Background: Urticaria is the commonest cutaneous reaction caused by aspirin or other NSAIDs. The pathogenesis of aspirin-induced urticaria (AIU) is not fully understood, but appears to involve mast cell activation and neutrophil infiltration.
Objectives: To investigate the genetic contribution of interleukin-18 (IL-18), which can amplify acute inflammation by promoting mast cell activation, neutrophil migration, and cytokine production, to the pathogenesis of AIU.
Methods: A case–control association study was performed using 247 patients with AIU and 196 normal healthy controls in a Korean population. Two promoter polymorphisms of the IL-18 gene (–607A/C and ...
A functional promoter polymorphism of the human IL-18 gene is associated with aspirin-induced urticaria is a post from: Skincare
A functional promoter polymorphism of the human IL-18 gene is associated with aspirin-induced urticaria via BuzzBlazer.com
No comments:
Post a Comment