High levels of LIGHT and low levels of soluble herpesvirus entry mediator in sera of patients with atopic dermatitis

High levels of LIGHT and low levels of soluble herpesvirus entry mediator in sera of patients with atopic dermatitis is a post from: Skincare

High levels of LIGHT and low levels of soluble herpesvirus entry mediator in sera of patients with atopic dermatitis is a post from: Skincare

High levels of LIGHT and low levels of soluble herpesvirus entry mediator in sera of patients with atopic dermatitis via BuzzBlazer.com

A rationale for systemic treatment in onychomycosis with negative results on fungal examination

Summary

Background.  Fungal infection of the nail affects millions of people worldwide, and has an estimated prevalence of about 10% of the general population. Laboratory confirmation of fungal infection is currently accepted as a requirement before initiation of antifungal treatment in clinical practice.


Aim.  To examine the rationale for systemic treatment in cases of clinical onychomycosis with negative results on fungal examination (potassium hydroxide test and fungal culture).


Methods.  In total, 147 patients with suspected clinical toenail onychomycosis but with negative results on fungal examination underwent up to three consecutive fungal examinations of ...

A rationale for systemic treatment in onychomycosis with negative results on fungal examination is a post from: Skincare

A rationale for systemic treatment in onychomycosis with negative results on fungal examination via BuzzBlazer.com

Accumulation of S-100+ CD1a+ Langerhans cells as a characteristic of lichen nitidus

Accumulation of S-100+ CD1a+ Langerhans cells as a characteristic of lichen nitidus is a post from: Skincare

Accumulation of S-100+ CD1a+ Langerhans cells as a characteristic of lichen nitidus is a post from: Skincare

Accumulation of S-100+ CD1a+ Langerhans cells as a characteristic of lichen nitidus via BuzzBlazer.com

Novel clinical and molecular findings in Chinese families with Hailey–Hailey disease

Novel clinical and molecular findings in Chinese families with Hailey–Hailey disease is a post from: Skincare

Novel clinical and molecular findings in Chinese families with Hailey–Hailey disease is a post from: Skincare

Novel clinical and molecular findings in Chinese families with Hailey–Hailey disease via BuzzBlazer.com

Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature

Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature is a post from: Skincare

Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature is a post from: Skincare

Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature via BuzzBlazer.com

Renbok phenomenon between psoriasis and alopecia areata

Renbok phenomenon between psoriasis and alopecia areata is a post from: Skincare

Renbok phenomenon between psoriasis and alopecia areata is a post from: Skincare

Renbok phenomenon between psoriasis and alopecia areata via BuzzBlazer.com

Botulinum toxin type A in the management of a neuropathic foot ulcer

Botulinum toxin type A in the management of a neuropathic foot ulcer is a post from: Skincare

Botulinum toxin type A in the management of a neuropathic foot ulcer is a post from: Skincare

Botulinum toxin type A in the management of a neuropathic foot ulcer via BuzzBlazer.com

Chronic granulomatous disease of childhood: an unusual cause of recurrent uncommon infections in a 61-year-old man

Summary

Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency that affects 1 : 250 000 of the population, which is characterized by recurrent bacterial and fungal infections and by granuloma formation. We investigated a 61-year-old man presented with a 20-year history of a relapsing skin rash appearing as mildly pruritic and erythematous plaques affecting various body regions. Cutaneous biopsies were taken and sent for histology and tissue culture. Leucocyte function was assessed by determining the generation of reactive oxygen species. Bactericidal activity was assessed in the presence of autologous and homologous sera. Western ...

Chronic granulomatous disease of childhood: an unusual cause of recurrent uncommon infections in a 61-year-old man is a post from: Skincare

Chronic granulomatous disease of childhood: an unusual cause of recurrent uncommon infections in a 61-year-old man via BuzzBlazer.com

Drug-induced bullous pemphigoid: cases triggered by intravenous iodine and etanercept

Summary

Bullous pemphigoid (BP) is one of the most common acquired immunobullous diseases. Rarely, the development of BP is attributed to drug exposure. We present two cases of BP, one triggered by intravenous iodine, and one associated with etanercept treatment in a patient with psoriasis; the first time, to our knowledge, that either of these associations has been reported. The recognition of occasional cases of drug-induced BP such as ours, with timely cessation of the offending agent, may produce rapid clinical improvement with decreased exposure to potent immunosuppressive therapy.

Drug-induced bullous pemphigoid: ...

Drug-induced bullous pemphigoid: cases triggered by intravenous iodine and etanercept is a post from: Skincare

Drug-induced bullous pemphigoid: cases triggered by intravenous iodine and etanercept via BuzzBlazer.com

The α-melanocyte-stimulating hormone–melanocortin receptor system influences the effects of ultraviolet A on skin and intestinal immunity in mice

Summary Irradiation by ultraviolet (UV) A is known to decrease Langerhans cells (LCs) in the skin and increase IgA expression in the intestine, specifically the jejunum. These changes were induced in C57BL/6j mice by exposure of the ear or the eyes to 11 J/cm2 UVA radiation, then a melanocortin receptor agonist (Agouti-related protein; AgRP) was introduced either intracerebrally or intracerebroventricularly. The degree of change in both LC number and IgA expression induced by UVA eye irradiation was reduced more by intracerebral than by intraperitoneal injection of AgRP. α-Melanocyte-stimulating hormone and melanocortin ...

The α-melanocyte-stimulating hormone–melanocortin receptor system influences the effects of ultraviolet A on skin and intestinal immunity in mice is a post from: Skincare

The α-melanocyte-stimulating hormone–melanocortin receptor system influences the effects of ultraviolet A on skin and intestinal immunity in mice via BuzzBlazer.com

Blinded versus Unblinded Peer Review of Manuscripts Submitted to a Dermatology Journal: A Randomized Multi-Rater Study

Abstract

Background:  Submissions to medical and scientific journals are vetted by peer review, but peer review itself has been poorly studied until recently. One concern has been that manuscript reviews in which the reviewer is unblinded (e.g., knows author identity) may be biased, with an increased likelihood that the evaluation will not be strictly on scientific merits.


Objectives:  The purpose of this study was to compare the outcomes of blinded and unblinded reviews of manuscripts submitted to a single dermatology journal via a randomized multi-rater study.


Patients/Methods:  Forty manuscripts submitted to the journal ...

Blinded versus Unblinded Peer Review of Manuscripts Submitted to a Dermatology Journal: A Randomized Multi-Rater Study is a post from: Skincare

Blinded versus Unblinded Peer Review of Manuscripts Submitted to a Dermatology Journal: A Randomized Multi-Rater Study via BuzzBlazer.com

Topical ALA-PDT produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo

Summary

Background:  Topical photodynamic therapy (PDT) elicits a therapeutic response in both skin cancer and immune-mediated skin disorders. While PDT induces direct cell death, host inflammatory and immune responses to PDT may contribute to the therapeutic effects.


Objectives:  To examine the impact of topical PDT on leucocyte trafficking and mediators of chemotaxis in healthy human skin.


