Sensory irritation caused by two organic solvents–short-time single application and repeated occlusive test in stingers and non-stingers

Background. Neurosensory irritation is a subjective phenomenon induced by a number of chemicals.


Objectives. To investigate the sensory irritation induced by two organic solvents – n-octane and cumene – between two groups of volunteers, stingers and non-stingers, identified as such according to the results of a lactic acid stinging test (LAST).


Methods. The immediate effects of the solvents were directly compared in a single simultaneous application test. The reaction intensities over time were studied in a repetitive irritation test over 4 days. The volunteers graded the reaction intensities by the use of ...

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