Background: Porphyria cutanea tarda (PCT), the most frequent type of porphyria, results from decreased uroporphyrinogen decarboxylase (UROD) activity. Two forms of PCT are described: a familial form (fPCT) characterized by inherited decrease of UROD activity in all tissues and a sporadic form (sPCT) characterized by decreased UROD activity in the liver. Cytochrome P450 (CYP1A2) plays a major role in triggering experimental uroporphyria in rodents. It has been suggested that the highly inducible -163A/A genotype of the CYP1A2 gene could confer a heightened risk of porphyria cutanea tarda in patients.
Objectives: To ...
Comprehensive cytochrome P450 CYP1A2 gene analysis in French Caucasian familial and sporadic porphyria cutanea tarda patients is a post from: Skincare
Comprehensive cytochrome P450 CYP1A2 gene analysis in French Caucasian familial and sporadic porphyria cutanea tarda patients via BuzzBlazer.com
No comments:
Post a Comment