Monday, April 4, 2011

Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch

Summary

Background:  Psoriasis is a complex, multifactorial inflammatory skin disease with genetic and environmental interactions. Patients with psoriasis exhibit erythematous plaques with itch, but the mechanisms of psoriatic itch are poorly understood.


Objectives:  This study was performed to investigate epidermal nerve density and opioid receptor levels in psoriatic skin with or without itch.


Methods:  Twenty-four patients suffering from psoriasis aged between 39 and 82 years old were included in this study. The number of epidermal nerve fibres, the levels of semaphorin 3A (Sema3A) and the expression patterns of μ- and κ-opioid systems were ...

Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch is a post from: Skincare




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