Ustekinumab in clinical practice: response depends on dose and previous treatment

Abstract

Objectives  To evaluate the efficacy of ustekinumab in a series of patients with moderate to severe psoriasis treated according to the European Medicines Agency (EMA) label and to identify factors such as dose, baseline PASI or previous treatment potentially related to therapeutic outcome.


Methods  Retrospective review of the clinical records from 36 consecutive patients treated with ustekinumab during at least 36 weeks at a single referral center. Candidates for treatment had a PASI ≥ 10 or a BSA ≥ 10 and either failure to respond to, or a contraindication to, or intolerance to some systemic ...

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