Methods:  Aminolevulinic acid (ALA)-PDT was performed on the buttock skin of 7 healthy volunteers. Biopsies for immunohistochemical assessment were taken 1, 4 and 24 h post-PDT and from untreated contralateral buttock skin (baseline).


Results:  A significant dermal neutrophilic ...

Topical ALA-PDT produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo is a post from: Skincare

Topical ALA-PDT produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo via BuzzBlazer.com

Increases in invasive melanoma in England, 1979-2006, by anatomic site

Abstract

Background:  National melanoma incidence trends with details of anatomic site have not been previously described for England.


Objectives:  To describe site-specific trends in cutaneous melanoma for England as a whole during the last 3 decades.


Methods:  Anonymised data 1979-2006 were obtained from national cancer registrations of all patients in England up to age 89 years with incident primary invasive cutaneous melanomas (n= 124 055). Sex-specific age-standardized incidence rates and average annual percentage change in rates were calculated for each broad anatomic site.


Results:  Overall incidence rates of cutaneous melanoma in England, 1979-2006, were ...

Increases in invasive melanoma in England, 1979-2006, by anatomic site is a post from: Skincare

Increases in invasive melanoma in England, 1979-2006, by anatomic site via BuzzBlazer.com

High-concentration all-trans retinoic acid induces dermal inflammation, and reduces the accumulation of type I procollagen in human skin in vivo

Abstract


Background

Because inflammation is an aging-promoting factor, all-trans-retinoic acid (RA)-induced irritation may have a negative influence on collagen accumulation in human skin despite its stimulation of collagen production.



Objectives

To determine whether RA-induced irritation detrimentally affects RA efficacy representing as new collagen synthesis.



Method

RA (0.01%, 0.025% or 0.05%) or vehicle were applied to the buttock skin of elderly male volunteers 3 times a week for 8 weeks under continuous occlusion. Every 2 weeks, biopsy specimens were obtained and immunohistochemical analysis was performed to determine levels of type I procollagen expression and inflammatory cell infiltration.



Results

Topical ...

High-concentration all-trans retinoic acid induces dermal inflammation, and reduces the accumulation of type I procollagen in human skin in vivo is a post from: Skincare

High-concentration all-trans retinoic acid induces dermal inflammation, and reduces the accumulation of type I procollagen in human skin in vivo via BuzzBlazer.com

Prevalence of skin lesions and need for treatment in a cohort of 90,880 workers

Summary

Background:  Healthcare planning requires robust data on the prevalence and need for care of dermatological diseases. To date, no systematic data in population-based samples are available for Germany.


Aim:  Determination of the prevalence of skin lesions and of the need for care based on dermatological exams in working adults in Germany.


Methodology:  From 2004 to 2009, workers aged between 16 and 70 years from different branches of industry throughout Germany underwent a single dermatological whole-body status on the occasion of company screening for skin cancer. The data were recorded electronically and evaluated ...

Prevalence of skin lesions and need for treatment in a cohort of 90,880 workers is a post from: Skincare

Prevalence of skin lesions and need for treatment in a cohort of 90,880 workers via BuzzBlazer.com

Paratumoral gene expression profiles: Promising markers of malignancy in melanocytic lesions

Summary

Gene expression analysis is becoming a useful tool for a better definition of neoplasms at diagnostic, prognostic and predictive levels. A method for gene expression analysis from the corneal layer overlying melanocytic lesions (paratumoral gene expression) offers promising results. The identification of these markers and the negative predictive value (100%) make this test an excellent way for the screening and selection of atypical melanocytic lesions to be biopsied. However, the nature and biological meaning of these markers still need further studies and clarifications: origin of the tested RNA, mechanism of ...

Paratumoral gene expression profiles: Promising markers of malignancy in melanocytic lesions is a post from: Skincare

Paratumoral gene expression profiles: Promising markers of malignancy in melanocytic lesions via BuzzBlazer.com

The mesenchymal stem cell profile in psoriasis.

Abstract

Background:  The expression of inducible nitric oxide synthase (iNOS) and vascular endothelial factor (VEGF) and the level of total oxyradical scavenging capacity have been extensively evaluated in psoriatic patients’ cutaneous cells.


No indications are still available about the undifferentiated cells, the mesenchymal stem cells (MSCs), isolated from skin.


Objectives:  to isolate MSCs in psoriatic patients, and comparing them with those obtained from atopic and healthy subjects, in order to analyzed if MSCs show some typical psoriatic profiles and to understand if physiopatological events leading to psoriasis start early at staminal level or ...

The mesenchymal stem cell profile in psoriasis. is a post from: Skincare

The mesenchymal stem cell profile in psoriasis. via BuzzBlazer.com

Adenovirus-relaxin Gene Therapy for Keloids: Implication for Reversing Pathologic Fibrosis

Summary

Background  Keloids or hypertrophic scars are pathologic proliferations of the dermal skin layer resulting from excessive collagen deposition. Because the hormone relaxin (RLX) inhibits collagen synthesis and expression in stimulated fibroblasts, an adenovirus expressing RLX (dE1-RGD/lacZ/RLX) was generated.


Objectives  To investigate the effect of relaxin-expressing adenovirus on expression of various extracellular matrixes in primary keloid spheroids.


Methods  The expression levels of type I and III collagen, fibronectin, and elastin were investigated by immunohistochemistry in primary keloid spheroids transduced with the RLX-expressing adenovirus.


Results  Immunohistochemical analysis showed that expression of major extracellular matrix (ECM) ...

Adenovirus-relaxin Gene Therapy for Keloids: Implication for Reversing Pathologic Fibrosis is a post from: Skincare

Adenovirus-relaxin Gene Therapy for Keloids: Implication for Reversing Pathologic Fibrosis via BuzzBlazer.com

Low dose Isotretinoin in Acne Vulgaris – A Critical Review

Low dose Isotretinoin in Acne Vulgaris – A Critical Review is a post from: Skincare

Low dose Isotretinoin in Acne Vulgaris – A Critical Review is a post from: Skincare

Low dose Isotretinoin in Acne Vulgaris – A Critical Review via BuzzBlazer.com

Outcomes of 11 Pregnancies in 3 Patients with Recessive Forms of Epidermolysis Bullosa

Outcomes of 11 Pregnancies in 3 Patients with Recessive Forms of Epidermolysis Bullosa is a post from: Skincare

Outcomes of 11 Pregnancies in 3 Patients with Recessive Forms of Epidermolysis Bullosa is a post from: Skincare

Outcomes of 11 Pregnancies in 3 Patients with Recessive Forms of Epidermolysis Bullosa via BuzzBlazer.com

Erythema scarlatiniforme desquamativum recidivans

Erythema scarlatiniforme desquamativum recidivans is a post from: Skincare

Erythema scarlatiniforme desquamativum recidivans is a post from: Skincare

Erythema scarlatiniforme desquamativum recidivans via BuzzBlazer.com

An investigation of the association between diet and occurrence of acne: a rational approach from a traditional Chinese medicine perspective – comment

An investigation of the association between diet and occurrence of acne: a rational approach from a traditional Chinese medicine perspective – comment is a post from: Skincare

An investigation of the association between diet and occurrence of acne: a rational approach from a traditional Chinese medicine perspective – comment is a post from: Skincare

An investigation of the association between diet and occurrence of acne: a rational approach from a traditional Chinese medicine perspective – comment via BuzzBlazer.com

Efficacy and Safety of Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment of Melasma

BACKGROUND
Melasma is a common pigmentary disorder that affects all skin types but is seen more in individuals with Fitzpatrick skin type IV to VI. Safe and effective treatment options for melasma need to be explored. Already proven effective for the treatment of pigmentary disorders, lasers have been used to treat melasma in recent years.


