Miniature swine model of phototoxicity testing

Summary

Background/Purpose

This study determined the threshold doses for ‘solar erythema’ and for phototoxic responses to 8-methoxypsoralen (8-MOP) in white skin Hanford and grey skin Yucatan miniature swine.



Methods

For threshold erythema determinations, the UVR exposures included both UVA (315–400 nm) and UVB (290–315 nm) radiation by positioning one fluorescent ‘sunlamp’ among 10 ‘PUVA’ lamps. With this configuration the UVR exposures ranged from 0.5–2.8 times the ‘instrumental MED’ (MEDi) for Hanford and from 1.0–5.6 times the MEDi for Yucatan. For phototoxicity determinations (i.e., with and without topically-applied graduated concentrations of 8-MOP), the UVB component was minimized ...

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