Background. Multipotent cells can be isolated from dermis, and have wound-healing and antioxidant effects on human and murine skin.
Aim. To investigate the changes in aged dermis after injection of dermal multipotent cells and adult fibroblasts.
Methods. Dermal multipotent cells were isolated and cultured from 3-day-old BALB/c mice by a regular dermal fibroblast culture system. We used various inducers to confirm the multilineage differentiation of these cells, then the dermal multipotent cells were transplanted into the dermis of aged (12-week-old) BALB/c mice. At 2 and 4 weeks after transplantation, we examined dermal thickness, ...
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