Dermal uptake study with 4,4′-diphenylmethane diisocyanate led to active sensitization

Background. To investigate the dermal uptake of 4,4′-diphenylmethane diisocyanate (4,4′-MDI), a study was performed in which 2 female volunteers were exposed to 10 and 25 mg, respectively, of 4,4′-MDI by applying 2.0% 4,4′-MDI in petrolatum over areas where the surface concentration corresponded to 800 µg/cm2. Ten days later, they developed eczematous dermatitis at the area of application.


Objectives. To investigate whether the dermal application caused active sensitization to 4,4′-MDI.


Methods. Chemical analysis of the 4,4′-MDI preparation used in the application and the amount of 4,4′-MDI not absorbed by the skin was performed ...

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