelengths over the UVA and UVB region. These theoretical results are then shown to be in reasonable agreement with experimental results for alkyl benzoate dispersions of three ...

UV Absorption & Scattering Properties of Inorganic Based Sun Screens is a post from: Skincare

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Recent developments in the specific dermatoses of pregnancy

Summary

During pregnancy, the mother undergoes changes to sustain and enable normal growth and development of the fetus. Common physiological changes include linea nigra, fibroepithelial polyps, striae, spider angioma, palmar erythema and pruritis gravidarum. However, there are some changes that are purely pathological, and these are termed the pregnancy-specific dermatoses (PSDs). The PSDs occur during pregnancy or in the immediate postpartum period. They do not include the various benign conditions or pre-existing dermatoses and tumours that may present or worsen with pregnancy. They do include a number of distinct and identifiable ...

Recent developments in the specific dermatoses of pregnancy is a post from: Skincare

Recent developments in the specific dermatoses of pregnancy via BuzzBlazer.com

G59A mutation in the GJB2 gene in a Taiwanese family with knuckle pads, palmoplantar keratoderma and sensorineural hearing loss

G59A mutation in the GJB2 gene in a Taiwanese family with knuckle pads, palmoplantar keratoderma and sensorineural hearing loss is a post from: Skincare

G59A mutation in the GJB2 gene in a Taiwanese family with knuckle pads, palmoplantar keratoderma and sensorineural hearing loss is a post from: Skincare

G59A mutation in the GJB2 gene in a Taiwanese family with knuckle pads, palmoplantar keratoderma and sensorineural hearing loss via BuzzBlazer.com

Elephantiasic pretibial myxoedema with upper-limb involvement, treated with low-dose intravenous immunoglobulins

Elephantiasic pretibial myxoedema with upper-limb involvement, treated with low-dose intravenous immunoglobulins is a post from: Skincare

Elephantiasic pretibial myxoedema with upper-limb involvement, treated with low-dose intravenous immunoglobulins is a post from: Skincare

Elephantiasic pretibial myxoedema with upper-limb involvement, treated with low-dose intravenous immunoglobulins via BuzzBlazer.com

Reactive hypertrophy of the nipples in a patient with atopic dermatitis

Reactive hypertrophy of the nipples in a patient with atopic dermatitis is a post from: Skincare

Reactive hypertrophy of the nipples in a patient with atopic dermatitis is a post from: Skincare

Reactive hypertrophy of the nipples in a patient with atopic dermatitis via BuzzBlazer.com

The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa

Summary

Background.  Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive skin disease caused by mutations in the type VII collagen gene (COL7A1), resulting in detachment of the entire epidermis due to loss or hypoplasticity of the anchoring fibrils that normally secure the basement membrane to the underlying dermis. Trauma-induced blistering is often complicated by chronic erosions and scarring. From that perspective, pregnancy in RDEB might be considered an indication for elective caesarean section in a bid to minimize perineal blistering. To date, only four cases of pregnancy and delivery in ...

The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa is a post from: Skincare

The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa via BuzzBlazer.com

Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease

Summary

Reiter disease (RD) is characterized by a triad of sterile arthritis, urethritis and conjunctivitis. The conditions occur concomitantly or sequentially, and are associated with mucocutaneous features such as circinate balanitis and stomatitis. Arthritis usually occurs in attacks followed by recovery, but it sometimes progresses to permanent damage of the affected joints. Because the symptoms of this disorder are attributable to activated neutrophils, we assessed the efficacy of granulocyte and monocyte adsorption apheresis (GCAP) in a 73-year-old man with RD who had skin rashes on his penis, scrotum and right hand, ...

Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease is a post from: Skincare

Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease via BuzzBlazer.com

Possible zoledronic acid-induced dermatomyositis

Possible zoledronic acid-induced dermatomyositis is a post from: Skincare

Possible zoledronic acid-induced dermatomyositis is a post from: Skincare

Possible zoledronic acid-induced dermatomyositis via BuzzBlazer.com

Complete remission of advanced extramammary Paget’s disease treated with docetaxel: a case report

Complete remission of advanced extramammary Paget’s disease treated with docetaxel: a case report is a post from: Skincare

Complete remission of advanced extramammary Paget’s disease treated with docetaxel: a case report is a post from: Skincare