OBJECTIVE
To evaluate the efficacy and safety profile of a 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser in the treatment of melasma.


METHODS
Fifty patients were recruited for this study (47 female; 3 male). All ...

Efficacy and Safety of Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment of Melasma is a post from: Skincare

Efficacy and Safety of Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment of Melasma via BuzzBlazer.com

Ethylene Vinyl Acetate (Foam): An Inexpensive and Useful Tool for Teaching Suture Techniques in Dermatologic Surgery

The authors have indicated no significant interest with commercial supporters.

Ethylene Vinyl Acetate (Foam): An Inexpensive and Useful Tool for Teaching Suture Techniques in Dermatologic Surgery is a post from: Skincare

Ethylene Vinyl Acetate (Foam): An Inexpensive and Useful Tool for Teaching Suture Techniques in Dermatologic Surgery is a post from: Skincare

Ethylene Vinyl Acetate (Foam): An Inexpensive and Useful Tool for Teaching Suture Techniques in Dermatologic Surgery via BuzzBlazer.com

Treatment of Refractory Discoid Lupus Erythematosus Using 1,064-nm Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser

The authors have indicated no significant interest with commercial supporters.

Treatment of Refractory Discoid Lupus Erythematosus Using 1,064-nm Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser is a post from: Skincare

Treatment of Refractory Discoid Lupus Erythematosus Using 1,064-nm Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser is a post from: Skincare

Treatment of Refractory Discoid Lupus Erythematosus Using 1,064-nm Long-Pulse Neodymium-Doped Yttrium Aluminum Garnet Laser via BuzzBlazer.com

Reconstruction of a Large Preauricular Defect

The authors have indicated no significant interest with commercial supporters.

Reconstruction of a Large Preauricular Defect is a post from: Skincare

Reconstruction of a Large Preauricular Defect is a post from: Skincare

Reconstruction of a Large Preauricular Defect via BuzzBlazer.com

Epidermal Growth Factor Receptor Inhibitors in the Treatment of Nonmelanoma Skin Cancers

BACKGROUND
A better understanding of the molecular pathways that characterize cell growth, apoptosis, angiogenesis, and invasion has provided novel targets in cancer therapy. Epidermal growth factor receptor (EGFR)-mediated signal transduction has been one of the most studied pathways in carcinogenesis. The phosphorylation of EGFR activates multiple biological processes, including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, DNA repair, and survival. EGFR is a transmembrane tyrosine kinase receptor involved in the proliferation and survival of cancer cells. EGFR is the first molecular target against which monoclonal antibodies have been developed for ...

Epidermal Growth Factor Receptor Inhibitors in the Treatment of Nonmelanoma Skin Cancers is a post from: Skincare

Epidermal Growth Factor Receptor Inhibitors in the Treatment of Nonmelanoma Skin Cancers via BuzzBlazer.com

A Descriptive Study of Bacterial Load of Full-Thickness Surgical Wounds in Dermatologic Surgery

BACKGROUND
Surgical site infections (SSIs) after dermatologic surgery cause pain, prolong healing, result in unaesthetic complications, and lead to excessive use of antibiotics. The pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors.


OBJECTIVE
To investigate bacterial dynamics at dermatosurgical sites at different time intervals and assess the correlation with postoperative outcomes and to examine different endo- and exogenous factors that may contribute to SSIs.


METHODS
Eighteen patients undergoing skin grafting of the face were studied. The following SSI-related factors were registered: age and ...

A Descriptive Study of Bacterial Load of Full-Thickness Surgical Wounds in Dermatologic Surgery is a post from: Skincare

A Descriptive Study of Bacterial Load of Full-Thickness Surgical Wounds in Dermatologic Surgery via BuzzBlazer.com

A tomato stem cell extract, containing antioxidant compounds and metal chelating factors, protects skin cells from heavy metal-induced damages

Synopsis

Heavy metals can cause several genotoxic effects on cells, including oxidative stress, DNA sequence breakage and protein modification. Among the body organs, skin is certainly the most exposed to heavy metal stress and thus the most damaged by the toxic effects that these chemicals cause. Moreover, heavy metals, in particular nickel, can induce the over-expression of collagenases (enzymes responsible for collagen degradation), leading to weakening of the skin extracellular matrix. Plants have evolved sophisticated mechanisms to protect their cells from heavy metal toxicity, including the synthesis of metal chelating proteins ...

A tomato stem cell extract, containing antioxidant compounds and metal chelating factors, protects skin cells from heavy metal-induced damages is a post from: Skincare

A tomato stem cell extract, containing antioxidant compounds and metal chelating factors, protects skin cells from heavy metal-induced damages via BuzzBlazer.com

Transverse fingernail curvature in adults: a quantitative evaluation and the influence of gender, age, and hand size and dominance

Synopsis

The nail plate’s convex shape in both the longitudinal and transverse directions is thought to contribute to its mechanical rigidity, and overcurvature can be a symptom of local and/or systemic disorders. Although a number of methods to measure the longitudinal nail curvature have been proposed, evaluation of the transverse nail curvature has been largely limited to visual estimation of overcurved nail plates. The aim of this study was therefore to measure the transverse curvature of healthy adult fingernail plates and thereby provide a baseline range for ‘normal curved’ nail plates. ...

Transverse fingernail curvature in adults: a quantitative evaluation and the influence of gender, age, and hand size and dominance is a post from: Skincare

Transverse fingernail curvature in adults: a quantitative evaluation and the influence of gender, age, and hand size and dominance via BuzzBlazer.com

Histopathology and Immunohistochemistry of Cutaneous Lupus Erythematosus after Pulsed Dye Laser Treatment

BACKGROUND
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disorder with a wide range of skin manifestations. Current treatment options include topical and systemic approaches. Few controlled prospective studies have been performed using the pulsed dye laser (PDL). Based on previous experience that supported the efficacy of PDL treatment of CLE, we decided to study the histological changes induced by PDL.


OBSERVATIONS
A prospective study was performed on nine patients with histologically confirmed CLE treated with PDL. Biopsies were taken before, immediately after, and 4 weeks after treatment and stained with ...

