EDNRB gene variants and melanoma risk in two southern European populations

Summary

Background. EDNRB gene variants were reported to be associated with melanoma risk in French patients, with the S305N variant showing the highest frequency.


Aim.  To verify the S305N association with melanoma risk in an independent larger French population (378 patients, 389 controls); to investigate the role of EDNRB variants in melanoma risk in an Italian population (133 patients, 118 controls); and to explore the association of CDKN2A or CDK4 mutations with the S305N EDNRB variant in a subgroup of patients (59 French, 12 Italian) with a suspected hereditary predisposition to melanoma (familial ...

EDNRB gene variants and melanoma risk in two southern European populations is a post from: Skincare

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