Complete remission of advanced extramammary Paget’s disease treated with docetaxel: a case report via BuzzBlazer.com

No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men

No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men is a post from: Skincare

No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men is a post from: Skincare

No improvement in male-pattern hair loss using laser hair-comb therapy: a 6-month, half-head, assessor-blinded investigation in two men via BuzzBlazer.com

Variable expression of naevoid basal cell carcinoma syndrome in a family with a novel mutation in the PTCH1 gene

Variable expression of naevoid basal cell carcinoma syndrome in a family with a novel mutation in the PTCH1 gene is a post from: Skincare

Variable expression of naevoid basal cell carcinoma syndrome in a family with a novel mutation in the PTCH1 gene is a post from: Skincare

Variable expression of naevoid basal cell carcinoma syndrome in a family with a novel mutation in the PTCH1 gene via BuzzBlazer.com

Off-label use of fumarate therapy for granulomatous and inflammatory skin diseases other than psoriasis vulgaris: a retrospective study

Abstract

Background  Fumarates are approved for the systemic treatment of moderate and severe psoriasis vulgaris in Germany. However, a number of studies and case reports indicate their efficacy in the treatment of further inflammatory skin disorders or granulomatous skin diseases.


Objectives  To examine the efficacy and safety of fumarates for the treatment of granulomatous and inflammatory skin diseases other than psoriasis vulgaris.


Patients and methods  The therapeutic efficacy and side-effects of fumarate therapy were analysed retrospectively in patients with granuloma annulare (GA, n = 4), cutaneous sarcoidosis (SA, n = 1), lichen planus (LP, n = 3), pityriasis rubra ...

Off-label use of fumarate therapy for granulomatous and inflammatory skin diseases other than psoriasis vulgaris: a retrospective study is a post from: Skincare

Off-label use of fumarate therapy for granulomatous and inflammatory skin diseases other than psoriasis vulgaris: a retrospective study via BuzzBlazer.com

IgE-mediated allergy: a rare cause of chronic spontaneous urticarial with allergen-specific immunotherapy as treatment option – a systematic review with meta-analysis from China

Abstract

Background  Allergen-specific immunotherapy (SIT) has long been a controversial treatment for chronic urticaria (CU), although SIT has been used in patients with allergic diseases for more than 90 years.


Objectives  To evaluate the efficacy and safety of SIT vs. conventional treatment (CT) in the treatment of CU.


Methods  Systematic searches were conducted without language restrictions in MEDLINE, EMBASE, the Cochrane Library, ISI Web of Knowledge, China National Knowledge Infrastructure, and Chinese Scientific Journals Full Text Database. The primary outcomes were efficacy and quality of life (QOL) and the secondary outcomes were relapse rate ...

IgE-mediated allergy: a rare cause of chronic spontaneous urticarial with allergen-specific immunotherapy as treatment option – a systematic review with meta-analysis from China is a post from: Skincare

IgE-mediated allergy: a rare cause of chronic spontaneous urticarial with allergen-specific immunotherapy as treatment option – a systematic review with meta-analysis from China via BuzzBlazer.com

Thalidomide in the treatment of refractory cutaneous lupus: prognostic factors of clinical outcome

Abstract

Introduction:  Although, thalidomide has been shown to be effective in patients with refractory cutaneous lupus erythematosus (CLE), its use is still hampered by its potential severe side effects and the current restricted availability. The aim of this observational study is to prospectively evaluate the clinical efficacy and safety of low-dose thalidomide and to establish prognostic factors of clinical outcome.


Methods:  Sixty consecutive patients with refractory CLE were treated with thalidomide (100 mg/day). Clinical response was assessed by the CLE disease area and severity index (CLASI). Clinical and immunological parameters were evaluated ...

Thalidomide in the treatment of refractory cutaneous lupus: prognostic factors of clinical outcome is a post from: Skincare

Thalidomide in the treatment of refractory cutaneous lupus: prognostic factors of clinical outcome via BuzzBlazer.com

Association Between Atopic Dermatitis and Obesity in Adulthood

Abstract

Background:  Obesity in early childhood is associated with increased risk for and severity of atopic dermatitis (AD).


Objective:  To determine whether obesity in adulthood is associated with risk of AD.


Methods:  A retrospective case-control study of 2,090 adults with questionnaire, height weight, and skin-prick testing between January 1994 and December 2003.


