Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa.

Abstract

Background:  The cause of follicular occlusion, a key early event in the pathogenesis of hidradenitis suppurativa (HS), also known as acne inversa, remains unknown.


Objectives:  To identify changes, if any, in the antimicrobial peptide (AMP) and cytokine expression profile of HS affected human skin.


Methods:  Quantitative immunohistomorphometry was used to compare the in situ protein expression of selected AMPs and cytokines in lesional HS skin from 18 patients with that in healthy skin (n=12). The lesional skin from patients with HS was histologically sub-classified based on the predominance of inflammation versus scarring.


Results:  ...

Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa. is a post from: Skincare

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