Histopathology and Immunohistochemistry of Cutaneous Lupus Erythematosus after Pulsed Dye Laser Treatment is a post from: Skincare

Histopathology and Immunohistochemistry of Cutaneous Lupus Erythematosus after Pulsed Dye Laser Treatment via BuzzBlazer.com

Soft Tissue Myoepithelioma of the Scalp in a 11-Year-Old Girl: A Challenging Diagnosis

Abstract:  Myoepithelioma is a well-known tumor in the salivary glands and breasts in adults. It is exceptionally rare in soft tissue and in children. We present a case of subcutaneous scalp myoepithelioma in an 11-year-old girl. On clinical examination, it appeared as a dermoid cyst. Myoepithelioma is uncommon in the subcutaneous tissue. Clinically, the neoplasm is nonspecific. Because of the variable appearance of myoepithelial cells and their phenotype, the pathological diagnosis is challenging. We report a case of subcutaneous myoepithelioma in a child and discuss the literature.

Soft Tissue Myoepithelioma of ...

Soft Tissue Myoepithelioma of the Scalp in a 11-Year-Old Girl: A Challenging Diagnosis is a post from: Skincare

Soft Tissue Myoepithelioma of the Scalp in a 11-Year-Old Girl: A Challenging Diagnosis via BuzzBlazer.com

Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot

BACKGROUND
Melanoma in dark-skinned individuals often develops in an acral lentiginous fashion on the foot. After wide excision, substantial defects usually develop and they may endure insufficient vascular flow. In addition, the final scar must withstand the mechanical stress of daily walking. Various repair methods are used to repair these defects, but secondary intention healing has not been evaluated in the repair of wounds of the foot.


OBJECTIVE
To compare the functional and cosmetic results of secondary intention healing and full-thickness skin graft after wide excision of melanoma on the foot.


METHODS
...

Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot is a post from: Skincare

Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot via BuzzBlazer.com

Foam Sclerotherapy: Investigating the Need for Sterile Air

BACKGROUND
Sclerotherapy with foam is becoming increasingly popular for the treatment of varicose veins. There is no consensus on the necessity of sterile air or other gases to produce foam.


OBJECTIVES
To evaluate the potential risk of bacterial inoculation of polidocanol (POL) foam using room air and the antimicrobial properties of polidocanol.


MATERIALS AND METHODS
The amount of airborne microorganisms was quantitatively measured. Four bacterial strains were tested for susceptibility to polidocanol: Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Streptococcus pyogenes.


RESULTS
Air measurements varied as a result of air movement and the ...

Foam Sclerotherapy: Investigating the Need for Sterile Air is a post from: Skincare

Foam Sclerotherapy: Investigating the Need for Sterile Air via BuzzBlazer.com

The effect of a corticosteroid cream and a barrier-strengthening moisturizer in hand eczema. A double-blind, randomized, prospective, parallel group clinical trial

Abstract

Background  Hand eczema is a common and persistent disease with a relapsing course. Clinical data suggest that once daily treatment with corticosteroids is just as effective as twice daily treatment.


Objectives  The aim of this study was to compare once and twice daily applications of a strong corticosteroid cream in addition to maintenance therapy with a moisturizer in patients with a recent relapse of hand eczema.


Methods  The study was a parallel, double-blind, randomized, clinical trial on 44 patients. Twice daily application of a strong corticosteroid cream (betamethasone valerate 0.1%) was compared ...

The effect of a corticosteroid cream and a barrier-strengthening moisturizer in hand eczema. A double-blind, randomized, prospective, parallel group clinical trial is a post from: Skincare

The effect of a corticosteroid cream and a barrier-strengthening moisturizer in hand eczema. A double-blind, randomized, prospective, parallel group clinical trial via BuzzBlazer.com

Not all that looks like eczema is atopic eczema

Not all that looks like eczema is atopic eczema is a post from: Skincare

Not all that looks like eczema is atopic eczema is a post from: Skincare

Not all that looks like eczema is atopic eczema via BuzzBlazer.com

Visceral lesions occurring during follow-up of melanoma patients: a true place for other diagnosis than melanoma metastasis

Abstract

Background  Diagnosis of melanoma metastasis is often based on a combination of clinical and radiological examinations in patients with a past history of melanoma. Chemotherapeutic treatment is often proposed without histological proof of the metastatic status.


Objective  The aim of this study was to investigate a cohort of melanoma patients with invasive diagnostic procedures (IDPs) for pathological confirmation of metastasis in case of suspicious visceral lesions.


Methods  A total of 109 melanoma patients with IDPs for suspicious visceral lesion(s) were included. Data about primary melanoma, IDPs characteristics, pathological result and therapeutic consequence ...

Visceral lesions occurring during follow-up of melanoma patients: a true place for other diagnosis than melanoma metastasis is a post from: Skincare

Visceral lesions occurring during follow-up of melanoma patients: a true place for other diagnosis than melanoma metastasis via BuzzBlazer.com

Presence of putative stem cells in Merkel cell carcinomas

Presence of putative stem cells in Merkel cell carcinomas is a post from: Skincare

Presence of putative stem cells in Merkel cell carcinomas is a post from: Skincare

Presence of putative stem cells in Merkel cell carcinomas via BuzzBlazer.com

Characterization of a new acne vulgaris treatment device combining light and thermal treatment methods

Background/purpose: Conventional treatment methods for acne vulgaris have various side effects such as the development of bacterial resistance, phototoxicity, vertigo, gastro-intestinal problems, and drug eruptions. To minimize such side effects, light and thermal methods have been alternately suggested. This study characterized a new acne vulgaris treatment device (AVTD) that combines both light and thermal methods and evaluated its clinical efficacy.


Methods: We characterized the thermal and light properties of the AVTD itself and evaluated its thermal characteristics in ex vivo porcine skin samples. The Arrhenius equation was used to ...

Characterization of a new acne vulgaris treatment device combining light and thermal treatment methods is a post from: Skincare

Characterization of a new acne vulgaris treatment device combining light and thermal treatment methods via BuzzBlazer.com

Thermography as a predictor of postherpetic neuralgia in acute herpes zoster patients: a preliminary study

Background/purpose: Infrared thermal images in patients suffering from herpes zoster (HZ) may exhibit thermal asymmetry due to the unilateral distribution of HZ lesions. This study examined the usefulness of infrared thermography in acute HZ as a predictor for the development of postherpetic neuralgia (PHN).


Methods: The authors collected demographic and clinical data including age, sex, onset of skin lesion, pain intensity by a visual analogue scale (VAS) and the development of PHN from a total of 55 patients diagnosed with HZ. We evaluated the body surface thermographic parameters between ...

Thermography as a predictor of postherpetic neuralgia in acute herpes zoster patients: a preliminary study is a post from: Skincare

Thermography as a predictor of postherpetic neuralgia in acute herpes zoster patients: a preliminary study via BuzzBlazer.com

Ability to estimate relative percutaneous penetration via a surrogate maker – trans epidermal water loss?