Results:  (1) Obesity in adults is associated with increased AD (multinomial logistic regression; aOR=1.42, 95% CI=1.07–1.87, P=0.01), but not non-atopic dermatitis (aOR=0.44, 95% CI=0.13–1.44, P=0.17). (2) Obesity was also associated with increased atopic asthma (aOR=1.98, 95% CI=1.47–2.66, P<0.0001), but not associated with ...

Association Between Atopic Dermatitis and Obesity in Adulthood is a post from: Skincare

Association Between Atopic Dermatitis and Obesity in Adulthood via BuzzBlazer.com

Long- Pulsed Nd:YAG laser versus IPL for hair removal in dark skin

Abstract

Background:  Although several lasers meet the wavelength criteria for selective follicular destruction, the treatment of darker skin phototypes is particularly challenging because absorption of laser energy by the targeted hairs is compromised by an increased concentration of epidermal melanin.


Objective:  To compare satisfaction level, safety and effectiveness of a long-pulsed Nd:YAG laser and IPL in axillary hair reduction in subjects with dark skin.


Methods:  The study design was a within-patient, right-left, assessor-blinded, comparison of long pulsed Nd:YAG laser and IPL. Fifty females (skin phototypes; IV-VI) volunteered to remove axillary hair. Five sessions ...

Long- Pulsed Nd:YAG laser versus IPL for hair removal in dark skin is a post from: Skincare

Long- Pulsed Nd:YAG laser versus IPL for hair removal in dark skin via BuzzBlazer.com

Possible modifier effects of keratin 17 gene mutation on keratitis-ichthyosis-deafness syndrome

Possible modifier effects of keratin 17 gene mutation on keratitis-ichthyosis-deafness syndrome is a post from: Skincare

Possible modifier effects of keratin 17 gene mutation on keratitis-ichthyosis-deafness syndrome is a post from: Skincare

Possible modifier effects of keratin 17 gene mutation on keratitis-ichthyosis-deafness syndrome via BuzzBlazer.com

Determinants of social anxiety and social avoidance in psoriasis outpatients

Abstract

Background  Psychological stressors can contribute to the first manifestation and to later exacerbations of psoriasis. As a result of the visible and disfiguring skin lesions, psoriasis patients often develop feelings of social anxiety and stigmatization and consecutive social avoidance, which can in turn affect employment and social activities and lead to psychological distress and impairment of quality of life. However, great differences regarding social anxiety and social avoidance can be observed between different individuals, even if their disfigurement appears comparable.


Objective  We intended to assess the joint impact of disease severity, ...

Determinants of social anxiety and social avoidance in psoriasis outpatients is a post from: Skincare

Determinants of social anxiety and social avoidance in psoriasis outpatients via BuzzBlazer.com

Safety and Tolerability of Combination Acyclovir 5% and Hydrocortisone 1% Cream in Adolescents with Recurrent Herpes Simplex Labialis

Abstract:  A Phase 3, open-label, multicenter study was conducted to assess the safety of the combination of 5% acyclovir and 1% hydrocortisone cream (AHC cream) in the treatment of recurrent herpes simplex labialis (HSL) in immunocompetent adolescents. Eligible subjects were aged 12 to 17 years and had a history of recurrent labial herpes with two or more episodes during the last 12 months. Subjects initiated treatment at the first signs or symptoms of a herpes recurrence—at the earliest prodromal phase and preferably before the presence of papules or vesicles. Subjects applied the ...

Safety and Tolerability of Combination Acyclovir 5% and Hydrocortisone 1% Cream in Adolescents with Recurrent Herpes Simplex Labialis is a post from: Skincare

Safety and Tolerability of Combination Acyclovir 5% and Hydrocortisone 1% Cream in Adolescents with Recurrent Herpes Simplex Labialis via BuzzBlazer.com

Pediatric Tinea Faciei in Southern Spain: A 30-Year Survey

Abstract:  Tinea faciei (TF) is a common clinical form of tinea in children that is frequently misdiagnosed and treated with corticosteroids. No large case series of TF focusing on children have been published. The aim of this study was to analyze the main epidemiologic, clinical, and microbiologic features of TF in children over a period of 30 years and compare these features with those of other tineas. We undertook a retrospective study of 818 cases of tinea in children at a referral hospital in southern Spain, diagnosed between 1977 and 2006, ...

