Practical experience of Ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland

Summary

Background:  There are limited data on the use of ustekinumab outside of clinical trials.


Objectives:  To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 Dermatology Centres in the UK and Ireland.


Methods:  A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab.


Results:  Baseline Psoriasis Area and Severity Index (PASI) was 22.9 ± 10.1 (mean ± SD). After 16 weeks’ treatment with ustekinumab PASI 75 (75% reduction in PASI) was observed in 63.0% (n=80/127) of patients, although 4 patients required concomitant therapy at the 16 ...

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