Aims: This study measures the dynamic change of the trans-epidermal water loss (TEWL) rate and in vitro skin permeation data of tritiated water and [14C]-clonidine HCl in order to refine our knowledge in the relationship between percutaneous penetration and TEWL.


Measures: TEWL values were measured before and during the experimental period. Single application of tritiated water and [14C]-clonidine HCl were dosed at the same time on dermatomed human skin samples collected from 12 donors in a flow through diffusion cell system. Radioactivity of absorbed dose: stratum corneum, epidermis, dermis, ...

Ability to estimate relative percutaneous penetration via a surrogate maker – trans epidermal water loss? is a post from: Skincare

Ability to estimate relative percutaneous penetration via a surrogate maker – trans epidermal water loss? via BuzzBlazer.com

Acne analysis, grading and computational assessment methods: an overview

Introduction: This paper presents a comprehensive review of acne grading and measurement. Acne is a chronic disorder of the pilosebaceous units, with excess sebum production, follicular epidermal hyperproliferation, inflammation and Propionibacterium acnes activity. Most patients are affected with acne vulgaris, which is the prevalent type of acne. Acne vulgaris consists of comedones (whitehead and blackhead), papules, pustules, nodules and cysts.


Objectives: To review and identify the issues for acne vulgaris grading and computational assessment methods. To determine the future direction for addressing the identified issues.


Methods: There are two ...

Acne analysis, grading and computational assessment methods: an overview is a post from: Skincare

Acne analysis, grading and computational assessment methods: an overview via BuzzBlazer.com

The linear excisional wound: an improved model for human ex vivo wound epithelialization studies

Background/purpose: Wound healing is a complex process that involves multiple intercellular and intracellular processes and extracellular interactions. Explanted human skin has been used as a model for the re-epithelialization phase of human wound healing. The currently used standard technique uses a circular punch biopsy tool to make the initial wound. Despite its wide use, the geometry of round wounds makes it difficult to measure them reliably.


Methods: Our group has designed a linear wounding tool, and compared the variability in ex vivo human linear and circular wounds.


Results: An ...

The linear excisional wound: an improved model for human ex vivo wound epithelialization studies is a post from: Skincare

The linear excisional wound: an improved model for human ex vivo wound epithelialization studies via BuzzBlazer.com

Mucosal contact urticaria to sesame seeds

Mucosal contact urticaria to sesame seeds is a post from: Skincare

Mucosal contact urticaria to sesame seeds is a post from: Skincare

Mucosal contact urticaria to sesame seeds via BuzzBlazer.com

Time trends of contact allergy to a modified European baseline series in Beijing between 2001 and 2006

Background. Monitoring trends of sensitivity rates in a population is useful for epidemiological surveillance. The time trends for sensitivity rates of allergens have not previously been reported in China.


Objectives. The aim of the present study was to determine the prevalence and trends of contact allergy in patients with suspected allergic contact dermatitis in Beijing, China.


Patients/Methods. A retrospective analysis of all patch test data from our database was performed. A total of 1354 patients with suspected allergic contact dermatitis between 2001 and 2006 were studied. Patch tests with 20 allergens or ...

Time trends of contact allergy to a modified European baseline series in Beijing between 2001 and 2006 is a post from: Skincare

Time trends of contact allergy to a modified European baseline series in Beijing between 2001 and 2006 via BuzzBlazer.com

CONFOCAL MICROSCOPIC FEATURES OF SCARRING ALOPECIA: PRELIMINARY REPORT

Abstract:

Background:  lichen planus pilaris (LPP), and discoid lupus erythematosus (DLE) are the most common causes of lymphocytic primary cicatricial alopecias. The management of scarring alopecias can be difficult. Combination of clinic, dermoscopy and reflectance confocal microscopy (RCM), a non-invasive, high-resolution imaging technique, have been already demonstrated to be useful for choosing the correct biopsy site in patients with inflammatory skin diseases and obtaining microscopic diagnostic criteria.


Objectives: we evaluated the real usefulness of RCM for identification of criteria for LPP and DLE involving the scalp and their management during therapeutical follow-up.


Methods:  7 ...

CONFOCAL MICROSCOPIC FEATURES OF SCARRING ALOPECIA: PRELIMINARY REPORT is a post from: Skincare

CONFOCAL MICROSCOPIC FEATURES OF SCARRING ALOPECIA: PRELIMINARY REPORT via BuzzBlazer.com

Is occupational solar UV-irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiologic literature

Abstract

Background:  The most important risk factor for basal cell carcinoma (BCC) is UV-radiation. It is reasonable to assume that outdoor workers with a long history of work-related UV-exposure are at increased risk of developing BCC.


Objectives:  To systematically analyse the epidemiologic literature concerning the evidence of an association between occupational UV-exposure and BCC risk in outdoor workers.


Methods:  Systematic literature review of cohort studies and case-control studies providing data on occupational UV-exposure and BCC occurrence. PubMed (until 28th January 2011) was searched, supplemented by hand searching and consultation of experts in the ...

Is occupational solar UV-irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiologic literature is a post from: Skincare

Is occupational solar UV-irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiologic literature via BuzzBlazer.com

Patients with Delusional Infestation (Delusional Parasitosis) often require prolonged treatment as recurrence of symptoms after cessation of treatment is common: An observational study

Abstract

Background:  Delusional infestation (DI) is an uncommon psychiatric disorder in which patients present with the false and fixed belief of infestation. Numerous studies have demonstrated improvement with pharmacological treatment, however recurrence rates on cessation of treatment remains unknown.


Objective:  To assess the clinical response and recurrence rates following treatment for DI


Methods:  All DI patients seen in our combined dermatology/psychiatry clinic to date (n = 73) were offered pharmacological therapy. Patients were contacted to complete a telephone questionnaire to assess clinical outcomes, including remission and recurrence rates following treatment.


Results:  81% (59/73) of ...

Patients with Delusional Infestation (Delusional Parasitosis) often require prolonged treatment as recurrence of symptoms after cessation of treatment is common: An observational study is a post from: Skincare

Patients with Delusional Infestation (Delusional Parasitosis) often require prolonged treatment as recurrence of symptoms after cessation of treatment is common: An observational study via BuzzBlazer.com

Multicentre patch testing with a resol resin based on phenol and formaldehyde

Background. Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin (PTBP-FR) included in most baseline patch test series.


Objectives. To investigate the rate of contact allergy to PFR-2 (a mixture of monomers and dimers from a resol resin based on phenol and formaldehyde) in a Swedish population, and to investigate associated simultaneous allergic reactions.


Methods. Five centres representing the Swedish Contact Dermatitis Research Group included PFR-2 in their patch test baseline series for a period of 1.5 years.


Results. Of 2504 patients tested, 27 ...

Multicentre patch testing with a resol resin based on phenol and formaldehyde is a post from: Skincare

Multicentre patch testing with a resol resin based on phenol and formaldehyde via BuzzBlazer.com

Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children

Background. According to clinical impression, extreme patch test reactions (+++) to p-phenylenediamine (PPD) are not uncommon in children.