Pediatric Tinea Faciei in Southern Spain: A 30-Year Survey is a post from: Skincare

Pediatric Tinea Faciei in Southern Spain: A 30-Year Survey via BuzzBlazer.com

Forehead Pressure Necrosis in Neonates Following Continuous Positive Airway Pressure

Abstract:  After treatment with continuous positive airway pressure (CPAP) via nasal masks and a face mask, three neonates developed pressure necrosis involving their central forehead and left eyebrow. The pressure necrosis resulted in permanent scarring in all three infants. We describe a case series of a new cutaneous iatrogenic complication of CPAP.

Forehead Pressure Necrosis in Neonates Following Continuous Positive Airway Pressure is a post from: Skincare

Forehead Pressure Necrosis in Neonates Following Continuous Positive Airway Pressure is a post from: Skincare

Forehead Pressure Necrosis in Neonates Following Continuous Positive Airway Pressure via BuzzBlazer.com

Propranolol versus Prednisone in the Treatment of Infantile Hemangiomas: A Retrospective Comparative Study

Abstract:  The goal of the current study was to compare the clinical effectiveness of oral propranolol with that of oral prednisone in the treatment of infantile hemangiomas (IH). Patients treated for IH with oral propranolol were retrospectively matched with patients treated with oral prednisone according to type, location, and size of the IH and age at start of treatment. Response to treatment was evaluated by rating serial medical photographs taken 1, 2, and 6 months after initiation of treatment. Degree of clinical improvement in overall appearance (including color and size) was ...

Propranolol versus Prednisone in the Treatment of Infantile Hemangiomas: A Retrospective Comparative Study is a post from: Skincare

Propranolol versus Prednisone in the Treatment of Infantile Hemangiomas: A Retrospective Comparative Study via BuzzBlazer.com

Hypothalamic–Pituitary–Adrenal Axis Suppression Related to Topical Glucocorticoid Therapy in a Child with Psoriatic Exfoliative Erythroderma

Abstract:  Exfoliative erythroderma is a rare presentation of psoriasis in children and adults. We report a 9-year-old girl with exfoliative erythroderma secondary to plaque-type psoriasis who developed hypothalamic–pituitary–adrenal axis suppression resulting from topical treatment with a medium-potency glucocorticoid. This case emphasizes the need for awareness of this potentially life-threatening complication of topical glucocorticoid use, particularly in patients who have significant compromise of barrier function secondary to widespread skin disease.

Hypothalamic–Pituitary–Adrenal Axis Suppression Related to Topical Glucocorticoid Therapy in a Child with Psoriatic Exfoliative Erythroderma is a post from: Skincare

Hypothalamic–Pituitary–Adrenal Axis Suppression Related to Topical Glucocorticoid Therapy in a Child with Psoriatic Exfoliative Erythroderma is a post from: Skincare

Hypothalamic–Pituitary–Adrenal Axis Suppression Related to Topical Glucocorticoid Therapy in a Child with Psoriatic Exfoliative Erythroderma via BuzzBlazer.com

A Prospective Study of Infantile Hemangiomas with a Focus on Incidence and Risk Factors

Abstract:  Infantile hemangiomas (IHs) are the most common tumor of infancy and have been estimated to occur in 4% of infants. Only two previous incidence studies of IH in a healthy population have been published, and both of these were performed in the first week of life. The objective was to identify the incidence of IH in an Australian neonatal population and characterize the risk factors. All women who presented to the postnatal ward in a 200-bed maternity hospital were asked to complete a questionnaire. Details of maternal history and ...

A Prospective Study of Infantile Hemangiomas with a Focus on Incidence and Risk Factors is a post from: Skincare

A Prospective Study of Infantile Hemangiomas with a Focus on Incidence and Risk Factors via BuzzBlazer.com

Nevus Sebaceous Revisited

Abstract:  Nevus sebaceous of Jadassohn is a hamartoma with a combination of abnormalities of the epidermis, hair follicles, and sebaceous and apocrine glands. Herein, we discuss the results of an extensive literature review on the topic of nevus sebaceous with a particular focus on the debate about the necessity for prophylactic excision. We also focus on the documentation of associated malignant tumors that were reported to develop within NS. In addition to reporting the number and types of neoplasms, we documented the recommendations of all authors for therapeutic handling of ...

