Alopecia as a rare but distinct manifestation of pemphigus vulgaris

Abstract

Background  Pemphigus vulgaris (PV) patients may develop scalp erosions, however, the development of alopecia has been reported to be extremely rare.


Objective  To delineate the clinicopathological features of alopecia in PV and provide insight into the pathogenesis of this rarely observed manifestation.


Methods  A retrospective case note review was performed on five PV patients presenting with progressive hair loss and alopecic patches. Data were collected on demographics and clinical findings. Results for hair pull tests, direct immunofluorescence study of plucked hairs, established laboratory tests to detect anti-desmoglein 1 and 3 autoantibodies and ...

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