Objectives. To investigate the patch test reactivity in children (aged 1–14 years) in comparison with other age groups and other allergens.


Methods. A retrospective analysis was performed of data from the German Information Network of Departments of Dermatology, including all patients consecutively patch tested between 1994 and 2004 with PPD, and, for comparison, nickel, fragrance mix I, and methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI). The distribution of +, ++ and +++ grades of positive reactions among those ...

Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children is a post from: Skincare

Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children via BuzzBlazer.com

Sustained remission of nodular inflammatory acne after treatment with infliximab

Sustained remission of nodular inflammatory acne after treatment with infliximab is a post from: Skincare

Sustained remission of nodular inflammatory acne after treatment with infliximab is a post from: Skincare

Sustained remission of nodular inflammatory acne after treatment with infliximab via BuzzBlazer.com

Clinical Efficacy of Different Doses of Rituximab in the Treatment of Pemphigus: A Retrospective Study of 27 patients

ABSTRACT

Background:  The treatment of pemphigus is still challenging and some pemphigus patients are unresponsive to conventional immunosuppressive treatments. Rituximab, a chimeric monoclonal anti-CD20 antibody, binds to the CD20 antigen on the surfaces of B cells and has been reported to be effective for the treatment of recalcitrant pemphigus.


Objective:  The aim of this study was to compare the efficacy of different doses of rituximab in patients with pemphigus who were unresponsive to conventional therapies.


Methods:  Twenty-seven pemphigus patients who received different doses of rituximab (375mg/m2 per infusion weekly) were analyzed retrospectively. We ...

Clinical Efficacy of Different Doses of Rituximab in the Treatment of Pemphigus: A Retrospective Study of 27 patients is a post from: Skincare

Clinical Efficacy of Different Doses of Rituximab in the Treatment of Pemphigus: A Retrospective Study of 27 patients via BuzzBlazer.com

Immunophenotype of skin lymphocytic infiltrate in M.leprae and HIV co-infected patients: a scenario dependent of CD8+ and/or CD20+ cells.

Abstract

Background.  Leprosy occurs rarely in human immunodeficiency virus (HIV) positive patients. As opposed to tuberculosis, neither an increase in HIV prevalence among leprosy patients nor differences in leprosy’s clinical spectrum has been reported so far. While several studies describe the systemic immune response profile in HIV-leprosy co-infected patients, local immune skin response has been only evaluated in a small number of case reports and limited series of patients.


Patients and methods.  We investigated the presence and frequency of CD4, CD8, CD20, TIA-1, FoxP3 and CD123 positive cells in lymphocytic infiltrates from ...

Immunophenotype of skin lymphocytic infiltrate in M.leprae and HIV co-infected patients: a scenario dependent of CD8+ and/or CD20+ cells. is a post from: Skincare

Immunophenotype of skin lymphocytic infiltrate in M.leprae and HIV co-infected patients: a scenario dependent of CD8+ and/or CD20+ cells. via BuzzBlazer.com

Mortality of bullous pemphigoid in Switzerland: a prospective study

Summary

Background:  Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and has been associated with a significant morbidity and an increased mortality rate.


Objectives:  Our aims were: (i) to evaluate the mortality rate of BP in Swiss patients during the first three years after the diagnosis of BP, as primary endpoint; and (ii) to compare this mortality rate to that of the general Swiss population and determine prognostics factors, as secondary endpoints.


Methods:  All new cases of BP diagnosed in Switzerland between 1 January 2001 and 31 ...

Mortality of bullous pemphigoid in Switzerland: a prospective study is a post from: Skincare

Mortality of bullous pemphigoid in Switzerland: a prospective study via BuzzBlazer.com

A founder synonymous COL7A1 mutation in three Danish families with dominant dystrophic epidermolysis bullosa pruriginosa identifies exonic regulatory sequences required for exon 87 splicing

A founder synonymous COL7A1 mutation in three Danish families with dominant dystrophic epidermolysis bullosa pruriginosa identifies exonic regulatory sequences required for exon 87 splicing is a post from: Skincare

A founder synonymous COL7A1 mutation in three Danish families with dominant dystrophic epidermolysis bullosa pruriginosa identifies exonic regulatory sequences required for exon 87 splicing is a post from: Skincare

A founder synonymous COL7A1 mutation in three Danish families with dominant dystrophic epidermolysis bullosa pruriginosa identifies exonic regulatory sequences required for exon 87 splicing via BuzzBlazer.com

“Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature”

ABSTRACT

As our understanding of the role of ultraviolet (UV) radiation exposure in causing skin cancer continues to be enhanced, it is important that clinicians and researchers are familiar with the various methods for assessing photodamage to skin. This paper provides a systematic review of the published literature on invasive and non-invasive methods used to quantify lifetime UV exposure (‘photoageing’). Clinical examination, histopathology, immunohistochemistry, skin surface topography and ultrasound, in addition to newer technologies such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT) and multiphoton tomography (MPT), were reviewed. It ...

“Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature” is a post from: Skincare

“Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature” via BuzzBlazer.com

Outdoor sports and risk of UV-related skin lesions in children: evaluation of risks, and prevention.

Summary

Background:  Excessive ultraviolet (UV) exposure can cause skin cancers, skin photoaging, and cataracts. Children are targeted by sun protection campaigns since high sun exposure and sunburn in childhood increase the risk of melanoma in adulthood. Little information is available about UV risk and exposure in children who take part in outdoor sports.


Objective:  To evaluate the risk of developing UV-induced skin lesions run by children who practice outdoor sports, and UV exposure and sun prevention measures during a soccer tournament.


Methods:  Firstly, we evaluated the relationship between melanocytic nevus – a skin ...

Outdoor sports and risk of UV-related skin lesions in children: evaluation of risks, and prevention. is a post from: Skincare

Outdoor sports and risk of UV-related skin lesions in children: evaluation of risks, and prevention. via BuzzBlazer.com

Human Papilloma Virus Types 1, 16 and 18 Detected in the Lesion of Verrucous Carcinoma of the Cheek

Human Papilloma Virus Types 1, 16 and 18 Detected in the Lesion of Verrucous Carcinoma of the Cheek is a post from: Skincare

Human Papilloma Virus Types 1, 16 and 18 Detected in the Lesion of Verrucous Carcinoma of the Cheek is a post from: Skincare

Human Papilloma Virus Types 1, 16 and 18 Detected in the Lesion of Verrucous Carcinoma of the Cheek via BuzzBlazer.com

Efficacy and Safety of Briakinumab Versus Etanercept and Placebo in Patients with Moderate to Severe Chronic Plaque Psoriasis

Abstract

Background:  The anti-IL-12/23p40 monoclonal antibody briakinumab has been shown in a Phase 2 study to be effective psoriasis treatment.


Objective:  The aim of the current study was to assess the efficacy, safety, and tolerability of briakinumab compared with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis.