Nevus Sebaceous Revisited is a post from: Skincare

Nevus Sebaceous Revisited via BuzzBlazer.com

Propranolol Therapy in 55 Infants with Infantile Hemangioma: Dosage, Duration, Adverse Effects, and Outcome

Abstract:  Propranolol has recently been reported to be a highly effective treatment for infantile hemangioma (IH) and is emerging as a first-line therapy. This study reports the observations after completed propranolol therapy in 55 patients. Propranolol was administered in a dosage of 2 mg/kg per day with initial monitoring of vital signs. Therapy duration was planned for 4 to 6 months; if there was significant relapse, the period of treatment was extended. The mean age of 55 patients at the beginning of the treatment was 6 months (52.7% <4 mos, 30.9% 4–9 mos, 16.3% >9 mos). ...

Propranolol Therapy in 55 Infants with Infantile Hemangioma: Dosage, Duration, Adverse Effects, and Outcome is a post from: Skincare

Propranolol Therapy in 55 Infants with Infantile Hemangioma: Dosage, Duration, Adverse Effects, and Outcome via BuzzBlazer.com

Vogt–Koyanagi–Harada Syndrome in a 6-Year-Old Hispanic Boy1

Abstract:  A 6-year-old Hispanic boy presented to the ophthalmology department with complaints of pain, photophobia, and blurry vision of both eyes. He was found to have bilateral granulomatous panuveitis, cataracts, and high intraocular pressures. He later developed multiple asymptomatic, ovoid, hypopigmented patches over the mid-lumbosacral back. Biopsy of lesional skin was significant for low melanocyte counts and a mild lymphocytic infiltrate. The patient was diagnosed with Vogt–Koyanagi–Harada syndrome (VKH). This article reviews the literature regarding the cutaneous presentation of VKH.

Vogt–Koyanagi–Harada Syndrome in a 6-Year-Old Hispanic Boy1 is a post from: ...

Vogt–Koyanagi–Harada Syndrome in a 6-Year-Old Hispanic Boy1 is a post from: Skincare

Vogt–Koyanagi–Harada Syndrome in a 6-Year-Old Hispanic Boy1 via BuzzBlazer.com

Aplasia Cutis Congenita and Other Anomalies Associated with Methimazole Exposure During Pregnancy

Abstract:  Aplasia cutis congenita (ACC) is a congenital defect consisting of a circumscribed absence of skin that usually involves the scalp. The etiology is uncertain, and several teratogenic agents such as methimazole have been involved. We report two cases of ACC and other anomalies in newborns exposed to methimazole during pregnancy.

Aplasia Cutis Congenita and Other Anomalies Associated with Methimazole Exposure During Pregnancy is a post from: Skincare

Aplasia Cutis Congenita and Other Anomalies Associated with Methimazole Exposure During Pregnancy is a post from: Skincare

Aplasia Cutis Congenita and Other Anomalies Associated with Methimazole Exposure During Pregnancy via BuzzBlazer.com

A novel mutation in the IRF6 gene associated with facial asymmetry in a family affected with Van der Woude Syndrome

Abstract:  This report describes a novel missense mutation in the interferon regulation factor 6 (IRF6) gene associated to facial asymmetry. This new feature widens the phenotype spectrum of Van der Woude syndrome (VWS).

A novel mutation in the IRF6 gene associated with facial asymmetry in a family affected with Van der Woude Syndrome is a post from: Skincare

A novel mutation in the IRF6 gene associated with facial asymmetry in a family affected with Van der Woude Syndrome is a post from: Skincare

A novel mutation in the IRF6 gene associated with facial asymmetry in a family affected with Van der Woude Syndrome via BuzzBlazer.com

Evaluation of the efficacy and safety of a CS20® protective barrier gel containing OGT compared with topical aciclovir and placebo on functional and objective symptoms of labial herpes recurrences: a randomized clinical trial

Abstract

Background  Topical or systemic antiviral drugs reduce the duration of herpes simplex virus 1 (HSV-1) recurrences but may not alleviate functional symptoms.


Objectives  To assess the efficacy and safety of CS20 (Acura 24®) protective barrier gel versus topical aciclovir and placebo in resolving functional symptoms in HSV-1 labial recurrences.


Methods  A prospective, randomized, single-centre, assessor-blinded study of CS20 versus topical aciclovir or placebo. The primary endpoint was the total score of four herpes-related functional symptoms (pain, burning, itching, and tingling sensations), evaluated by visual analogue scale (VAS). Secondary endpoints encompassed objective skin ...

