Analyses of CDC2L1 gene mutations in keloid tissue

Summary

Background.  Keloid disease is the result of a deregulated wound-healing process. Loss of heterozygosity on chromosome 1p36 has been shown to be associated with keloid formation in humans. The cell division cycle 2-like 1 (CDC2L1) gene is known to be essential for eukaryotic cell-cycle control, and has also been mapped to 1p36.


Aim.  To verify the possible association between keloid disease and somatic mutation of the CDC2L1 gene on chromosome 1p36.


Methods.  Mutations of the CDC2L1 gene in keloid and healthy skin tissues were screened by denaturing high-performance liquid chromatography, and confirmed ...

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