Thursday, September 29, 2011

Associations between eNOS polymorphisms and susceptibility to Behcet’s disease: a meta-analysis

Abstract

Objective  To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet’s disease (BD).


Methods  A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model.


Results  A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one ...

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