Inherited ichthyoses are rare genodermatoses caused by mutations in the genes involved in epidermal development. Although there have been case reports on ichthyosis patients who developed skin malignancies, it is still unknown whether ichthyosis patients have an increased risk of skin malignancies. Here, we review case series of skin malignancies in ichthyosis patients and show biological findings which might lead to cancer susceptibility. A survey of the literature found 28 cases of inherited ichthyoses with skin malignancy, including 12 cases of keratitis-ichthyosis-deafness (KID) syndrome, 7 of autosomal recessive congenital ichthyosis, ...
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