Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

Abstract

Background:  Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT-induced immunosuppression leading to ineffective anti-tumour immune responses may be a factor in treatment failure.


Objective:  To examine the impact of topical PDT on leucocyte trafficking following clinical treatment of BCC.


Methods:  Superficial BCC in eight white Caucasian patients were treated with methyl aminolaevulinate (MAL)-PDT. Biopsies for immunohistochemical assessment were taken from BCC pre-PDT, 1h and 24h post-PDT and from untreated healthy skin.


Results:  Treatment of BCC with MAL-PDT produced a rapid neutrophil infiltration, commencing by 1h and ...

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