A comparison of in vitro and in vivo characteristics of tumor cells derived from patients with mucosal melanoma treated with imatinib was performed with respect to KIT mutations.
Three patients with mucosal melanoma were treated with imatinib. Patient derived tumor material was used to establish melanoma cell cultures ex vivo. We evaluated tumor material and cell cultures for KIT protein expression and KIT mutation status. In addition, proliferation assays with melanoma cell cultures were performed with imatinib.
Expression of KIT protein and KIT mutation was shown in two patients that responded to ...
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