Wednesday, January 11, 2012

Peripheral Natural Killer cells exhibit qualitative and quantitative changes in psoriasis and atopic dermatitis patients

Summary

Background:  Psoriasis and atopic dermatitis are the most recurrent skin inflammatory disorders. Despite their distinct etiology and clinical aspects, these diseases share several immunological features. Besides the largely documented role of T cells, emerging literature supports a potential involvement of innate immune effectors, the Natural Killer (NK) cells, in both pathologies. In the peripheral blood, NK cells consist of CD3-CD56dim and CD3-CD56bright cell subsets, harboring distinct cell surface phenotype, but both endowed with the main NK cell effector functions: cytotoxicity and cytokine production.


Objectives:  We investigated whether the frequency, the cell ...

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