FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis

Abstract

Background:  Benign lichenoid keratoses (BLK) are solitary skin lesions which have been proposed to represent a regressive form of pre-existent epidermal tumors such as solar lentigo or seborrheic keratosis. However, the genetic basis of BLK is unknown.


Objectives: FGFR3, PIK3CA and RAS mutations have been shown to be involved in the pathogenesis of seborrheic keratosis and solar lentigo. We thus investigated whether these mutations are also present in BLK.


Methods:  After manual microdissection and DNA isolation, 52 BLK were screened for FGFR3, PIK3CA and RAS hotspot mutations using SNaPshot® multiplex assays.


Results:  We identified ...

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