Methods:  In this Phase III, 12-week study (M10-114, NCT00691964), 347 patients were randomised in a 2:2:1 ratio to receive 200 mg briakinumab at Weeks 0 and 4 followed by 100 mg briakinumab at Week 8 (n=138); 50 mg of etanercept twice weekly ...

Efficacy and Safety of Briakinumab Versus Etanercept and Placebo in Patients with Moderate to Severe Chronic Plaque Psoriasis is a post from: Skincare

Efficacy and Safety of Briakinumab Versus Etanercept and Placebo in Patients with Moderate to Severe Chronic Plaque Psoriasis via BuzzBlazer.com

Efficacy and Safety Results from a Phase III, Randomised Controlled Trial Comparing the Safety and Efficacy of Briakinumab to Etanercept and Placebo in Patients with Moderate to Severe Chronic Plaque Psoriasis

Abstract

Background:  The TNF-α antagonist etanercept, and the IL-12/23p40 antagonist ustekinumab, have been shown to be effective psoriasis therapies. The IL-12/23 p40 antagonist briakinumab was shown to be effective psoriasis treatment in a Phase 2 study.


Objective:  To assess the efficacy, safety, and tolerability of briakinumab compared with etanercept and placebo in moderate to severe psoriasis patients.


Methods:  350 patients were enroled in this Phase III, 12-week study (M10-315, NCT00710580) and randomised in the following 2:2:1 ratio: 139 patients received 200 mg briakinumab at Weeks 0 and 4 followed by 100 mg briakinumab ...

Efficacy and Safety Results from a Phase III, Randomised Controlled Trial Comparing the Safety and Efficacy of Briakinumab to Etanercept and Placebo in Patients with Moderate to Severe Chronic Plaque Psoriasis is a post from: Skincare

Efficacy and Safety Results from a Phase III, Randomised Controlled Trial Comparing the Safety and Efficacy of Briakinumab to Etanercept and Placebo in Patients with Moderate to Severe Chronic Plaque Psoriasis via BuzzBlazer.com

The Operative Management of Melanoma: Where Does Mohs Surgery Fit In?

BACKGROUND
Melanoma is a life-threatening malignancy. Surgery is the primary management for melanoma, and management guidelines have evolved gradually over a century from radical surgery with lymph node dissection to conservative margin surgery. There are specific rationales and problems with Mohs micrographic (MMS) surgery for managing melanoma.


OBJECTIVE
To review the literature for the surgical management of melanoma and to understand where MMS fits in this spectrum of management options.


CONCLUSIONS
MMS should be considered as an option for melanoma surgery, especially when the tumor is found in photodamaged skin. Further randomized ...

The Operative Management of Melanoma: Where Does Mohs Surgery Fit In? is a post from: Skincare

The Operative Management of Melanoma: Where Does Mohs Surgery Fit In? via BuzzBlazer.com

Electrosurgery and Implantable Electronic Devices: Review and Implications for Office-Based Procedures

The authors have indicated no significant interest with commercial supporters.

Electrosurgery and Implantable Electronic Devices: Review and Implications for Office-Based Procedures is a post from: Skincare

Electrosurgery and Implantable Electronic Devices: Review and Implications for Office-Based Procedures is a post from: Skincare

Electrosurgery and Implantable Electronic Devices: Review and Implications for Office-Based Procedures via BuzzBlazer.com

Acne Scar Treatment with Subcision Using a 20-G Cataract Blade

The authors have indicated no significant interest with commercial supporters.

Acne Scar Treatment with Subcision Using a 20-G Cataract Blade is a post from: Skincare

Acne Scar Treatment with Subcision Using a 20-G Cataract Blade is a post from: Skincare

Acne Scar Treatment with Subcision Using a 20-G Cataract Blade via BuzzBlazer.com

Aesthetic Dermatology for Aging Ethnic Skin

BACKGROUND
Dark-skinned patients manifest the signs of skin aging differently than their fair-skinned counterparts in that the former exhibit more intrinsic facial aging, whereas the later shows more photodamage. Nevertheless, common cosmetic procedures can be used in skin of color to treat the signs of aging.


OBJECTIVE
To provide updated clinical information on the use of cosmetic procedures for skin aging in darker phototypes for the safe treatment of this population.


METHODS
A Medline literature search was performed for publications on the safety and efficacy of botulinum toxin, dermal fillers, chemical peels, ...

Aesthetic Dermatology for Aging Ethnic Skin is a post from: Skincare

Aesthetic Dermatology for Aging Ethnic Skin via BuzzBlazer.com

Eyebrow Epilation by Threading: An Increasingly Popular Procedure With Some Less-Popular Outcomes—A Comprehensive Review

The authors have indicated no significant interest with commercial supporters.

Eyebrow Epilation by Threading: An Increasingly Popular Procedure With Some Less-Popular Outcomes—A Comprehensive Review is a post from: Skincare

Eyebrow Epilation by Threading: An Increasingly Popular Procedure With Some Less-Popular Outcomes—A Comprehensive Review is a post from: Skincare

Eyebrow Epilation by Threading: An Increasingly Popular Procedure With Some Less-Popular Outcomes—A Comprehensive Review via BuzzBlazer.com

Efficacy of 694-nm Q-Switched Ruby Fractional Laser Treatment of Melasma in Female Korean Patients

BACKGROUND
Melasma is a common acquired symmetrical hypermelanosis of sun-exposed areas of the skin. Although the classical Q-switched ruby laser (QSRL) has been used successfully for the removal of tattoos and for the treatment of cutaneous pigmented lesions, its efficacy for melasma remains controversial.


OBJECTIVE
We used repeat low-dose fractional QSRL treatment for melasma and analyzed the clinical results.


METHODS
Fifteen Korean women with melasma were enrolled. Each patient received six low-dose fractional QSRL treatments to the face at 2-week intervals. Two investigators independently evaluated Melasma Area and Severity Index (MASI) scores ...

Efficacy of 694-nm Q-Switched Ruby Fractional Laser Treatment of Melasma in Female Korean Patients is a post from: Skincare

Efficacy of 694-nm Q-Switched Ruby Fractional Laser Treatment of Melasma in Female Korean Patients via BuzzBlazer.com

Facilitated Scalp Measuring Using Phototrichogram with a Headband and Tapeline

The authors have indicated no significant interest with commercial supporters.

Facilitated Scalp Measuring Using Phototrichogram with a Headband and Tapeline is a post from: Skincare

Facilitated Scalp Measuring Using Phototrichogram with a Headband and Tapeline is a post from: Skincare

Facilitated Scalp Measuring Using Phototrichogram with a Headband and Tapeline via BuzzBlazer.com

Hair Transplantation for Reconstruction of Scalp Defects Using Artificial Dermis

The authors have indicated no significant interest with commercial supporters.

