Background Microphthalmia associated transcription factor (Mitf) is a key regulatory transcriptional factor of pigmentation-related genes including tyrosinase. Inhibition of tyrosinase transcription by blocking the binding of Mitf with its promoter E-box DNA can control the pigmentation. However, no such chemicals were reported so far.
Objective To discover and evaluate the small molecule inhibitors of Mitf-E-box DNA.
Methods Candidate chemicals were screened by virtual screening from pharmacophore data followed by Mitf E-box DNA protein chip. After selecting the chemical, its inhibitory activity on binding interaction between Mitf and E-box DNA, electrophoretic mobility shift ...
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells is a post from: Skincare
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