Background: Alopecia areata (AA) is a hair loss disease caused by T cell-mediated autoimmune reactions against anagen stage hair follicles. Although the exact etiology is poorly understood, there is evidence to suggest that both genetic and environmental factors are involved in AA pathogenesis.
Objectives: To analyze DNA methylation and histone modification patterns in peripheral blood mononuclear cells (PBMCs) of patients with AA.
Methods: PBMC samples were obtained from 25 patients with AA and 20 healthy controls. Global DNA methylcytosine levels, as well as histone acetylation and methylation levels were measured by enzyme-linked ...
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