Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis

Abstract

Background:  Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by keratinocyte apoptosis and necrosis, resulting in epidermal detachment. Although monocytes abundantly infiltrate the epidermis in SJS/TEN skin lesions, the properties and functions of these cells have not been fully examined.


Objectives:  To determine the properties of monocytes infiltrating into the epidermis in SJS/TEN.


Methods:  Immunostaining of skin sections was performed to examine the membrane markers of monocytes infiltrating into skin lesions.


Results:  Immunostaining of cryo-sections from 11 SJS/TEN skin lesions revealed numerous CD14+ monocytes located along the dermo-epidermal junction and throughout ...

Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis is a post from: Skincare

Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis via BuzzBlazer.com