Electrochemotherapy of Cutaneous Metastases of Melanoma—A Case Series Study and Systematic Review of the Evidence

OBJECTIVES
Electrochemotherapy (ECT) is a novel therapeutic option for the treatment of cutaneous and subcutaneous metastases of malignant melanoma. During the treatment, electric pulses are applied to tumor nodules to deliver nonpermeant or poorly permeant chemotherapeutic agents into the cells, increasing local cytotoxicity of anticancer drugs. We compared the clinical effectiveness of ECT as an alternative palliative treatment option for unresectable metastatic lesions of malignant melanoma with a systematic review of reported outcomes.


METHODS
One hundred fifty-eight cutaneous and subcutaneous metastases of nine patients were treated with ECT. All treatments were ...

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