Background Eczema lesions are characterized by impaired expression of antimicrobial peptides such as cathelicidin, which play crucial roles in the innate immune defence against cutaneous infections. LL-37 corresponds to amino acids 134–170 of human cathelicidin and is a multifunctional host defence molecule essential for normal immune responses to infection and tissue injury.
Objectives The aim of this study was to investigate the relationship between childhood eczema and circulating LL-37 levels.
Methods One hundred and forty-four eczema children and 36 controls were recruited. Eczema severity was assessed by SCORing Atopic Dermatitis (SCORAD) and ...
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