Background: Information concerning cross-reactivity among metal-allergens is scarce. We previously devised a murine metal-allergy model using lipopolysaccharide (LPS) as an adjuvant. LPS reduces the minimum allergy-inducing concentration (MAIC) of metals at both the sensitization and elicitation steps.
Objectives: Here, we examined allergic cross-reactivity among some metals in this murine model, and compared the effects of ultra-pure (99.99% or more) and low-purity (93-99%) metal salts.
Methods: A mixture of a metal salt and E. coli LPS was injected intraperitoneally into BALB/c mice (0.25 mL/mouse). Ten days later, metal salts (with or without LPS) ...
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