Background. Numerous molecular events have been associated with the development of malignant melanoma (MM). The cellular FLICE-like inhibitory protein (c-FLIP) was originally identified as an inhibitor of death-receptor signalling through competition with FADD-like interleukin-1β-converting enzyme (FLICE; also known as caspase-8) for recruitment to the FAS-associated death domain (FADD), and it has been suggested recently that c-FLIP is required for the survival and proliferation of various cell types.
Aim. To investigate the relationship of c-FLIP expression with the clinicopathological features of MM.
Methods. Immunohistochemical staining with anti-c-FLIP antibody was performed on tissue samples ...
Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease is a post from: Skincare
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