Evaluation of the efficacy and safety of a CS20® protective barrier gel containing OGT compared with topical aciclovir and placebo on functional and objective symptoms of labial herpes recurrences: a randomized clinical trial is a post from: Skincare

Evaluation of the efficacy and safety of a CS20® protective barrier gel containing OGT compared with topical aciclovir and placebo on functional and objective symptoms of labial herpes recurrences: a randomized clinical trial via BuzzBlazer.com

Insulin-like growth factor-I gene polymorphism in acne vulgaris

Abstract

Background  Acne vulgaris is a multifactorial disease of the skin. Several studies have shown that elevated levels of serum insulin-like growth factor-I (IGF-I) correlate with overproduction of sebum and acne. Recently functional relationship between IGF-I (CA) polymorphism and circulating IGF-I levels in adults has been reported.


Aims  The aim of our study was to investigate for the first time whether IGF-I (CA) polymorphism might be involved in the pathogenesis of acne or not.


Methods  We included 115 acne patients and 117 healthy subjects to the study. The clinical grade of acne was ...

Insulin-like growth factor-I gene polymorphism in acne vulgaris is a post from: Skincare

Insulin-like growth factor-I gene polymorphism in acne vulgaris via BuzzBlazer.com

Risk of multiple primary cancers following melanoma and non-melanoma skin cancer

Abstract

Background  The relationship between cutaneous malignancies and successive primary cancers has been studied since several years, but it still remains controversial.


Objective  The aim of this study was to evaluate the excess risk of multiple primary cancer among the population of Umbria, Italy, that survived a skin cancer.


Methods  The data registered in the Umbrian Population Cancer Registry from 1994 to 2006 were collected, recorded, and analysed in accordance to the standard methods recommended for cancer registries. Among skin cancer patients, those with multiple cutaneous and non-cutaneous cancers were selected. Only sites ...

Risk of multiple primary cancers following melanoma and non-melanoma skin cancer is a post from: Skincare

Risk of multiple primary cancers following melanoma and non-melanoma skin cancer via BuzzBlazer.com

Tensegrity and plasma for skin regeneration

Background

Mechanical stresses induce variations in tissue tensegrity leading to cell proliferation and differentiation thus contributing to tissue remodelling. Besides mechanical forces, skin remodelling may be induced by the application of plasma, a new type of energy delivery resulting in controlled heat damage. Here we demonstrate that mechanical stress induced by the application of vacuum increases the efficacy of plasma in skin regeneration treatment.



Methods

Vacuum alone and vacuum plus plasma at different energies were applied to rat skin and biopsies collected at different time intervals after treatments. Skin integrity, collagen arrangement, inflammation ...

Tensegrity and plasma for skin regeneration is a post from: Skincare

Tensegrity and plasma for skin regeneration via BuzzBlazer.com

A comparison between laser-doppler imaging and colorimetry in the assessment of scarring: “a pilot study”

Background:

This cross-sectional pilot-study investigated the reproducibility of the LDI (Moor-LDI-B2; Moor Instruments) and the chromameter (Minolta chromameter CR-300) when used in scar assessment.



Methods:

Twenty-seven scars in 14 subjects were included between January and June 2003. One observer performed two times both measurements with 10 min apart. The intra-observer agreement is quantified by means of the intra-class correlations (ICC) and the standard errors of measurement (SEM) for both the LDI and the chromameter.



Results:

Ignoring one outlier, the ICC of the LDI = 0.856 and the SEM = 34.56. The chromameter shows a better reproducibility with an ICC of ...

A comparison between laser-doppler imaging and colorimetry in the assessment of scarring: “a pilot study” is a post from: Skincare

A comparison between laser-doppler imaging and colorimetry in the assessment of scarring: “a pilot study” via BuzzBlazer.com

The Aberdeen Knot: A Sliding Knot for Dermatology

The Aberdeen Knot: A Sliding Knot for Dermatology is a post from: Skincare

The Aberdeen Knot: A Sliding Knot for Dermatology is a post from: Skincare

The Aberdeen Knot: A Sliding Knot for Dermatology via BuzzBlazer.com

An Investigation of Coagulation Cascade Activation and Induction of Fibrinolysis Using Foam Sclerotherapy of Reticular Veins

Background

Coagulation parameters have not been investigated when foam sclerotherapy is used to treat reticular leg veins.



