Background Knowledge on the underlying mechanisms for non-healing chronic wounds is fragmentary. Objective To increase our understanding of the pathogenesis the relationship between healing ability and a large panel of proteins was studied using a specially designed wound-healing antibody-based microarray. Methods Wound fluids from non-diabetic patients with non-healing venous leg ulcers were compared with those from patients with healing open granulating acute wounds. The high-throughput method enabled simultaneous measurement of the relative levels of 48 different proteins representing major categories of wound-healing modulators. Results Unexpectedly several of the examined proteins including various pro-inflammatory cytokines, ...
S100A8/A9 deficiency in non-healing venous leg ulcers uncovered by multiplexed antibody microarray profiling is a post from: Skincare
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