IF serration pattern analysis as a diagnostic criterion in anti-laminin-332 mucous membrane pemphigoid – immunopathological findings and clinical experience in 10 Dutch patients

Abstract

Background:  Anti-laminin-332 mucous membrane pemphigoid (anti-LN-332 MMP) is a chronic subepidermal blistering disease characterized by IgG anti-epidermal basement membrane zone (BMZ) autoantibodies against laminin-332 (LN-332). Patients with anti-LN-332 MMP have an increased relative risk of malignancy. For diagnosis of anti-LN-332 MMP difficult to obtain laboratory techniques are needed.


Objectives:  To incorporate direct immunofluorescence (DIF) serration pattern analysis of IgG depositions in the diagnostic criteria of anti-LN-332 MMP.


Patients/Methods:  Patients that met our revised inclusion criteria for anti-LN-332 MMP were selected from our biobank over the period 1997-2009. Inclusion criteria were clinical symptoms, ...

IF serration pattern analysis as a diagnostic criterion in anti-laminin-332 mucous membrane pemphigoid – immunopathological findings and clinical experience in 10 Dutch patients is a post from: Skincare

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