Estimation of tissue osteopontin levels before and after different traditional therapeutic modalities in psoriatic patients

Abstract

Background  Several lines of evidences support a major role for Th1 cells in psoriasis. Treatment of psoriasis with cyclosporine, methotrexate and psoralen plus ultraviolet A (PUVA) is associated with clinical improvement and decrease in epidermal hyperplasia. Osteopontin (OPN) exerts a T-helper type 1 (Th1) cytokine function, regulating inflammatory cell accumulation and function.


Objective  To detect the effects of methotrexate, cyclosporine and PUVA on OPN expression in psoriatic plaques, and whether these changes correlate with clinical response.


Methods  For three groups of psoriatic patients (each including 12 patients), the Psoriasis Area Severity Index ...

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