Is drug allergy less prevalent than previously assumed? A 5-year analysis

Abstract

Background:  Rashes are a frequent conundrum in clinical practice since they may be reactive, drug-induced or disease-specific. Identification of the culprit drug is important since re-exposure may be harmful or even life-threatening and unnecessary avoidance of ‘innocent’ drugs leads to limitations of treatment options.


Objective:  To objectify the cause of suspected cutaneous drug reactions in a larger patient population.


Method:  Over the past 5 years, 612 patients with suspected cutaneous drug reactions were evaluated. Histology was assessed as indicated. About 200 patients were invited for complete work-up with skin tests (prick/intracutaneous testing ...

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