Objective

To evaluate the effect of foam bubbles on coagulation and fibrinolysis by measuring platelet count and concentrations of clotting factors and fibrinogen after foam sclerotherapy with sodium tetradecyl sulfate (STS) mixed with room air.



Materials and Methods

Patients with reticular veins received treatment with up to 30 mL of foam sclerotherapy prepared with STS and room air in a 1:4 ratio (1 mL STS, 4 mL room air) using the double-syringe technique. Venous blood was drawn immediately beforesclerotherapy and 15 minutes ...

An Investigation of Coagulation Cascade Activation and Induction of Fibrinolysis Using Foam Sclerotherapy of Reticular Veins is a post from: Skincare

An Investigation of Coagulation Cascade Activation and Induction of Fibrinolysis Using Foam Sclerotherapy of Reticular Veins via BuzzBlazer.com

Surgical-Site Infections and Routes of Bacterial Transfer: Which Ones Are Most Plausible?

Background

Surgical-site infections (SSIs) are an unfortunate consequence of cutaneous surgery. Their incidence can be a significant problem for patients and surgeons. Most SSIs are presumed to originate from the patient and operating room staff.



Objectives

To review the potential routes of iatrogenic bacterial transfer during cutaneous surgery.



Methods

A review of the medical literature.



Conclusions

Potential routes of bacterial transfer during surgery include respiratory droplets and nuclei, skin scales carried on air currents, direct contact with the surgical team’s skin, and contaminated fomites. The route with the most significant potential for iatrogenic bacterial transfer is direct ...

Surgical-Site Infections and Routes of Bacterial Transfer: Which Ones Are Most Plausible? is a post from: Skincare

Surgical-Site Infections and Routes of Bacterial Transfer: Which Ones Are Most Plausible? via BuzzBlazer.com

Rejuvenation of Periorbital Area: Treatment with an Injectable Nonanimal Non-Crosslinked Glycerol Added Hyaluronic Acid Preparation

Background

Therapeutic approaches to aging of the periorbital region are unique because of the delicacy of the anatomical structures and the possibility of adverse events. The synthesis of hyaluronic acid (HA) and other components responsible for skin hydration and elasticity diminish with age.



Objective

To evaluate the efficacy and safety of an injectable product containing non-crosslinked HA of nonanimal origin in association with glycerol to treat aging of the periorbital region.



Materials and Methods

A pilot study in which 20 women were administered three monthly superficial intradermal injections of non-crosslinked HA of nonanimal origin containing ...

Rejuvenation of Periorbital Area: Treatment with an Injectable Nonanimal Non-Crosslinked Glycerol Added Hyaluronic Acid Preparation is a post from: Skincare

Rejuvenation of Periorbital Area: Treatment with an Injectable Nonanimal Non-Crosslinked Glycerol Added Hyaluronic Acid Preparation via BuzzBlazer.com

Diagnosis and Demarcation of Skin Malignancy Using Elastic Light Single-Scattering Spectroscopy: A Pilot Study

Background

Elastic light single-scattering spectroscopy (ELSSS) is a noninvasive and real-time technique that has been used to differentiate tumors from surrounding nontumor tissue in animal models and humans.



Objective

To investigate potential application of ELSSS as an adjunctive tool for noninvasive, in vivo, real-time differentiation of malignant and benign skin lesions and to detect positive surgical margins of excised biopsy samples.



Methods

In vivo spectroscopic measurements were performed on 28 lesions in 23 patients. The distribution of the lesions was as follows: nine basal cell carcinoma (BCC), four melanoma, two squamous cell carcinoma (SCC), and ...

Diagnosis and Demarcation of Skin Malignancy Using Elastic Light Single-Scattering Spectroscopy: A Pilot Study is a post from: Skincare

Diagnosis and Demarcation of Skin Malignancy Using Elastic Light Single-Scattering Spectroscopy: A Pilot Study via BuzzBlazer.com

Providing optimal care pathways for young people with skin cancer

Providing optimal care pathways for young people with skin cancer is a post from: Skincare

Providing optimal care pathways for young people with skin cancer is a post from: Skincare

Providing optimal care pathways for young people with skin cancer via BuzzBlazer.com