Background: Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.
Objectives: Single nucleotide polymorphisms (GSTP1) and copy number variants (GSTM1 and GSTT1) may be candidate low-penetrance variants with a role in susceptibility to malignant melanoma (MM).
Methods: In this case-control study, 562 Spanish sporadic melanoma patients and 338 cancer-free control subjects were included, and the role of these GST polymorphisms was investigated. Genotypes were established by quantitative real time-PCR for GSTM1 ...
Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism. is a post from: Skincare
Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism. via BuzzBlazer.com
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