Background Former studies have shown that Propionibacterium acnes may stimulate expression of toll-like receptor 4 (TLR4) in keratinocytes of patients with acne vulgaris.
Objective To investigate the impact of single nucleotide polumorphisms (SNPs) of the TLR4 gene in acne vulgaris.
Methods Genomic DNA was isolated from 191 patients with acne vulgaris and 75 healthy controls. Asp299Gly and Thr399Ile SNPs were defined after cutting of the PCR products by restriction enzymes. Sebum of lesions was cultured for P. acnes.
Results No differences in SNP allele frequencies were found between patients and healthy controls. 46.5% ...
Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata is a post from: Skincare
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