Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure?

Abstract

Background  Cutaneous granulomas after a soft filler injection represent one of the worst scenarios for both patient and injector.


Objectives  To present clinical and histopathological features of granulomatous nodular reactions induced by a new alginate-based dermal filler (Novabel®), and put it in context of the process of injectable soft tissue fillers approval and promotion in the EU.


Methods  A case series of four patients injected with Novabel® for volume restoration of the face and hands, who developed severe foreign body reactions.


Results  Four patients injected with Novabel® into tear troughs and/or dorsa of ...

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