Hair Transplantation for Reconstruction of Scalp Defects Using Artificial Dermis is a post from: Skincare

Hair Transplantation for Reconstruction of Scalp Defects Using Artificial Dermis is a post from: Skincare

Hair Transplantation for Reconstruction of Scalp Defects Using Artificial Dermis via BuzzBlazer.com

Technical Feasibility and Early Results of Radiologically Guided Foam Sclerotherapy for Treatment of Varicose Veins

BACKGROUND
Duplex ultrasound guidance of foam sclerotherapy has been established as a routine and standard treatment of varicose veins, but duplex-guided technique is not perfect because of its inherent shortcomings, and correlative complications have been reported. Moreover, not every country or region of the world can use duplex ultrasound guidance for foam sclerotherapy.


OBJECTIVE
To describe an original technique of using radiologically guided foam sclerotherapy for the treatment of leg varicose veins and to evaluate the technical feasibility and early results.


MATERIALS AND METHODS
Fifty-nine legs of 41 patients (23 male, 18 ...

Technical Feasibility and Early Results of Radiologically Guided Foam Sclerotherapy for Treatment of Varicose Veins is a post from: Skincare

Technical Feasibility and Early Results of Radiologically Guided Foam Sclerotherapy for Treatment of Varicose Veins via BuzzBlazer.com

Patients with early-onset psoriasis achieve better results following Dead Sea climatotherapy

Abstract

Background  Plaque psoriasis has recently been divided in two types, which differ in severity and inheritance according to the age of the patient at the onset of the disease.


Aim  To compare the effect of Dead Sea climatotherapy (DSC) on these two types of disease, with early vs. late onset, and to determine the impact of this treatment on the response rate.


Methods  The files of 605 patients who were suffering from plaque psoriasis were retrieved from the database of the Research Institute at the Dead Sea (RIDS) and divided in two ...

Patients with early-onset psoriasis achieve better results following Dead Sea climatotherapy is a post from: Skincare

Patients with early-onset psoriasis achieve better results following Dead Sea climatotherapy via BuzzBlazer.com

The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients

Abstract

Background  Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, the pre-identification of transplant patients at increased risk for non-melanoma skin cancer remains difficult.


Objective  To investigate the Hp polymorphism as a marker for the identification of a subset of patients with an increased susceptibility to develop SCC/Bowen’s disease.


Methods  Haptoglobin phenotyping was performed with haemoglobin-supplemented starch gel electrophoresis in 300 kidney transplant patients. High-performance gel permeation chromatography was used in case of low serum haptoglobin concentration.


Results  Cox regression analysis (adjusted for age, gender and Mediterranean ...

The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients is a post from: Skincare

The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients via BuzzBlazer.com

In response to ‘A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment.’

In response to ‘A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment.’ is a post from: Skincare

In response to ‘A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment.’ is a post from: Skincare

In response to ‘A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment.’ via BuzzBlazer.com

The Harlequin phenomenon

Abstract

The Harlequin phenomenon (HF) is a rare event that consists of a sudden paroxystic change in skin colour, resulting in two different body colours. It is most common in the newborn and can be a generalized phenomenon or only involve a specific body area. The HF of the newborn is thought to be secondary to a relative hypothalamic control immaturity of the sympathetic peripheral vascular tonus, although it has also been described in other age groups, primarily located to the face and neck and mostly caused by a sympathetic disautonomy. ...

The Harlequin phenomenon is a post from: Skincare

The Harlequin phenomenon via BuzzBlazer.com

Point and period prevalences of eczema in rural and urban schoolchildren in Ghana, Gabon and Rwanda

Abstract

Background  Eczema is a growing problem in Africa, particularly amongst children.


Objectives  To investigate the point-prevalences of eczema by physical examination in schoolchildren living in rural and urban areas and with different socioeconomic backgrounds in Ghana, Gabon and Rwanda. In Ghana period-prevalences were also estimated by questionnaire and compared with the point-prevalences.


Methods  In total, 4839 schoolchildren in Ghana, Gabon and Rwanda were seen by at least one dermatologist. The point-prevalences of eczema were estimated on the basis of physical examination. Period-prevalences were measured in Ghana with questionnaire based-interviews adapted from the ...

Point and period prevalences of eczema in rural and urban schoolchildren in Ghana, Gabon and Rwanda is a post from: Skincare

Point and period prevalences of eczema in rural and urban schoolchildren in Ghana, Gabon and Rwanda via BuzzBlazer.com

Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China

Abstract

Background  Defect in the SPINK5 gene is known to be implicated in Netherton syndrome (NS), and has been suggested to be a locus predisposing to atopy in general. Coding polymorphisms in SPINK5 exons 13, 14 and 26 have been reported to be associated with atopic dermatitis (AD), asthma and high level of IgE.


Objectives  To examine whether the SPINK5 gene polymorphisms are associated with AD in Northeast China, and to assess how variants influence selected phenotypic traits.


Methods  A case–control study was conducted on four non-synonymous polymorphisms in the coding region of ...

Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China is a post from: Skincare

Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China via BuzzBlazer.com

Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype

Abstract

Background  Amelanotic melanomas remain challenging to diagnose.


Objective  To analyze and describe the clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype.


Patients/Methods  We conducted a retrospective review of 20 consecutively diagnosed amelanotic melanomas. The clinical and dermoscopic images of pathologically confirmed amelanotic melanomas that were not of the nodular subtype were analyzed. In addition, the clinical diagnosis and the reasons why these lesions were biopsied were examined.


Results  All 20 amelanotic melanomas were erythematous and lacked any of the clinical ABCD features commonly attributed to melanoma. The ...

Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype is a post from: Skincare

Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype via BuzzBlazer.com

A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment

A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment is a post from: Skincare

A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment is a post from: Skincare

A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment via BuzzBlazer.com

Bullous lymphomatoid papulosis

Bullous lymphomatoid papulosis is a post from: Skincare

Bullous lymphomatoid papulosis is a post from: Skincare

Bullous lymphomatoid papulosis via BuzzBlazer.com

Sir Archibald Grey 1880–1967: founding father of the British Association of Dermatologists

Sir Archibald Grey 1880–1967: founding father of the British Association of Dermatologists is a post from: Skincare

Sir Archibald Grey 1880–1967: founding father of the British Association of Dermatologists is a post from: Skincare

Sir Archibald Grey 1880–1967: founding father of the British Association of Dermatologists via BuzzBlazer.com

Utilizing hydroglycolic extract from myrobalan fruits to counteract reactive oxygen species

Synopsis

The hydroglycolic (HG) extract from 70% propylene glycol (PG) extraction of myrobalan fruits showed the most appreciable antioxidant efficiency towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) in comparison to the extracts from 30, 50, 70 and 100% ethyl alcohol (EA), and 30, 50 and 100% PG . Its total polyphenols were also higher than others. The additional analysis of antioxidant power revealed that this HG extract was able to counteract the induced oxidation caused by hydrogen peroxide (H2O2) and 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH). The quantification for the antioxidant capacity of the extract showed it was ...

Utilizing hydroglycolic extract from myrobalan fruits to counteract reactive oxygen species is a post from: Skincare

Utilizing hydroglycolic extract from myrobalan fruits to counteract reactive oxygen species via BuzzBlazer.com