Background: There is increased expression of type I interferon (IFN)-regulated proteins in the blood and target tissues of patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). Patients with SLE have increased IFN-regulated gene expression pointing towards a possible underlying genetic defect.
Objectives: We measured expression levels of five type I IFN-regulated genes that are highly expressed in SLE in the peripheral blood of patients with CLE and correlated expression levels with cutaneous disease activity.
Methods: Peripheral blood was obtained from 10 healthy controls and 30 patients with CLE, including ...
The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score is a post from: Skincare
The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score via BuzzBlazer.com
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