Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris – A multicenter, randomised, double-blind controlled study

Abstract

Background:  Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris.


Objectives:  To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0.1%-BPO 2.5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris.


Methods:  378 subjects were randomised in a double-blind controlled trial to receive once daily lymecycline with either A/BPO or vehicle for 12 weeks. Evaluations included ...

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