Wednesday, January 4, 2012

A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions

Abstract

Background  The usefulness of the drug patch testing for Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is still controversial. Recent studies have shown that HLA-B*1502 is strongly associated with CBZ-SJS/TEN in Chinese and Southeast Asian populations.


Objective  To evaluate the usefulness of patch tests for patients with carbamazepine (CBZ)-induced SJS, TEN and drug reaction with eosinophilia and systemic symptoms (DRESS) and the cross-reactivity in patch tests among the aromatic antiepileptic drugs.


Methods  We measure the frequency of positive patch test reactions and cross-sensitivity to structure-related aromatic anti-epileptic drugs (AEDs) for patients after ...

A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions is a post from: Skincare




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