Purpose: The objective of the present study was to assess the effect of sonophoresis on the permeation rate of peptide dendrimers through human skin.
Methods: Peptide dendrimers containing arginine and histidine as terminal amino acids and having varying positive charges (arginine group: R4, R8 and R16 dendrimers, having 4+, 8+ and 16+ charges, respectively; histidine group: H4, H8 and H16 dendrimers, having 4+, 8+ and 16+ charges, respectively) were synthesized by Fmoc solid-phase peptide synthesis. The in vitro skin permeation studies were conducted using vertical-type diffusion cells and ultrasound ...
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